desmethylcarvedilol has been researched along with carvedilol in 5 studies
*Carvedilol: A carbazole and propanol derivative that acts as a non-cardioselective beta blocker and vasodilator. It has blocking activity for ALPHA 1 ADRENERGIC RECEPTORS and, at higher doses, may function as a blocker of CALCIUM CHANNELS; it also has antioxidant properties. Carvedilol is used in the treatment of HYPERTENSION; ANGINA PECTORIS; and HEART FAILURE. It can also reduce the risk of death following MYOCARDIAL INFARCTION. [MeSH]
*Carvedilol: A carbazole and propanol derivative that acts as a non-cardioselective beta blocker and vasodilator. It has blocking activity for ALPHA 1 ADRENERGIC RECEPTORS and, at higher doses, may function as a blocker of CALCIUM CHANNELS; it also has antioxidant properties. Carvedilol is used in the treatment of HYPERTENSION; ANGINA PECTORIS; and HEART FAILURE. It can also reduce the risk of death following MYOCARDIAL INFARCTION. [MeSH]
| Studies (desmethylcarvedilol) | Trials (desmethylcarvedilol) | Recent Studies (post-2010) (desmethylcarvedilol) | Studies (carvedilol) | Trials (carvedilol) | Recent Studies (post-2010) (carvedilol) |
|---|---|---|---|---|---|
| 5 | 0 | 2 | 2,933 | 680 | 1,052 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (40.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Back, TG; Chen, SR; Smith, CD; Vembaiyan, K; Wang, A; Wu, G; Xie, C; Zhang, J; Zhou, Q | 1 |
| Brei, R; Caspary, S; Harder, S; Merz, PG | 1 |
| Eisenberg, EJ; Kahn, GC; Patterson, WR | 1 |
| Reiff, K | 1 |
| Coelho, EB; Della Pasqua, O; Lanchote, VL; Nardotto, GHB | 1 |
5 other study(ies) available for desmethylcarvedilol and carvedilol
| Article | Year |
|---|---|
Novel carvedilol analogues that suppress store-overload-induced Ca2+ release.
Topics: Carbazoles; Carvedilol; Dose-Response Relationship, Drug; HEK293 Cells; Humans; Molecular Structure; Propanolamines; Ryanodine Receptor Calcium Release Channel; Structure-Activity Relationship | 2013 |
Interaction profile of carvedilol: investigations with digitoxin and phenprocoumon.
Topics: Biological Availability; Carbazoles; Carvedilol; Chromatography, High Pressure Liquid; Digitoxin; Drug Interactions; Humans; Phenprocoumon; Propanolamines; Vasodilator Agents | 1992 |
High-performance liquid chromatographic method for the simultaneous determination of the enantiomers of carvedilol and its O-desmethyl metabolite in human plasma after chiral derivatization.
Topics: Adrenergic beta-Antagonists; Carbazoles; Carvedilol; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Humans; Propanolamines; Spectrometry, Fluorescence; Stereoisomerism; Vasodilator Agents | 1989 |
High-performance liquid chromatographic method for the determination of carvedilol and its desmethyl metabolite in body fluids.
Topics: Adrenergic beta-Antagonists; Carbazoles; Carvedilol; Chromatography, High Pressure Liquid; Dealkylation; Humans; Propanolamines; Spectrometry, Fluorescence | 1987 |
Population pharmacokinetics of carvedilol enantiomers and their metabolites in healthy subjects and type-2 diabetes patients.
Topics: Adrenergic beta-Antagonists; Adult; Blood Glucose; Carbazoles; Carvedilol; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2C9 Inhibitors; Cytochrome P-450 CYP2D6; Diabetes Mellitus, Type 2; Female; Glyburide; Healthy Volunteers; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Propanolamines; Stereoisomerism | 2017 |