desipramine and zimeldine

desipramine has been researched along with zimeldine in 88 studies

Research

Studies (88)

Timeframe	Studies, this research(%)	All Research%
pre-1990	63 (71.59)	18.7374
1990's	14 (15.91)	18.2507
2000's	6 (6.82)	29.6817
2010's	5 (5.68)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET	1
Högberg, T; Renyi, AL; Ross, SB; Ulff, B	1
Adkison, KK; Humphreys, JE; Mahar Doan, KM; Polli, JW; Serabjit-Singh, CJ; Shampine, LJ; Webster, LO; Wring, SA	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Glen, RC; Lowe, R; Mitchell, JB	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Jones, LH; Nadanaciva, S; Rana, P; Will, Y	1
Calil, HM; Extein, I; Goodwin, FK; Potter, WZ; Zavadil, AP	1
Goromaru, T; Hashimoto, K	1
Hole, K; Lund, A; Mjellem-Joly, N	1
Fujimoto, K; Ookuma, K; Sakata, T	1
Hole, K; Lund, A; Tjølsen, A	2
Schraven, E; Syha, K	1
Alterman, I; Insel, TR; Linnoila, M; Mueller, EA; Murphy, DL	1
Calil, HM; Cowdry, RW; Golden, RN; Linnoila, M; Potter, WZ; Ross, RJ; Rudorfer, MV; Scheinin, M	1
Chuang, LW; Karoum, F; Korpi, ER; Linnoila, M; Wyatt, RJ	2
Asnis, GM; Brown, SL; Kahn, R; Lemus, CZ; van Praag, HM	1
Hilakivi, I; Hilakivi, LA; Kiianmaa, K	1
Buckett, WR; Butler, SA; Heal, DJ; Hurst, EM	1
Cross, JA; Horton, RW; Kimber, JR	1
Godfrey, PP; Heal, DJ; McClue, SJ; Young, MM	1
Cross, JA; Horton, RW	1
Cooper, MM; Day, JS; Sethy, VH	1
Ballenger, JC; Gold, PW; Post, RM; Rubinow, DR	1
Cools, AR	1
Green, AR	1
Moyer, JA; Sigg, EB; Silver, PJ	1
Guthrie, S; Karoum, F; Lane, EA; Linnoila, M; Potter, WZ; Rudorfer, M	1
Kim, SS; Reith, ME	1
Coble, PA; Kupfer, DJ; Perel, JM; Pollock, B; Shipley, JA; Spiker, DG	1
Hilakivi, LA; Kiianmaa, K; Sinclair, JD; Stenberg, D	1
Hilakivi, I; Hilakivi, LA	1
Bäckström, IT; Marcusson, J; Ross, SB	1
Archer, T; Danysz, W; Hiltunen, AJ; Järbe, TU; Kostowski, W; Malatynska, E; Plaznik, A	1
Aberg-Wistedt, A; Bertilsson, L; Dumont, E; Lundström, J	1
Hilakivi, I; Hilakivi, LA; Loikas, P; Taira, T	1
Fernstrom, MH; Kupfer, DJ	1
Hilakivi, I; Hilakivi, LA; Taira, T	1
Archer, T; Danysz, W; Fowler, CJ	1
Brown, GM; Calil, HM; Gold, PW; Lesieur, P; Potter, WZ; Zavadil, AP	1
Aberg-Wistedt, A; Jostell, KG; Ross, SB; Sjöquist, B	2
Jones, RS; Olpe, HR	1
Bartko, J; Linnoila, M; Miller, TL; Potter, WZ	1
Calil, HM; Karoum, F; Kopin, IJ; Linnoila, M; Potter, WZ	1
Aberg-Wistedt, A	2
Prakash, R	1
Kupfer, D	1
Karoum, F; Linnoila, M; Potter, WZ; Rosenthal, N	1
Bratfos, O; Bratlid, T; Haug, JO; Lingjaerde, O	1
Karoum, F; Linnoila, M; Potter, WZ	2
Harms, HH	1
Buchsbaum, M; Dubyoski, T; Johnson, J; Linnoila, M; Potter, WZ; Ross, R; Weingartner, H	1
Lingjaerde, O	1
Archer, T; Minor, BG; Ross, SB	1
Agnati, LF; Benfenati, F; Fuxe, K; Ogren, SO	1
Goodwin, GM; Green, AR; Johnson, P	1
Meyerson, BJ; Smith, LA	1
Buchsbaum, MS; Dubyoski, K; Johnson, J; Kilts, C; Linnoila, M; Schneinin, M	1
Agnati, LF; Andersson, K; Eneroth, P; Fuxe, K; Ogren, SO	1
Scuvée-Moreau, JJ; Svensson, TH	1
Agnati, LF; Calza, L; Fuxe, K; Ogren, SO	1
Hall, H; Ross, SB; Sällemark, M	1
Holm, AC; Ogren, SO	1
Calil, HM; Extein, I; Gold, PW; Goodwin, FK; Potter, WZ; Wehr, TA	1
Aberg, A	1
Calil, HM; Extein, I; Goodwin, FK; Muscettola, G; Potter, WZ	1
Aberg-Wistedt, A; Jostell, KG; Ross, SB; Westerlund, D	1
Archer, T; Fuxe, K; Hall, H; Holm, AC; Köhler, C; Ogren, SO	1
Hilakivi, I	1
Hornby, PJ; Paul, D	1
Borowski, TB; Kirkby, RD; Kokkinidis, L	1
Alhaider, AA; Mustafa, AA	1
Ahtee, L; Attila, LM; Hilakivi, I; Marjamaki, P; Rinne, JO; Taira, T	1
Frank, MG; Heller, HC	1
Frank, MG; Heller, HC; Page, J	1
Chen, JX; Gershon, MD; Pan, H; Rothman, TP; Wade, PR	1
Esteban, S; García-Sevilla, JA; Lladó, J; Sastre-Coll, A	1
Ignatowski, TA; Nickola, TJ; Spengler, RN	1
Cassella, JV; Coverdale, S; Hoffman, DC; Kehne, JH; McCloskey, TC	1
Ignatowski, TA; Nickola, TJ; Reynolds, JL; Spengler, RN	1
Guimarães, FS; Joca, SR; Zanelati, T	1

Reviews

3 review(s) available for desipramine and zimeldine

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Evolving concepts on the interactions between antidepressant treatments and monoamine neurotransmitters. Neuropharmacology, 1987, Volume: 26, Issue:7B Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antidepressive Agents; Body Temperature Regulation; Brain Chemistry; Cerebral Cortex; Clonidine; Desipramine; Drug Interactions; Electroshock; Neurons; Neurotransmitter Agents; Receptors, Adrenergic, beta; Receptors, GABA-A; Receptors, Serotonin; Serotonin; Tetrahydronaphthalenes; Zimeldine	1987
Central 5-HT neurons as targets for antidepressant drug action: differential modulation of 5-HT receptor populations in the central nervous system of the rat. Advances in biochemical psychopharmacology, 1984, Volume: 39 Topics: Animals; Antidepressive Agents; Autoradiography; Avoidance Learning; Binding Sites; Central Nervous System; Desipramine; Histocytochemistry; Imipramine; Immunochemistry; Methoxydimethyltryptamines; Movement; Rats; Receptors, Serotonin; Spiperone; Zimeldine	1984

Trials

17 trial(s) available for desipramine and zimeldine

Article	Year
Comparative pharmacokinetics of zimelidine and desipramine in man following acute and chronic administration. Psychiatry research, 1979, Volume: 1, Issue:3 Topics: Adolescent; Adult; Affective Disorders, Psychotic; Aged; Antidepressive Agents; Brompheniramine; Desipramine; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Male; Middle Aged; Pyridines; Zimeldine	1979
Obsessive-compulsive disorder and serotonin: is there a connection? Biological psychiatry, 1985, Volume: 20, Issue:11 Topics: Adult; Blood Platelets; Central Nervous System; Clinical Trials as Topic; Desipramine; Female; Humans; Hydroxyindoleacetic Acid; Male; Obsessive-Compulsive Disorder; Serotonin; Zimeldine	1985
Selective antidepressants and cerebrospinal fluid. Lack of specificity on norepinephrine and serotonin metabolites. Archives of general psychiatry, 1985, Volume: 42, Issue:12 Topics: Adolescent; Adult; Aged; Bipolar Disorder; Clorgyline; Depressive Disorder; Desipramine; Female; Glycols; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Male; Methoxyhydroxyphenylglycol; Middle Aged; Norepinephrine; Propylamines; Serotonin; Zimeldine	1985
Antidepressant-induced weight gain: a comparison study of four medications. Psychiatry research, 1988, Volume: 26, Issue:3 Topics: Adult; Amitriptyline; Antidepressive Agents; Depressive Disorder; Desipramine; Female; Humans; Male; Middle Aged; Nortriptyline; Weight Gain; Zimeldine	1988
Hormonal responses to zimelidine and desipramine in depressed patients. Psychiatry research, 1984, Volume: 13, Issue:3 Topics: Adolescent; Adult; Aged; Brain; Clinical Trials as Topic; Depressive Disorder; Desipramine; Double-Blind Method; Female; Growth Hormone; Humans; Hydrocortisone; Luteinizing Hormone; Male; Middle Aged; Prolactin; Receptors, Adrenergic; Receptors, Serotonin; Zimeldine	1984
Five antidepressant treatments in depressed patients. Effects on urinary serotonin and 5-hydroxyindoleacetic acid output. Archives of general psychiatry, 1984, Volume: 41, Issue:7 Topics: Antidepressive Agents; Clorgyline; Depressive Disorder; Desipramine; Electroconvulsive Therapy; Female; Humans; Hydroxyindoleacetic Acid; Lithium; Lithium Carbonate; Male; Middle Aged; Placebos; Serotonin; Zimeldine	1984
A double-blind study of zimelidine, a serotonin uptake inhibitor, and desipramine, a norepinephrine uptake inhibitor, in endogenous depression: clinical and biochemical findings. Advances in biochemical psychopharmacology, 1984, Volume: 39 Topics: Adult; Aged; Clinical Trials as Topic; Depressive Disorder; Desipramine; Female; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Male; Methoxyhydroxyphenylglycol; Middle Aged; Zimeldine	1984
Alteration of norepinephrine metabolism with desipramine and zimelidine in depressed patients. Archives of general psychiatry, 1982, Volume: 39, Issue:9 Topics: Antidepressive Agents; Brain; Brompheniramine; Depressive Disorder; Desipramine; Female; Humans; Male; Methoxyhydroxyphenylglycol; Middle Aged; Norepinephrine; Normetanephrine; Pyridines; Vanilmandelic Acid; Zimeldine	1982
A double-blind study of zimelidine, a serotonin uptake inhibitor, and desipramine, a noradrenaline uptake inhibitor, in endogenous depression. I. Clinical findings. Acta psychiatrica Scandinavica, 1982, Volume: 66, Issue:1 Topics: Adult; Aged; Antidepressive Agents; Bipolar Disorder; Brompheniramine; Depressive Disorder; Desipramine; Double-Blind Method; Female; Humans; Male; Middle Aged; Norepinephrine; Psychiatric Status Rating Scales; Pyridines; Serotonin; Zimeldine	1982
Evaluation of role of the biogenic amines in affective illness: a clinical strategy. Medical hypotheses, 1982, Volume: 9, Issue:1 Topics: Antidepressive Agents; Biogenic Amines; Brompheniramine; Clinical Trials as Topic; Desipramine; Humans; Mood Disorders; Zimeldine	1982
Comparison between zimelidine and desipramine in endogenous depression. A cross-over study. Acta psychiatrica Scandinavica, 1982, Volume: 66, Issue:2 Topics: Antidepressive Agents; Bipolar Disorder; Brompheniramine; Depressive Disorder; Desipramine; Double-Blind Method; Female; Humans; Male; Middle Aged; Norepinephrine; Pyridines; Serotonin; Zimeldine	1982
A double-blind comparison of zimelidine and desipramine in endogenous depression. Acta psychiatrica Scandinavica, 1983, Volume: 68, Issue:1 Topics: Adolescent; Adult; Aged; Brompheniramine; Depressive Disorder; Desipramine; Double-Blind Method; Female; Humans; Male; Middle Aged; Psychiatric Status Rating Scales; Pyridines; Serotonin; Zimeldine	1983
Effects of antidepressant treatments on dopamine turnover in depressed patients. Archives of general psychiatry, 1983, Volume: 40, Issue:9 Topics: 3,4-Dihydroxyphenylacetic Acid; Adult; Antidepressive Agents; Bipolar Disorder; Brompheniramine; Clorgyline; Depressive Disorder; Desipramine; Dopamine; Electroconvulsive Therapy; Female; Homovanillic Acid; Humans; Male; Middle Aged; Zimeldine	1983
Platelet serotonin uptake inhibition as a basis for monitoring antidepressant drug treatment. Journal of clinical psychopharmacology, 1984, Volume: 4, Issue:2 Topics: Adult; Aged; Blood Platelets; Depressive Disorder; Desipramine; Female; Humans; Kinetics; Male; Middle Aged; Serotonin; Zimeldine	1984
Controlled cross-over study of a 5-HT uptake inhibiting and an NA uptake inhibiting antidepressant. Acta psychiatrica Scandinavica. Supplementum, 1981, Volume: 290 Topics: Antidepressive Agents; Brompheniramine; Depressive Disorder; Desipramine; Female; Humans; Male; Norepinephrine; Psychiatric Status Rating Scales; Serotonin Antagonists; Zimeldine	1981
Crossover study of zimelidine and desipramine in depression: evidence for amine specificity [proceedings]. Psychopharmacology bulletin, 1981, Volume: 17, Issue:1 Topics: Brompheniramine; Clinical Trials as Topic; Depressive Disorder; Desipramine; Double-Blind Method; Humans; Pyridines; Time Factors; Zimeldine	1981
Effects of zimelidine and desipramine on serotonin and noradrenaline uptake mechanisms in relation to plasma concentrations and to therapeutic effects during treatment of depression. Psychopharmacology, 1981, Volume: 74, Issue:4 Topics: Animals; Antidepressive Agents; Blood Platelets; Brompheniramine; Depressive Disorder; Desipramine; Female; Humans; In Vitro Techniques; Male; Norepinephrine; Pyridines; Rats; Serotonin; Synaptosomes; Zimeldine	1981

Other Studies

68 other study(ies) available for desipramine and zimeldine

Article	Year
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs. Journal of medicinal chemistry, 1985, Volume: 28, Issue:3 Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium	1985
Synthesis of pyridylallylamines related to zimelidine and their inhibition of neuronal monoamine uptake. Journal of medicinal chemistry, 1981, Volume: 24, Issue:12 Topics: Animals; Biogenic Amines; Brain; Brompheniramine; Chemical Phenomena; Chemistry; In Vitro Techniques; Male; Mice; Molecular Conformation; Neurons; Norepinephrine; Pyridines; Serotonin; Structure-Activity Relationship; Zimeldine	1981
Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs. The Journal of pharmacology and experimental therapeutics, 2002, Volume: 303, Issue:3 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Cell Line; Cell Membrane Permeability; Central Nervous System Agents; Dogs; Drug Delivery Systems; Permeability; Pharmaceutical Preparations	2002
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Predicting phospholipidosis using machine learning. Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5 Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine	2010
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships. Bioorganic & medicinal chemistry letters, 2016, 08-15, Volume: 26, Issue:16 Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone	2016
High-affinity [3H]6-nitroquipazine binding to the 5-hydroxytryptamine transport system in rat lung. Biochemical pharmacology, 1991, Jun-01, Volume: 41, Issue:11 Topics: Animals; Biological Transport; Desipramine; Imipramine; Kinetics; Lung; Male; Maprotiline; Membranes; Quipazine; Rats; Rats, Inbred Strains; Serotonin; Stereoisomerism; Temperature; Tritium; Zimeldine	1991
Chronic administration of desipramine and zimelidine changes the behavioural response in the formalin test in rats. Neuropharmacology, 1991, Volume: 30, Issue:5 Topics: Animals; Behavior, Animal; Body Temperature; Body Weight; Desipramine; Drinking; Male; Pain Measurement; Rats; Rats, Inbred Strains; Reaction Time; Skin Temperature; Zimeldine	1991
Evidence for feeding elicited through antihistaminergic effects of tricyclic antidepressants in the rat hypothalamus. Psychopharmacology, 1990, Volume: 101, Issue:4 Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Desipramine; Doxepin; Drinking; Eating; Histamine H1 Antagonists; Hypothalamus; Imipramine; Injections, Intraventricular; Male; Methylhistidines; Microinjections; Rats; Rats, Inbred Strains; Zimeldine	1990
Antinociceptive effect of intrathecally-administered desipramine and zimelidine in rats. Neuropharmacology, 1990, Volume: 29, Issue:9 Topics: Analgesics; Animals; Desipramine; Injections, Spinal; Male; Rats; Rats, Inbred Strains; Reaction Time; Temperature; Zimeldine	1990
Effects of a chronic administration of the new antidepressant pirlindole on biogenic amine receptors in rat prefrontal cortex and hippocampus. Comparison with desipramine, nomifensine and zimelidine. Arzneimittel-Forschung, 1990, Volume: 40, Issue:8 Topics: Animals; Antidepressive Agents; Biogenic Monoamines; Carbazoles; Cerebral Cortex; Desipramine; Hippocampus; Kinetics; Male; Nomifensine; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Neurotransmitter; Receptors, Serotonin; Thermodynamics; Zimeldine	1990
The effects of desipramine, zimelidine, electroconvulsive treatment and lithium on rat brain biogenic amines: a comparison with peripheral changes. European journal of pharmacology, 1986, Mar-04, Volume: 121, Issue:3 Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Biogenic Amines; Brain; Catecholamines; Desipramine; Electroshock; Homovanillic Acid; Hydroxyindoleacetic Acid; Lithium; Male; Methoxyhydroxyphenylglycol; Rats; Rats, Inbred Strains; Serotonin; Zimeldine	1986
Therapeutic indications for serotonin-potentiating compounds: a hypothesis. Biological psychiatry, 1987, Volume: 22, Issue:2 Topics: 5-Hydroxytryptophan; Aggression; Antidepressive Agents; Anxiety; Brain; Depressive Disorder; Desipramine; Humans; Hydroxyindoleacetic Acid; Norepinephrine; Serotonin; Zimeldine	1987
Neonatal antidepressant administration suppresses concurrent active (REM) sleep and increases adult alcohol consumption in rats. Alcohol and alcoholism (Oxford, Oxfordshire). Supplement, 1987, Volume: 1 Topics: 3,4-Dihydroxyphenylacetic Acid; Alcohol Drinking; Animals; Animals, Newborn; Brain Chemistry; Desipramine; Dopamine; Homovanillic Acid; Hydroxyindoleacetic Acid; Male; Nomifensine; Norepinephrine; Rats; Rats, Inbred Strains; Serotonin; Sleep, REM; Zimeldine	1987
The apparent antinociceptive effect of desipramine and zimelidine in the tail flick test in rats is mainly caused by changes in tail skin temperature. Pain, 1989, Volume: 38, Issue:1 Topics: Analgesics; Animals; Body Temperature Regulation; Desipramine; Hot Temperature; Male; Pain; Rats; Rats, Inbred Strains; Zimeldine	1989
Antidepressant treatments, including sibutramine hydrochloride and electroconvulsive shock, decrease beta 1- but not beta 2-adrenoceptors in rat cortex. Journal of neurochemistry, 1989, Volume: 53, Issue:4 Topics: Amitriptyline; Animals; Antidepressive Agents; Binding, Competitive; Cerebral Cortex; Clenbuterol; Cyclobutanes; Desipramine; Dihydroalprenolol; Electroshock; Kinetics; Male; Rats; Receptors, Adrenergic, beta; Reference Values; Tranylcypromine; Zimeldine	1989
Benzodiazepine and GABAA receptors in rat brain following chronic antidepressant drug administration. Biochemical pharmacology, 1987, Dec-01, Volume: 36, Issue:23 Topics: Animals; Antidepressive Agents; Brain; Desipramine; Flunitrazepam; gamma-Aminobutyric Acid; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A; Tranylcypromine; Zimeldine	1987
5-Hydroxytryptamine-stimulated inositol phospholipid hydrolysis in the mouse cortex has pharmacological characteristics compatible with mediation via 5-HT2 receptors but this response does not reflect altered 5-HT2 function after 5,7-dihydroxytryptamine l Journal of neurochemistry, 1988, Volume: 50, Issue:3 Topics: 5,7-Dihydroxytryptamine; Animals; Antidepressive Agents; Cerebral Cortex; Desipramine; Electroshock; Head; Hydrolysis; Inositol Phosphates; Male; Mice; Mice, Inbred C57BL; Muscle Contraction; Phosphatidylinositols; Receptors, Serotonin; Serotonin; Stimulation, Chemical; Zimeldine	1988
Effects of chronic oral administration of the antidepressants, desmethylimipramine and zimelidine on rat cortical GABAB binding sites: a comparison with 5-HT2 binding site changes. British journal of pharmacology, 1988, Volume: 93, Issue:2 Topics: Animals; Antidepressive Agents; Body Weight; Cerebral Cortex; Desipramine; Hippocampus; Ketanserin; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A; Zimeldine	1988
Dose-dependent down-regulation of beta-adrenergic receptors after chronic intravenous infusion of antidepressants. Progress in neuro-psychopharmacology & biological psychiatry, 1988, Volume: 12, Issue:5 Topics: Amitriptyline; Animals; Antidepressive Agents; Cerebral Cortex; Cyclopentanes; Desipramine; Dose-Response Relationship, Drug; Female; Imipramine; Infusions, Intravenous; Iprindole; Kinetics; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta; Reference Values; Zimeldine	1988
CSF somatostatin in affective illness and normal volunteers. Progress in neuro-psychopharmacology & biological psychiatry, 1985, Volume: 9, Issue:4 Topics: Bipolar Disorder; Carbamazepine; Depressive Disorder; Desipramine; Humans; Imipramine; Lithium; Lithium Carbonate; Somatostatin; Zimeldine	1985
The nucleus accumbens and antidepressants: modulation of ergometrine-induced hyperactivity by typical and atypical antidepressants and neuroleptics in rats. Psychopharmacology, 1987, Volume: 92, Issue:3 Topics: Amitriptyline; Animals; Antidepressive Agents; Antipsychotic Agents; Clorgyline; Clozapine; Desipramine; Ergonovine; Male; Mianserin; Nucleus Accumbens; Rats; Rats, Inbred Strains; Septal Nuclei; Sulpiride; Zimeldine	1987
Antidepressants and protein kinases: desipramine treatment affects pineal gland cAMP-dependent protein kinase activity. European journal of pharmacology, 1986, Feb-11, Volume: 121, Issue:1 Topics: Animals; Antidepressive Agents; Desipramine; Fluoxetine; Iprindole; Isoproterenol; Male; Pineal Gland; Protein Kinases; Rats; Rats, Inbred Strains; Zimeldine	1986
Clinical studies on norepinephrine metabolism: how to interpret the numbers. Psychiatry research, 1986, Volume: 17, Issue:3 Topics: Adult; Aged; Bipolar Disorder; Depressive Disorder; Desipramine; Female; Glycols; Humans; Kinetics; Male; Methoxyhydroxyphenylglycol; Middle Aged; Norepinephrine; Zimeldine	1986
Effect of serotonin on the dissociation of high-affinity binding of [3H]imipramine in mouse cerebral cortex. Neuroscience letters, 1986, Jun-18, Volume: 67, Issue:2 Topics: Animals; Blood Platelets; Cerebral Cortex; Desipramine; Drug Interactions; Imipramine; Male; Mice; Mice, Inbred BALB C; Serotonin; Zimeldine	1986
Antidepressants and EEG sleep: search for specificity. Psychopharmacology series, 1987, Volume: 3 Topics: Amitriptyline; Antidepressive Agents; Depressive Disorder; Desipramine; Humans; Nortriptyline; Sleep; Sleep Stages; Zimeldine	1987
Neonatal desipramine or zimeldine treatment causes long-lasting changes in brain monoaminergic systems and alcohol related behavior in rats. Psychopharmacology, 1987, Volume: 91, Issue:4 Topics: Alcohol Drinking; Animals; Animals, Newborn; Behavior, Animal; Biogenic Amines; Brain; Desipramine; Male; Rats; Rats, Inbred Strains; Sleep; Zimeldine	1987
Increased adult behavioral 'despair' in rats neonatally exposed to desipramine or zimeldine: an animal model of depression? Pharmacology, biochemistry, and behavior, 1987, Volume: 28, Issue:3 Topics: Animals; Animals, Newborn; Behavior, Animal; Depression; Desipramine; Disease Models, Animal; Male; Rats; Rats, Inbred Strains; Zimeldine	1987
Unaltered 5-HT- and desipramine-sensitive [3H]imipramine binding and [3H]5-HT uptake in rat brain after chronic imipramine and norzimeldine treatment. Psychopharmacology, 1988, Volume: 94, Issue:2 Topics: Animals; Antidepressive Agents; Brain; Cerebral Cortex; Desipramine; Imipramine; Male; Rats; Rats, Inbred Strains; Serotonin; Synaptosomes; Zimeldine	1988
Comparison of desipramine, amitriptyline, zimeldine and alaproclate in six animal models used to investigate antidepressant drugs. Pharmacology & toxicology, 1988, Volume: 62, Issue:1 Topics: Alanine; Amitriptyline; Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Behavior, Animal; Desipramine; Male; Rats; Rats, Inbred Strains; Time Factors; Zimeldine	1988
Rapid conjugation in an extremely rapid hydroxylator of debrisoquine: a case report supporting a coregulation of certain phase I and II metabolic reactions. Therapeutic drug monitoring, 1988, Volume: 10, Issue:2 Topics: Adult; Antidepressive Agents; Debrisoquin; Desipramine; Female; Glucuronates; Humans; Hydroxylation; In Vitro Techniques; Isoniazid; Isoquinolines; Oxazepam; Zimeldine	1988
Neonatal treatment with monoamine uptake inhibitors alters later response in behavioural 'despair' test to beta and GABA-B receptor agonists. Pharmacology & toxicology, 1988, Volume: 63, Issue:1 Topics: Albuterol; Animals; Animals, Newborn; Antidepressive Agents; Baclofen; Behavior, Animal; Desipramine; gamma-Aminobutyric Acid; Male; Nomifensine; Rats; Rats, Inbred Strains; Time Factors; Zimeldine	1988
Early postnatal deprivation of active sleep with desipramine or zimeldine impairs later behavioural reactivity to auditory stimuli in rats. Acta physiologica Scandinavica, 1988, Volume: 132, Issue:2 Topics: Acoustic Stimulation; Animals; Auditory Perception; Behavior, Animal; Desipramine; Male; Motor Activity; Rats; Rats, Inbred Strains; Sleep Deprivation; Sleep, REM; Zimeldine	1988
Noradrenaline-stimulated inositol phospholipid breakdown as a measure of alpha 1-adrenoceptor function in rat hippocampal miniprisms after repeated antidepressant treatment. Journal of neural transmission, 1986, Volume: 66, Issue:3-4 Topics: Animals; Antidepressive Agents; Desipramine; Hippocampus; Male; Maprotiline; Mianserin; Norepinephrine; Phosphatidylinositols; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Zimeldine	1986
A double-blind study of zimelidine, a serotonin uptake inhibitor, and desipramine, a noradrenaline uptake inhibitor, in endogenous depression. II. Biochemical findings. Acta psychiatrica Scandinavica, 1982, Volume: 66, Issue:1 Topics: Adult; Aged; Animals; Antidepressive Agents; Blood Platelets; Brompheniramine; Depressive Disorder; Desipramine; Double-Blind Method; Female; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Hypothalamus; Male; Methoxyhydroxyphenylglycol; Middle Aged; Norepinephrine; Pyridines; Rats; Serotonin; Synaptosomes; Zimeldine	1982
An increase in sensitivity of rat cingulate cortical neurones to substance P occurs following withdrawal of chronic administration of antidepressant drugs. British journal of pharmacology, 1984, Volume: 81, Issue:4 Topics: Action Potentials; Animals; Antidepressive Agents; Clomipramine; Desipramine; Diazepam; Drug Resistance; Fluphenazine; Gyrus Cinguli; Male; Neurons; Rats; Substance P; Time Factors; Trimipramine; Zimeldine	1984
Interaction of EEG sleep, antidepressants, and affective disease. The Journal of clinical psychiatry, 1982, Volume: 43, Issue:11 Pt 2 Topics: Amitriptyline; Antidepressive Agents; Brompheniramine; Depressive Disorder; Desipramine; Electroencephalography; Humans; Sleep; Sleep, REM; Zimeldine	1982
Electroconvulsive treatment and lithium carbonate. Their effects on norepinephrine metabolism in patients with primary, major depressions. Archives of general psychiatry, 1983, Volume: 40, Issue:6 Topics: Brompheniramine; Clorgyline; Depressive Disorder; Desipramine; Electroconvulsive Therapy; Female; Humans; Lithium; Lithium Carbonate; Male; Methoxyhydroxyphenylglycol; Middle Aged; Norepinephrine; Normetanephrine; Vanilmandelic Acid; Zimeldine	1983
The antidepressant agents desipramine, fluoxetine, fluvoxamine and norzimelidine inhibit uptake of [3H]noradrenaline and [3H]5-hydroxytryptamine in slices of human and rat cortical brain tissue. Brain research, 1983, Sep-19, Volume: 275, Issue:1 Topics: Absorption; Animals; Antidepressive Agents; Cerebral Cortex; Desipramine; Fluoxetine; Fluvoxamine; Humans; In Vitro Techniques; Male; Norepinephrine; Oximes; Rats; Serotonin; Zimeldine	1983
Effects of amitriptyline, desipramine and zimeldine, alone and in combination with ethanol, on information processing and memory in healthy volunteers. Acta psychiatrica Scandinavica. Supplementum, 1983, Volume: 308 Topics: Adult; Amitriptyline; Cognition; Desipramine; Drug Interactions; Ethanol; Humans; Male; Memory; Psychomotor Performance; Zimeldine	1983
Common mechanism of action of biochemically "specific" antidepressants. Progress in neuro-psychopharmacology & biological psychiatry, 1984, Volume: 8, Issue:1 Topics: Adult; Affective Disorders, Psychotic; Antidepressive Agents; Clorgyline; Desipramine; Female; Humans; Male; Methoxyhydroxyphenylglycol; Middle Aged; Norepinephrine; Normetanephrine; Propylamines; Vanilmandelic Acid; Zimeldine	1984
Reduced metabolism and turnover rates of rat brain dopamine, norepinephrine and serotonin by chronic desipramine and zimelidine treatments. European journal of pharmacology, 1984, Apr-20, Volume: 100, Issue:2 Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain; Caudate Nucleus; Cerebral Cortex; Desipramine; Dopamine; Homovanillic Acid; Hypothalamus; Male; Methoxyhydroxyphenylglycol; Norepinephrine; Rats; Rats, Inbred Strains; Serotonin; Zimeldine	1984
Attenuation of the post-decapitation convulsions after repeated treatment of rats with desipramine, imipramine and maprotiline. Acta pharmacologica et toxicologica, 1984, Volume: 54, Issue:5 Topics: Alanine; Animals; Anticonvulsants; Antidepressive Agents; Desipramine; Imipramine; Male; Maprotiline; Rats; Rats, Inbred Strains; Time Factors; Zimeldine	1984
5-HT2 receptor characteristics in frontal cortex and 5-HT2 receptor-mediated head-twitch behaviour following antidepressant treatment to mice. British journal of pharmacology, 1984, Volume: 83, Issue:1 Topics: 5-Hydroxytryptophan; Animals; Antidepressive Agents; Behavior, Animal; Brain; Cerebral Cortex; Desipramine; Frontal Lobe; Kinetics; Male; Mianserin; Mice; Mice, Inbred C57BL; Monoamine Oxidase; Radioligand Assay; Receptors, Serotonin; Spiperone; Tranylcypromine; Zimeldine	1984
Long-term effects of two antidepressants on copulatory and exploratory behaviour in the female rat. Acta pharmacologica et toxicologica, 1984, Volume: 55, Issue:3 Topics: Animals; Antidepressive Agents; Castration; Copulation; Desipramine; Estradiol; Exploratory Behavior; Female; Progesterone; Rats; Rats, Inbred Strains; Zimeldine	1984
Effects of antidepressants on skilled performance. British journal of clinical pharmacology, 1984, Volume: 18 Suppl 1 Topics: Adult; Amitriptyline; Antidepressive Agents; Breath Tests; Desipramine; Ethanol; Humans; Kinetics; Male; Posture; Psychomotor Performance; Reaction Time; Zimeldine	1984
The effects of subchronic antidepressant drug treatment on the secretion of adenohypophyseal hormones and of corticosterone in the male rat. Advances in biochemical psychopharmacology, 1982, Volume: 31 Topics: Animals; Antidepressive Agents; Brompheniramine; Corticosterone; Desipramine; Male; Norepinephrine; Pituitary Hormones, Anterior; Rats; Rats, Inbred Strains; Serotonin; Synaptic Transmission; Time Factors; Zimeldine	1982
Sensitivity in vivo of central alpha 2- and opiate receptors after chronic treatment with various antidepressants. Journal of neural transmission, 1982, Volume: 54, Issue:1-2 Topics: Animals; Antidepressive Agents; Brompheniramine; Chlorpromazine; Clomipramine; Clonidine; Desipramine; Evoked Potentials; Imipramine; Iprindole; Locus Coeruleus; Male; Mianserin; Morphine; Neural Inhibition; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Opioid; Zimeldine	1982
Evidence for stabilization of cortical 5HT neurotransmission by chronic treatment with antidepressant drugs: induction of a high and low affinity component in 3H-5HT binding sites. Acta physiologica Scandinavica, 1982, Volume: 114, Issue:3 Topics: Animals; Antidepressive Agents; Binding Sites; Brompheniramine; Cerebral Cortex; Desipramine; Imipramine; Male; Rats; Rats, Inbred Strains; Serotonin; Synaptic Transmission; Tritium; Zimeldine	1982
Effect of destruction of central noradrenergic and serotonergic nerve terminals by systemic neurotoxins on the long-term effects of antidepressants on beta-adrenoceptors and 5-HT2 binding sites in the rat cerebral cortex. Journal of neural transmission, 1984, Volume: 59, Issue:1 Topics: Alanine; Amines; Animals; Antidepressive Agents; Benzylamines; Binding Sites; Cerebral Cortex; Clenbuterol; Desipramine; Dihydroalprenolol; Male; Mianserin; p-Chloroamphetamine; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta; Receptors, Serotonin; Serotonin; Spiperone; Zimeldine	1984
Test-specific effects of the 5-HT reuptake inhibitors alaproclate and zimelidine on pain sensitivity and morphine analgesia. Journal of neural transmission, 1980, Volume: 47, Issue:4 Topics: Alanine; Analgesia; Animals; Behavior, Animal; Brompheniramine; Desipramine; Dose-Response Relationship, Drug; Male; Morphine; Naloxone; p-Chloroamphetamine; Pain; Pyridines; Rats; Serotonin; Zimeldine	1980
Specific norepinephrine and serotonin uptake inhibitors in man: a crossover study with pharmacokinetic, biochemical, neuroendocrine and behavioral parameters. Acta psychiatrica Scandinavica. Supplementum, 1981, Volume: 290 Topics: Adolescent; Adult; Affective Disorders, Psychotic; Aged; Behavior; Brompheniramine; Desipramine; Double-Blind Method; Female; Hormones; Humans; Kinetics; Male; Middle Aged; Norepinephrine; Serotonin; Zimeldine	1981
Studies on the role of central 5-HT neurons in avoidance learning: a behavioral and biochemical analysis. Advances in experimental medicine and biology, 1981, Volume: 133 Topics: Animals; Avoidance Learning; Brain; Brompheniramine; Cerebral Cortex; Desipramine; Fenclonine; Lysergic Acid Diethylamide; Male; Neurons; p-Chloroamphetamine; Rats; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Synaptosomes; Zimeldine	1981
Early postnatal antidepressant treatment and juvenile stereotyped behaviour in rats. European journal of pharmacology, 1994, Dec-12, Volume: 271, Issue:1 Topics: Animals; Animals, Newborn; Antidepressive Agents; Apomorphine; Desipramine; Male; Monoamine Oxidase Inhibitors; Nomifensine; Rats; Rats, Wistar; Stereotyped Behavior; Zimeldine	1994
Potentiation of intrathecal DAMGO antinociception, but not gastrointestinal transit inhibition, by 5-hydroxytryptamine and norepinephrine uptake blockade. Life sciences, 1995, Volume: 56, Issue:4 Topics: Animals; Desipramine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Gastrointestinal Motility; Injections, Spinal; Male; Mice; Norepinephrine; Pain; Receptors, Opioid, mu; Serotonin; Zimeldine	1995
Amphetamine and antidepressant drug effects on GABA- and NMDA-related seizures. Brain research bulletin, 1993, Volume: 30, Issue:5-6 Topics: Amphetamine; Animals; Antidepressive Agents; Bupropion; Desipramine; Male; Mice; N-Methylaspartate; Picrotoxin; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Seizures; Zimeldine	1993
Differential effects of fluoxetine on isoprenaline-stimulated water intake in ethanol-treated rats: a role for beta-adrenoceptors. European journal of pharmacology, 1993, Jun-24, Volume: 237, Issue:2-3 Topics: Analysis of Variance; Animals; Desipramine; Drinking; Drug Interactions; Ethanol; Fluoxetine; Fluvoxamine; Injections, Intraperitoneal; Isoproterenol; Male; Propranolol; Rats; Rats, Wistar; Receptors, Adrenergic, beta; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists; Zimeldine	1993
Effects of monoamine uptake inhibitors given early postnatally on monoamines in the brain stem, caudate/putamen and cortex, and on dopamine D1 and D2 receptors in the caudate/putamen. Journal of neural transmission. General section, 1995, Volume: 102, Issue:2 Topics: Animals; Animals, Newborn; Binding, Competitive; Biogenic Monoamines; Brain Stem; Caudate Nucleus; Desipramine; Male; Monoamine Oxidase Inhibitors; Nomifensine; Putamen; Radioligand Assay; Rats; Rats, Wistar; Receptors, Dopamine; Zimeldine	1995
Neonatal treatments with the serotonin uptake inhibitors clomipramine and zimelidine, but not the noradrenaline uptake inhibitor desipramine, disrupt sleep patterns in adult rats. Brain research, 1997, Sep-12, Volume: 768, Issue:1-2 Topics: Adrenergic Uptake Inhibitors; Animals; Animals, Newborn; Clomipramine; Desipramine; Electroencephalography; Male; Rats; Selective Serotonin Reuptake Inhibitors; Sleep; Zimeldine	1997
The effects of REM sleep-inhibiting drugs in neonatal rats: evidence for a distinction between neonatal active sleep and REM sleep. Brain research, 1997, Dec-05, Volume: 778, Issue:1 Topics: Adrenergic Uptake Inhibitors; Animals; Animals, Newborn; Arousal; Atropine; Behavior, Animal; Desipramine; Electroencephalography; Electromyography; Muscarinic Antagonists; Rats; Selective Serotonin Reuptake Inhibitors; Sleep; Sleep, REM; Synapses; Zimeldine	1997
Guinea pig 5-HT transporter: cloning, expression, distribution, and function in intestinal sensory reception. The American journal of physiology, 1998, Volume: 275, Issue:3 Topics: Amino Acid Sequence; Animals; Base Sequence; Biological Transport; Brain Stem; Carrier Proteins; Clomipramine; Cloning, Molecular; Desipramine; DNA, Complementary; Fluoxetine; Guinea Pigs; HeLa Cells; Humans; Imipramine; Intestinal Mucosa; Kinetics; Membrane Glycoproteins; Membrane Transport Proteins; Molecular Sequence Data; Nerve Tissue Proteins; Neurons; Peristalsis; Polymerase Chain Reaction; Rats; Recombinant Proteins; RNA, Messenger; Serotonin; Serotonin Plasma Membrane Transport Proteins; Transcription, Genetic; Zimeldine	1998
Activation and desensitization by cyclic antidepressant drugs of alpha2-autoreceptors, alpha2-heteroreceptors and 5-HT1A-autoreceptors regulating monamine synthesis in the rat brain in vivo. Naunyn-Schmiedeberg's archives of pharmacology, 1999, Volume: 360, Issue:2 Topics: 5-Hydroxytryptophan; Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents, Tricyclic; Autoreceptors; Brain; Carboxy-Lyases; Cerebral Cortex; Desipramine; Dihydroxyphenylalanine; Dose-Response Relationship, Drug; Drug Interactions; Fluoxetine; Hippocampus; Male; Norepinephrine; Protriptyline; Rats; Rats, Sprague-Dawley; Serotonin; Time Factors; Tryptophan; Tyrosine; Zimeldine	1999
Antidepressant drug administration modifies the interactive relationship between alpha(2)-adrenergic sensitivity and levels of TNF in the rat brain. Journal of neuroimmunology, 2000, Jul-10, Volume: 107, Issue:1 Topics: Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Brain; Desipramine; Hippocampus; In Vitro Techniques; Locus Coeruleus; Male; Norepinephrine; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha; Recombinant Proteins; Reference Values; Sympathetic Nervous System; Tumor Necrosis Factor-alpha; Zimeldine	2000
Effects of the CRF(1) receptor antagonist, CP 154,526, in the separation-induced vocalization anxiolytic test in rat pups. Neuropharmacology, 2000, Jun-08, Volume: 39, Issue:8 Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Antipsychotic Agents; Anxiety; Behavior, Animal; Buspirone; Clozapine; Desipramine; Diazepam; Dose-Response Relationship, Drug; Female; Haloperidol; Injections, Intraperitoneal; Male; Pyrimidines; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Corticotropin-Releasing Hormone; Social Isolation; Stress, Psychological; Vocalization, Animal; Zimeldine	2000
Antidepressant drug-induced alterations in neuron-localized tumor necrosis factor-alpha mRNA and alpha(2)-adrenergic receptor sensitivity. The Journal of pharmacology and experimental therapeutics, 2001, Volume: 297, Issue:2 Topics: Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents; Brain Chemistry; Desipramine; Electric Stimulation; Hippocampus; Idazoxan; Immunohistochemistry; In Situ Hybridization; In Vitro Techniques; Male; Neurons; Norepinephrine; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; RNA, Messenger; Selective Serotonin Reuptake Inhibitors; Tumor Necrosis Factor-alpha; Zimeldine	2001
Post-stress facilitation of serotonergic, but not noradrenergic, neurotransmission in the dorsal hippocampus prevents learned helplessness development in rats. Brain research, 2006, May-04, Volume: 1087, Issue:1 Topics: Adrenergic Uptake Inhibitors; Animals; Behavior, Animal; Desipramine; Dose-Response Relationship, Drug; Electroshock; Escape Reaction; Functional Laterality; Helplessness, Learned; Hippocampus; Male; Norepinephrine; Rats; Rats, Wistar; Reaction Time; Selective Serotonin Reuptake Inhibitors; Serotonin; Stress, Physiological; Zimeldine	2006