desipramine has been researched along with gamma-aminobutyric acid in 45 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 23 (51.11) | 18.7374 |
1990's | 9 (20.00) | 18.2507 |
2000's | 7 (15.56) | 29.6817 |
2010's | 6 (13.33) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Andrews, PR; Craik, DJ; Martin, JL | 1 |
Bauer, C; Caldwell, L; Kinnier, WJ; Lancaster, J; McMillan, B; Price, CH; Sweetnam, PM | 1 |
Carmody, LC; Dandapani, S; Donckele, E; Feng, Y; Fernandez, C; Germain, AR; Gupta, PB; Lander, ES; Morgan, B; Munoz, B; Nag, PP; Palmer, M; Perez, JR; Schreiber, SL; Verplank, L | 1 |
Bellman, K; Knegtel, RM; Settimo, L | 1 |
Stone, TW; Taylor, DA | 1 |
Aghajanian, GK; Wang, RY | 1 |
Constantinides, SM; Lal, H; Patel, GJ; Schatz, RP | 1 |
Baker, GB; Greenshaw, AJ; Martin, IL; McKenna, KF; McManus, DJ | 1 |
Blier, P; Curet, O; de Montigny, C; Lacroix, D | 1 |
Malinowska, B; Molderings, G; Schlicker, E; Schneider, D | 1 |
Kane, JM; Sorensen, SM; Zwolshen, JM | 1 |
Ikeda, M; Knapp, RJ; Malatynska, E; Yamamura, HI | 1 |
Harris, KM; Miller, RJ; Reynolds, IJ | 1 |
Kostowski, W; Płaźnik, A; Stefański, R | 1 |
Cross, JA; Horton, RW; Kimber, JR | 1 |
Hilakivi, I; Hilakivi, LA; Loikas, P; Taira, T | 1 |
Lloyd, KG; Pilc, A; Thuret, F | 1 |
Håkanson, R; Kannisto, P; Owman, C; Schmidt, G; Wahlestedt, C | 1 |
Dudley, MW; Kane, JM; Miller, FP; Sorensen, SM | 1 |
Cubeddu, LX; Ferro, CP; Hoffmann, IS; Talmaciu, RK | 1 |
Lloyd, KG; Pilc, A | 1 |
Petty, F; Sherman, AD | 1 |
Korf, J; Venema, K | 1 |
Woodward, DJ; Yeh, HH | 1 |
Geller, HM; Moises, HC; Waterhouse, BD; Woodward, DJ; Yeh, HH | 1 |
Olpe, HR; Schellenberg, A | 1 |
Aghajanian, GK; De Montigny, C; Reader, TA; Wang, RY | 1 |
Avdulov, NA; Maĭsov, NI | 1 |
Hamon, M; Jobert, A; Soubrié, P; Thiébot, MH | 1 |
Korf, J; Postema, F; van der Heyden, JA; Venema, K | 1 |
Goodwin, WB; Guyenet, PG; Huangfu, D | 1 |
Cannizzaro, C; Cannizzaro, G; Flugy, A; Gagliand, M; Mineo, A; Sabatino, M | 1 |
Fulton, M; Kramer, GL; Moeller, FG; Petty, F; Steinberg, J | 1 |
Blier, P; de Montigny, C; Mongeau, R; Weiss, M | 1 |
Chou, J; Jeng, CH; Morales, M; Wang, JY; Wang, Y | 1 |
Asahi, Y; Yonehara, N | 1 |
Enna, SJ; McCarson, KE; Sands, SA | 1 |
Kobayashi, K; Yamamoto, T; Yasoshima, Y | 1 |
Holloway, RG; Noyes, K; O'Connor, AB | 2 |
Barrot, M; Doridot, S; Freund-Mercier, MJ; Hein, L; Petit-Demoulière, N; Tessier, LH; Yalcin, I | 1 |
Di Benedetto, B; Gilling, KE; Holsboer, F; Nothdurfter, C; Parsons, CG; Rammes, G; Rein, T; Rupprecht, R; Tanasic, S; Uhr, M; Wagner, EM | 1 |
Bellows, BK; LaFleur, J; Nelson, RE; Oderda, GM | 1 |
Baj, G; Bernareggi, A; Bittolo, T; Deiana, C; Ferrazzo, S; Raminelli, CA; Tongiorgi, E; Vaghi, V | 1 |
Adongo, DW; Benneh, CK; Biney, RP; Mante, PK; Tandoh, A; Woode, E | 1 |
2 review(s) available for desipramine and gamma-aminobutyric acid
Article | Year |
---|---|
The role of receptor binding in drug discovery.
Topics: Animals; Drug Design; Humans; Receptors, Drug | 1993 |
A cost-effectiveness comparison of desipramine, gabapentin, and pregabalin for treating postherpetic neuralgia.
Topics: Aged; Amines; Analgesics; Antidepressive Agents, Tricyclic; Cost-Benefit Analysis; Cyclohexanecarboxylic Acids; Desipramine; Gabapentin; gamma-Aminobutyric Acid; Humans; Middle Aged; Neuralgia, Postherpetic; Pregabalin; Randomized Controlled Trials as Topic; Severity of Illness Index | 2007 |
43 other study(ies) available for desipramine and gamma-aminobutyric acid
Article | Year |
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Functional group contributions to drug-receptor interactions.
Topics: Animals; Calorimetry; Kinetics; Models, Biological; Protein Binding; Receptors, Cell Surface; Receptors, Drug; Structure-Activity Relationship | 1984 |
Cinnamides as selective small-molecule inhibitors of a cellular model of breast cancer stem cells.
Topics: Amides; Breast Neoplasms; Cell Line, Tumor; Drug Screening Assays, Antitumor; Female; Humans; Neoplastic Stem Cells; Small Molecule Libraries; Structure-Activity Relationship | 2013 |
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation | 2014 |
Antidepressant drugs potentiate suppression by adenosine of neuronal firing in rat cerebral cortex.
Topics: Adenosine; Adenosine Monophosphate; Animals; Antidepressive Agents; Cerebral Cortex; Desipramine; Drug Synergism; gamma-Aminobutyric Acid; Male; Norepinephrine; Rats | 1979 |
Antidromically identified serotonergic neurons in the rat midbrain raphe: evidence for collateral inhibition.
Topics: Action Potentials; Animals; Clomipramine; Desipramine; Electric Stimulation; Evoked Potentials; gamma-Aminobutyric Acid; Hydroxydopamines; Mesencephalon; Neural Inhibition; Neurons, Afferent; Rats; Serotonin; Tegmentum Mesencephali | 1977 |
Effect of desipramine and pargyline on brain gamma-aminobutyric acid.
Topics: Aminobutyrates; Analysis of Variance; Animals; Barbiturates; Body Temperature; Brain Chemistry; Desipramine; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Mice; Pargyline; Sleep; Temperature; Time Factors; Tritium | 1975 |
Effects of the antidepressant/antipanic drug phenelzine on GABA concentrations and GABA-transaminase activity in rat brain.
Topics: 4-Aminobutyrate Transaminase; Animals; Antidepressive Agents; Brain; Desipramine; Dose-Response Relationship, Drug; Frontal Lobe; gamma-Aminobutyric Acid; Imipramine; Male; Panic; Phenelzine; Rats; Rats, Inbred Strains; Tranylcypromine | 1992 |
Effects of long-term desipramine administration on noradrenergic neurotransmission: electrophysiological studies in the rat brain.
Topics: Animals; Brain; Clonidine; Desipramine; Drug Administration Schedule; Electric Stimulation; Electrophysiology; gamma-Aminobutyric Acid; Hippocampus; Locus Coeruleus; Male; Neurons; Norepinephrine; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Synaptic Transmission | 1991 |
Noradrenaline release in the rat vena cava is inhibited by gamma-aminobutyric acid via GABAB receptors but not affected by histamine.
Topics: Animals; Baclofen; Bicuculline; Corticosterone; Desipramine; Electric Stimulation; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Histamine; In Vitro Techniques; Male; Muscimol; Norepinephrine; Organophosphorus Compounds; Rats; Rats, Inbred Strains; Receptors, GABA-A; Vena Cava, Inferior; Yohimbine | 1991 |
The effects of a potential antidepressant, 2,4-dimethyl-5-(3-fluorophenyl)-3H-1,2,4-triazole-3-thione, in an electrophysiological model responsive to desipramine.
Topics: Action Potentials; Animals; Antidepressive Agents; Desipramine; Electrophysiology; gamma-Aminobutyric Acid; Male; Models, Biological; Norepinephrine; Purkinje Fibers; Rats; Rats, Inbred Strains; Triazoles | 1990 |
Antidepressants and seizure-interactions at the GABA-receptor chloride-ionophore complex.
Topics: Amitriptyline; Animals; Antidepressive Agents; Cerebral Cortex; Chlorides; Desipramine; gamma-Aminobutyric Acid; Imipramine; Ion Channels; Ionophores; Male; Mianserin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures | 1988 |
NMDA receptor antagonists that bind to the strychnine-insensitive glycine site and inhibit NMDA-induced Ca2+ fluxes and [3H]GABA release.
Topics: Animals; Anticonvulsants; Aspartic Acid; Brain; Calcium; Desipramine; Dibenzocycloheptenes; Dizocilpine Maleate; gamma-Aminobutyric Acid; Ketamine; Kynurenine; Membranes; N-Methylaspartate; Piperazines; Pyrrolidinones; Radioligand Assay; Rats; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Strychnine | 1989 |
The influence of antidepressive treatment on GABA-related mechanisms in the rat hippocampus: behavioral studies.
Topics: Animals; Behavior, Animal; Desipramine; Dose-Response Relationship, Drug; Drug Interactions; Electroshock; gamma-Aminobutyric Acid; Hippocampus; Male; Motor Activity; Muscimol; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Stimulation, Chemical | 1989 |
Benzodiazepine and GABAA receptors in rat brain following chronic antidepressant drug administration.
Topics: Animals; Antidepressive Agents; Brain; Desipramine; Flunitrazepam; gamma-Aminobutyric Acid; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A; Tranylcypromine; Zimeldine | 1987 |
Neonatal treatment with monoamine uptake inhibitors alters later response in behavioural 'despair' test to beta and GABA-B receptor agonists.
Topics: Albuterol; Animals; Animals, Newborn; Antidepressive Agents; Baclofen; Behavior, Animal; Desipramine; gamma-Aminobutyric Acid; Male; Nomifensine; Rats; Rats, Inbred Strains; Time Factors; Zimeldine | 1988 |
Upregulation of gamma-aminobutyric acid (GABA) B binding sites in rat frontal cortex: a common action of repeated administration of different classes of antidepressants and electroshock.
Topics: Animals; Antidepressive Agents; Cerebral Cortex; Desipramine; Dose-Response Relationship, Drug; Electroshock; Fluoxetine; gamma-Aminobutyric Acid; Hippocampus; Kinetics; Male; Monoamine Oxidase Inhibitors; Nomifensine; Rats; Rats, Inbred Strains; Receptors, GABA-A; Serotonin Antagonists; Time Factors; Viloxazine | 1985 |
GABA suppresses stimulation-induced release of [3H]-noradrenaline from sympathetic nerve fibres in bovine ovarian follicles.
Topics: Animals; Baclofen; Bicuculline; Cattle; Desipramine; Electric Stimulation; Female; gamma-Aminobutyric Acid; Hydroxydopamines; In Vitro Techniques; Muscimol; Norepinephrine; Normetanephrine; Ovarian Follicle; Oxidopamine; Potassium Chloride; Sympathectomy, Chemical; Sympathetic Nervous System | 1987 |
2,4-Dihydro-3H-1,2,4-triazole-3-thiones as potential antidepressant agents.
Topics: Animals; Antidepressive Agents; Desipramine; gamma-Aminobutyric Acid; Male; Mice; Monoamine Oxidase Inhibitors; Norepinephrine; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Triazoles | 1988 |
Sustained high release at rapid stimulation rates and reduced functional autoreceptors characterize prefrontal cortex dopamine terminals.
Topics: Animals; Apomorphine; Corpus Striatum; Desipramine; Dopamine; Electric Stimulation; Ergolines; Frontal Lobe; gamma-Aminobutyric Acid; In Vitro Techniques; Nomifensine; Norepinephrine; Quinpirole; Rabbits; Receptors, Dopamine; Serotonin | 1988 |
Chronic antidepressants and GABA "B" receptors: a GABA hypothesis of antidepressant drug action.
Topics: Amitriptyline; Animals; Antidepressive Agents; Citalopram; Desipramine; Frontal Lobe; gamma-Aminobutyric Acid; Hippocampus; Male; Nipecotic Acids; Pargyline; Proline; Propylamines; Rats; Rats, Inbred Strains; Receptors, GABA-A; Viloxazine | 1984 |
Neurochemical basis of the action of antidepressants on learned helplessness.
Topics: Animals; Brain; Depressive Disorder; Desipramine; Frontal Lobe; gamma-Aminobutyric Acid; Geniculate Bodies; Hippocampus; Humans; Limbic System; Male; Neurotransmitter Agents; Norepinephrine; Rats; Serotonin | 1980 |
Desmethylimipramine enhances the release of endogenous GABA and other neurotransmitter amino acids from the rat thalamus.
Topics: Amino Acids; Animals; Calcium Chloride; Desipramine; Female; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glutamine; In Vitro Techniques; Kinetics; Magnesium; Magnesium Chloride; Male; Neurotransmitter Agents; Rats; Rats, Inbred Strains; Thalamus | 1983 |
Alterations in beta adrenergic physiological response characteristics after long-term treatment with desmethylimipramine: interaction between norepinephrine and gamma-aminobutyric acid in rat cerebellum.
Topics: Action Potentials; Animals; Desipramine; Drug Interactions; Female; gamma-Aminobutyric Acid; Norepinephrine; Purkinje Cells; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Adrenergic, beta; Time Factors | 1983 |
Comparison of norepinephrine- and benzodiazepine-induced augmentation of Purkinje cell responses to gamma-aminobutyric acid (GABA).
Topics: Animals; Binding Sites; Depression, Chemical; Desipramine; Drug Interactions; Female; Flurazepam; gamma-Aminobutyric Acid; Iontophoresis; Norepinephrine; Purkinje Cells; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Synaptic Transmission | 1984 |
The sensitivity of cortical neurons to serotonin: effect of chronic treatment with antidepressants, serotonin-uptake inhibitors and monoamine-oxidase-blocking drugs.
Topics: Animals; Benzofurans; Cerebral Cortex; Clomipramine; Clorgyline; Desipramine; Electric Conductivity; gamma-Aminobutyric Acid; Male; Monoamine Oxidase Inhibitors; Neurons; Piperidines; Rats; Selegiline; Serotonin; Serotonin Antagonists | 1981 |
Monoaminergic denervation of the rat hippocampus: microiontophoretic studies on pre- and postsynaptic supersensitivity to norepinephrine and serotonin.
Topics: Animals; Denervation; Desipramine; Dihydroxytryptamines; Fluoxetine; gamma-Aminobutyric Acid; Hippocampus; Hydroxydopamines; Isoproterenol; Locus Coeruleus; Male; Norepinephrine; Rats; Serotonin; Synapses | 1980 |
[Atypical antidepressants: effect on synaptosomal uptake of serotonin and GABA].
Topics: Animals; Antidepressive Agents; Brain; Carbazoles; Carbolines; Clomipramine; Depression, Chemical; Desipramine; gamma-Aminobutyric Acid; Imipramine; In Vitro Techniques; Oxazines; Piperazines; Rats; Serotonin; Synaptosomes; Trazodone | 1981 |
Serotoninergic control of punished behavior: effects of intra-raphe microinjections of chlordiazepoxide, GABA and 5-HT on behavioral suppression in rats.
Topics: 5,7-Dihydroxytryptamine; Animals; Behavior, Animal; Chlordiazepoxide; Desipramine; Flunitrazepam; gamma-Aminobutyric Acid; Male; Punishment; Raphe Nuclei; Rats; Rats, Inbred Strains; Serotonin | 1981 |
Distribution and release of GABA in the basal ganglia.
Topics: 3-Mercaptopropionic Acid; Animals; Apomorphine; Basal Ganglia; Brain; Corpus Striatum; Desipramine; Dopamine; gamma-Aminobutyric Acid; Kainic Acid; Organ Specificity; Rats; Rats, Inbred Strains; Substantia Nigra; Tetrodotoxin | 1981 |
Sympatholytic effect of tricyclic antidepressants: site and mechanism of action in anesthetized rats.
Topics: Adrenergic alpha-Antagonists; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Baclofen; Blood Pressure; Brain Mapping; Desipramine; Dioxanes; Fluoxetine; gamma-Aminobutyric Acid; Idazoxan; Imidazoles; Male; Medulla Oblongata; Microinjections; Nordefrin; Oxidopamine; Rats; Rats, Sprague-Dawley; Splanchnic Nerves; Sympatholytics; Time Factors | 1995 |
NMDA-GABA interactions in an animal model of behaviour: a gating mechanism from motivation toward psychotic-like symptoms.
Topics: Alprazolam; Animals; Behavior, Animal; Desipramine; Disease Models, Animal; Dizocilpine Maleate; gamma-Aminobutyric Acid; Kindling, Neurologic; Male; Motivation; Motor Activity; Muscimol; N-Methylaspartate; Pentylenetetrazole; Psychotic Disorders; Rats; Rats, Wistar; Swimming | 1994 |
Desipramine does not alter plasma GABA in patients with major depression.
Topics: Adult; Aged; Biomarkers; Depressive Disorder; Desipramine; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Psychiatric Status Rating Scales; Severity of Illness Index | 1993 |
Effect of acute, short- and long-term milnacipran administration on rat locus coeruleus noradrenergic and dorsal raphe serotonergic neurons.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-Agonists; Adrenergic Uptake Inhibitors; Animals; Biological Transport; Brimonidine Tartrate; Clonidine; Cyclopropanes; Desipramine; Drug Administration Schedule; gamma-Aminobutyric Acid; Hippocampus; Hypothalamus; Injections, Subcutaneous; Kinetics; Locus Coeruleus; Lysergic Acid Diethylamide; Male; Mesencephalon; Milnacipran; Neurons; Norepinephrine; Quinoxalines; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin; Spiperone; Time Factors | 1998 |
Chronic methamphetamine exposure decreases high affinity uptake function in norepinephrine afferents in the cerebellar cortex: an electrophysiological and electrochemical study.
Topics: Action Potentials; Adrenergic beta-Agonists; Adrenergic Uptake Inhibitors; Animals; Cerebellar Cortex; Desipramine; gamma-Aminobutyric Acid; Isoproterenol; Male; Methamphetamine; Norepinephrine; Purkinje Cells; Rats; Rats, Sprague-Dawley | 2000 |
Involvement of GABAergic systems in manifestation of pharmacological activity of desipramine.
Topics: Animals; Antidepressive Agents, Tricyclic; Baclofen; Desipramine; Freund's Adjuvant; GABA Antagonists; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Male; Membrane Potentials; Muscimol; Picrotoxin; Rats; Rats, Sprague-Dawley; Reaction Time | 2001 |
Relationship between the antinociceptive response to desipramine and changes in GABAB receptor function and subunit expression in the dorsal horn of the rat spinal cord.
Topics: Analgesics; Animals; Antidepressive Agents, Tricyclic; Baclofen; Desipramine; gamma-Aminobutyric Acid; Gene Expression; Guanosine 5'-O-(3-Thiotriphosphate); Male; Posterior Horn Cells; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, GABA-B; Spinal Cord | 2004 |
Amygdala-dependent mechanisms underlying memory retrieval of conditioned taste aversion.
Topics: Amygdala; Animals; Benzodiazepines; Conditioning, Classical; Desipramine; Dopamine; gamma-Aminobutyric Acid; Glutamine; Memory; Midazolam; Models, Biological; Norepinephrine; Rats; Receptors, AMPA; Taste | 2005 |
A cost-utility comparison of four first-line medications in painful diabetic neuropathy.
Topics: Amines; Analgesics; Antidepressive Agents, Tricyclic; Cost-Benefit Analysis; Cross-Sectional Studies; Cyclohexanecarboxylic Acids; Desipramine; Diabetic Neuropathies; Duloxetine Hydrochloride; Economics, Pharmaceutical; Gabapentin; gamma-Aminobutyric Acid; Humans; Middle Aged; Pregabalin; Quality-Adjusted Life Years; Randomized Controlled Trials as Topic; Thiophenes | 2008 |
Beta2-adrenoceptors are essential for desipramine, venlafaxine or reboxetine action in neuropathic pain.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Amines; Animals; Anticonvulsants; Antidepressive Agents; Cyclohexanecarboxylic Acids; Cyclohexanols; Desipramine; Gabapentin; gamma-Aminobutyric Acid; Male; Mice; Mice, Transgenic; Morpholines; Pain; Pain Threshold; Propanolamines; Reboxetine; Receptors, Adrenergic, alpha-2; Receptors, Adrenergic, beta-2; Sciatic Nerve; Venlafaxine Hydrochloride; Yohimbine | 2009 |
Lipid raft integrity affects GABAA receptor, but not NMDA receptor modulation by psychopharmacological compounds.
Topics: Animals; Anti-Anxiety Agents; Caveolin 1; Cells, Cultured; Desipramine; Diazepam; Dose-Response Relationship, Drug; Electric Stimulation; Embryo, Mammalian; gamma-Aminobutyric Acid; Hippocampus; Humans; Membrane Microdomains; Membrane Proteins; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Rats; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate | 2013 |
Long-term cost-effectiveness of initiating treatment for painful diabetic neuropathy with pregabalin, duloxetine, gabapentin, or desipramine.
Topics: Amines; Analgesics; Cost-Benefit Analysis; Cyclohexanecarboxylic Acids; Desipramine; Diabetic Neuropathies; Duloxetine Hydrochloride; Gabapentin; gamma-Aminobutyric Acid; Health Care Costs; Humans; Models, Economic; Pregabalin; Quality-Adjusted Life Years | 2016 |
Pharmacological treatment with mirtazapine rescues cortical atrophy and respiratory deficits in MeCP2 null mice.
Topics: Animals; Antidepressive Agents; Atrophy; Breath Tests; Cerebral Cortex; Desipramine; GABAergic Neurons; gamma-Aminobutyric Acid; Heart Rate; Humans; Methyl-CpG-Binding Protein 2; Mianserin; Mice; Mirtazapine; Rett Syndrome; Seizures; Somatosensory Cortex | 2016 |
Maerua angolensis stem bark extract reverses anxiety and related behaviours in zebrafish-Involvement of GABAergic and 5-HT systems.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Capparaceae; Desipramine; Diazepam; Disease Models, Animal; gamma-Aminobutyric Acid; Locomotion; Motor Activity; Plant Bark; Receptors, GABA-A; Serotonin; Stress, Psychological; Zebrafish | 2017 |