desmethylastemizole has been researched along with tecastemizole in 6 studies
| Studies (desmethylastemizole) | Trials (desmethylastemizole) | Recent Studies (post-2010) (desmethylastemizole) | Studies (tecastemizole) | Trials (tecastemizole) | Recent Studies (post-2010) (tecastemizole) |
|---|---|---|---|---|---|
| 12 | 1 | 2 | 18 | 0 | 3 |
| Protein | Taxonomy | desmethylastemizole (IC50) | tecastemizole (IC50) |
|---|---|---|---|
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | 0.028 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 4 (66.67) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Keserü, GM | 1 |
| Chen, X; Chong, CR; Liu, JO; Shi, L; Sullivan, DJ | 1 |
| Bianucci, AM; Calderone, V; Coi, A; Massarelli, I; Testai, L | 1 |
| Jia, L; Sun, H | 1 |
| Dalvit, C; Vulpetti, A | 1 |
| Gong, Q; January, CT; Vorperian, VR; Zhang, S; Zhou, Z | 1 |
6 other study(ies) available for desmethylastemizole and tecastemizole
| Article | Year |
|---|---|
Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods.
Topics: Cation Transport Proteins; Databases, Factual; Discriminant Analysis; Ether-A-Go-Go Potassium Channels; Holography; Linear Models; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship | 2003 |
A clinical drug library screen identifies astemizole as an antimalarial agent.
Topics: Animals; Antimalarials; Astemizole; Chloroquine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Resistance; Drug Resistance, Multiple; Humans; Mice; Plasmodium falciparum; Plasmodium yoelii | 2006 |
Identification of "toxicophoric" features for predicting drug-induced QT interval prolongation.
Topics: Amino Acid Sequence; Heart; Humans; Models, Molecular; Molecular Sequence Data; Molecular Structure; Protein Subunits; Sequence Alignment; Structure-Activity Relationship; Trans-Activators; Transcriptional Regulator ERG | 2008 |
Support vector machines classification of hERG liabilities based on atom types.
Topics: Animals; Arrhythmias, Cardiac; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Chemical; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Predictive Value of Tests; ROC Curve | 2008 |
Ligand-Based Fluorine NMR Screening: Principles and Applications in Drug Discovery Projects.
Topics: Drug Discovery; Fluorine; Ligands; Magnetic Resonance Spectroscopy; Protein Binding; Quality Control | 2019 |
Block of HERG potassium channels by the antihistamine astemizole and its metabolites desmethylastemizole and norastemizole.
Topics: Astemizole; Benzimidazoles; Cation Transport Proteins; Cell Line; DNA-Binding Proteins; Dose-Response Relationship, Drug; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Histamine H1 Antagonists; Humans; Piperidines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Terfenadine; Trans-Activators; Transcriptional Regulator ERG | 1999 |