desmethylclomipramine and dixyrazine

desmethylclomipramine has been researched along with dixyrazine* in 1 studies

Trials

1 trial(s) available for desmethylclomipramine and dixyrazine

Article	Year
Increased antipanic efficacy in combined treatment with clomipramine and dixyrazine. Acta psychiatrica Scandinavica, 1994, Volume: 89, Issue:4 A double-blind 12 week trial was undertaken to compare the effects of clomipramine + dixyrazine with clomipramine + placebo in the treatment of panic disorder with or without agoraphobia. Of 45 patients included (21 dixyrazine, 24 placebo), 16 dropped out (6 dixyrazine, 10 placebo). The number of panic attacks and the scores on the panic disorder subscale of the Hamilton Anxiety Rating Scale were significantly reduced in response to both treatment regimens, but the reduction was significantly greater in the dixyrazine group. The patients' daily functioning was significantly more improved with the dixyrazine combination. The serum concentration of desmethylclomipramine monotherapy was significantly higher and the side effects significantly lower in the combined treatment with dixyrazine than with clomipramine monotherapy. Clomipramine combined with dixyrazine seems superior to clomipramine in the treatment of panic disorder. Topics: Adult; Ambulatory Care; Antipsychotic Agents; Clomipramine; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Panic Disorder; Phenothiazines; Placebos; Psychiatric Status Rating Scales; Stimulation, Chemical; Treatment Outcome	1994

Article

Year

Increased antipanic efficacy in combined treatment with clomipramine and dixyrazine.

Acta psychiatrica Scandinavica, 1994, Volume: 89, Issue:4

A double-blind 12 week trial was undertaken to compare the effects of clomipramine + dixyrazine with clomipramine + placebo in the treatment of panic disorder with or without agoraphobia. Of 45 patients included (21 dixyrazine, 24 placebo), 16 dropped out (6 dixyrazine, 10 placebo). The number of panic attacks and the scores on the panic disorder subscale of the Hamilton Anxiety Rating Scale were significantly reduced in response to both treatment regimens, but the reduction was significantly greater in the dixyrazine group. The patients' daily functioning was significantly more improved with the dixyrazine combination. The serum concentration of desmethylclomipramine monotherapy was significantly higher and the side effects significantly lower in the combined treatment with dixyrazine than with clomipramine monotherapy. Clomipramine combined with dixyrazine seems superior to clomipramine in the treatment of panic disorder.

Topics: Adult; Ambulatory Care; Antipsychotic Agents; Clomipramine; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Panic Disorder; Phenothiazines; Placebos; Psychiatric Status Rating Scales; Stimulation, Chemical; Treatment Outcome

1994