desipramine has been researched along with naloxone in 46 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (28.26) | 18.7374 |
| 1990's | 12 (26.09) | 18.2507 |
| 2000's | 11 (23.91) | 29.6817 |
| 2010's | 10 (21.74) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bauer, C; Caldwell, L; Kinnier, WJ; Lancaster, J; McMillan, B; Price, CH; Sweetnam, PM | 1 |
| Strassburg, CP; Tukey, RH | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Adkison, KK; Humphreys, JE; Mahar Doan, KM; Polli, JW; Serabjit-Singh, CJ; Shampine, LJ; Webster, LO; Wring, SA | 1 |
| Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Sun, Y; Yan, Z | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Campillo, NE; Guerra, A; Páez, JA | 1 |
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Gozalbes, R; Pineda-Lucena, A | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Chen, L; Fei, J; Mei, Y; Ren, S; Yan, SF; Zeng, J; Zhang, JZ | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Bellman, K; Knegtel, RM; Settimo, L | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Cassens, G; Orsulak, P; Reigle, T; Roffman, M; Schildkraut, JJ | 1 |
| Cowan, A; Macfarlane, IR | 1 |
| Molina, VA; Murua, VS | 1 |
| Dafny, N; Dougherty, PM; Qiao, JT; Wiggins, RC | 3 |
| Hernandez, DE; Jennes, L | 1 |
| Chaouloff, F; Elghozi, JL; Guezennec, Y; Laude, D | 1 |
| Carenzi, A; Della Bella, D; Reggiani, A | 1 |
| O'Neill, KA; Valentino, D | 1 |
| Tuominen, RK | 1 |
| Buder, M; Fuder, H; Riers, HD; Rothacher, G | 1 |
| Jacobson, W; Wilkinson, DA; Wilkinson, M | 1 |
| Mayer, DJ; Watkins, LR | 1 |
| Fanelli, RJ; Gallagher, M; Rapp, PR | 1 |
| Carmichael, FJ; Israel, Y | 1 |
| Reisine, T; Soubrie, P | 1 |
| Holm, AC; Ogren, SO | 1 |
| Lester, BR; Sun, Z; Wilcox, GL; Wu, HH | 1 |
| Crosbie, GV; Grice, JE; Hockings, GI; Jackson, RV; Torpy, DJ; Walters, MM | 1 |
| Cooper, RL; Goldman, JM; McElroy, WK; Parrish, MB; Stoker, TE | 1 |
| Gergen, KA; Kastin, AJ; Paul, D; Zadina, JE | 1 |
| Freund, RK; Palmer, MR; Wang, Y | 1 |
| Besson, A; Eschalier, A; Fialip, J; Privat, AM | 1 |
| Alvarez, I; Andreu, F; Buxens, J; Colombo, M; Dordal, A; Farré, AJ; Fort, M; Gutiérrez, B | 1 |
| Minami, K; Sagata, K; Shigematsu, A; Shiraishi, M; Toyohira, Y; Ueno, S; Yanagihara, N | 1 |
| Aydin, S; Beis, R; Herekman-Demir, T; Oztürk, Y | 1 |
| Gibert-Rahola, J; Mico, JA; Rojas-Corrales, MO | 1 |
4 review(s) available for desipramine and naloxone
| Article | Year |
|---|---|
The role of receptor binding in drug discovery.
Topics: Animals; Drug Design; Humans; Receptors, Drug | 1993 |
Human UDP-glucuronosyltransferases: metabolism, expression, and disease.
Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; Neoplasms; Steroids; Terminology as Topic | 2000 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Multiple endogenous opiate and non-opiate analgesia systems: evidence of their existence and clinical implications.
Topics: Acupuncture Therapy; Analgesia; Animals; Cholecystokinin; Conditioning, Classical; Desipramine; Dimethyl Sulfoxide; Drug Interactions; Electroshock; Endorphins; Enkephalin, Leucine; Mecamylamine; Morphine; N-Methylscopolamine; Naloxone; Naltrexone; Norepinephrine; Proglumide; Rats; Receptors, Cell Surface; Receptors, Cholecystokinin; Scopolamine; Scopolamine Derivatives; Serotonin; Spinal Cord | 1986 |
1 trial(s) available for desipramine and naloxone
| Article | Year |
|---|---|
The effect of desipramine on basal and naloxone-stimulated cortisol secretion in humans: interaction of two drugs acting on noradrenergic control of adrenocorticotropin secretion.
Topics: Adrenocorticotropic Hormone; Adult; Desipramine; Double-Blind Method; Drug Interactions; Humans; Hydrocortisone; Male; Middle Aged; Naloxone; Norepinephrine; Synaptic Transmission | 1995 |
41 other study(ies) available for desipramine and naloxone
| Article | Year |
|---|---|
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Cell Line; Cell Membrane Permeability; Central Nervous System Agents; Dogs; Drug Delivery Systems; Permeability; Pharmaceutical Preparations | 2002 |
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution | 2004 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
First-principle, structure-based prediction of hepatic metabolic clearance values in human.
Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metabolic Clearance Rate; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship; Sensitivity and Specificity; Software | 2009 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical | 2010 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
QSAR-based solubility model for drug-like compounds.
Topics: Databases, Factual; Models, Molecular; Pharmaceutical Preparations; Quantitative Structure-Activity Relationship; Solubility; Water | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors.
Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Microsomes, Liver; Models, Molecular; Molecular Dynamics Simulation; Substrate Specificity | 2013 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation | 2014 |
Further studies of the effects of morphine on the levels of MHPG-SO4 in rat brain.
Topics: Animals; Brain; Desipramine; Glycols; Male; Methoxyhydroxyphenylglycol; Morphine; Naloxone; Norepinephrine; Pargyline; Rats; Time Factors | 1979 |
Effect of morphine antagonists on drug-induced hypothermia in mice and rats.
Topics: Animals; Antidepressive Agents; Apomorphine; Body Temperature; Cyclazocine; Desipramine; Dextroamphetamine; Diprenorphine; Drug Evaluation, Preclinical; Female; Male; Methyltyrosines; Mice; Morphine; Naloxone; Narcotic Antagonists; Oxotremorine; Rats; Reserpine | 1976 |
Chronic antidepressant counteracts the conditioned analgesia induced by a context previously associated with inescapable shock.
Topics: Analgesia; Animals; Antidepressive Agents; Clomipramine; Conditioning, Classical; Desipramine; Electroshock; Male; Naloxone; Phenelzine; Rats; Rats, Inbred Strains; Reaction Time | 1991 |
Cocaine interaction with sulpiride, methysergide, naloxone and desipramine: neurophysiological effects of mesolimbic and neostriatal neuronal activity.
Topics: Animals; Caudate Nucleus; Cocaine; Desipramine; Drug Interactions; In Vitro Techniques; Limbic System; Methysergide; Naloxone; Neurons; Putamen; Rats; Rats, Inbred Strains; Sulpiride | 1990 |
Inhibition of neurotensin-induced miosis by blockade of ocular dopamine pathways.
Topics: Animals; Atropine; Autonomic Nervous System; Desipramine; Dopamine; Dopamine Antagonists; Eye; Haloperidol; Hydroxydopamines; Iris; Miosis; Muscarinic Antagonists; Naloxone; Narcotic Antagonists; Nerve Endings; Neurotensin; Neurotransmitter Agents; Oxidopamine; Rabbits; Receptors, Opioid, mu | 1990 |
Effects of microiontophoretic application of cocaine, alone and with receptor antagonists, upon the neurons of the medial prefrontal cortex, nucleus accumbens and caudate nucleus of rats.
Topics: Animals; Caudate Nucleus; Cerebral Cortex; Cocaine; Desipramine; Electrodes; In Vitro Techniques; Iontophoresis; Male; Methysergide; Naloxone; Neurons; Nucleus Accumbens; Rats; Rats, Inbred Strains; Sulpiride; Thalamic Nuclei | 1990 |
Microiontophoresis of cocaine, desipramine, sulpiride, methysergide, and naloxone in habenula and parafasciculus.
Topics: Animals; Antidepressive Agents; Cocaine; Corpus Striatum; Desipramine; Diencephalon; Dose-Response Relationship, Drug; Iontophoresis; Male; Methysergide; Naloxone; Neurons; Nociceptors; Rats; Rats, Inbred Strains; Sulpiride; Thalamic Nuclei | 1990 |
Effects of conditioned running on plasma, liver and brain tryptophan and on brain 5-hydroxytryptamine metabolism of the rat.
Topics: Animals; Brain; Conditioning, Operant; Desipramine; Hydroxyindoleacetic Acid; Liver; Male; Naloxone; Niacin; Physical Exertion; Rats; Rats, Inbred Strains; Running; Serotonin; Time Factors; Tryptophan; Valine | 1985 |
Influence of opioids on beta-receptors down-regulation: studies in cultured C6 glioma cells.
Topics: Animals; Cell Line; Cell Membrane; Cyclic AMP; Desipramine; Glioma; Isoproterenol; Kinetics; Morphine; Naloxone; Rats; Receptors, Adrenergic, beta; Receptors, Opioid | 1987 |
Chronic desipramine attenuates morphine analgesia.
Topics: Analgesics, Opioid; Animals; Desipramine; Drug Interactions; Male; Mice; Morphine; Naloxone; Naltrexone; Propranolol; Reaction Time | 1986 |
Attempts to antagonize the effect of histamine on the cold-stimulated thyrotropin secretion in male rats.
Topics: Adrenergic alpha-Antagonists; Animals; Cold Temperature; Desipramine; Dopamine Antagonists; GABA Antagonists; Histamine; Histamine Antagonists; Injections, Intraventricular; Iodoacetates; Iodoacetic Acid; Male; Naloxone; Parasympatholytics; Rats; Rats, Inbred Strains; Stereotaxic Techniques; Stress, Physiological; Thyrotropin | 1985 |
On the opioid receptor subtype inhibiting the evoked release of 3H-noradrenaline from guinea-pig atria in vitro.
Topics: Animals; Atropine; Benzomorphans; Binding, Competitive; Corticosterone; Cyclazocine; Desipramine; Dynorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Etorphine; Guinea Pigs; Heart Atria; In Vitro Techniques; Morphine; Myocardium; Naloxone; Norepinephrine; Peptide Fragments; Phentolamine; Receptors, Opioid; Receptors, Opioid, kappa; Synapses | 1986 |
The noradrenergic neurotoxins DSP4 and xylamine bind to opiate receptors.
Topics: Amines; Animals; Benzylamines; Binding, Competitive; Cerebral Cortex; Cocaine; Desipramine; Female; In Vitro Techniques; Male; Naloxone; Nitrogen Mustard Compounds; Rats; Rats, Inbred Strains; Receptors, Opioid | 1985 |
Opiate antagonist facilitation of time-dependent memory processes: dependence upon intact norepinephrine function.
Topics: Amygdala; Animals; Behavior, Animal; Brain Chemistry; Desipramine; Hydroxydopamines; Injections, Intraventricular; Locus Coeruleus; Memory, Short-Term; Naloxone; Nerve Crush; Norepinephrine; Oxidopamine; Rats; Rats, Inbred Strains; Time Factors | 1985 |
In vitro inhibitory effects of narcotic analgesics and other psychotropic drugs on the active uptake of norepinephrine in mouse brain tissue.
Topics: Animals; Atropine; Benztropine; Brain; Chlorpromazine; Cocaine; Codeine; Desipramine; Dose-Response Relationship, Drug; Female; In Vitro Techniques; Levorphanol; Lipids; Meperidine; Methadone; Mice; Morphine; Naloxone; Narcotics; Norepinephrine; Solubility; Synaptosomes; Tritium | 1973 |
Loss of rat cerebral cortical opiate receptors following chronic desimipramine treatment.
Topics: Animals; Brain; Cerebral Cortex; Corpus Striatum; Desipramine; Hippocampus; Male; Naloxone; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Adrenergic, beta; Receptors, Opioid | 1982 |
Test-specific effects of the 5-HT reuptake inhibitors alaproclate and zimelidine on pain sensitivity and morphine analgesia.
Topics: Alanine; Analgesia; Animals; Behavior, Animal; Brompheniramine; Desipramine; Dose-Response Relationship, Drug; Male; Morphine; Naloxone; p-Chloroamphetamine; Pain; Pyridines; Rats; Serotonin; Zimeldine | 1980 |
Antinociception following implantation of mouse B16 melanoma cells in mouse and rat spinal cord.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Catecholamines; Cell Transplantation; Desipramine; Dioxanes; Idazoxan; Injections, Spinal; Male; Melanoma, Experimental; Mice; Mice, Inbred ICR; Morphine; Naloxone; Neoplasm Transplantation; Nociceptors; Pain Threshold; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Spinal Cord; Substance P; Transplantation, Heterotopic | 1994 |
Suppression of oocyte release in rats by local administration of the noradrenergic neurotoxin DSP4.
Topics: Adrenergic Agents; Animals; Benzylamines; Desipramine; Dose-Response Relationship, Drug; Female; Naloxone; Narcotic Antagonists; Neurotoxins; Norepinephrine; Ovary; Ovulation; Rats; Rats, Inbred Strains | 1996 |
Intrathecal Tyr-W-MIF-1 produces potent, naloxone-reversible analgesia modulated by alpha 2-adrenoceptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Amino Acid Sequence; Animals; Desipramine; Dose-Response Relationship, Drug; Injections, Spinal; Male; Mice; Molecular Sequence Data; MSH Release-Inhibiting Hormone; Naloxone; Naltrexone; Narcotic Antagonists; Norepinephrine; Receptors, Adrenergic, alpha-2; Yohimbine | 1996 |
Potentiation of ethanol effects in cerebellum by activation of endogenous noradrenergic inputs.
Topics: Adrenergic Uptake Inhibitors; Animals; Ataxia; Central Nervous System Depressants; Cerebellum; Depression; Desipramine; Drug Tolerance; Electric Stimulation; Ethanol; Locus Coeruleus; Male; Naloxone; Narcotic Antagonists; Norepinephrine; Purkinje Cells; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome | 1999 |
Dopaminergic and opioidergic mediations of tricyclic antidepressants in the learned helplessness paradigm.
Topics: Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents, Tricyclic; Desipramine; Dibenzocycloheptenes; Dopamine; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Drug Interactions; Escape Reaction; Haloperidol; Helplessness, Learned; Imipramine; Male; Motor Activity; Naloxone; Narcotic Antagonists; Opioid Peptides; Rats; Rats, Wistar | 1999 |
Pharmacology of cizolirtine: a new analgesic agent.
Topics: Analgesics; Animals; Desipramine; Dinoprostone; Dose-Response Relationship, Drug; Gastric Mucosa; Idazoxan; Male; Mice; Naloxone; Pyrazoles; Rats; Rats, Wistar | 2000 |
Tramadol inhibits norepinephrine transporter function at desipramine-binding sites in cultured bovine adrenal medullary cells.
Topics: Adrenal Medulla; Analgesics, Opioid; Animals; Binding, Competitive; Carrier Proteins; Cattle; Cell Membrane; Cells, Cultured; Desipramine; Dose-Response Relationship, Drug; Naloxone; Narcotic Antagonists; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Receptors, Drug; Symporters; Tramadol | 2002 |
The involvement of endogenous opioid mechanisms in the antinociceptive effects induced by antidepressant drugs, desipramine and trimipramine.
Topics: Analgesics; Animals; Antidepressive Agents; Desipramine; Male; Mice; Morphine; Naloxone; Naltrexone; Receptors, Opioid; Receptors, Opioid, delta; Trimipramine | 2006 |
Role of atypical opiates in OCD. Experimental approach through the study of 5-HT(2A/C) receptor-mediated behavior.
Topics: 5-Hydroxytryptophan; Analgesics, Opioid; Animals; Clozapine; Desipramine; Disease Models, Animal; Dose-Response Relationship, Drug; Fluvoxamine; Indophenol; Levorphanol; Male; Methadone; Mice; Morphine; Naloxone; Narcotic Antagonists; Obsessive-Compulsive Disorder; Piperazines; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Stereotyped Behavior; Tics; Tourette Syndrome; Tramadol; Triazoles | 2007 |