desipramine and methyldopa

desipramine has been researched along with methyldopa in 28 studies

Research

Studies (28)

Timeframe	Studies, this research(%)	All Research%
pre-1990	12 (42.86)	18.7374
1990's	0 (0.00)	18.2507
2000's	4 (14.29)	29.6817
2010's	12 (42.86)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Lombardo, F; Obach, RS; Waters, NJ	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Campillo, NE; Guerra, A; Páez, JA	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Avdeef, A; Tam, KY	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Glen, RC; Lowe, R; Mitchell, JB	1
Ekins, S; Williams, AJ; Xu, JJ	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Bellman, K; Knegtel, RM; Settimo, L	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Clineschmidt, BV; Scriabine, A; Sweet, CS	1
Dean, CR; Hamilton, CA; Polak, G; Porsius, AJ; Reid, JL; Zamboulis, C	1
van Spanning, HW; van Zwieten, PA	1
van Zwieten, PA	1
Carlsson, A	1
Jackson, DM	1
Baldessarini, RJ; Karobath, M	1
Ehinger, B; Falck, B	1
Brown, RM; Lal, H	1
Arias, L; Cavanaugh, JH; Mitchell, JR; Oates, JA	1
Carlsson, A; Fuxe, K; Hökfelt, T	1
Aebert, K	1

Reviews

2 review(s) available for desipramine and methyldopa

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Pseudo-transmitters. Journal of neuro-visceral relations, 1969, Volume: 31 Topics: Animals; Antihypertensive Agents; Cell Membrane; Central Nervous System; Chemical Phenomena; Chemistry; Desipramine; Metaraminol; Methyldopa; Mice; Myocardium; Neurons; Rats; Reserpine; Sympathetic Nervous System; Synaptic Transmission	1969

Trials

1 trial(s) available for desipramine and methyldopa

Article	Year
The effects of desmethylimipramine on the pharmacological actions of alpha methyldopa in man. European journal of clinical pharmacology, 1979, Volume: 16, Issue:2 Topics: Adult; Blood Pressure; Catecholamines; Desipramine; Heart Rate; Humans; Hypnotics and Sedatives; Kinetics; Male; Methyldopa; Salivation; Time Factors	1979

Other Studies

25 other study(ies) available for desipramine and methyldopa

Article	Year
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Neural computational prediction of oral drug absorption based on CODES 2D descriptors. European journal of medicinal chemistry, 2010, Volume: 45, Issue:3 Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical	2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability? Journal of medicinal chemistry, 2010, May-13, Volume: 53, Issue:9 Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological; Permeability; Porosity; Regression Analysis	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
Predicting phospholipidosis using machine learning. Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5 Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds. Pharmaceutical research, 2014, Volume: 31, Issue:4 Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation	2014
Central noradrenergic control of blood pressure. Annual review of pharmacology and toxicology, 1976, Volume: 16 Topics: Adrenergic alpha-Agonists; Animals; Blood Pressure; Cats; Clonidine; Desipramine; Dogs; Drug Interactions; Hemodynamics; Hypertension; Methyldopa; Neurons; Norepinephrine; Rabbits; Rats; Receptors, Drug	1976
The interaction between alpha-methyl-dopa and tricyclic antidepressants. International journal of clinical pharmacology and biopharmacy, 1975, Volume: 11, Issue:1 Topics: Animals; Antidepressive Agents, Tricyclic; Blood Pressure; Cats; Desipramine; Drug Interactions; Female; Imipramine; Male; Methyldopa	1975
Interaction between centrally acting hypotensive drugs and tricyclic antidepressants. Archives internationales de pharmacodynamie et de therapie, 1975, Volume: 214, Issue:1 Topics: Amphetamine; Animals; Antidepressive Agents, Tricyclic; Antihypertensive Agents; Benzimidazoles; Blood Pressure; Cats; Clonidine; Cocaine; Desipramine; Dioxanes; Drug Interactions; Ephedrine; Female; Male; Methyldopa; Piperidines; Reserpine	1975
The effect of -phenethylamine upon spontaneous motor activity in mice: a dual effect on locomotor activity. The Journal of pharmacy and pharmacology, 1972, Volume: 24, Issue:5 Topics: Animals; Desipramine; Dibenzocycloheptenes; Disulfiram; Equipment and Supplies; Injections, Intraperitoneal; Male; Methyldopa; Methyltyrosines; Methysergide; Mice; Motor Activity; Phenethylamines; Reserpine; Time Factors	1972
Effects of L-DOPA and L-3-O-methyl-DOPA on uptake of (3H)L-methionine by synaptosomes. Neuropharmacology, 1972, Volume: 11, Issue:5 Topics: Animals; Binding, Competitive; Biological Transport, Active; Brain; Centrifugation; Cocaine; Depression, Chemical; Desipramine; Dihydroxyphenylalanine; Dinitrophenols; In Vitro Techniques; Kinetics; Male; Methionine; Methyldopa; Mitochondria; Nerve Endings; Ouabain; Rats; Sodium; Synaptosomes; Temperature; Time Factors; Tritium	1972
Cellular uptake of some amino acids and amines in vitro into rabbit and monkey anterior eye segment preparations. Experimental eye research, 1970, Volume: 10, Issue:2 Topics: 5-Hydroxytryptophan; Amino Acids; Animals; Biological Transport, Active; Capillaries; Ciliary Body; Cocaine; Desipramine; Dihydroxyphenylalanine; Dopamine; Epithelium; Formaldehyde; Haplorhini; In Vitro Techniques; Iris; Melanocytes; Methyldopa; Methyltyrosines; Microscopy, Fluorescence; Norepinephrine; Normetanephrine; Ouabain; Pilocarpine; Quaternary Ammonium Compounds; Rabbits	1970
A possible relationship between catecholamines and acute toxicity of desipramine. Psychopharmacologia, 1968, Volume: 12, Issue:4 Topics: 5-Hydroxytryptophan; Animals; Catecholamines; Chlorpromazine; Desipramine; Dihydroxyphenylalanine; Disulfiram; Male; Methyldopa; Mice; Mortality; Phenylalanine; Reserpine	1968
Guanethidine and related agents. 3. Antagonism by drugs which inhibit the norepinephrine pump in man. The Journal of clinical investigation, 1970, Volume: 49, Issue:8 Topics: Antidepressive Agents; Antihypertensive Agents; Blood Pressure; Desipramine; Drug Antagonism; Guanethidine; Humans; Hypertension; Methyldopa; Norepinephrine; Phentolamine; Pulse; Tyramine	1970
Effect of desmethylimipramine, protriptyline and (+)-amphetamine on fluorescence of central adrenergic neurons of rats pretreated with alpha-methyl-DOPA and tetrabenazine or reserpine. European journal of pharmacology, 1967, Volume: 2, Issue:3 Topics: Amphetamine; Animals; Antidepressive Agents; Behavior, Animal; Brain; Desipramine; Fluorescence; Histocytochemistry; Male; Methyldopa; Microscopy, Fluorescence; Mixed Function Oxygenases; Norepinephrine; Normetanephrine; Rats; Reserpine; Sympathetic Nervous System; Tetrabenazine	1967
[What success does L-Dopa have in the treatment of parkinsonian akinesia?]. Deutsche medizinische Wochenschrift (1946), 1967, Mar-17, Volume: 92, Issue:11 Topics: Aged; Biperiden; Blood-Brain Barrier; Desipramine; Dihydroxyphenylalanine; Dopa Decarboxylase; Female; Humans; Infusions, Parenteral; Male; Methyldopa; Middle Aged; Parasympatholytics; Parkinson Disease	1967