desipramine has been researched along with rolipram in 13 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (23.08) | 18.7374 |
| 1990's | 3 (23.08) | 18.2507 |
| 2000's | 4 (30.77) | 29.6817 |
| 2010's | 3 (23.08) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET | 1 |
| Carmody, LC; Dandapani, S; Donckele, E; Feng, Y; Fernandez, C; Germain, AR; Gupta, PB; Lander, ES; Morgan, B; Munoz, B; Nag, PP; Palmer, M; Perez, JR; Schreiber, SL; Verplank, L | 1 |
| An, B; Hu, J; Huang, L; Li, X; Li, Z; Pan, T | 1 |
| Luscombe, DK; Mustafa, MR; Stolz, JF | 1 |
| Bobon, D; Breulet, M; Gerard-Vandenhove, MA; Guiot-Goffioul, F; Plomteux, G; Sastre-y-Hernández, M; Schratzer, M; Troisfontaines, B; von Frenckell, R; Wachtel, H | 1 |
| Duman, RS; Nestler, EJ; Nibuya, M | 1 |
| Chen, M; Conti, M; Farooqui, SM; Houslay, MD; O'Donnell, JM; Ye, Y | 1 |
| Frith, S; O'Donnell, JM | 1 |
| Duman, RS; Fujimaki, K; Morinobu, S | 1 |
| Cherry, JA; Farooqui, SM; Farooqui, SQ; Jackson, K; Makhay, M; O'Donnell, JM; Zhang, K | 1 |
| O'Donnell, JM; Zhang, HT; Zhao, Y | 1 |
| Beanlands, RS; Bevilacqua, L; Dasilva, JN; Greene, M; Harper, ME; Kenk, M; Thackeray, JT; Thorn, SL | 1 |
| Beanlands, RS; DaSilva, JN; deKemp, RA; Kenk, M; Lortie, M; Renaud, JM; Thomas, AJ | 1 |
1 trial(s) available for desipramine and rolipram
| Article | Year |
|---|---|
Is phosphodiesterase inhibition a new mechanism of antidepressant action? A double blind double-dummy study between rolipram and desipramine in hospitalized major and/or endogenous depressives.
Topics: Adolescent; Adult; Aged; Clinical Trials as Topic; Depressive Disorder; Desipramine; Double-Blind Method; Humans; Middle Aged; Phosphodiesterase Inhibitors; Psychological Tests; Psychometrics; Pyrrolidinones; Random Allocation; Rolipram | 1988 |
12 other study(ies) available for desipramine and rolipram
| Article | Year |
|---|---|
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium | 1985 |
Cinnamides as selective small-molecule inhibitors of a cellular model of breast cancer stem cells.
Topics: Amides; Breast Neoplasms; Cell Line, Tumor; Drug Screening Assays, Antitumor; Female; Humans; Neoplastic Stem Cells; Small Molecule Libraries; Structure-Activity Relationship | 2013 |
Synthesis and evaluation of clioquinol-rolipram/roflumilast hybrids as multitarget-directed ligands for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Aminopyridines; Animals; Benzamides; Clioquinol; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclopropanes; Drug Design; Humans; Ligands; Mice; Rats; Rolipram | 2019 |
Effect of long-term rolipram administration on the sensitivity of alpha 2-adrenoceptors in rat brain.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Brain; Clonidine; Desipramine; Drug Administration Schedule; Locomotion; Male; Phosphodiesterase Inhibitors; Pyrimidines; Pyrrolidinones; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Rolipram | 1988 |
Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus.
Topics: 1-Naphthylamine; Animals; Antidepressive Agents; Base Sequence; Blotting, Northern; Brain-Derived Neurotrophic Factor; Cyclic AMP Response Element-Binding Protein; Desipramine; Electric Stimulation; Fluoxetine; Hippocampus; Imipramine; In Situ Hybridization; Male; Molecular Sequence Data; Nerve Growth Factors; Nerve Tissue Proteins; Phosphodiesterase Inhibitors; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptor Protein-Tyrosine Kinases; Receptor, trkB; Receptors, Nerve Growth Factor; RNA, Messenger; Rolipram; Sertraline; Time Factors; Tranylcypromine | 1996 |
Noradrenergic activity differentially regulates the expression of rolipram-sensitive, high-affinity cyclic AMP phosphodiesterase (PDE4) in rat brain.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Binding, Competitive; Brain; Desipramine; Immunoblotting; Male; Norepinephrine; Oxidopamine; Phosphodiesterase Inhibitors; Propranolol; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Rolipram; Time Factors | 1997 |
Behavioral effects of family-selective inhibitors of cyclic nucleotide phosphodiesterases.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Antidepressive Agents, Tricyclic; Conditioning, Operant; Cyclic Nucleotide Phosphodiesterases, Type 1; Desipramine; Isoquinolines; Male; Milrinone; Phosphodiesterase Inhibitors; Purinones; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Reinforcement Schedule; Rolipram; Tetrahydroisoquinolines; Vinca Alkaloids | 1999 |
Administration of a cAMP phosphodiesterase 4 inhibitor enhances antidepressant-induction of BDNF mRNA in rat hippocampus.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Cyclic Nucleotide Phosphodiesterases, Type 4; Desipramine; Gene Expression Regulation; Hippocampus; Male; Phosphodiesterase Inhibitors; Pyridines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Rolipram; Transcription, Genetic | 2000 |
Noradrenergic lesions differentially alter the expression of two subtypes of low Km cAMP-sensitive phosphodiesterase type 4 (PDE4A and PDE4B) in rat brain.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Antibodies; Brain; Brain Chemistry; Cerebellum; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Desipramine; Dopamine; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Hypothalamus; Injections, Intraventricular; Male; Neostriatum; Nerve Tissue Proteins; Norepinephrine; Oxidopamine; Phosphodiesterase Inhibitors; Rats; Rats, Sprague-Dawley; Rolipram; Signal Transduction; Sympatholytics | 2000 |
Antidepressant-induced increase in high-affinity rolipram binding sites in rat brain: dependence on noradrenergic and serotonergic function.
Topics: Animals; Antidepressive Agents; Benzamides; Binding Sites; Brain; Cell Membrane; Cerebral Cortex; Desipramine; Dose-Response Relationship, Drug; Drug Interactions; Hippocampus; Male; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic; Receptors, Serotonin; Rolipram; Time Factors; Tritium | 2003 |
Reduced in vivo phosphodiesterase-4 response to acute noradrenaline challenge in diet-induced obese rats.
Topics: Animals; Calorimetry, Indirect; Cyclic Nucleotide Phosphodiesterases, Type 4; Desipramine; Dietary Fats; Male; Norepinephrine; Obesity; Rats; Rats, Sprague-Dawley; Rolipram; Signal Transduction; Sympathetic Nervous System | 2009 |
PET of (R)-11C-rolipram binding to phosphodiesterase-4 is reproducible and sensitive to increased norepinephrine in the rat heart.
Topics: Adrenergic alpha-Agonists; Adrenergic Uptake Inhibitors; Animals; Carbon Radioisotopes; Cyclic Nucleotide Phosphodiesterases, Type 4; Desipramine; Dose-Response Relationship, Drug; Heart; Image Processing, Computer-Assisted; Male; Myocardium; Norepinephrine; Phosphodiesterase Inhibitors; Positron-Emission Tomography; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Rolipram | 2011 |