desipramine has been researched along with propranolol in 175 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 93 (53.14) | 18.7374 |
| 1990's | 20 (11.43) | 18.2507 |
| 2000's | 34 (19.43) | 29.6817 |
| 2010's | 27 (15.43) | 24.3611 |
| 2020's | 1 (0.57) | 2.80 |
| Authors | Studies |
|---|---|
| Andrews, PR; Craik, DJ; Martin, JL | 1 |
| Strassburg, CP; Tukey, RH | 1 |
| Danelian, E; Hämäläinen, MD; Hansson, A; Karlén, A; Karlsson, R; Lennernäs, H; Löfâs, S; Winiwarter, S | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Faller, B; Wohnsland, F | 1 |
| Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA | 1 |
| Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL | 1 |
| Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY | 2 |
| Bacsó, Z; Cianfriglia, M; Fenyvesi, F; Goda, K; Kappelmayer, J; Lustyik, G; Nagy, H; Szabó, G; Szilasi, M | 1 |
| Johans, C; Kinnunen, PK; Söderlund, T; Suomalainen, P | 1 |
| Caron, G; Ermondi, G | 1 |
| Akamatsu, M; Fujikawa, M; Nakao, K; Shimizu, R | 1 |
| Briand, X; Faller, B; Lázaro, E; Lowe, PJ | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Alimuddin, M; Bulloch, D; Dahl, R; Grant, D; Lee, N; Peacock, M | 1 |
| He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Sun, Y; Yan, Z | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Ahman, M; Holmén, AG; Wan, H | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S | 1 |
| Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM | 1 |
| Campillo, NE; Guerra, A; Páez, JA | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Avdeef, A; Tam, KY | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Glen, RC; Lowe, R; Mitchell, JB | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Akamatsu, M | 1 |
| Cooper, J; Cui, Y; Fink, M; Gavaghan, DJ; Heath, BM; McMahon, NC; Mirams, GR; Noble, D; Sher, A | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Fijorek, K; Glinka, A; Mendyk, A; Polak, S; Wiśniowska, B | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Chen, L; Fei, J; Mei, Y; Ren, S; Yan, SF; Zeng, J; Zhang, JZ | 1 |
| Buckley, DB; Funk, RS; Hensley, T; Kazmi, F; Loewen, GJ; Parkinson, A; Pope, C | 1 |
| Dalvie, D; Loi, CM; Smith, DA | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Bellman, K; Knegtel, RM; Settimo, L | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Jones, LH; Nadanaciva, S; Rana, P; Will, Y | 1 |
| Acevedo, O; Dasararaju, G; Devadasan, V; Halakova, D; Jayaprakash, V; Kovacikova, L; Mohd Siddique, MU; Mondal, SK; Prnova, MS; Shilkar, D; Stefek, M; Thakur, A; Yasmin, S | 1 |
| Chiba, S | 4 |
| McMillen, BA; Shore, PA | 1 |
| Buckley, JP; Lokhandwala, MF | 1 |
| Ablad, B; Dahlöf, C; Ljung, B | 1 |
| Harden, TK; Molinoff, PB; Sporn, JR; Wolfe, BB | 1 |
| Burgess, CD; Turner, P; Wadsworth, J | 1 |
| Loeb, JM; Vassalle, M | 1 |
| Buda, M; Klein, DC; Weller, JL; Yuwiler, A | 1 |
| Ozawa, H; Uematsu, T | 1 |
| Freinkel, N; Mager, M; Robinson, S | 1 |
| Himori, N; Taira, N | 1 |
| Bevan, JA; Ljung, B; Pegram, BL; Purdy, RE; Su, M | 1 |
| Barde, YA; Chinet, A; Girardier, L | 1 |
| Bevan, JA; Lee, TJ; Su, C | 1 |
| Austin, CE; Chess-Williams, R; O'Brien, HL | 1 |
| Borsini, F; D'Aranno, V; Lecci, A; Mancinelli, A; Meli, A; Stasi, MA | 1 |
| Cuadra, GR; Keller, EA; Molina, VA; Orsingher, OA | 1 |
| Badia, A; Sallés, J; Vila, E | 1 |
| Persad, E; Remington, G; Rosenblat, R; Tang, SW | 1 |
| Higashi, Y; Murakami, T; Nishiura, A; Toyoda, T; Yata, N | 1 |
| McElroy, JF; O'Donnell, JM; Stimmel, JJ | 1 |
| O'Neill, KA; Valentino, D | 1 |
| Fischer, W; Lasek, R; Müller, M | 1 |
| Moulds, RF; Stevens, MJ | 1 |
| Finberg, JP; Tal, A | 1 |
| Ensinger, H; Hedler, L; Majewski, H; Starke, K | 1 |
| Hauser, G; Leli, U | 3 |
| Blaschke, D; Laakmann, G; Meissner, R; Schoen, HW; Weiss, A; Wittmann, M; Zygan, K | 1 |
| Laakmann, G; Meissner, R; Schoen, HW; Weiss, A; Wittmann, M; Zygan, K | 1 |
| Laakmann, G; Meissner, R; Mueller, OA; Schoen, HW; Stalla, GK; Weiss, A; Wittmann, M; Zygan, K | 1 |
| Hauser, G; Koul, O | 1 |
| Depaulis, A; Marescaux, C; Micheletti, G; Rumbach, L; Tranchant, C; Vergnes, M; Warter, JM | 1 |
| Bickford-Wimer, PC; Freedman, R; Hoffer, BJ; Parfitt, K | 1 |
| Benzi, RH; Girardier, L; Seydoux, J; Shibata, M | 1 |
| Le Bras, YM; Pennec, JP | 2 |
| Ishida, Y; Kihara, M; Kobayashi, S; Koga, N; Nanbu, T | 1 |
| O'Donnell, JM | 1 |
| Prosdocimi, M; Tessari, F | 1 |
| Rosenbaum, JF; Tesar, GE | 1 |
| Boksa, P | 1 |
| Abrahamsen, J; Nedergaard, OA | 1 |
| Farnebo, LO; Hamberger, B | 1 |
| Chu, H; Opitz, K | 1 |
| Barth, N | 1 |
| Barth, N; Muscholl, E | 1 |
| Chesher, GB; Jackson, DM; Starmer, GA | 1 |
| Booth, DA | 1 |
| Kodama, T; Matsukado, Y; Shimizu, H; Suzuki, T; Tanaka, S | 1 |
| Goldstein, FJ; Malseed, RT; Rossi, GV | 1 |
| Bloom, FE; Segal, M | 1 |
| Morgan, HE; Rannels, SR; Whitfield, CF | 1 |
| Carrara, C; Garattini, S; Jori, A; Paglialunga, S | 1 |
| Blum, JJ | 2 |
| Garattini, S; Jori, A; Paglialunga, S | 1 |
| Dixon, AK | 1 |
| Day, MD; Owen, DA; Warren, PR | 1 |
| Finch, L; Leach, GD | 1 |
| Clarke, DE | 1 |
| Burger, A; Philippu, A; Schümann, HJ; Tjoe, S | 1 |
| Chang, CC; Wang, WH | 1 |
| Hamilton, TC | 1 |
| Chiba, S; Iwatsuki, K; Ono, H | 1 |
| Cooper, F; Leonard, BE; Schnieden, H | 1 |
| König, J; Mlejnková, M; Rysánek, K; Spánková, H; Synek, P | 1 |
| Dollery, CT; Lewis, PJ; Myers, MG; Reid, JL | 1 |
| Kuchi, M; Shibata, S | 1 |
| Oates, JA; Shand, DG | 1 |
| de Champlain, J; Elharrar, V; Nadeau, RA | 1 |
| Whittle, BA | 1 |
| Shimamoto, K; Toda, N | 1 |
| Brody, TM; McNeill, JH | 1 |
| Scriabine, A | 1 |
| Swann, AC | 1 |
| Liebowitz, MR | 1 |
| Cardinal, JA; Hill, AG; Midha, KK; Verbeeck, RK | 1 |
| Borsini, F; Nowakowska, E; Samanin, R | 1 |
| Collett, AR; Story, DF | 1 |
| Downes, H; Koga, Y; Taylor, SM | 1 |
| Frazer, A; Heydorn, WE; Weiss, B | 1 |
| Brunswick, DJ; Frazer, A; Heydorn, WE | 1 |
| Kajiyama, H; Nomura, Y; Oki, K | 1 |
| Minneman, KP; Molinoff, PB; Wolfe, BB | 1 |
| Cardinal, JA; Verbeeck, RK; Wallace, SM | 1 |
| Nobrega, JN; Wiener, NI | 1 |
| Prasad, V; Sheard, MH | 1 |
| Mogilnicka, E | 1 |
| Hedler, L; Majewski, H; Starke, K | 1 |
| Balks, HJ; Beckh, K; Jungermann, K | 1 |
| Falko, JM; Jones, BA; Mencer, DL; Pariser, SF; Reynolds, JC | 1 |
| Beek, D; Kenakin, TP | 1 |
| Ashbrook, DW; Hurlbut, DE; Purdy, RE; Reidy, JP; Stratford, RE; Watanabe, MY | 1 |
| Chiba, K; Echizen, H; Ishizaki, T; Tani, M; Yoshimoto, K | 1 |
| Matsumoto, K; Ohta, H; Ojima, K; Watanabe, H | 1 |
| Klemfuss, H; Kripke, DF | 1 |
| Little, KY; Mason, GA; Walker, CH | 1 |
| Kanakubo, Y; Kitada, M; Kiuchi, M; Ohmori, S; Rikihisa, T; Takeda, S | 1 |
| Alhaider, AA; Mustafa, AA | 1 |
| Ball, WA; Gresch, PJ; Morrison, AR; Ross, RJ; Sanford, LD | 1 |
| Nishikawa, T; Shirayama, Y; Takahashi, K | 1 |
| Chen, M; Conti, M; Farooqui, SM; Houslay, MD; O'Donnell, JM; Ye, Y | 1 |
| Kleven, MS; Koek, W | 1 |
| Daws, LC; Frazer, A; Lopez, R | 1 |
| de la Lande, IS; Ivar, PM; Marino, V; Parker, DA | 1 |
| Kurz, T; Richardt, G; Schneider, I; Tölg, R | 1 |
| Fujiseki, Y; Inagaki, C; Kinoshita, T; Okugawa, G; Omori, K; Suzukawa, J | 1 |
| Baez, S; Jimenez, V; John, E; Lechin, F; Lechin, ME; Orozco, B; Pardey-Maldonado, B; van der Dijs, B | 1 |
| Nott, MW; Rand, MJ; Thaina, P | 1 |
| Alpstäg-Wöhrle, AL; Christen, B; Krämer, SD; Marenchino, M; Wunderli-Allenspach, H | 1 |
| Abdiche, YN; Myszka, DG | 1 |
| Baez, S; Jahn, E; Lechin, F; Orozco, B; Rodriguez, S; van der Dijs, B | 1 |
| Dendorfer, A; Dominiak, P; Raasch, W; Ziegler, A | 1 |
| Swant, J; Thompson, AM; Wagner, JJ | 1 |
| Barnum, CJ; Blandino, P; Deak, T | 1 |
| Horinouchi, T; Koike, K; Michikawa, H; Tanaka, Y; Yamashita, Y | 1 |
| Aksu, F; Belzung, C; Bodard, S; Chalon, S; Yalcin, I | 1 |
| Huang, Y; O'Donnell, JM; Whisler, LR; Xiang, Y; Zhang, HT | 1 |
| Gorzalka, BB; Hill, MN; Morrish, AC; Riebe, CJ | 1 |
| Feinstein, DL; Garcia-Bueno, B; Hinojosa, AE; Leza, JC; Madrigal, JL; Polak, P | 1 |
| Barnum, CJ; Bhide, N; Bishop, C; Goldenberg, AA; Klioueva, A; Lindenbach, D; Surrena, MA; Tignor, S; Walters, H | 1 |
| Bravo-Zehnder, M; González, A; López, A; Metz, C; Montecino, FJ; Norambuena, A; Oyanadel, C; Retamal, C; Shaughnessy, R; Soza, A | 1 |
| Bielecka, AM; Daniel, WA; Drzyzga, Ł; Kot, M; Obuchowicz, E; Paul-Samojedny, M; Prymus, A | 1 |
| Badaoui, M; Dickson, CJ; Hornak, V; Kells, A; Molteni, C; Rosta, E | 1 |
3 review(s) available for desipramine and propranolol
| Article | Year |
|---|---|
Human UDP-glucuronosyltransferases: metabolism, expression, and disease.
Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; Neoplasms; Steroids; Terminology as Topic | 2000 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Newer uses for older psychotropic medications.
Topics: Adrenergic beta-Antagonists; Agoraphobia; Anxiety Disorders; Bipolar Disorder; Clonidine; Depressive Disorder; Desipramine; Humans; Imipramine; Lithium; Monoamine Oxidase Inhibitors; Personality Disorders; Phenelzine; Propranolol; Psychotropic Drugs; Schizophrenia | 1982 |
3 trial(s) available for desipramine and propranolol
| Article | Year |
|---|---|
Cardiovascular responses to mianserin hydrochloride: a comparison with tricyclic antidepressant drugs.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Bethanidine; Blood Pressure; Cardiovascular System; Clinical Trials as Topic; Clomipramine; Depression; Desipramine; Dibenzazepines; Double-Blind Method; Drug Interactions; Female; Guanethidine; Heart Rate; Humans; Hydralazine; Hypertension; Male; Mianserin; Propranolol | 1978 |
Coadministration of a beta-adrenergic antagonist and a tricyclic antidepressant: a pilot study.
Topics: Depressive Disorder; Desipramine; Drug Therapy, Combination; Humans; Pilot Projects; Propranolol; Psychometrics | 1990 |
Enhancement of noradrenergic neural transmission: an effective therapy of myasthenia gravis: a report on 52 consecutive patients.
Topics: Adolescent; Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Adrenergic Uptake Inhibitors; Adult; Aged; Benzhydryl Compounds; Buspirone; Desipramine; Drug Therapy, Combination; Electromyography; Epinephrine; Female; Humans; Hydroxamic Acids; Male; Middle Aged; Modafinil; Myasthenia Gravis; Neuroprotective Agents; Neurotransmitter Agents; Norepinephrine; Phenylalanine; Platelet Aggregation; Propranolol; Serotonin; Serotonin Receptor Agonists; Sympathetic Nervous System; Tyrosine | 2000 |
169 other study(ies) available for desipramine and propranolol
| Article | Year |
|---|---|
Functional group contributions to drug-receptor interactions.
Topics: Animals; Calorimetry; Kinetics; Models, Biological; Protein Binding; Receptors, Cell Surface; Receptors, Drug; Structure-Activity Relationship | 1984 |
SPR biosensor studies of the direct interaction between 27 drugs and a liposome surface: correlation with fraction absorbed in humans.
Topics: Humans; Intestinal Absorption; Liposomes; Pharmaceutical Preparations; Pharmacokinetics; Predictive Value of Tests; Surface Plasmon Resonance | 2000 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
High-throughput permeability pH profile and high-throughput alkane/water log P with artificial membranes.
Topics: Alkanes; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Membranes, Artificial; Octanols; Permeability; Pharmaceutical Preparations; Solubility; Water | 2001 |
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds.
Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water | 2001 |
Cheminformatic models to predict binding affinities to human serum albumin.
Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids | 2001 |
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data.
Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding | 2002 |
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution | 2004 |
Distinct groups of multidrug resistance modulating agents are distinguished by competition of P-glycoprotein-specific antibodies.
Topics: Adenosine Triphosphatases; Animals; Anti-Bacterial Agents; Antibodies, Monoclonal; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding, Competitive; Calcium Channel Blockers; Cyclosporine; Detergents; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Flow Cytometry; Fluoresceins; Humans; Ivermectin; Mice; NIH 3T3 Cells; Substrate Specificity | 2004 |
Surface activity profiling of drugs applied to the prediction of blood-brain barrier permeability.
Topics: Blood-Brain Barrier; Lipid Bilayers; Micelles; Permeability; Pharmaceutical Preparations; Structure-Activity Relationship; Surface Properties | 2004 |
Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).
Topics: 1-Octanol; Alkanes; Hydrogen-Ion Concentration; Least-Squares Analysis; Mathematics; Models, Chemical; Models, Molecular; Solvents; Water | 2005 |
QSAR study on permeability of hydrophobic compounds with artificial membranes.
Topics: Biological Transport; Caco-2 Cells; Drug Evaluation, Preclinical; Humans; Hydrophobic and Hydrophilic Interactions; Membranes, Artificial; Permeability; Pharmaceutical Preparations; Quantitative Structure-Activity Relationship | 2007 |
New approach to measure protein binding based on a parallel artificial membrane assay and human serum albumin.
Topics: Humans; Kinetics; Membranes, Artificial; Permeability; Protein Binding; Serum Albumin | 2008 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
Determination of log D via automated microfluidic liquid-liquid extraction.
Topics: Automation; Biopharmaceutics; Microfluidic Analytical Techniques; Pharmacokinetics | 2008 |
First-principle, structure-based prediction of hepatic metabolic clearance values in human.
Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metabolic Clearance Rate; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship; Sensitivity and Specificity; Software | 2009 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs.
Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry | 2009 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship | 2009 |
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
Topics: | 2008 |
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability?
Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological; Permeability; Porosity; Regression Analysis | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
Predicting phospholipidosis using machine learning.
Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Importance of physicochemical properties for the design of new pesticides.
Topics: Anabasine; Animals; Biological Availability; Cell Membrane Permeability; Chemical Phenomena; Drug Design; Humans; Imidazoles; Insecticides; Neonicotinoids; Nitro Compounds; Pesticides; Quantitative Structure-Activity Relationship; Receptors, Nicotinic | 2011 |
Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk.
Topics: Action Potentials; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Computer Simulation; Dogs; Dose-Response Relationship, Drug; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Guinea Pigs; HEK293 Cells; Humans; Ion Channels; Kinetics; Models, Cardiovascular; NAV1.5 Voltage-Gated Sodium Channel; Patch-Clamp Techniques; Potassium Channel Blockers; Rabbits; Risk Assessment; Risk Factors; Sodium Channel Blockers; Sodium Channels; Torsades de Pointes; Transfection | 2011 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration | 2011 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Predictive model for L-type channel inhibition: multichannel block in QT prolongation risk assessment.
Topics: Artificial Intelligence; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Line; Computational Biology; Computer Simulation; Drugs, Investigational; Ether-A-Go-Go Potassium Channels; Expert Systems; Heart Rate; Humans; Models, Biological; Myocytes, Cardiac; NAV1.5 Voltage-Gated Sodium Channel; Potassium Channel Blockers; Quantitative Structure-Activity Relationship; Risk Assessment; Shaker Superfamily of Potassium Channels; Torsades de Pointes; Voltage-Gated Sodium Channel Blockers | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors.
Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Microsomes, Liver; Models, Molecular; Molecular Dynamics Simulation; Substrate Specificity | 2013 |
Lysosomal sequestration (trapping) of lipophilic amine (cationic amphiphilic) drugs in immortalized human hepatocytes (Fa2N-4 cells).
Topics: Adrenergic beta-Antagonists; Amines; Ammonium Chloride; Antidepressive Agents, Tricyclic; Atorvastatin; Cell Line, Transformed; Diuretics; Hepatocytes; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Imipramine; Lysosomes; Monensin; Nigericin; Propranolol; Pyrroles | 2013 |
Which metabolites circulate?
Topics: Humans; Metabolic Clearance Rate; Pharmaceutical Preparations | 2013 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation | 2014 |
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships.
Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone | 2016 |
Non-carboxylic acid inhibitors of aldose reductase based on N-substituted thiazolidinedione derivatives.
Topics: Aldehyde Reductase; Animals; Caco-2 Cells; Catalytic Domain; Dogs; Enzyme Inhibitors; Humans; Hypoglycemic Agents; Madin Darby Canine Kidney Cells; Male; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Structure; Protein Binding; Rats, Wistar; Structure-Activity Relationship; Thiazolidinediones | 2021 |
Pharmacologic analysis of chronotropic and inotropic responses to 5-hydroxytryptamine in the dog heart.
Topics: Adrenergic beta-Antagonists; Animals; Atropine; Depression, Chemical; Desipramine; Dogs; Heart Rate; In Vitro Techniques; Methysergide; Myocardial Contraction; Propanolamines; Propranolol; Quinolines; Serotonin; Serotonin Antagonists; Stimulation, Chemical; Tetrodotoxin; Tyramine | 1977 |
Amfonelic acid, a non-amphetamine stimulant, has marked effects on brain dopamine metabolism but not noradrenaline metabolism: association with differences in neuronal storage systems.
Topics: Animals; Brain; Central Nervous System; Desipramine; Dopamine; Female; Haloperidol; Methyltyrosines; Nalidixic Acid; Naphthyridines; Neurons; Norepinephrine; Phenoxybenzamine; Propranolol; Rats; Tyrosine 3-Monooxygenase | 1978 |
Analysis of presynaptic inhibitory actions of various dopamine analogs on sympathetic neurotransmission in mongrel dogs.
Topics: Animals; Blood Pressure; Deoxyepinephrine; Desipramine; Dogs; Dopamine; Female; Haloperidol; Heart; Heart Rate; Male; Neural Inhibition; Phentolamine; Propranolol; Receptors, Adrenergic, alpha; Receptors, Dopamine; Sympathetic Nervous System; Synaptic Transmission | 1977 |
Increased noradrenaline release in rat portal vein during sympathetic nerve stimulation due to activation of presynaptic beta-adrenoceptors by noradrenaline and adrenaline.
Topics: Animals; Blood Vessels; Desipramine; Epinephrine; In Vitro Techniques; Norepinephrine; Normetanephrine; Phenoxybenzamine; Portal Vein; Propranolol; Rats; Receptors, Adrenergic; Receptors, Adrenergic, beta; Stimulation, Chemical | 1978 |
Presynaptic modulation of beta adrenergic receptors in rat cerebral cortex after treatment with antidepressants.
Topics: Adenylyl Cyclases; Animals; Cerebral Cortex; Desipramine; Guanosine Triphosphate; Iprindole; Male; Pargyline; Propranolol; Rats; Receptors, Adrenergic; Receptors, Adrenergic, beta | 1978 |
Adrenergic mechanisms in postvagal tachycardia.
Topics: Animals; Atrial Function; Cardiac Pacing, Artificial; Catecholamines; Desipramine; Dopamine beta-Hydroxylase; Heart Rate; Hydroxydopamines; Norepinephrine; Phenoxybenzamine; Phentolamine; Propranolol; Receptors, Dopamine; Sympathetic Nervous System; Vagus Nerve; Ventricular Function | 1979 |
Procaine-induced positive chronotropic and inotropic responses of the isolated, blood-perfused dog atrium.
Topics: Acetylcholine; Animals; Atropine; Desipramine; Dogs; Drug Interactions; Female; Heart Rate; In Vitro Techniques; Male; Myocardial Contraction; Nicotine; Norepinephrine; Procaine; Propranolol; Stimulation, Chemical; Tetrodotoxin; Tyramine | 1977 |
Adrenergic control of pineal N-acetyltransferase activity: developmental aspects.
Topics: Acetyltransferases; Animals; Animals, Newborn; Circadian Rhythm; Desipramine; Female; Isoproterenol; Male; Norepinephrine; Organ Culture Techniques; Pineal Gland; Propranolol; Rats; Sympathetic Nervous System | 1977 |
Centrally mediated cardiovascular effects of intracisternal application of carbachol in anesthetized rats.
Topics: Animals; Atropine; Blood Pressure; Carbachol; Chlorpromazine; Cisterna Magna; Desipramine; Drug Interactions; Hemodynamics; Hexamethonium Compounds; Injections; Male; Parasympathomimetics; Propranolol; Rats; Sympatholytics; Vagus Nerve | 1976 |
Drug modification of hypothermia induced by CNS glucopenia in the mouse.
Topics: Animals; Blood Glucose; Body Temperature; Body Temperature Regulation; Brain; Desipramine; Dose-Response Relationship, Drug; Glucose; Injections, Intraventricular; Insulin; Male; Mice; Norepinephrine; Oxygen Consumption; Phentolamine; Propranolol | 1976 |
Release of noradrenaline proposed as a mechanisms for the positive inotropic action of dipyridamole.
Topics: Animals; Desipramine; Dipyridamole; Dogs; Myocardial Contraction; Norepinephrine; Papillary Muscles; Propranolol; Reserpine; Stimulation, Chemical; Tetrodotoxin; Tyramine | 1976 |
Vasomotor nerve control of isolated arteries and veins.
Topics: Animals; Arteries; Desipramine; Dose-Response Relationship, Drug; Ear; Electric Stimulation; Iliac Vein; Muscle, Smooth; Neural Conduction; Norepinephrine; Portal Vein; Propranolol; Pulmonary Artery; Rabbits; Rats; Receptors, Adrenergic; Saphenous Vein; Stimulation, Chemical; Vasomotor System | 1975 |
Potassium-induced increase in oxygen consumption of brown adipose tissue from the rat.
Topics: Adipose Tissue, Brown; Animals; Calcium; Denervation; Desipramine; Hydroxydopamines; In Vitro Techniques; Male; Oxygen Consumption; Potassium; Potassium Chloride; Propranolol; Rats; Reserpine; Stimulation, Chemical | 1975 |
Neurogenic sympathetic vasoconstriction of the rabbit basilar artery.
Topics: Animals; Basilar Artery; Bretylium Tosylate; Cerebrovascular Circulation; Cocaine; Desipramine; Female; Guanethidine; Male; Microscopy, Fluorescence; Muscle Contraction; Norepinephrine; Phenoxybenzamine; Phentolamine; Propranolol; Rabbits; Reserpine; Tetrodotoxin; Vasomotor System | 1976 |
Alpha-adrenoceptors do not contribute to the chronotropic or inotropic responses of the avian heart to noradrenaline.
Topics: Animals; Chickens; Cocaine; Corticosterone; Desipramine; Electric Stimulation; Heart; Heart Rate; In Vitro Techniques; Isoproterenol; Methoxamine; Myocardial Contraction; Norepinephrine; Phentolamine; Propranolol; Receptors, Adrenergic, alpha | 1991 |
Effect of enantiomers of propranolol on desipramine-induced anti-immobility in the forced swimming test in the rat.
Topics: Animals; Behavior, Animal; Brain; Desipramine; Imipramine; Male; Propranolol; Rats; Rats, Inbred Strains; Stereoisomerism; Swimming | 1991 |
Perinatal undernutrition affects brain modulatory capacity of beta-adrenergic receptors in adult rats.
Topics: Analysis of Variance; Animals; Brain; Caseins; Cerebral Cortex; Desipramine; Dihydroalprenolol; Female; Hippocampus; Male; Pregnancy; Prenatal Exposure Delayed Effects; Propranolol; Protein Deficiency; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta | 1990 |
Effects of chronic antidepressant treatment on alpha 1- and alpha 2-adrenoceptors in the rat anococcygeus muscle.
Topics: Animals; Antidepressive Agents; Cocaine; Desipramine; Electric Stimulation; Male; Mianserin; Muscle Contraction; Muscles; Nomifensine; Normetanephrine; Nortriptyline; Phenylephrine; Propranolol; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Xylazine | 1990 |
Phosphatidylserine as a determinant for the tissue distribution of weakly basic drugs in rats.
Topics: Animals; Desipramine; Hydrogen-Ion Concentration; Imipramine; Injections, Intravenous; Male; Models, Biological; Phosphatidylserines; Propranolol; Quinidine; Rats; Rats, Inbred Strains; Tissue Distribution | 1990 |
Effects of centrally acting beta adrenergic agonists on discrete trial conditioned avoidance behavior in rats.
Topics: Adrenergic beta-Agonists; Animals; Avoidance Learning; Desipramine; Haloperidol; Male; Propranolol; Rats; Rats, Inbred Strains | 1989 |
Chronic desipramine attenuates morphine analgesia.
Topics: Analgesics, Opioid; Animals; Desipramine; Drug Interactions; Male; Mice; Morphine; Naloxone; Naltrexone; Propranolol; Reaction Time | 1986 |
[The influence of central monoaminergic systems on the anticonvulsive action of propranolol].
Topics: 5-Hydroxytryptophan; Animals; Anticonvulsants; Apomorphine; Biogenic Amines; Desipramine; Dose-Response Relationship, Drug; Electroshock; Fenclonine; Hydroxydopamines; Male; Mice; Norepinephrine; Oxidopamine; Propranolol; Serotonin | 1986 |
Factors determining alpha-adrenoceptor-mediated responses of human digital arteries and metacarpal veins.
Topics: Desipramine; Dose-Response Relationship, Drug; Fingers; Humans; Hydrocortisone; Metacarpus; Muscle, Smooth, Vascular; Norepinephrine; Phenylephrine; Prazosin; Propranolol; Quinazolines; Receptors, Adrenergic, alpha; Yohimbine | 1985 |
Reduced peripheral presynaptic adrenoceptor sensitivity following chronic antidepressant treatment in rats.
Topics: Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Clorgyline; Cocaine; Desipramine; Electric Stimulation; In Vitro Techniques; Liver; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Muscle Contraction; Muscle, Smooth; Norepinephrine; Propranolol; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Neurotransmitter; Selegiline; Tranylcypromine; Vas Deferens | 1985 |
Neuronal and postjunctional components in the blood pressure effects of dopamine and bromocriptine in rabbits.
Topics: Anesthesia; Animals; Benzazepines; Blood Pressure; Bromocriptine; Clonidine; Decerebrate State; Desipramine; Domperidone; Dopamine; Female; Male; Neurons; Nitroprusside; Norepinephrine; Propranolol; Rabbits; Receptors, Dopamine; Receptors, Neurotransmitter | 1985 |
Chlorpromazine induces accumulation of inositol phosphates in C6 glioma cells.
Topics: Animals; Cell Line; Chlorpromazine; Desipramine; Glioma; Inositol; Inositol Phosphates; Lysophospholipids; Phosphatidylinositols; Propranolol; Rats; Sugar Phosphates | 1986 |
Modifications of phospholipid metabolism induced by chlorpromazine, desmethylimipramine and propranolol in C6 glioma cells.
Topics: Animals; Cell Line; Chlorpromazine; Desipramine; Diglycerides; Dose-Response Relationship, Drug; Glioma; Phosphatidylinositol Phosphates; Phosphatidylinositols; Phospholipids; Propranolol; Tetradecanoylphorbol Acetate | 1987 |
Effect of receptor blockers (methysergide, propranolol, phentolamine, yohimbine and prazosin) on desimipramine-induced pituitary hormone stimulation in humans--I. Growth hormone.
Topics: Adolescent; Adult; Blood Glucose; Blood Pressure; Carrier Proteins; Desipramine; Drug Interactions; Growth Hormone; Humans; Male; Methysergide; Phentolamine; Pituitary Hormones; Prazosin; Propranolol; Receptors, Drug; Receptors, Neurotransmitter; Time Factors; Yohimbine | 1986 |
Effects of receptor blockers (methysergide, propranolol, phentolamine, yohimbine and prazosin) on desimipramine-induced pituitary hormone stimulation in humans--II. Prolactin.
Topics: Blood Glucose; Blood Pressure; Carrier Proteins; Desipramine; Drug Interactions; Heart Rate; Humans; Male; Methysergide; Phentolamine; Pituitary Hormones; Prazosin; Prolactin; Propranolol; Receptors, Drug; Receptors, Neurotransmitter; Time Factors; Yohimbine | 1986 |
Effects of receptor blockers (methysergide, propranolol, phentolamine, yohimbine and prazosin) on desimipramine-induced pituitary hormone stimulation in humans--III. Hypothalamo-pituitary-adrenocortical axis.
Topics: Blood Glucose; Blood Pressure; Carrier Proteins; Desipramine; Drug Interactions; Heart Rate; Humans; Hypothalamo-Hypophyseal System; Male; Methysergide; Phentolamine; Pituitary Hormones; Pituitary-Adrenal System; Prazosin; Propranolol; Receptors, Drug; Receptors, Neurotransmitter; Yohimbine | 1986 |
Modulation of rat brain cytosolic phosphatidate phosphohydrolase: effect of cationic amphiphilic drugs and divalent cations.
Topics: Animals; Brain; Cations; Chlorpromazine; Cytosol; Desipramine; Kinetics; Male; Microscopy, Electron; Microsomes, Liver; Phosphatidate Phosphatase; Phosphoric Monoester Hydrolases; Propranolol; Rats; Rats, Inbred Strains; Sonication | 1987 |
Effects of drugs affecting noradrenergic neurotransmission in rats with spontaneous petit mal-like seizures.
Topics: Animals; Desipramine; Electroencephalography; Epilepsy, Absence; Iproniazid; Isoproterenol; Male; Norepinephrine; Propranolol; Rats; Rats, Inbred Strains; Synaptic Transmission | 1987 |
Desipramine and noradrenergic neurotransmission in aging: failure to respond in aged laboratory animals.
Topics: Action Potentials; Aging; Animals; Desipramine; Electric Stimulation; Hydroxydopamines; Male; Norepinephrine; Oxidopamine; Propranolol; Purkinje Cells; Rats; Rats, Inbred F344; Rats, Inbred Strains; Synaptic Transmission | 1987 |
Prepontine knife cut-induced hyperthermia in the rat. Effect of chemical sympathectomy and surgical denervation of brown adipose tissue.
Topics: Adipose Tissue, Brown; Animals; Body Temperature; Body Temperature Regulation; Colon; Denervation; Desipramine; Fever; Hydroxydopamines; Male; Oxidopamine; Propranolol; Rats; Rats, Inbred Strains; Sympathectomy, Chemical; Sympathetic Nervous System | 1988 |
Diel and seasonal rhythms of the heart rate in the common eel (Anguilla anguilla L.): role of cardiac innervation.
Topics: Acetylcholine; Anguilla; Animals; Atropine; Catecholamines; Circadian Rhythm; Desipramine; Electrocardiography; Electronic Data Processing; Fourier Analysis; Heart; Heart Rate; Propranolol; Seasons; Sympathetic Nervous System | 1988 |
4-Hydroxy-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline (PI-OH): a new potentiator of sympathomimetic amines on the rat anococcygeus muscle.
Topics: Animals; Cocaine; Desipramine; Drug Synergism; Electric Stimulation; In Vitro Techniques; Male; Muscles; Nomifensine; Propranolol; Rats; Rats, Inbred Strains; Sympathomimetics | 1988 |
Effects of clenbuterol and prenalterol on performance during differential reinforcement of low response rate in the rat.
Topics: Animals; Behavior, Animal; Clenbuterol; Desipramine; Ethanolamines; Isomerism; Male; Mathematics; Prenalterol; Propranolol; Rats; Rats, Inbred Strains; Reinforcement, Psychology | 1987 |
[Release of norepinephrine by cardiac sympathetic fibers in vitro. Pharmacologic modulation].
Topics: Adrenergic Fibers; Animals; Chromatography, High Pressure Liquid; Desipramine; Electric Stimulation; Heart Rate; In Vitro Techniques; Male; Myocardium; Norepinephrine; Propranolol; Rats; Yohimbine | 1987 |
Successful use of clonazepam in patients with treatment-resistant panic disorder.
Topics: Adult; Agoraphobia; Alprazolam; Anxiety Disorders; Benzodiazepines; Benzodiazepinones; Clonazepam; Desipramine; Fear; Female; Humans; Imipramine; Male; Middle Aged; Panic; Phenelzine; Propranolol; Psychiatric Status Rating Scales | 1986 |
Mechanism of modification of rat brain lysophospholipase A activity by cationic amphiphilic drugs.
Topics: Animals; Brain; Cations; Chlorpromazine; Cytosol; Desipramine; Fatty Acids, Nonesterified; Lysophospholipase; Micelles; Microscopy, Electron; Microsomes; Phospholipases; Propranolol; Psychotropic Drugs; Rats | 1987 |
Studies on the uptake and release of propranolol and the effects of propranolol on catecholamines in cultures of bovine adrenal chromaffin cells.
Topics: Acetylcholine; Adrenal Medulla; Animals; Biological Transport; Carbachol; Catecholamines; Cattle; Cells, Cultured; Desipramine; Kinetics; Norepinephrine; Propranolol; Sodium; Stereoisomerism; Tyramine; Veratridine | 1986 |
Accumulation of 3H-adrenaline by rabbit aorta.
Topics: Animals; Aorta; Catechol O-Methyltransferase Inhibitors; Clonidine; Cocaine; Desipramine; Epinephrine; Hypoxia; In Vitro Techniques; Iodoacetates; Iodoacetic Acid; Male; Monoamine Oxidase Inhibitors; Norepinephrine; Normetanephrine; Ouabain; Propranolol; Rabbits; Radionuclide Imaging; Tritium | 1985 |
Influence of alpha- and beta-adrenoceptors on the release of noradrenaline from field stimulated atria and cerebral cortex slices.
Topics: Animals; Atrial Function; Cerebral Cortex; Clonidine; Desipramine; Electric Stimulation; Guanidines; Heart Atria; In Vitro Techniques; Isoproterenol; Mice; Mice, Inbred Strains; Norepinephrine; Phenoxybenzamine; Phentolamine; Propranolol; Rats; Receptors, Adrenergic | 1974 |
[A study of the calorigenic action of catecholamines].
Topics: Adipose Tissue; Animals; Desipramine; Epinephrine; Fatty Acids, Nonesterified; Hyperglycemia; Hypolipidemic Agents; Isoproterenol; Nicotinic Acids; Norepinephrine; Oxygen Consumption; Propranolol; Rats; Stimulation, Chemical; Triglycerides | 1968 |
Proceedings: Arrhythmias evoked by infusion of tricyclic antidepressants and noradrenaline on isolated rabbit hearts.
Topics: Animals; Antidepressive Agents; Arrhythmias, Cardiac; Desipramine; Dose-Response Relationship, Drug; Doxepin; Heart Conduction System; In Vitro Techniques; Iprindole; Norepinephrine; Propranolol; Rabbits; Time Factors | 1974 |
The effects of the tricyclic antidepressants desipramine, doxepin and iprindole on the isolated perfused rabbit heart.
Topics: Animals; Antidepressive Agents; Arrhythmias, Cardiac; Atropine; Autonomic Fibers, Postganglionic; Cocaine; Desipramine; Doxepin; Drug Antagonism; Electric Stimulation; Female; Heart; Heart Rate; Iprindole; Male; Perfusion; Propranolol; Quinidine; Rabbits; Sympathetic Nervous System; Time Factors | 1974 |
Interaction of cannabis and general anaesthetic agents in mice.
Topics: Anesthesia, General; Animals; Cannabis; Desipramine; Dronabinol; Drug Synergism; Ethyl Ethers; Fenclonine; Hypothermia; Iproniazid; Male; Methyltyrosines; Mice; Mice, Inbred Strains; Pentobarbital; Phentolamine; Preanesthetic Medication; Propranolol; Protriptyline; Reserpine | 1974 |
Mechanism of action of norepinephrine in eliciting an eating response on injection into the rat hypothalamus.
Topics: Amphetamine; Angiotensin II; Animals; Behavior, Animal; Brain Chemistry; Desipramine; Drinking; Eating; Ephedrine; Epinephrine; Histamine; Hypothalamus; Injections; Isoproterenol; Male; Methods; Norepinephrine; Normetanephrine; Octopamine; Phenoxybenzamine; Phentolamine; Phenylephrine; Propranolol; Rats; Stimulation, Chemical; Tritium; Tyramine | 1968 |
Stimulated formation of adenosine 3',5'-monophosphate by desipramine in brain slices.
Topics: Adenine; Adenosine Triphosphate; Amitriptyline; Animals; Brain; Carbon Isotopes; Chlorpromazine; Cyclic AMP; Desipramine; Guinea Pigs; Histamine; Imipramine; Male; Norepinephrine; Perphenazine; Phentolamine; Phosphoric Monoester Hydrolases; Propranolol; Rats; Rats, Inbred Strains; Theophylline; Tritium; Veratrine | 1971 |
Potentiation of monoaminergic activity in peripheral ganglia by tricyclic antidepressants.
Topics: Action Potentials; Animals; Antidepressive Agents; Cats; Desipramine; Dibenzocycloheptenes; Dopamine; Drug Synergism; Epinephrine; Ganglia; Norepinephrine; Nortriptyline; Propranolol; Serotonin; Synaptic Transmission; Time Factors | 1972 |
The action of norepinephrine in the rat hippocampus. I. Iontophoretic studies.
Topics: Acetylcholine; Action Potentials; Adenosine Triphosphate; Amino Alcohols; Aminobutyrates; Aminophylline; Anilides; Animals; Bucladesine; Cyclic AMP; Desipramine; Dextroamphetamine; Dibenzylchlorethamine; Dopamine; Drug Synergism; Electric Stimulation; Glutamates; Hippocampus; Hydroxydopamines; Iontophoresis; Male; Neural Inhibition; Norepinephrine; Papaverine; Phentolamine; Propranolol; Prostaglandins; Rats; Serotonin; Synaptic Transmission; Tyramine | 1974 |
Acceleration of sugar transport in avian erythrocytes by catecholamines.
Topics: Adenosine Triphosphate; Animals; Caffeine; Carbon Radioisotopes; Catechols; Cell Membrane; Cyclic AMP; Desipramine; Dopamine; Ephedrine; Epinephrine; Erythrocytes; Galactose; Geese; Glucose; Iproniazid; Isoproterenol; Methylglycosides; Norepinephrine; Phentolamine; Phloretin; Potassium; Propranolol; Sorbitol; Stereoisomerism | 1974 |
Pharmacological studies on modaline sulphate (w 3207).
Topics: Antidepressive Agents; Desipramine; Dibenzylchlorethamine; Dihydroxyphenylalanine; Fever; Hydrazines; Isoproterenol; Monoamine Oxidase Inhibitors; Nortriptyline; Phentolamine; Proadifen; Propranolol; Reserpine; Sympatholytics; Tryptamines | 1965 |
An adrenergic control system in Tetrahymena.
Topics: Caffeine; Catecholamines; Desipramine; Glycogen; Hydrazines; Isoproterenol; Phenoxybenzamine; Propranolol; Reserpine; Tetrahymena; Triiodothyronine | 1967 |
Effect of antidepressant and adrenergic blocking drugs on hyperthermia induced by reserpine.
Topics: Amitriptyline; Animals; Antidepressive Agents; Atropine; Body Temperature; Chlorisondamine; Chlorpromazine; Desipramine; Ethanolamines; Female; Fever; Hydrazines; Imipramine; Monoamine Oxidase Inhibitors; Norepinephrine; Nortriptyline; Phenoxybenzamine; Phentolamine; Propranolol; Rats; Reserpine; Sympatholytics; Tetrabenazine | 1967 |
Effect of adrenergically reactive drugs on peroxisomal enzymes in Tetrahymena.
Topics: Aminophylline; Aniline Compounds; Animals; Catalase; D-Amino-Acid Oxidase; Desipramine; Glycogen; Isocitrate Dehydrogenase; Isoproterenol; Lyases; Malate Dehydrogenase; Propranolol; Reserpine; Sympathomimetics; Tetrahymena; Tranquilizing Agents; Tranylcypromine; Triiodothyronine | 1968 |
Evidence of catecholamine mediation in the "aberrant" behaviour induced by lysergic acid diethylamide (LSD) in the rat.
Topics: Animals; Behavior, Animal; Catecholamines; Chlorpromazine; Desipramine; Dibenzylchlorethamine; Disulfiram; Dopamine; Ethanolamines; Locomotion; Lysergic Acid Diethylamide; Male; Methysergide; Perphenazine; Phenoxybenzamine; Phenylalanine; Propranolol; Rats; Reserpine; Serotonin | 1968 |
An adrenergic neuron blocking action of propranolol in isolated tissues.
Topics: Amphetamine; Animals; Arteries; Desipramine; Ear; Guanethidine; Ileum; In Vitro Techniques; Lidocaine; Male; Muscle Contraction; Muscle, Smooth; Norepinephrine; Propranolol; Rabbits; Rats; Vas Deferens | 1968 |
The role of the sympathetic nervous system in the cardiovascular responses to angiotensin in the pithed rat.
Topics: Adrenalectomy; Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Cardiovascular System; Desipramine; Ganglionic Blockers; Heart Rate; Male; Phentolamine; Propranolol; Rats; Reserpine; Sympathetic Nervous System | 1969 |
The effect of bretylium on the cardiovascular response to tyramine in the rat.
Topics: Amphetamine; Animals; Blood Pressure; Bretylium Compounds; Catecholamines; Cordotomy; Desipramine; Drug Synergism; Female; Guanethidine; Heart; Heart Rate; Hydrazines; Myocardium; Nialamide; Norepinephrine; Pentobarbital; Phentolamine; Propranolol; Pyrogallol; Rats; Reserpine; Thiocarbamates; Tyramine; Urethane | 1969 |
[Isolated noradrenaline granules from guinea pig heart].
Topics: Adenosine Triphosphate; Animals; Cell Fractionation; Cytoplasmic Granules; Depression, Chemical; Desipramine; Ethanolamines; Guinea Pigs; Magnesium; Myocardium; Norepinephrine; Phenoxybenzamine; Propranolol | 1970 |
Antagonism by propranolol of the inhibitory effect of phenoxybenzamine on noradrenaline uptake in vivo.
Topics: Animals; Binding Sites; Cocaine; Cold Temperature; Desipramine; Drug Antagonism; Female; Guanethidine; Injections, Subcutaneous; Male; Mice; Myocardium; Norepinephrine; Phenoxybenzamine; Phentolamine; Propranolol; Rats; Time Factors; Tritium | 1971 |
Effects of dopamine on the conductance of perfused vascular beds of the chloralosed cat.
Topics: Animals; Atropine; Blood Pressure; Blood Vessels; Cats; Cocaine; Constriction; Desipramine; Dilatation; Dopamine; Dopamine Antagonists; Drug Synergism; Female; Haloperidol; Heart Rate; Hindlimb; Histamine H1 Antagonists; Isoproterenol; Male; Perfusion; Phenoxybenzamine; Propranolol; Receptors, Adrenergic; Vascular Resistance | 1972 |
Analysis of a positive chronotropic response to epinine.
Topics: Animals; Depression, Chemical; Desipramine; Dogs; Dopamine; Dose-Response Relationship, Drug; Female; Heart Rate; Male; Methane; Norepinephrine; Propranolol; Sinoatrial Node; Stimulation, Chemical; Sympathomimetics; Tetrodotoxin; Time Factors | 1974 |
Effect of desmethylimipramine on the canine SA node.
Topics: Acetylcholine; Animals; Atropine; Blood Pressure; Depression, Chemical; Desipramine; Dogs; Electrocardiography; Female; Heart Rate; Male; Norepinephrine; Propranolol; Sinoatrial Node; Stimulation, Chemical; Tetrodotoxin; Tyramine | 1974 |
The role of catecholamines in the reversal of reserpine-induced hypothermia in mice by desipramine and chlorpromazine.
Topics: Animals; Body Temperature; Catecholamines; Chlorpromazine; Desipramine; Dihydroxyphenylalanine; Dose-Response Relationship, Drug; Hypothermia; Male; Mice; Norepinephrine; Phenoxybenzamine; Phentolamine; Propranolol; Reserpine; Thiocarbamates | 1972 |
Relationship between substances strengthening of the thrombocyte cell membrane on the aggregation of thrombocytes and on the uptake and release of serotonin.
Topics: Adenosine Diphosphate; Amitriptyline; Benzothiepins; Blood Platelets; Cell Membrane; Cell Membrane Permeability; Chlorpromazine; Colorimetry; Desipramine; Epinephrine; Humans; Imipramine; In Vitro Techniques; Nortriptyline; Phentolamine; Piperazines; Platelet Adhesiveness; Propranolol; Receptors, Adrenergic; Serotonin; Serotonin Antagonists; Spectrometry, Fluorescence; Tranquilizing Agents | 1972 |
Proceedings: Mechanism of the early pressor effect of centrally administered propranolol in the conscious rabbit.
Topics: Animals; Blood Pressure; Desipramine; Heart Rate; Premedication; Propranolol; Rabbits; Receptors, Adrenergic; Stimulation, Chemical | 1974 |
In vitro effect of 6-hydroxydopamine on isolated rat atria.
Topics: Animals; Bretylium Compounds; Cocaine; Desipramine; Female; Heart; Heart Atria; In Vitro Techniques; Male; Nerve Endings; Phenethylamines; Phentolamine; Propranolol; Rats; Reserpine; Tachyphylaxis | 1972 |
Metabolism of propranolol by rat liver microsomes and its inhibition by phenothiazine and tricyclic antidepressant drugs.
Topics: Amitriptyline; Animals; Antidepressive Agents; Chlorpromazine; Desipramine; Imipramine; Kinetics; Liver; Male; Metabolism; Microsomes, Liver; NAD; NADP; Nitrogen; Nortriptyline; Perphenazine; Phenothiazines; Prochlorperazine; Promazine; Promethazine; Propranolol; Rats; Subcellular Fractions; Trifluoperazine; Triflupromazine | 1971 |
Effects of 6-hydroxydopamine on the canine sinus node.
Topics: Acetylcholine; Animals; Cardiac Catheterization; Desipramine; Dogs; Dopamine; Dopamine Antagonists; Electrocardiography; Heart Rate; Injections, Intra-Arterial; Methods; Microscopy, Fluorescence; Nerve Endings; Norepinephrine; Propranolol; Sinoatrial Node; Stellate Ganglion; Sympathectomy; Tritium; Tyramine | 1971 |
Reversal of reserpine-induced hypothermia by pharmacological agents other than antidepressants.
Topics: Animals; Antidepressive Agents; Aspirin; Body Temperature; Chlorpromazine; Depression, Chemical; Desipramine; Male; Mice; Morphine; Phenoxybenzamine; Propranolol; Reserpine; Sympatholytics | 1967 |
Modifications by propranolol of the response of isolated rabbit atria to endogenous and exogenous noradrenaline.
Topics: Animals; Atrial Function; Depression, Chemical; Desipramine; Drug Antagonism; Electric Stimulation; Female; Heart; Heart Atria; Male; Muscle Contraction; Norepinephrine; Propranolol; Rabbits; Sympathetic Nervous System; Tyramine | 1968 |
The effect of various drug pretreatments on amine-induced phosphorylase activation and amine uptake.
Topics: Amitriptyline; Animals; Carbon Isotopes; Depression, Chemical; Desipramine; Diphenhydramine; Drug Synergism; Female; Glucosyltransferases; Heart; Imipramine; Isoproterenol; Methylphenidate; Myocardium; Norepinephrine; Promethazine; Propranolol; Rats; Stimulation, Chemical; Tranylcypromine; Triprolidine; Tritium; Tyramine | 1968 |
Some observations on the adrenergic blocking activity of desipramine and amitriptyline on aortic strips of rabbits.
Topics: Amitriptyline; Animals; Aorta; Calcium; Chlorpromazine; Desipramine; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Norepinephrine; Propranolol; Rabbits; Receptors, Drug | 1969 |
Caloric intake and Na+-K+-ATPase: differential regulation by alpha 1- and beta-noradrenergic receptors.
Topics: 4-Nitrophenylphosphatase; Adipose Tissue, Brown; Animals; Body Weight; Desipramine; Diet; Eating; Energy Intake; Fasting; Male; Ouabain; Prazosin; Propranolol; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Sodium-Potassium-Exchanging ATPase | 1984 |
Binding of phenothiazine neuroleptics to plasma proteins.
Topics: Antipsychotic Agents; Blood Proteins; Chlorpromazine; Desipramine; Humans; Kinetics; Perphenazine; Propranolol; Protein Binding; Salicylates; Salicylic Acid; Structure-Activity Relationship; Trifluoperazine; Tritium | 1983 |
Storage and release of catecholamines by nervous endings in the isolated heart of the eel (Anguilla anguilla L.).
Topics: Action Potentials; Anguilla; Animals; Atropine; Blood Pressure; Catecholamines; Desipramine; Electric Stimulation; Heart; Heart Rate; Nerve Endings; Perfusion; Propranolol; Systole; Vagus Nerve | 1984 |
Effect of repeated treatment with desipramine in the behavioral "despair" test in rats: antagonism by "atypical" but not "classical" neuroleptics or antiadrenergic drugs.
Topics: Adrenergic alpha-Antagonists; Animals; Antipsychotic Agents; Butyrophenones; Chlorpromazine; Clonidine; Clozapine; Depressive Disorder; Desipramine; Dibenzazepines; Haloperidol; Humans; Male; Metoclopramide; Phentolamine; Prazosin; Propranolol; Rats; Sulpiride | 1984 |
Effects of adrenoceptor antagonists and neuronal uptake inhibitors on dimethylphenylpiperazinium-induced release of catecholamines from the rabbit isolated adrenal gland and guinea-pig atria.
Topics: Adrenal Glands; Adrenergic alpha-Antagonists; Animals; Catecholamines; Clonidine; Cocaine; Desipramine; Dimethylphenylpiperazinium Iodide; Epinephrine; Guinea Pigs; Hexamethonium Compounds; In Vitro Techniques; Myocardium; Neurotransmitter Uptake Inhibitors; Phentolamine; Piperazines; Propranolol; Rabbits; Sympatholytics; Tritium | 1984 |
Direct and indirect actions of dopamine on tracheal smooth muscle.
Topics: Animals; Desipramine; Dopamine; Dose-Response Relationship, Drug; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Phentolamine; Propranolol; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Receptors, Dopamine; Reserpine; Trachea | 1980 |
Electrical stimulation of sympathetic nerves increases the concentration of cyclic AMP in rat pineal gland.
Topics: Animals; Bretylium Compounds; Cyclic AMP; Desipramine; Electric Stimulation; Ganglia, Sympathetic; Kinetics; Male; Phentolamine; Pineal Gland; Propranolol; Rats; Rats, Inbred Strains; Reserpine | 1981 |
Effect of treatment of rats with antidepressants on melatonin concentrations in the pineal gland and serum.
Topics: Animals; Antidepressive Agents; Darkness; Desipramine; Isoproterenol; Male; Melatonin; Nialamide; Pineal Gland; Propranolol; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta; Stimulation, Chemical | 1982 |
Influence of repeated administration of desmethylimipramine on beta adrenergic and muscarinic cholinergic receptors and 45Ca++ binding to sarcoplasmic reticulum in the rat heart.
Topics: Acetylcholine; Animals; Calcium; Desipramine; Dihydroalprenolol; Heart; Isoproterenol; Male; Myocardial Contraction; Myocardium; Norepinephrine; Ornithine Decarboxylase; Propranolol; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Adrenergic, beta; Receptors, Cholinergic; Receptors, Muscarinic; Sarcoplasmic Reticulum | 1982 |
Selective changes in the density of beta 1-adrenergic receptors in rat striatum following chronic drug treatment and adrenalectomy.
Topics: Adrenalectomy; Animals; Caudate Nucleus; Corpus Striatum; Desipramine; Male; Pargyline; Pindolol; Propranolol; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Adrenergic, beta | 1982 |
Effect of age and sex on the plasma binding of acidic and basic drugs.
Topics: Adolescent; Adult; Age Factors; Aged; Blood Proteins; Chlorpromazine; Desipramine; Female; Humans; Male; Meperidine; Middle Aged; Pharmaceutical Preparations; Phenytoin; Propranolol; Protein Binding; Salicylates; Salicylic Acid; Serum Albumin; Sex Factors | 1984 |
Effects of catecholamine agonist and antagonist drugs on acute stomach ulceration induced by medial hypothalamic lesions in rats.
Topics: Amphetamine; Animals; Catecholamines; Chlorpromazine; Clozapine; Desipramine; Haloperidol; Hypothalamus, Middle; Isoproterenol; Male; Pargyline; Phentolamine; Propranolol; Rats; Rats, Inbred Strains; Stomach Ulcer | 1983 |
Synergistic effect of propranolol and quipazine on desipramine enhanced shock-elicited fighting in rats.
Topics: Aggression; Animals; Desipramine; Dose-Response Relationship, Drug; Drug Synergism; Electroshock; Humans; Male; Propranolol; Quinolines; Quipazine; Rats; Rats, Inbred Strains; Stimulation, Chemical | 1983 |
The effects of acute and repeated treatment with salbutamol, a beta-adrenoceptor agonist, on clonidine-induced hypoactivity in rats.
Topics: Albuterol; Animals; Clonidine; Desipramine; Drug Interactions; Exploratory Behavior; Fluoxetine; Imipramine; Male; Propranolol; Rats; Rats, Inbred Strains; Yohimbine | 1982 |
The noradrenaline rate in the anaesthetized rabbit: facilitation by adrenaline.
Topics: Anesthesia; Animals; Blood Pressure; Catecholamines; Desipramine; Epinephrine; Heart Rate; Kinetics; Norepinephrine; Propranolol; Rabbits; Time Factors | 1982 |
Activation of glycogenolysis and norepinephrine overflow in the perfused rat liver during repetitive perivascular nerve stimulation.
Topics: Animals; Desipramine; Electric Stimulation; Liver; Liver Glycogen; Male; Norepinephrine; Perfusion; Phentolamine; Propranolol; Rats; Rats, Inbred Strains | 1982 |
Arrhythmia induced by a tricyclic antidepressant in a patient with undiagnosed mitral valve prolapse.
Topics: Adult; Arrhythmias, Cardiac; Depressive Disorder; Desipramine; Female; Humans; Mitral Valve Prolapse; Propranolol | 1981 |
The measurement of antagonist potency and the importance of selective inhibition of agonist uptake processes.
Topics: Albuterol; Amitriptyline; Animals; Desipramine; Guinea Pigs; In Vitro Techniques; Isoproterenol; Male; Metanephrine; Methoxamine; Models, Biological; Muscle Contraction; Muscle, Smooth; Neurons; Norepinephrine; Phentolamine; Propranolol; Rats; Rats, Inbred Strains; Receptors, Drug; Regression Analysis | 1981 |
Effects of reserpinization, surgical denervation and in vitro chemical denervation with 6-hydroxydopamine on the contractile response of isolated rabbit ear artery to propranolol.
Topics: Animals; Arteries; Denervation; Desipramine; Dose-Response Relationship, Drug; Ear; Hydroxydopamines; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Propranolol; Rabbits; Reserpine | 1981 |
Effect of N-(4-butoxybenzyl) hyoscyaminium bromide (butropium bromide) on the isolated, blood-perfused canine atrium preparation.
Topics: Animals; Atropine Derivatives; Desipramine; Dogs; Female; Heart; Heart Atria; Heart Rate; In Vitro Techniques; Male; Myocardial Contraction; Perfusion; Propranolol; Stimulation, Chemical; Tetrodotoxin | 1980 |
Identification of human CYP isoforms involved in the metabolism of propranolol enantiomers--N-desisopropylation is mediated mainly by CYP1A2.
Topics: Aged; Benzoflavones; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Desipramine; Ditiocarb; Female; Humans; Hydroxylation; In Vitro Techniques; Isoenzymes; Male; Mephenytoin; Microsomes, Liver; Middle Aged; Oxazines; Phenacetin; Propranolol; Quinidine; Recombinant Proteins; Stereoisomerism; Substrate Specificity; Sulfaphenazole; Tolbutamide; Troleandomycin | 1995 |
Beta 2- but not beta 1-adrenoceptors are involved in desipramine enhancement of aggressive behavior in long-term isolated mice.
Topics: Aggression; Animals; Clenbuterol; Desipramine; Dose-Response Relationship, Drug; Drug Interactions; Male; Metoprolol; Mice; Mice, Inbred Strains; Propranolol; Receptors, Adrenergic, beta-1; Receptors, Adrenergic, beta-2; Social Isolation | 1994 |
Antidepressant and depressogenic drugs lack consistent effects on hamster circadian rhythms.
Topics: Animals; Antidepressive Agents; Arousal; Circadian Rhythm; Clonidine; Clorgyline; Cricetinae; Desipramine; Dose-Response Relationship, Drug; Fluoxetine; Male; Mesocricetus; Motor Activity; Phenelzine; Propranolol | 1994 |
Effects of concurrent subchronic treatments with desmethylimipramine and propranolol on beta-adrenergic and serotonin2 receptors in rat brain.
Topics: Animals; Brain Chemistry; Cerebral Cortex; Desipramine; Dihydroalprenolol; Hippocampus; In Vitro Techniques; Ketanserin; Male; Membranes; Neostriatum; Propranolol; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta; Receptors, Serotonin | 1993 |
Studies on cytochrome P450 responsible for oxidative metabolism of imipramine in human liver microsomes.
Topics: Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Desipramine; Electrophoresis, Polyacrylamide Gel; Humans; Imipramine; Immunoblotting; In Vitro Techniques; Microsomes, Liver; Mixed Function Oxygenases; NADPH-Ferrihemoprotein Reductase; Oxidation-Reduction; Oxidoreductases, N-Demethylating; Propranolol; Quinidine; Quinine; Testosterone; Troleandomycin | 1993 |
Differential effects of fluoxetine on isoprenaline-stimulated water intake in ethanol-treated rats: a role for beta-adrenoceptors.
Topics: Analysis of Variance; Animals; Desipramine; Drinking; Drug Interactions; Ethanol; Fluoxetine; Fluvoxamine; Injections, Intraperitoneal; Isoproterenol; Male; Propranolol; Rats; Rats, Wistar; Receptors, Adrenergic, beta; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists; Zimeldine | 1993 |
REM sleep inhibition by desipramine: evidence for an alpha-1 adrenergic mechanism.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Adrenergic Uptake Inhibitors; Animals; Antihypertensive Agents; Cats; Desipramine; Female; Hydralazine; Prazosin; Propranolol; Sleep, REM | 1995 |
Uncompetitive inhibition of [3H]1,3-di-o-tolyl-guanidine-defined sigma binding sites by desipramine, propranolol and alprenolol in rat brain.
Topics: Adrenergic beta-Antagonists; Alprenolol; Animals; Antidepressive Agents, Tricyclic; Desipramine; Guanidines; Kinetics; Male; Propranolol; Rats; Rats, Wistar; Receptors, sigma | 1997 |
Noradrenergic activity differentially regulates the expression of rolipram-sensitive, high-affinity cyclic AMP phosphodiesterase (PDE4) in rat brain.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Binding, Competitive; Brain; Desipramine; Immunoblotting; Male; Norepinephrine; Oxidopamine; Phosphodiesterase Inhibitors; Propranolol; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Rolipram; Time Factors | 1997 |
Discriminative stimulus properties of cocaine: enhancement by monoamine reuptake blockers.
Topics: Animals; Cocaine; Desipramine; Discrimination Learning; Dopamine; Dose-Response Relationship, Drug; Fluoxetine; Male; Neurotransmitter Uptake Inhibitors; Norepinephrine; Prazosin; Propranolol; Rats; Rats, Sprague-Dawley; Serotonin; Ventral Tegmental Area | 1998 |
Effects of antidepressant treatment on inhibitory avoidance behavior and amygdaloid beta-adrenoceptors in rats.
Topics: Adrenergic beta-Antagonists; Amygdala; Animals; Antidepressive Agents; Avoidance Learning; Desipramine; Fluoxetine; Injections, Intraventricular; Male; Muscarinic Antagonists; Phenelzine; Propranolol; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta-1; Scopolamine | 1998 |
Modulation by presynaptic beta-adrenoceptors of noradrenaline release from sympathetic nerves in human dental pulp.
Topics: Adolescent; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Adrenergic Uptake Inhibitors; Adult; Albuterol; Anti-Inflammatory Agents; Corticosterone; Dental Pulp; Desipramine; Electric Stimulation; Ethanolamines; Female; Humans; Isoproterenol; Male; Norepinephrine; Propranolol; Radiopharmaceuticals; Receptors, Adrenergic, beta; Receptors, Presynaptic; Sympathetic Nervous System; Sympatholytics; Sympathomimetics; Tritium; Yohimbine | 1998 |
Alpha 1-adrenergic receptor-mediated increase in the mass of phosphatidic acid and 1,2-diacylglycerol in ischemic rat heart.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Adrenergic Uptake Inhibitors; Analysis of Variance; Animals; Chromatography, Thin Layer; Desipramine; Diacylglycerol Kinase; Diglycerides; Estrenes; Male; Myocardial Ischemia; Myocardial Reperfusion; Myocardium; Norepinephrine; Perfusion; Phosphatidic Acids; Piperidines; Prazosin; Propranolol; Pyrrolidinones; Quinazolines; Quinazolinones; Rats; Rats, Wistar; Receptors, Adrenergic, alpha; Time Factors; Type C Phospholipases | 1999 |
Long-term treatment with antidepressants increases glucocorticoid receptor binding and gene expression in cultured rat hippocampal neurones.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Cells, Cultured; Desipramine; Dexamethasone; Gene Expression Regulation; Haloperidol; Hippocampus; Ketanserin; Mianserin; Neurons; Paroxetine; Phentolamine; Propranolol; Radioligand Assay; Rats; Receptors, Glucocorticoid; Receptors, Mineralocorticoid; RNA, Messenger; Sulpiride; Transcription, Genetic; Tritium | 1999 |
A morpholinocatechol compound (UK42620) with clonidine- and tyramine-like actions.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Adrenergic Uptake Inhibitors; Animals; Cardiotonic Agents; Catechols; Clonidine; Desipramine; Dose-Response Relationship, Drug; Female; Heart Rate; Hemodynamics; Morpholines; Myocardial Contraction; Propranolol; Rats; Rats, Sprague-Dawley; Tyramine | 2001 |
Alpha-tocopherol influences the lipid membrane affinity of desipramine in a pH-dependent manner.
Topics: alpha-Tocopherol; Antidepressive Agents, Tricyclic; Antioxidants; Cholesterol; Chromans; Desipramine; Hydrogen-Ion Concentration; Liposomes; Membrane Lipids; Phosphatidylcholines; Phosphatidylinositols; Potentiometry; Propranolol; Tocopherols; Warfarin | 2004 |
Probing the mechanism of drug/lipid membrane interactions using Biacore.
Topics: Adrenergic beta-Antagonists; Binding Sites; Binding, Competitive; Desipramine; Dibucaine; Kinetics; Lipidoses; Lipids; Liposomes; Permeability; Pharmaceutical Preparations; Propranolol; Reproducibility of Results; Surface Plasmon Resonance; Surface Properties | 2004 |
Neuropharmacological treatment of refractory idiopathic thrombocytopenic purpura: roles of circulating catecholamines and serotonin.
Topics: Adult; Blood Platelets; Catecholamines; Child; Desipramine; Female; Hemorrhage; Humans; Male; Middle Aged; Neuropharmacology; Propranolol; Purpura, Thrombocytopenic, Idiopathic; Salvage Therapy; Serotonin; Th2 Cells; Tyrosine | 2004 |
Reduction of vascular noradrenaline sensitivity by AT1 antagonists depends on functional sympathetic innervation.
Topics: Adrenergic alpha-Antagonists; Angiotensin II Type 1 Receptor Blockers; Animals; Atropine; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Desipramine; Diastole; Dose-Response Relationship, Drug; Losartan; Male; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Propranolol; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Reserpine; Sympathectomy, Chemical; Sympathetic Nervous System; Symporters; Tetrazoles; Tubocurarine; Yohimbine | 2004 |
Cocaine-induced modulation of long-term potentiation in the CA1 region of rat hippocampus.
Topics: Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Benzazepines; Cocaine; Desipramine; Dopamine Antagonists; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Fluoxetine; Hippocampus; In Vitro Techniques; Lidocaine; Long-Term Potentiation; Neurotransmitter Uptake Inhibitors; Piperazines; Propranolol; Rats; Rats, Sprague-Dawley; Salicylamides; Tetrodotoxin | 2005 |
The involvement of norepinephrine and microglia in hypothalamic and splenic IL-1beta responses to stress.
Topics: Adrenergic Uptake Inhibitors; Animals; Anti-Anxiety Agents; Anti-Bacterial Agents; Desipramine; Hypothalamus; Interleukin-1; Male; Microglia; Minocycline; Norepinephrine; Propranolol; Rats; Rats, Sprague-Dawley; Spleen; Stress, Psychological | 2006 |
Pharmacological characterization of the beta-adrenoceptor that mediates the relaxant response to noradrenaline in guinea-pig tracheal smooth muscle.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-1 Receptor Antagonists; Adrenergic beta-Antagonists; Adrenergic Uptake Inhibitors; Albuterol; Animals; Atenolol; Bupranolol; Butoxamine; Desipramine; Desoxycorticosterone; Dose-Response Relationship, Drug; Female; Guinea Pigs; Histamine; Imidazoles; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth; Norepinephrine; Phentolamine; Propanolamines; Propranolol; Receptors, Adrenergic, beta-1; Trachea | 2007 |
Antidepressant-like effect of tramadol in the unpredictable chronic mild stress procedure: possible involvement of the noradrenergic system.
Topics: Adrenergic beta-Antagonists; Animals; Antidepressive Agents; Behavior, Animal; Cerebellum; Chronic Disease; Desipramine; Hippocampus; Hypothalamus; Locus Coeruleus; Male; Methoxyhydroxyphenylglycol; Mice; Mice, Inbred BALB C; Norepinephrine; Propanolamines; Propranolol; Receptors, Adrenergic, beta-2; Stress, Psychological; Tramadol | 2007 |
Postsynaptic alpha-2 adrenergic receptors are critical for the antidepressant-like effects of desipramine on behavior.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic beta-Antagonists; Animals; Antidepressive Agents, Tricyclic; Depression; Desipramine; Idazoxan; Male; Mice; Mice, Knockout; Motor Activity; Prazosin; Propanolamines; Propranolol; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Receptors, Adrenergic, beta; Synapses | 2009 |
Protracted cannabinoid administration elicits antidepressant behavioral responses in rats: role of gender and noradrenergic transmission.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Behavior, Animal; Cannabinoids; Desipramine; Dronabinol; Female; Male; Norepinephrine; Piperidines; Prazosin; Propranolol; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Sex Characteristics; Substance Withdrawal Syndrome; Swimming; Synaptic Transmission | 2009 |
Regulation of MCP-1 production in brain by stress and noradrenaline-modulating drugs.
Topics: Adrenergic beta-Antagonists; Adrenergic Uptake Inhibitors; Aldehyde-Lyases; Animals; Astrocytes; Benserazide; Brain; Chemokine CCL2; Corticosterone; Desipramine; Drug Administration Routes; Enzyme Inhibitors; Female; Gene Expression Regulation; Male; Metyrapone; Mice; Mice, Inbred C57BL; Norepinephrine; Propranolol; Rats; Rats, Wistar; Restraint, Physical; RNA, Messenger; Stress, Physiological | 2010 |
Effects of noradrenergic denervation on L-DOPA-induced dyskinesia and its treatment by α- and β-adrenergic receptor antagonists in hemiparkinsonian rats.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Adrenergic Neurons; Animals; Behavior, Animal; Corpus Striatum; Desipramine; Disease Models, Animal; Dyskinesia, Drug-Induced; Hippocampus; Idazoxan; Levodopa; Male; Molecular Targeted Therapy; Neuroprotective Agents; Oxidopamine; Parkinson Disease; Propranolol; Rats; Rats, Sprague-Dawley; Severity of Illness Index; Sympathectomy, Chemical | 2012 |
Epidermal growth factor receptor endocytic traffic perturbation by phosphatidate phosphohydrolase inhibition: new strategy against cancer.
Topics: Desipramine; Endocytosis; Endosomes; Enzyme Inhibitors; ErbB Receptors; HeLa Cells; Humans; Ligands; Neoplasms; Phosphatidate Phosphatase; Phosphorylation; Propranolol | 2014 |
Desipramine administered chronically inhibits lipopolysaccharide-stimulated production of IL-1β in the brain and plasma of rats.
Topics: Administration, Oral; Animals; Antidepressive Agents, Tricyclic; Antihypertensive Agents; Brain; Desipramine; Drug Administration Schedule; Hypothalamus; Interleukin-1beta; Lipopolysaccharides; Olfactory Bulb; Prazosin; Propranolol; Rats | 2016 |
Calculating Kinetic Rates and Membrane Permeability from Biased Simulations.
Topics: Cell Membrane Permeability; Chlorpromazine; Desipramine; Domperidone; Kinetics; Labetalol; Lipid Bilayers; Loperamide; Molecular Dynamics Simulation; Molecular Structure; Propranolol; Thermodynamics; Verapamil | 2018 |