desmethylastemizole has been researched along with astemizole in 10 studies
| Studies (desmethylastemizole) | Trials (desmethylastemizole) | Recent Studies (post-2010) (desmethylastemizole) | Studies (astemizole) | Trials (astemizole) | Recent Studies (post-2010) (astemizole) |
|---|---|---|---|---|---|
| 12 | 1 | 2 | 1,130 | 117 | 578 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (20.00) | 18.7374 |
| 1990's | 2 (20.00) | 18.2507 |
| 2000's | 5 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Janssen, M; Janssen, PA; Janssens, F; Luyckx, M; Stokbroekx, RA; Torremans, J | 1 |
| Keserü, GM | 1 |
| Chen, X; Chong, CR; Liu, JO; Shi, L; Sullivan, DJ | 1 |
| Bianucci, AM; Calderone, V; Coi, A; Massarelli, I; Testai, L | 1 |
| Jia, L; Sun, H | 1 |
| Chen, K; Ding, Y; Du, D; Duan, W; Fan, S; Jiang, H; Kong, X; Li, Y; Liu, J; Liu, Y; Luo, C; Luo, Z; Min, J; Stazi, G; Valente, S; Xu, D; Zhang, N; Zhang, Y; Zhao, K; Zhu, K; Zhu, L; Zwergel, C | 1 |
| Embrechts, L; Heykants, J; Woestenborghs, R | 1 |
| Hoon, TJ; January, CT; Mohammad, S; Studenik, C; Vorperian, VR; Zhou, Z | 1 |
| Gong, Q; January, CT; Vorperian, VR; Zhang, S; Zhou, Z | 1 |
| Hsieh, Y; Kang, L; Korfmacher, WA; Lachowicz, J; Li, F; Sondey, C | 1 |
10 other study(ies) available for desmethylastemizole and astemizole
| Article | Year |
|---|---|
New antihistaminic N-heterocyclic 4-piperidinamines. 2. Synthesis and antihistaminic activity of 1-[(4-fluorophenyl)methyl]-N-(4-piperidinyl)-1H-benzimidazol-2-a mines.
Topics: Administration, Oral; Animals; Astemizole; Benzimidazoles; Chemical Phenomena; Chemistry; Guinea Pigs; Histamine; Histamine Antagonists; Male; p-Methoxy-N-methylphenethylamine; Piperidines; Pupil; Rats; Rats, Inbred Strains; Serotonin; Skin Tests; Structure-Activity Relationship | 1985 |
Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods.
Topics: Cation Transport Proteins; Databases, Factual; Discriminant Analysis; Ether-A-Go-Go Potassium Channels; Holography; Linear Models; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship | 2003 |
A clinical drug library screen identifies astemizole as an antimalarial agent.
Topics: Animals; Antimalarials; Astemizole; Chloroquine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Resistance; Drug Resistance, Multiple; Humans; Mice; Plasmodium falciparum; Plasmodium yoelii | 2006 |
Identification of "toxicophoric" features for predicting drug-induced QT interval prolongation.
Topics: Amino Acid Sequence; Heart; Humans; Models, Molecular; Molecular Sequence Data; Molecular Structure; Protein Subunits; Sequence Alignment; Structure-Activity Relationship; Trans-Activators; Transcriptional Regulator ERG | 2008 |
Support vector machines classification of hERG liabilities based on atom types.
Topics: Animals; Arrhythmias, Cardiac; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Chemical; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Predictive Value of Tests; ROC Curve | 2008 |
Structure-Guided Development of Small-Molecule PRC2 Inhibitors Targeting EZH2-EED Interaction.
Topics: Astemizole; Cell Line, Tumor; Cell Proliferation; Drug Repositioning; Enhancer of Zeste Homolog 2 Protein; Enzyme Inhibitors; Humans; Molecular Docking Simulation; Molecular Structure; Polycomb Repressive Complex 2; Protein Binding; Structure-Activity Relationship | 2021 |
Simultaneous determination of astemizole and its demethylated metabolite in animal plasma and tissues by high-performance liquid chromatography.
Topics: Animals; Astemizole; Benzimidazoles; Chromatography, High Pressure Liquid; Dealkylation; Dogs; Humans; Kinetics; Male | 1983 |
Torsade de pointes with an antihistamine metabolite: potassium channel blockade with desmethylastemizole.
Topics: Aged; Aged, 80 and over; Animals; Astemizole; Electrocardiography; Female; Heart; Heart Arrest; Histamine H1 Antagonists; Humans; Potassium Channels; Rabbits; Torsades de Pointes | 1996 |
Block of HERG potassium channels by the antihistamine astemizole and its metabolites desmethylastemizole and norastemizole.
Topics: Astemizole; Benzimidazoles; Cation Transport Proteins; Cell Line; DNA-Binding Proteins; Dose-Response Relationship, Drug; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Histamine H1 Antagonists; Humans; Piperidines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Terfenadine; Trans-Activators; Transcriptional Regulator ERG | 1999 |
MALDI-tandem mass spectrometry imaging of astemizole and its primary metabolite in rat brain sections.
Topics: Animals; Astemizole; Brain Chemistry; Cerebral Ventricles; Chromatography, High Pressure Liquid; Diagnostic Imaging; Histamine H1 Antagonists, Non-Sedating; Rats; Spectrometry, Mass, Electrospray Ionization; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2009 |