desipramine has been researched along with idazoxan in 51 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (19.61) | 18.7374 |
| 1990's | 23 (45.10) | 18.2507 |
| 2000's | 8 (15.69) | 29.6817 |
| 2010's | 10 (19.61) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Carmody, LC; Dandapani, S; Donckele, E; Feng, Y; Fernandez, C; Germain, AR; Gupta, PB; Lander, ES; Morgan, B; Munoz, B; Nag, PP; Palmer, M; Perez, JR; Schreiber, SL; Verplank, L | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Blier, P; Curet, O; De Montigny, C | 1 |
| Antonelli, T; Beani, L; Bianchi, C; Caló, G; Ferioli, V; Gaist, G; Morari, M | 1 |
| Angus, JA; Cox, HS; Dorward, PK; Eisenhofer, G; Esler, MD; Saigusa, T | 1 |
| Holman, RB; Thomas, DN | 1 |
| Cervo, L; Samanin, R | 1 |
| Gustafson, I; Westerberg, EJ; Wieloch, T | 1 |
| Marshall, IG; Prior, C; Wannan, G | 1 |
| Grealy, M; O'Donnell, JM | 1 |
| Cervo, L; Grignaschi, G; Samanin, R | 1 |
| Ball, DM; Jackson, HC; Nutt, DJ | 1 |
| Lacroix, JS; Lundberg, JM | 1 |
| Limberger, N; Mayer, A; Singer, EA; Starke, K; Valenta, B; Zier, G | 1 |
| Atterwill, CK; Bloomfield, JG; Bristow, LJ; Catto, LC; Elliott, JM; Heal, DJ | 1 |
| Drobny, H; Singer, EA; Valenta, B | 1 |
| Doxey, JC; Roach, AG; Samuel, J | 1 |
| Arbilla, S; Benkirane, S; Langer, SZ | 1 |
| Curet, O; Dennis, T; L'Heureux, R; Scatton, B | 1 |
| Carter, C; Dennis, T; L'Heureux, R; Scatton, B | 1 |
| Pettibone, DJ; Pflueger, AB; Totaro, JA | 1 |
| Galzin, AM; Langer, SZ; Moret, C | 1 |
| Lester, BR; Sun, Z; Wilcox, GL; Wu, HH | 1 |
| Goodwin, WB; Guyenet, PG; Huangfu, D | 1 |
| Finlay, JM; Gresch, PJ; Sved, AF; Zigmond, MJ | 1 |
| Ignatowski, TA; Spengler, RN | 1 |
| Kengatharan, M; Mackay, D | 1 |
| Kulkarni, SK; Sharma, A | 1 |
| Fabiani, ME; Story, DF | 1 |
| Dailey, JW; Jobe, PC; Steenbergen, JL; Yan, QS | 1 |
| Najbar-Kaszkiel, AT; Rand, MJ | 1 |
| Mateo, Y; Meana, JJ; Pineda, J | 1 |
| Callado, LF; Gabilondo, AM; Meana, JJ | 1 |
| Brock, JA; Dunn, WR; Hardy, TA | 1 |
| Callado, L; Cowen, PJ; McTavish, SF; Sharp, T | 1 |
| Alvarez, I; Andreu, F; Buxens, J; Colombo, M; Dordal, A; Farré, AJ; Fort, M; Gutiérrez, B | 1 |
| Bouvard, M; Rénéric, JP; Stinus, L | 1 |
| Bernini, M; Gobbi, M; Mennini, T; Parini, S; Pirona, L; Sacchetti, G; Samanin, R | 1 |
| Ignatowski, TA; Nickola, TJ; Reynolds, JL; Spengler, RN | 1 |
| Herpfer, I; Hunt, SP; Stanford, SC | 1 |
| Fisher, AS; Hunt, SP; Stanford, SC; Stewart, RJ; Yan, T | 1 |
| Huang, Y; O'Donnell, JM; Whisler, LR; Xiang, Y; Zhang, HT | 1 |
| Barnum, CJ; Bhide, N; Bishop, C; Goldenberg, AA; Klioueva, A; Lindenbach, D; Surrena, MA; Tignor, S; Walters, H | 1 |
| Alba-Delgado, C; Berrocoso, E; Borges, G; Horrillo, I; Meana, JJ; Mico, JA; Neto, F; Ortega, JE; Sánchez-Blázquez, P | 1 |
| Brock, JA; McLachlan, EM; Tripovic, D | 1 |
| Ago, Y; Hasebe, S; Hashimoto, H; Matsuda, T; Nishiyama, S; Oka, S; Takuma, K | 1 |
| Chau, DT; Dawson, R; Green, AI; Khokhar, JY | 1 |
| García-Fuster, MJ; García-Sevilla, JA | 1 |
51 other study(ies) available for desipramine and idazoxan
| Article | Year |
|---|---|
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
Cinnamides as selective small-molecule inhibitors of a cellular model of breast cancer stem cells.
Topics: Amides; Breast Neoplasms; Cell Line, Tumor; Drug Screening Assays, Antitumor; Female; Humans; Neoplastic Stem Cells; Small Molecule Libraries; Structure-Activity Relationship | 2013 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Effect of desipramine and amphetamine on noradrenergic neurotransmission: electrophysiological studies in the rat brain.
Topics: Animals; Brain; Desipramine; Dextroamphetamine; Dioxanes; Hippocampus; Idazoxan; In Vitro Techniques; Locus Coeruleus; Male; Norepinephrine; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha; Serotonin; Synaptic Transmission | 1992 |
Comparison of [3H]choline and D-[3H]aspartate efflux from guinea pig and human neocortex.
Topics: Animals; Aspartic Acid; Atropine; Cerebral Cortex; Choline; Desipramine; Dioxanes; Electric Stimulation; Guinea Pigs; Humans; Idazoxan; Norepinephrine; Reference Values; Tritium | 1992 |
Central sympathoinhibition and peripheral neuronal uptake blockade after desipramine in rabbits.
Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Central Nervous System; Desipramine; Dioxanes; Female; Idazoxan; Kidney; Male; Methoxyhydroxyphenylglycol; Neurons; Norepinephrine; Peripheral Nerves; Rabbits; Receptors, Adrenergic, alpha; Sympathetic Nervous System | 1991 |
A microdialysis study of the regulation of endogenous noradrenaline release in the rat hippocampus.
Topics: Adrenergic alpha-Antagonists; Animals; Desipramine; Dialysis; Dioxanes; Hippocampus; Idazoxan; Male; Norepinephrine; Rats; Rats, Inbred Strains | 1991 |
Clonidine causes antidepressant-like effects in rats by activating alpha 2-adrenoceptors outside the locus coeruleus.
Topics: Adrenergic alpha-Antagonists; Animals; Antidepressive Agents; Behavior, Animal; Clonidine; Desipramine; Dioxanes; Dose-Response Relationship, Drug; Drug Administration Schedule; Hydroxydopamines; Idazoxan; Locus Coeruleus; Male; Neurons; Norepinephrine; Oxidopamine; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha | 1991 |
Extracellular brain cortical levels of noradrenaline in ischemia: effects of desipramine and postischemic administration of idazoxan.
Topics: Adrenergic alpha-Antagonists; Animals; Cerebral Cortex; Desipramine; Dialysis; Dioxanes; Extracellular Space; Heart; Hippocampus; Idazoxan; Injections; Ischemic Attack, Transient; Male; Norepinephrine; Potassium Chloride; Rats; Rats, Inbred Strains; Stereotaxic Techniques | 1991 |
Alpha-adrenoceptor blocking properties of vesamicol.
Topics: Adrenergic alpha-Antagonists; Animals; Clonidine; Corticosterone; Desipramine; Dioxanes; Electric Stimulation; Idazoxan; Male; Muscle Contraction; Muscle, Smooth; Norepinephrine; Piperidines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Stereoisomerism; Vas Deferens | 1991 |
Secretion of growth hormone elicited by intravenous desipramine in the conscious, unrestrained rat.
Topics: Animals; Clonidine; Corticosterone; Desipramine; Dioxanes; Growth Hormone; Hypothalamo-Hypophyseal System; Idazoxan; Injections, Intravenous; Male; Pituitary-Adrenal System; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Yohimbine | 1991 |
Alpha 2-adrenoceptor blockade prevents the effect of desipramine in the forced swimming test.
Topics: Adrenergic alpha-Antagonists; Animals; Buspirone; Depression; Desipramine; Dioxanes; Hydroxydopamines; Idazoxan; Locus Coeruleus; Male; Motor Activity; Oxidopamine; Rats; Swimming | 1990 |
Noradrenergic mechanisms appear not to be involved in cocaine-induced seizures and lethality.
Topics: Adrenergic alpha-Antagonists; Animals; Cocaine; Desipramine; Dioxanes; Hyperkinesis; Idazoxan; Injections, Intraperitoneal; Mice; Norepinephrine; Seizures | 1990 |
Sympathetic vascular control of the pig nasal mucosa: adrenoceptor mechanisms in blood flow and volume control.
Topics: Animals; Antihypertensive Agents; Brimonidine Tartrate; Desipramine; Dioxanes; Electric Stimulation; Female; Idazoxan; Male; Nasal Mucosa; Norepinephrine; Oxymetazoline; Phenylephrine; Prazosin; Quinoxalines; Receptors, Adrenergic; Regional Blood Flow; Rheology; Swine; Sympathetic Nervous System | 1989 |
Estimation of pA2 values at presynaptic alpha 2-autoreceptors in rabbit and rat brain cortex in the absence of autoinhibition.
Topics: Animals; Cerebral Cortex; Clonidine; Desipramine; Dioxanes; Electric Stimulation; Female; Idazoxan; In Vitro Techniques; Kinetics; Male; Nordefrin; Norepinephrine; Rabbits; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Synapses; Yohimbine | 1989 |
The influence of L-triiodothyronine (T3) on the effects of repeated administration of desipramine or electroconvulsive shock on alpha 2- and beta-adrenoceptor function in the brain of the rat: implications for the potentiation of antidepressant therapy by
Topics: Animals; Brain; Clonidine; Desipramine; Dihydroalprenolol; Dioxanes; Electroshock; Idazoxan; Kinetics; Male; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Triiodothyronine | 1987 |
Presynaptic autoinhibition of central noradrenaline release in vitro: operational characteristics and effects of drugs acting at alpha-2 adrenoceptors in the presence of uptake inhibition.
Topics: Animals; Brain; Clonidine; Desipramine; Dioxanes; Electric Stimulation; Idazoxan; In Vitro Techniques; Male; Norepinephrine; Rats; Receptors, Adrenergic, alpha; Tritium | 1988 |
Effects of desipramine on stimulation-induced contractions of the vas deferens of rats pretreated either chronically with desipramine or acutely with idazoxan.
Topics: Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Desipramine; Dioxanes; Dioxins; Drug Interactions; Electric Stimulation; Idazoxan; Male; Muscle Contraction; Muscle, Smooth; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Time Factors; Vas Deferens | 1985 |
Supersensitivity of alpha 2-adrenoceptors modulating [3H]5-HT release after noradrenergic denervation with DSP4.
Topics: Adrenergic alpha-Antagonists; Amines; Animals; Benzylamines; Clonidine; Desipramine; Dioxanes; Electric Stimulation; Hippocampus; Idazoxan; Norepinephrine; Rats; Receptors, Adrenergic, alpha; Serotonin; Sympathectomy, Chemical | 1985 |
Measurement of endogenous noradrenaline release in the rat cerebral cortex in vivo by transcortical dialysis: effects of drugs affecting noradrenergic transmission.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide; Calcium; Cerebral Cortex; Clonidine; Desipramine; Dialysis; Dioxanes; Edetic Acid; Idazoxan; Male; Microchemistry; Norepinephrine; Rats; Rats, Inbred Strains | 1986 |
Presynaptic alpha-2 adrenoceptors play a major role in the effects of idazoxan on cortical noradrenaline release (as measured by in vivo dialysis) in the rat.
Topics: 5,7-Dihydroxytryptamine; Animals; Cerebral Cortex; Desipramine; Dioxanes; Dioxins; Drug Synergism; Electrocoagulation; Ibotenic Acid; Idazoxan; Injections, Intraventricular; Male; Norepinephrine; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha | 1987 |
Tetrabenazine-induced depletion of brain monoamines: mechanism by which desmethylimipramine protects cortical norepinephrine.
Topics: Adrenergic alpha-Antagonists; Animals; Biogenic Amines; Brain Chemistry; Cerebral Cortex; Desipramine; Dihydroxyphenylalanine; Dioxanes; Drug Interactions; Idazoxan; Male; Norepinephrine; Rats; Rats, Inbred Strains; Tetrabenazine; Time Factors | 1984 |
Evidence that exogenous but not endogenous norepinephrine activates the presynaptic alpha-2 adrenoceptors on serotonergic nerve endings in the rat hypothalamus.
Topics: Animals; Cocaine; Desipramine; Dioxins; Hypothalamus; Idazoxan; In Vitro Techniques; Male; Norepinephrine; Phentolamine; Rabbits; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Serotonin; Serotonin; Yohimbine | 1984 |
Antinociception following implantation of mouse B16 melanoma cells in mouse and rat spinal cord.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Catecholamines; Cell Transplantation; Desipramine; Dioxanes; Idazoxan; Injections, Spinal; Male; Melanoma, Experimental; Mice; Mice, Inbred ICR; Morphine; Naloxone; Neoplasm Transplantation; Nociceptors; Pain Threshold; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Spinal Cord; Substance P; Transplantation, Heterotopic | 1994 |
Sympatholytic effect of tricyclic antidepressants: site and mechanism of action in anesthetized rats.
Topics: Adrenergic alpha-Antagonists; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Baclofen; Blood Pressure; Brain Mapping; Desipramine; Dioxanes; Fluoxetine; gamma-Aminobutyric Acid; Idazoxan; Imidazoles; Male; Medulla Oblongata; Microinjections; Nordefrin; Oxidopamine; Rats; Rats, Sprague-Dawley; Splanchnic Nerves; Sympatholytics; Time Factors | 1995 |
Local influence of endogenous norepinephrine on extracellular dopamine in rat medial prefrontal cortex.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Animals; Clonidine; Desipramine; Dioxanes; Dopamine; Dopamine Uptake Inhibitors; Electroshock; Extracellular Space; Idazoxan; Male; Microdialysis; Norepinephrine; Prefrontal Cortex; Rats; Rats, Sprague-Dawley | 1995 |
Tumor necrosis factor-alpha: presynaptic sensitivity is modified after antidepressant drug administration.
Topics: Animals; Antidepressive Agents; Desipramine; Dioxanes; Drug Resistance; Electric Stimulation; Hippocampus; Idazoxan; Male; Neurons; Norepinephrine; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Sympathetic Nervous System; Time Factors; Tumor Necrosis Factor-alpha | 1994 |
pKI values of prazosin and idazoxan for receptors stimulated by neuronally released transmitter in the epididymal portion of rat isolated vas deferens.
Topics: Adenosine Triphosphate; Animals; Binding, Competitive; Corticosterone; Desipramine; Dioxanes; Epididymis; Idazoxan; In Vitro Techniques; Male; Mathematics; Norepinephrine; Prazosin; Rats; Rats, Wistar; Receptors, Adrenergic, alpha; Vas Deferens | 1994 |
On the characterization of dopamine-induced contractile response of rat anococcygeus muscle preparation.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Azepines; Benzazepines; Desipramine; Dioxanes; Dopamine; Female; Haloperidol; Idazoxan; Male; Muscle Contraction; Prazosin; Rats; Receptors, Adrenergic; Receptors, Dopamine; Reserpine; Sulpiride; Yohimbine | 1994 |
Inhibition of sympathetic noradrenergic transmission by guanabenz and guanethidine in rat isolated mesenteric artery: involvement of neuronal potassium channels.
Topics: Adrenergic Agents; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Animals; Apamin; Desipramine; Drug Interactions; Female; Guanabenz; Guanethidine; Idazoxan; In Vitro Techniques; Male; Mesenteric Arteries; Neurons, Efferent; Norepinephrine; Pargyline; Rats; Rats, Sprague-Dawley; Stimulation, Chemical; Synaptic Transmission; Tritium | 1996 |
Anticonvulsant effect of enhancement of noradrenergic transmission in the superior colliculus in genetically epilepsy-prone rats (GEPRs): a microinjection study.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Animals; Anticonvulsants; Desipramine; Drug Interactions; Epilepsy; Female; Fluoxetine; Idazoxan; Methoxamine; Microinjections; Norepinephrine; Phenylephrine; Prazosin; Rats; Rats, Inbred Strains; Superior Colliculi; Synaptic Transmission | 1998 |
Effects of P2-receptor agonists on sympathetic neuroeffector transmission in the rat isolated anococcygeus muscle.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Desipramine; Electric Stimulation; Enzyme Inhibitors; Idazoxan; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; NADP; NG-Nitroarginine Methyl Ester; Purinergic P2 Receptor Agonists; Purinergic P2 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Sympathetic Nervous System; Synaptic Transmission; Thionucleotides | 1998 |
Somatodendritic alpha2-adrenoceptors in the locus coeruleus are involved in the in vivo modulation of cortical noradrenaline release by the antidepressant desipramine.
Topics: Adrenergic alpha-Antagonists; Animals; Antidepressive Agents, Tricyclic; Dendrites; Desipramine; Electrophysiology; Gyrus Cinguli; Idazoxan; Locus Coeruleus; Male; Microdialysis; Neurons; Norepinephrine; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2 | 1998 |
Differential modulation of alpha2-adrenoceptor subtypes in rat kidney by chronic desipramine treatment.
Topics: Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Animals; Binding, Competitive; Clorgyline; Desipramine; Epinephrine; Idazoxan; Imidazoles; In Vitro Techniques; Indoles; Isoindoles; Isoquinolines; Kidney; Kinetics; Male; Monoamine Oxidase Inhibitors; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2 | 1999 |
Electrochemical and electrophysiological characterization of neurotransmitter release from sympathetic nerves supplying rat mesenteric arteries.
Topics: Adenosine Triphosphate; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Animals; Cadmium; Corticosterone; Desipramine; Electric Conductivity; Electric Stimulation; Electrophysiology; Excitatory Postsynaptic Potentials; Female; Idazoxan; In Vitro Techniques; Kinetics; Membrane Potentials; Mesenteric Arteries; Norepinephrine; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Sympathetic Nervous System; Tetrodotoxin | 1999 |
Comparison of the effects of alpha-methyl-p-tyrosine and a tyrosine-free amino acid load on extracellular noradrenaline in the rat hippocampus in vivo.
Topics: Adrenergic alpha-2 Receptor Antagonists; alpha-Methyltyrosine; Amino Acids; Animals; Desipramine; Hippocampus; Idazoxan; Kinetics; Male; Microdialysis; Norepinephrine; Rats; Rats, Sprague-Dawley; Tyrosine | 1999 |
Pharmacology of cizolirtine: a new analgesic agent.
Topics: Analgesics; Animals; Desipramine; Dinoprostone; Dose-Response Relationship, Drug; Gastric Mucosa; Idazoxan; Male; Mice; Naloxone; Pyrazoles; Rats; Rats, Wistar | 2000 |
Idazoxan and 8-OH-DPAT modify the behavioral effects induced by either NA, or 5-HT, or dual NA/5-HT reuptake inhibition in the rat forced swimming test.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Animals; Behavior, Animal; Cyclopropanes; Desipramine; Dose-Response Relationship, Drug; Drug Interactions; Fluoxetine; Idazoxan; Male; Milnacipran; Motor Activity; Rats; Selective Serotonin Reuptake Inhibitors; Serotonin Receptor Agonists | 2001 |
Chronic treatment with desipramine facilitates its effect on extracellular noradrenaline in the rat hippocampus: studies on the role of presynaptic alpha2-adrenoceptors.
Topics: Adrenergic alpha-Agonists; Adrenergic Uptake Inhibitors; Animals; Binding, Competitive; Clonidine; Desipramine; Dose-Response Relationship, Drug; Extracellular Space; Hippocampus; Idazoxan; Locus Coeruleus; Male; Microdialysis; Norepinephrine; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Presynaptic; Synaptosomes; Time Factors; Tritium | 2001 |
Antidepressant drug-induced alterations in neuron-localized tumor necrosis factor-alpha mRNA and alpha(2)-adrenergic receptor sensitivity.
Topics: Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents; Brain Chemistry; Desipramine; Electric Stimulation; Hippocampus; Idazoxan; Immunohistochemistry; In Situ Hybridization; In Vitro Techniques; Male; Neurons; Norepinephrine; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; RNA, Messenger; Selective Serotonin Reuptake Inhibitors; Tumor Necrosis Factor-alpha; Zimeldine | 2001 |
A comparison of neurokinin 1 receptor knock-out (NK1-/-) and wildtype mice: exploratory behaviour and extracellular noradrenaline concentration in the cerebral cortex of anaesthetised subjects.
Topics: Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Area Under Curve; Behavior, Animal; Cerebral Cortex; Chromatography, High Pressure Liquid; Desipramine; Drug Interactions; Electrochemistry; Enzyme Inhibitors; Exploratory Behavior; Extracellular Space; Idazoxan; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microdialysis; Motor Activity; Norepinephrine; Reaction Time; Receptors, Neurokinin-1; Time Factors | 2005 |
Disruption of noradrenergic transmission and the behavioural response to a novel environment in NK1R-/- mice.
Topics: Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Analysis of Variance; Animals; Autoradiography; Behavior, Animal; Desipramine; Drug Interactions; Electrochemistry; Exploratory Behavior; Frontal Lobe; Guanosine 5'-O-(3-Thiotriphosphate); Idazoxan; Mice; Mice, Inbred C57BL; Mice, Knockout; Microdialysis; Norepinephrine; Phosphorus Isotopes; Reaction Time; Receptors, Neurokinin-1 | 2007 |
Postsynaptic alpha-2 adrenergic receptors are critical for the antidepressant-like effects of desipramine on behavior.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic beta-Antagonists; Animals; Antidepressive Agents, Tricyclic; Depression; Desipramine; Idazoxan; Male; Mice; Mice, Knockout; Motor Activity; Prazosin; Propanolamines; Propranolol; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Receptors, Adrenergic, beta; Synapses | 2009 |
Effects of noradrenergic denervation on L-DOPA-induced dyskinesia and its treatment by α- and β-adrenergic receptor antagonists in hemiparkinsonian rats.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Adrenergic Neurons; Animals; Behavior, Animal; Corpus Striatum; Desipramine; Disease Models, Animal; Dyskinesia, Drug-Induced; Hippocampus; Idazoxan; Levodopa; Male; Molecular Targeted Therapy; Neuroprotective Agents; Oxidopamine; Parkinson Disease; Propranolol; Rats; Rats, Sprague-Dawley; Severity of Illness Index; Sympathectomy, Chemical | 2012 |
The function of alpha-2-adrenoceptors in the rat locus coeruleus is preserved in the chronic constriction injury model of neuropathic pain.
Topics: Action Potentials; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Animals; Brimonidine Tartrate; Clonidine; Desipramine; Disease Models, Animal; Idazoxan; Locus Coeruleus; Male; MAP Kinase Signaling System; Medulla Oblongata; Neuralgia; Norepinephrine; Prefrontal Cortex; Quinoxalines; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Signal Transduction; Spinal Cord | 2012 |
Removal of half the sympathetic innervation does not reduce vasoconstrictor responses in rat tail artery.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Arteries; Clonidine; Desipramine; Idazoxan; Isometric Contraction; Muscle Denervation; Myocytes, Smooth Muscle; Neuromuscular Junction; Norepinephrine; Phenylephrine; Rats; Sympathetic Nervous System; Synaptic Potentials; Tail; Vasoconstriction | 2013 |
Pharmacological profile of encounter-induced hyperactivity in isolation-reared mice.
Topics: Animals; Animals, Outbred Strains; Benzimidazoles; Bridged Bicyclo Compounds, Heterocyclic; Desipramine; Duloxetine Hydrochloride; Fluvoxamine; Hydroxycorticosteroids; Idazoxan; Indoles; Male; Mice; Motor Activity; Neuropsychological Tests; Oxazines; Paroxetine; Piperazines; Psychotropic Drugs; Pyridines; Risperidone; Ritanserin; Social Behavior; Social Isolation; Sulfonamides; Venlafaxine Hydrochloride | 2015 |
Clozapine reconstructed: Haloperidol's ability to reduce alcohol intake in the Syrian golden hamster can be enhanced through noradrenergic modulation by desipramine and idazoxan.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic Uptake Inhibitors; Adult; Alcohol Drinking; Animals; Clozapine; Desipramine; Dose-Response Relationship, Drug; Drug Synergism; Eating; Female; Haloperidol; Humans; Idazoxan; Male; Mesocricetus; Receptors, Dopamine D2 | 2015 |
Effects of anti-depressant treatments on FADD and p-FADD protein in rat brain cortex: enhanced anti-apoptotic p-FADD/FADD ratio after chronic desipramine and fluoxetine administration.
Topics: Adrenergic alpha-Antagonists; Animals; Antidepressive Agents; Apoptosis; Autoreceptors; Blotting, Western; Brain; CASP8 and FADD-Like Apoptosis Regulating Protein; Cerebral Cortex; Clorgyline; Desipramine; Electroshock; Excitatory Amino Acid Antagonists; Fas-Associated Death Domain Protein; Fluoxetine; Idazoxan; Indans; Ketamine; Male; Mianserin; Mirtazapine; Monoamine Oxidase Inhibitors; Norepinephrine Plasma Membrane Transport Proteins; Phenelzine; Phosphoproteins; Phosphorylation; Rats; RNA-Binding Proteins; Thiazoles | 2016 |