desmethylcyproheptadine has been researched along with cyproheptadine in 7 studies
| Studies (desmethylcyproheptadine) | Trials (desmethylcyproheptadine) | Recent Studies (post-2010) (desmethylcyproheptadine) | Studies (cyproheptadine) | Trials (cyproheptadine) | Recent Studies (post-2010) (cyproheptadine) |
|---|---|---|---|---|---|
| 8 | 0 | 0 | 2,297 | 262 | 201 |
| Protein | Taxonomy | desmethylcyproheptadine (IC50) | cyproheptadine (IC50) |
|---|---|---|---|
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | 0.0024 | |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | 0.564 | |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | 0.035 | |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | 0.016 | |
| 5-hydroxytryptamine receptor 2C | Rattus norvegicus (Norway rat) | 0.0031 | |
| Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | 0.0038 | |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | 0.283 | |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | 0.016 | |
| D(2) dopamine receptor | Homo sapiens (human) | 0.164 | |
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | 0.0031 | |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | 0.038 | |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | 1.275 | |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | 0.122 | |
| Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | 0.046 | |
| D(1A) dopamine receptor | Homo sapiens (human) | 0.158 | |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | 0.564 | |
| Histamine H2 receptor | Homo sapiens (human) | 0.198 | |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | 0.107 | |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | 0.001 | |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | 0.0024 | |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | 0.122 | |
| 5-hydroxytryptamine receptor 2B | Rattus norvegicus (Norway rat) | 0.0031 | |
| Histamine H1 receptor | Homo sapiens (human) | 0.0037 | |
| D(3) dopamine receptor | Homo sapiens (human) | 0.048 | |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | 0.0094 | |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | 0.281 | |
| D(2) dopamine receptor | Rattus norvegicus (Norway rat) | 0.14 | |
| Histone-lysine N-methyltransferase SETD7 | Homo sapiens (human) | 2.2 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (71.43) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fujii, Y; Iwaki, M; Ogiso, T; Tanino, T; Yamashita, K | 1 |
| Chatterjee, AK; Fischer, LJ; Varayotha, V | 1 |
| Chow, SA; Falany, JL; Fischer, LJ | 1 |
| Chow, SA; Fischer, LJ; Rickert, DE | 1 |
| Chow, SA; Fischer, LJ | 1 |
| Bons, EG; Hackeng, WH; Lamberts, SW; Uitterlinden, P | 1 |
| Bons, EG; Lamberts, SW; Oosterom, R; Uitterlinden, P; Verleun, T | 1 |
7 other study(ies) available for desmethylcyproheptadine and cyproheptadine
| Article | Year |
|---|---|
Drug interaction between cyproheptadine and tipepidine. Effect of single and repeated administrations.
Topics: Administration, Oral; Aminopyrine N-Demethylase; Animals; Blood; Cyproheptadine; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Induction; Injections, Intravenous; Male; Microsomes, Liver; Piperidines; Rats; Rats, Inbred Strains | 1991 |
Interactions of diabetogenic compounds: cyproheptadine and alloxan.
Topics: Alloxan; Animals; Cyproheptadine; Diabetes Mellitus, Experimental; Drug Interactions; Insulin; Iodine Radioisotopes; Islets of Langerhans; Male; Mannoheptulose; Mice; Organ Culture Techniques | 1991 |
Cyproheptadine metabolites inhibit proinsulin and insulin biosynthesis and insulin release in isolated rat pancreatic islets.
Topics: Animals; Chromatography, High Pressure Liquid; Cyproheptadine; Female; Fetus; In Vitro Techniques; Insulin; Islets of Langerhans; Leucine; Male; Proinsulin; Protein Synthesis Inhibitors; Rats; Rats, Inbred Strains; Tritium | 1989 |
Evidence that drug metabolites are involved in cyproheptadine-induced loss of pancreatic insulin.
Topics: Animals; Cyproheptadine; Insulin; Liver; Lung; Male; Pancreas; Pyridines; Pyrimethamine; Rats; Rats, Inbred Strains | 1988 |
Susceptibility of fetal rat endocrine pancreas to the diabetogenic action of cyproheptadine.
Topics: Administration, Oral; Animals; Blood Glucose; Body Weight; Cyproheptadine; Female; Fetus; Glucagon; Insulin; Maternal-Fetal Exchange; Organ Size; Pancreas; Pregnancy; Radioimmunoassay; Rats; Rats, Inbred Strains | 1986 |
Cyproheptadine and desmethylcyproheptadine directly inhibit the release of adrenocorticotrophin and beta-lipotrophin/beta-endorphin activity from the neurointermediate lobe of the rat pituitary gland.
Topics: Adrenocorticotropic Hormone; Animals; beta-Endorphin; beta-Lipotropin; Cyproheptadine; Endorphins; Female; In Vitro Techniques; Pituitary Gland, Anterior; Pituitary Gland, Posterior; Rats; Rats, Inbred Strains; Serotonin | 1983 |
Effect of cyproheptadine, desmethylcyproheptadine, gamma-amino-butyric acid and sodium valproate on adrenocorticotrophin secretion by cultured pituitary tumour cells from three patients with Nelson's syndrome.
Topics: Adrenocorticotropic Hormone; Cyproheptadine; Female; gamma-Aminobutyric Acid; Humans; Nelson Syndrome; Pituitary Neoplasms; Serotonin; Valproic Acid | 1983 |