desipramine and methotrimeprazine

desipramine has been researched along with methotrimeprazine in 17 studies

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19909 (52.94)18.7374
1990's0 (0.00)18.2507
2000's5 (29.41)29.6817
2010's3 (17.65)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Topliss, JG; Yoshida, F1
Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY1
Lombardo, F; Obach, RS; Waters, NJ1
Bleich, S; Kornhuber, J; Rupprecht, R; Terfloth, L; Wiltfang, J1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Bellman, K; Knegtel, RM; Settimo, L1
Boissier, J; Buschsenschultz, E; Oliver-Marti n, R; Pichot, P1
Frisk-Holmberg, M; van der Kleijn, E1
Maxwell, DR; Sumpter, EA2
Gelb, F; Gurfein, L; Kammerer, M; Wartel, R; Weil, J; Wysoki, V1
Fischbach, R1
Núnek, K1
Broussot, T; Margat, P; Pouly, JP1
Gálfi, M; Lózsa, A; Molnár, J; Nakamura, MJ1

Trials

1 trial(s) available for desipramine and methotrimeprazine

ArticleYear
[Clinical experimentation with desipramine with statistical control].
    Annales medico-psychologiques, 1968, Volume: 1, Issue:1

    Topics: Adult; Aged; Anorexia Nervosa; Barbiturates; Bipolar Disorder; Chlordiazepoxide; Chlorpromazine; Clinical Trials as Topic; Depression; Desipramine; Diazepam; Haloperidol; Humans; Methotrimeprazine; Middle Aged; Schizophrenia

1968

Other Studies

16 other study(ies) available for desipramine and methotrimeprazine

ArticleYear
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds.
    Journal of medicinal chemistry, 2001, Jul-19, Volume: 44, Issue:15

    Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water

2001
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
    Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5

    Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution

2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Molecular properties of psychopharmacological drugs determining non-competitive inhibition of 5-HT3A receptors.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:6

    Topics: Binding Sites; Computer Simulation; Databases, Factual; Models, Chemical; Models, Molecular; Molecular Structure; Molecular Weight; Psychotropic Drugs; Serotonin 5-HT3 Receptor Antagonists; Structure-Activity Relationship

2009
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
    Pharmaceutical research, 2014, Volume: 31, Issue:4

    Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation

2014
[Plasma levels of imipramine and desmethylimipramine and antidepressant effect during controlled therapy(author's transl)].
    Psychopharmacologia, 1975, Volume: 41, Issue:2

    Topics: Adjustment Disorders; Aged; Desipramine; Drug Interactions; Drug Synergism; Humans; Imipramine; Methotrimeprazine; Middle Aged; Time Factors

1975
The relationship between the lipophilic nature of tricyclic neuroleptics and antidepressants, and histamine release.
    European journal of pharmacology, 1972, Volume: 18, Issue:2

    Topics: Amitriptyline; Animals; Antidepressive Agents; Cell Membrane Permeability; Chemical Phenomena; Chemistry; Chlorpromazine; Chlorprothixene; Clopenthixol; Desipramine; Fluphenazine; Histamine Release; Imipramine; Kinetics; Male; Mast Cells; Methotrimeprazine; Nortriptyline; Perphenazine; Phenothiazines; Prochlorperazine; Promazine; Promethazine; Rats; Solvents; Structure-Activity Relationship; Thioridazine; Tranquilizing Agents; Trifluoperazine

1972
Noradrenergic receptors and the control of fusimotor activity.
    The Journal of physiology, 1972, Volume: 222, Issue:2

    Topics: Animals; Cats; Decerebrate State; Desipramine; Methotrimeprazine; Moxisylyte; Muscle Spindles; Neurons, Afferent; Norepinephrine; Phenothiazines; Receptors, Adrenergic; Receptors, Drug

1972
A comparison of the actions of some drugs on decerebrate rigidity, muscle spindle activity and alpha-adrenoceptors.
    British journal of pharmacology, 1974, Volume: 50, Issue:3

    Topics: Animals; Blood Pressure; Cats; Chlorpromazine; Decerebrate State; Desipramine; Dimethylamines; Dose-Response Relationship, Drug; Methotrimeprazine; Muscle Rigidity; Muscle Spindles; Nictitating Membrane; Norepinephrine; Phenothiazines; Receptors, Adrenergic; Serotonin Antagonists; Structure-Activity Relationship; Valerates

1974
[Effect of thymoleptics on acid production of the stomach. Preliminary report].
    Arzneimittel-Forschung, 1969, Volume: 19, Issue:10

    Topics: Amitriptyline; Chlorpromazine; Depression; Depression, Chemical; Desipramine; Dibenzazepines; Gastric Acidity Determination; Gastric Juice; Gastric Mucosa; Humans; Imipramine; Methotrimeprazine; Stomach; Tranquilizing Agents

1969
[Current problems of endogenous depression].
    Activitas nervosa superior, 1970, Jan-12, Volume: 12, Issue:1

    Topics: Amitriptyline; Antidepressive Agents; Chlorpromazine; Convulsive Therapy; Depression; Desipramine; Fluphenazine; Humans; Imipramine; Methotrimeprazine; Nortriptyline; Perphenazine; Thioridazine

1970
[Trial of G. 35020 in 52 cases of depression].
    Annales medico-psychologiques, 1968, Volume: 1, Issue:1

    Topics: Adult; Aged; Bipolar Disorder; Depression; Depressive Disorder, Major; Desipramine; Female; Humans; Male; Meprobamate; Methotrimeprazine; Middle Aged; Phenothiazines

1968
Inhibition of bacterial plasmid replication by stereoselective binding by tricyclic psychopharmacons.
    Research communications in chemical pathology and pharmacology, 1984, Volume: 43, Issue:2

    Topics: Adenosine Triphosphate; Antidepressive Agents, Tricyclic; Conjugation, Genetic; Culture Media; Desipramine; Escherichia coli; Methotrimeprazine; Plasmids; Psychotropic Drugs; R Factors; Stereoisomerism

1984