desipramine and promethazine

desipramine has been researched along with promethazine in 38 studies

Research

Studies (38)

TimeframeStudies, this research(%)All Research%
pre-199022 (57.89)18.7374
1990's0 (0.00)18.2507
2000's9 (23.68)29.6817
2010's6 (15.79)24.3611
2020's1 (2.63)2.80

Authors

AuthorsStudies
Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET1
Chiang, GH; Unger, SH1
Strassburg, CP; Tukey, RH1
Topliss, JG; Yoshida, F1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY1
Bleich, S; Gulbins, E; Kornhuber, J; Reichel, M; Terfloth, L; Tripal, P; Wiltfang, J1
Lombardo, F; Obach, RS; Waters, NJ1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ1
Glen, RC; Lowe, R; Mitchell, JB1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Bellman, K; Knegtel, RM; Settimo, L1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Cardoso, FC; Duggan, PJ; Kuiper, MJ; Lewis, RJ; Schmit, M; Tuck, KL1
Klimek, V; Maj, J; Rawlów, A; Sarnek, J1
Frisk-Holmberg, M; van der Kleijn, E1
Bolan, JC; Glenn, CH; Hardison, MD; Mason, RG; Mohammad, SF; Morton, BD1
Gaut, ZN2
Green, AL1
Colson, SH; Tolson, WW; Umberger, EJ1
Schrold, J1
Korduba, CA; Symchowicz, S; Veals, J1
Mainard, F; Stephan, Y; Welin, L1
Iriye, TT; Simmonds, FA2
Oates, JA; Shand, DG1
Gross, R; Linker, H; Reuter, H1
Anton-Tay, F; Axelrod, J; Wurtman, RJ1
Brody, TM; McNeill, JH1
Nybäck, H; Sedvall, G1
Borzecki, Z; Nybäck, H; Sedvall, G1
Schechter, MD1
BOFF, E; SCHECKEL, CL1
Gbotosho, GO; Gerena, L; Happi, CT; Kyle, DE; Milhous, WK; Oduola, AM; Ogundahunsi, OA; Salako, LA; Sowunmi, A1

Reviews

2 review(s) available for desipramine and promethazine

ArticleYear
Human UDP-glucuronosyltransferases: metabolism, expression, and disease.
    Annual review of pharmacology and toxicology, 2000, Volume: 40

    Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; Neoplasms; Steroids; Terminology as Topic

2000
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Other Studies

36 other study(ies) available for desipramine and promethazine

ArticleYear
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:3

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium

1985
Octanol-physiological buffer distribution coefficients of lipophilic amines by reversed-phase high-performance liquid chromatography and their correlation with biological activity.
    Journal of medicinal chemistry, 1981, Volume: 24, Issue:3

    Topics: Amines; Animals; Buffers; Chromatography, High Pressure Liquid; Histamine Release; Lipid Metabolism; Octanols; Protein Binding; Rats; Serum Albumin, Bovine; Sodium-Potassium-Exchanging ATPase; Solubility; Structure-Activity Relationship

1981
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
    Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5

    Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution

2004
Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model.
    Journal of medicinal chemistry, 2008, Jan-24, Volume: 51, Issue:2

    Topics: Algorithms; Animals; Cell Line; Cell Line, Tumor; Chemical Phenomena; Chemistry, Physical; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Molecular Conformation; Quantitative Structure-Activity Relationship; Rats; Sphingomyelin Phosphodiesterase

2008
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
    Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19

    Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
    Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3

    Topics:

2008
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
    Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6

    Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics

2010
Predicting phospholipidosis using machine learning.
    Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5

    Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine

2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics

2010
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
    Pharmaceutical research, 2014, Volume: 31, Issue:4

    Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation

2014
Inhibition of N-type calcium ion channels by tricyclic antidepressants - experimental and theoretical justification for their use for neuropathic pain.
    RSC medicinal chemistry, 2022, Feb-23, Volume: 13, Issue:2

    Topics:

2022
On the anticataleptic action of cyproheptadine.
    Pharmacology, biochemistry, and behavior, 1976, Volume: 5, Issue:2

    Topics: Animals; Atropine; Catalepsy; Clomipramine; Cyproheptadine; Desipramine; Female; Fluphenazine; Humans; Imipramine; Male; Methyltyrosines; Pilocarpine; Pimozide; Promethazine; Rats; Reserpine; Spiperone

1976
The relationship between the lipophilic nature of tricyclic neuroleptics and antidepressants, and histamine release.
    European journal of pharmacology, 1972, Volume: 18, Issue:2

    Topics: Amitriptyline; Animals; Antidepressive Agents; Cell Membrane Permeability; Chemical Phenomena; Chemistry; Chlorpromazine; Chlorprothixene; Clopenthixol; Desipramine; Fluphenazine; Histamine Release; Imipramine; Kinetics; Male; Mast Cells; Methotrimeprazine; Nortriptyline; Perphenazine; Phenothiazines; Prochlorperazine; Promazine; Promethazine; Rats; Solvents; Structure-Activity Relationship; Thioridazine; Tranquilizing Agents; Trifluoperazine

1972
Adhesion of human blood platelets to glass and polymer surfaces. I. Studies with platelets in plasma.
    Haemostasis, 1974, Volume: 3, Issue:5-6

    Topics: Adult; Age Factors; Amitriptyline; Aspirin; Blood Coagulation Disorders; Chloromercuribenzoates; Chlorpromazine; Citrates; Desipramine; Edetic Acid; Glass; Glucosamine; Heparin; Humans; Imipramine; Middle Aged; Platelet Adhesiveness; Polyethylenes; Polymers; Polytetrafluoroethylene; Polyvinyl Chloride; Promethazine; Sulfinpyrazone

1974
Influence of various substances which induce and inhibit aggregation on the uptake of deoxyglucose by human blood platelets.
    The Journal of pharmacology and experimental therapeutics, 1974, Volume: 190, Issue:1

    Topics: Adenosine Diphosphate; Amitriptyline; Antidepressive Agents; Blood Glucose; Blood Platelets; Bucladesine; Carbon Radioisotopes; Chlorpromazine; Cyproheptadine; Desipramine; Epinephrine; Glucose; Humans; In Vitro Techniques; Norepinephrine; Nortriptyline; Platelet Adhesiveness; Promethazine; Serotonin; Thrombin

1974
Ionization constants and water solubilities of some aminoalkylphenothiazine tranquillizers and related compounds.
    The Journal of pharmacy and pharmacology, 1967, Volume: 19, Issue:1

    Topics: Amitriptyline; Chemical Phenomena; Chemistry; Chlorpromazine; Desipramine; Hydrogen-Ion Concentration; Imipramine; Perphenazine; Phenothiazines; Prochlorperazine; Promethazine; Solubility; Thioridazine; Tranquilizing Agents; Trifluoperazine; Water

1967
The effects of some centrally acting drugs on the glucocorticoid induction of hepatic tyrosine transaminase.
    Life sciences, 1969, Nov-15, Volume: 8, Issue:22

    Topics: Adrenalectomy; Amitriptyline; Animals; Chlorpheniramine; Chlorpromazine; Desipramine; Diphenhydramine; Enzyme Induction; Female; Fluocinolone Acetonide; Fluorometholone; Glucocorticoids; Hydrocortisone; Imipramine; Liver; Male; Prednisone; Proadifen; Promazine; Promethazine; Rats; Reserpine; Sex Factors; Triflupromazine; Tyrosine Transaminase

1969
Behavioural effects od d-amphetamine alone and in combination with antidepressants, antihistamines or other psychotropic drugs in young chicks.
    Psychopharmacologia, 1972, Volume: 23, Issue:2

    Topics: Amitriptyline; Animals; Antidepressive Agents; Behavior, Animal; Chickens; Chlorpheniramine; Cocaine; Desipramine; Dextroamphetamine; Diphenhydramine; Drug Antagonism; Drug Interactions; Histamine H1 Antagonists; Imipramine; Male; Nortriptyline; Promethazine

1972
Binding of cyproheptadine-(N-methyl- 14 C) by human blood platelets: inhibition by phenothiazines and tricyclic antidepressants.
    The Journal of pharmacology and experimental therapeutics, 1973, Volume: 185, Issue:1

    Topics: Amitriptyline; Blood Platelets; Carbon Isotopes; Centrifugation; Chlorpromazine; Cyproheptadine; Desipramine; Humans; Imipramine; In Vitro Techniques; Nortriptyline; Phenothiazines; Platelet Adhesiveness; Promethazine

1973
The effect of pheniramine and its structural analogues on 5-hydroxytryptamine in rat and mouse brain.
    Life sciences, 1973, Dec-01, Volume: 13, Issue:11

    Topics: Amines; Amphetamine; Animals; Biological Transport; Brompheniramine; Chlorine; Chlorpheniramine; Chlorpromazine; Corpus Striatum; Desipramine; Fluorine; Hydroxyindoleacetic Acid; Male; Mice; Pheniramine; Promethazine; Rats; Serotonin; Structure-Activity Relationship; Synaptosomes; Time Factors

1973
[Binding to human serum proteins of drugs belonging to phenothiazine series, iminodibenzyle, thioxanthene and thiophenylpyridylamine].
    Comptes rendus hebdomadaires des seances de l'Academie des sciences. Serie D: Sciences naturelles, 1971, Mar-08, Volume: 272, Issue:10

    Topics: Antidepressive Agents; Blood Proteins; Chemical Phenomena; Chemistry; Chlorpromazine; Chlorprothixene; Chromatography, Gel; Desipramine; Dibenzazepines; Humans; Imipramine; Phenothiazines; Prochlorperazine; Promazine; Promethazine; Protein Binding; Spectrophotometry; Thiazines; Trimeprazine

1971
Effect of tranquilizers and antidepressants on glycogen phosphorylase of rat brain.
    Biochemical pharmacology, 1971, Volume: 20, Issue:8

    Topics: Adenosine Monophosphate; Animals; Antidepressive Agents; Brain; Depression, Chemical; Desipramine; Dextroamphetamine; Female; Freezing; Glucosyltransferases; Iproniazid; Norepinephrine; Pargyline; Perphenazine; Phosphorylases; Prochlorperazine; Promazine; Promethazine; Rats; Receptors, Adrenergic; Reserpine; Tranquilizing Agents; Triflupromazine

1971
Metabolism of propranolol by rat liver microsomes and its inhibition by phenothiazine and tricyclic antidepressant drugs.
    Biochemical pharmacology, 1971, Volume: 20, Issue:7

    Topics: Amitriptyline; Animals; Antidepressive Agents; Chlorpromazine; Desipramine; Imipramine; Kinetics; Liver; Male; Metabolism; Microsomes, Liver; NAD; NADP; Nitrogen; Nortriptyline; Perphenazine; Phenothiazines; Prochlorperazine; Promazine; Promethazine; Propranolol; Rats; Subcellular Fractions; Trifluoperazine; Triflupromazine

1971
Possible involvement of glycogen phosphorylase of brain in the affective states.
    International pharmacopsychiatry, 1971, Volume: 6, Issue:2

    Topics: Amphetamine; Animals; Antidepressive Agents; Brain; Chlorpromazine; Depression; Desipramine; Drug Interactions; Female; Humans; Iproniazid; Pargyline; Phenothiazines; Phosphorylases; Prochlorperazine; Promazine; Promethazine; Rats; Receptors, Adrenergic; Reserpine; Stereoisomerism; Tranquilizing Agents

1971
[A possible mechanism of disaggregation of ADP-induced aggregates by imipramin and structurally related compouds].
    Thrombosis et diathesis haemorrhagica, 1969, Nov-15, Volume: 22, Issue:2

    Topics: Adenine Nucleotides; Amitriptyline; Blood Platelets; Chlorpromazine; Desipramine; Diphenhydramine; Humans; Imipramine; Nortriptyline; Optical Rotatory Dispersion; Platelet Adhesiveness; Promazine; Promethazine

1969
Inhibition of the metabolism of H3-melatonin by phenothiazines.
    The Journal of pharmacology and experimental therapeutics, 1968, Volume: 161, Issue:2

    Topics: Amphetamine; Animals; Antimetabolites; Body Temperature; Brain; Chlorpromazine; Depression, Chemical; Desipramine; Female; Imipramine; Liver; Melatonin; Phenobarbital; Phenothiazines; Promazine; Promethazine; Rats; Tritium

1968
The effect of various drug pretreatments on amine-induced phosphorylase activation and amine uptake.
    The Journal of pharmacology and experimental therapeutics, 1968, Volume: 162, Issue:1

    Topics: Amitriptyline; Animals; Carbon Isotopes; Depression, Chemical; Desipramine; Diphenhydramine; Drug Synergism; Female; Glucosyltransferases; Heart; Imipramine; Isoproterenol; Methylphenidate; Myocardium; Norepinephrine; Promethazine; Propranolol; Rats; Stimulation, Chemical; Tranylcypromine; Triprolidine; Tritium; Tyramine

1968
Influence of drugs on catecholamine metabolism in brain as studied by 14C-tyrosine.
    British journal of pharmacology, 1968, Volume: 34, Issue:1

    Topics: Animals; Brain; Carbon Isotopes; Catecholamines; Chlorpromazine; Desipramine; Dopamine; Haloperidol; Mice; Norepinephrine; Promethazine; Rats; Stimulation, Chemical; Tyrosine

1968
Accumulation and disappearance of catecholamines formed from tyrosine-14C in mouse brain; effect of some psychotropic drugs.
    European journal of pharmacology, 1968, Volume: 4, Issue:4

    Topics: Animals; Brain Chemistry; Carbon Isotopes; Catecholamines; Chlorpromazine; Desipramine; Dopamine; Haloperidol; Injections, Intravenous; Mice; Norepinephrine; Promethazine; Tyrosine

1968
Effect of neuroleptics and tricyclic antidepressants upon d-amphetamine discrimination.
    Pharmacology, biochemistry, and behavior, 1980, Volume: 12, Issue:1

    Topics: Animals; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Chlorpromazine; Clozapine; Desipramine; Dextroamphetamine; Discrimination, Psychological; Dose-Response Relationship, Drug; Fluphenazine; Haloperidol; Imipramine; Male; Nortriptyline; Promethazine; Rats; Sodium Chloride; Thioridazine; Trifluoperazine

1980
BEHAVIORAL EFFECTS OF INTERACTING IMIPRAMINE AND OTHER DRUGS WITH D-AMPHETAMINE, COCAINE, AND TETRABENAZINE.
    Psychopharmacologia, 1964, Feb-12, Volume: 5

    Topics: Amitriptyline; Atropine; Avoidance Learning; Chlorpromazine; Cocaine; Desipramine; Dextroamphetamine; Guanethidine; Imipramine; Iproniazid; Isocarboxazid; Methylphenidate; Parasympatholytics; Pharmacology; Piperidines; Promazine; Promethazine; Rats; Research; Scopolamine; Tetrabenazine; Trihexyphenidyl; Tyramine

1964
The effects of alpha1-acid glycoprotein on the reversal of chloroquine resistance in Plasmodium falciparum.
    Annals of tropical medicine and parasitology, 2006, Volume: 100, Issue:7

    Topics: Animals; Antimalarials; Calcium Channel Blockers; Chloroquine; Chlorpheniramine; Desipramine; Dose-Response Relationship, Drug; Drug Interactions; Drug Resistance; Enzyme Inhibitors; Histamine H1 Antagonists; Orosomucoid; Plasmodium falciparum; Promethazine; Verapamil

2006