desipramine and diazepam

desipramine has been researched along with diazepam in 115 studies

Research

Studies (115)

Timeframe	Studies, this research(%)	All Research%
pre-1990	54 (46.96)	18.7374
1990's	15 (13.04)	18.2507
2000's	28 (24.35)	29.6817
2010's	17 (14.78)	24.3611
2020's	1 (0.87)	2.80

Authors

Authors	Studies
Baldy, WJ; Davis, CB; DiStefano, DL; Elgin, RJ; Fedde, CL; Kesslick, JM; Martin, GE; Mathiasen, JR; Scott, MK; Shank, RP	1
Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET	1
Andrews, PR; Craik, DJ; Martin, JL	1
Lucas, RA; Smith, RG; Wasley, JW	1
Carrupt, PA; Crivori, P; Cruciani, G; Testa, B	1
Duffy, EM; Jorgensen, WL	1
Topliss, JG; Yoshida, F	1
Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA	1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY	2
Johans, C; Kinnunen, PK; Söderlund, T; Suomalainen, P	1
Caron, G; Ermondi, G	1
Briand, X; Faller, B; Lázaro, E; Lowe, PJ	1
Lombardo, F; Obach, RS; Waters, NJ	1
He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Sun, Y; Yan, Z	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Ahman, M; Holmén, AG; Wan, H	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Campillo, NE; Guerra, A; Páez, JA	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Avdeef, A; Tam, KY	1
Glen, RC; Lowe, R; Mitchell, JB	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Carmody, LC; Dandapani, S; Donckele, E; Feng, Y; Fernandez, C; Germain, AR; Gupta, PB; Lander, ES; Morgan, B; Munoz, B; Nag, PP; Palmer, M; Perez, JR; Schreiber, SL; Verplank, L	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Buckle, P; Jameson, D	1
Mason, MF	1
Lehmann, K; Schmidt, J	1
Keim, KL; Sigg, EB	1
Kleber, RJ	1
Evans, DB; Liu, SJ; Wang, RI	1
Henry, BW; Overall, JE; Woodward, JA	1
Cannizzaro, C; Cannizzaro, G; Flugy, A; Gagliano, M; Novara, V	1
Mos, J; Olivier, B; Tilders, FJ; Van Dijken, HH	1
Carnoy, P; Hervé, D; Ravard, S; Soubrié, P; Tassin, JP; Thiébot, MH	1
Cinicola, DP; Esposito, FM; Winek, CL	1
De Souza, EB; Grigoriadis, DE; Pearsall, D	1
Carli, M; Prontera, C; Samanin, R	1
Kostowski, W; Płaźnik, A; Stefański, R	1
Feet, PO; Holm, V; Larsen, S; Liden, A; Lillevold, PE; Robak, OH	1
Igarashi, T; Kitagawa, H; Ohmori, S; Okiyama, M; Ueno, K	1
Bergman, J; Spealman, RD	1
Bidziński, A; Hauptmann, M; Kostowski, W; Płaźnik, A; Tamborska, E	1
Feet, PO; Larsen, S; Lillevold, PE; Robak, OH	1
Cagiano, R; Cuomo, V; De Salvia, MA; Maselli, MA; Racagni, G; Renna, G	1
Aitken, DH; Bodnoff, SR; Meaney, MJ; Quirion, R; Suranyi-Cadotte, B	1
Böke-Kuhn, K; Knappen, F	1
Baiguerra, G; Kostowski, W; Valzelli, L	1
Fischer, W; Heydenreich, F; Rabending, G; Streubel, FR	1
McNair, DM	1
Baltzer, V; Bein, HJ	1
Hartmann, E	1
Kaniike, K; Kurogochi, Y	1
Gisler, RH	1
Bruun, A; Ehinger, B	1
Consolo, S; Garattini, S; Ladinsky, H; Peri, G	1
Markham, CH	1
Falk, MA	1
Gelb, F; Gurfein, L; Kammerer, M; Wartel, R; Weil, J; Wysoki, V	1
Treitman, P	1
Webb, WL	1
Garriott, JC; Stolman, A	1
Cosmides, GJ	1
Roux, JT; Wolpowitz, B	1
McLaughlin, BE	1
Milner, G	1
Sofia, RD	1
Heilig, P; Heiss, WD; Hoyer, J	2
Gugath, M; Laakmann, G; Mueller, OA; Stalla, GK; Treusch, J; Wahlster, U; Wittmann, M	1
Reilly, MA; Sigg, EB	1
Hertrich, O	1
Fairchild, MD; Jenden, DJ; Mickey, MR; Yale, C	1
Jones, RS; Olpe, HR	1
Das, S; Datta, SC; Dey, S; Guin, AK; Sengupta, D	1
Nakanishi, H; Shibata, S; Ueki, S; Watanabe, S	1
Blavet, N; DeFeudis, FV	1
Laakmann, G; Schmauss, M; Schmitt, E; Treusch, J; Treusch, U	1
Cannizzaro, C; Cannizzaro, E; Cannizzaro, G; Gagliano, M; Mineo, A; Sabatino, M	1
Hori, T; Nakane, H; Shimizu, N	1
Corbett, R; Cornfeldt, M; Dunn, RW; Smith, C; Szewczak, M; Woods, A	1
Armario, A; Martí, J	1
Bickel, MH; Daniel, WA; Honegger, UE	1
Cannizzaro, C; Cannizzaro, E; Gagliano, M; Mangiapane, N	1
Gan, Q; Knuepfer, MM	1
Barcellos, CK; Dias, RD; Sarkis, JJ; Schetinger, MR	1
Bizot, JC	1
Chabac, S; Durbin, P; Houin, G; Hulot, T; Potgieter, A; Saivin, S	1
Bustos, SG; Lacerra, C; Martijena, ID; Molina, VA	1
Cassella, JV; Coverdale, S; Hoffman, DC; Kehne, JH; McCloskey, TC	1
Hara, K; Hirano, H; Izumi, F; Minami, K; Sata, T; Shigematsu, A; Yanagihara, N	1
Cecil, A; Crites, G; Goldenberg, R; Knapp, RJ; Malatynska, E; Miller, C; Shuck, C; Watkins, J	1
Mitsunaga, H; Ukai, M	1
Kamei, J; Miyata, S; Morita, K; Saitoh, A; Takeda, H	1
FUKUCHI, G	1
Ben-Amir, E; Doljansky, J; Flaisher, S; Joel, D	1
Furukawa, K; Kinoshita, T; Kita, A; Kohayakawa, H; Kurumiya, S; Nakamichi, K; Ochi, Y; Oka, M	1
Bertotto, ME; Bustos, SG; Martijena, ID; Molina, VA	1
Biba, A; Christodoulou, A; Chrysikakou, S; Giannou, H; Kontis, D; Maillis, A; Pallidi, S; Rabavilas, A; Tsaltas, E	1
Calil, CM; Marcondes, FK	1
Crabbe, JC; Kliethermes, CL	1
Lin, Y; Quartermain, D; Stone, EA	1
Balci, F; Campbell, U; Hanania, T; Olivier, BE; Paterson, NE	1
Curley, A; Kelly, JP; Mulcaire, J; Ryan, C; Simpson, J	1
Kelly, JP; Simpson, J	1
Clark, JA; Klee, N; Nizami, M; Platt, B; Schulenberg, J	1
Di Benedetto, B; Gilling, KE; Holsboer, F; Nothdurfter, C; Parsons, CG; Rammes, G; Rein, T; Rupprecht, R; Tanasic, S; Uhr, M; Wagner, EM	1
Adongo, DW; Benneh, CK; Biney, RP; Mante, PK; Tandoh, A; Woode, E	1
Barbui, C; Bighelli, I; Caldwell, DM; Cipriani, A; Davies, SJ; Dawson, S; Dias, S; Furukawa, TA; Guaiana, G; Imai, H; Koesters, M; Meader, N; Pompoli, A; Robertson, L; Tajika, A	1

Reviews

6 review(s) available for desipramine and diazepam

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Drug impairment reviews: opiates, minor tranquilizers. NIDA research monograph, 1977, Volume: Series 11 Topics: Amitriptyline; Anti-Anxiety Agents; Automobile Driving; Behavior; Desipramine; Dextropropoxyphene; Diazepam; Ethanol; Humans; Imipramine; Lithium; Methadone; Motor Skills; Narcotics; Task Performance and Analysis	1977
Self-evaluations of antidepressants. Psychopharmacologia, 1974, Volume: 37, Issue:4 Topics: Amitriptyline; Antidepressive Agents; Chlordiazepoxide; Clinical Trials as Topic; Depression; Desipramine; Dextroamphetamine; Diazepam; Doxepin; Drug Evaluation; Drug Therapy, Combination; Humans; Imipramine; Methylphenidate; MMPI; Nialamide; Pargyline; Placebos; Psychiatric Status Rating Scales; Psychological Tests; Statistics as Topic; Thioridazine; Tranylcypromine	1974
Pharmacological studies of sleep and dreaming: chemical and clinical relationships. Biological psychiatry, 1969, Volume: 1, Issue:3 Topics: Amitriptyline; Amphetamine; Antidepressive Agents; Atropine; Chloralose; Chlordiazepoxide; Chlorpromazine; Desipramine; Dextroamphetamine; Diazepam; Diphenhydramine; Dreams; Glutethimide; Humans; Hypnotics and Sedatives; Imipramine; Lysergic Acid Diethylamide; Meprobamate; Methaqualone; Morphine; Nialamide; Pentobarbital; Reserpine; Sleep; Sleep, REM; Tranquilizing Agents; Tranylcypromine; Triiodothyronine; Tryptophan	1969
Clinical pharmacokinetics of acamprosate. Clinical pharmacokinetics, 1998, Volume: 35, Issue:5 Topics: Acamprosate; Age Factors; Alcohol Deterrents; Animals; Desipramine; Diazepam; Disulfiram; Dose-Response Relationship, Drug; Drug Interactions; Ethanol; Food-Drug Interactions; Humans; Imipramine; Psychotropic Drugs; Sex Characteristics; Taurine	1998
Pharmacological treatments in panic disorder in adults: a network meta-analysis. The Cochrane database of systematic reviews, 2023, 11-28, Volume: 11 Topics: Adult; Alprazolam; Antidepressive Agents; Antidepressive Agents, Tricyclic; Benzodiazepines; Clomipramine; Clonazepam; Desipramine; Diazepam; Fluoxetine; Humans; Network Meta-Analysis; Panic Disorder; Paroxetine; Reboxetine; Selective Serotonin Reuptake Inhibitors; Serotonin and Noradrenaline Reuptake Inhibitors; Venlafaxine Hydrochloride	2023

Trials

8 trial(s) available for desipramine and diazepam

Article	Year
A double-blind comparative study of desipramine hydrochloride and diazepam in the control of mixed anxiety/depression symptomatology. The Journal of clinical psychiatry, 1979, Volume: 40, Issue:4 Topics: Adjustment Disorders; Adolescent; Adult; Anxiety Disorders; Clinical Trials as Topic; Desipramine; Diazepam; Double-Blind Method; Female; Humans; Male; Middle Aged; Psychiatric Status Rating Scales	1979
Comparison of the serum levels in primary non-agitated depressed out-patients treated with imipramine in combination with placebo, diazepam or dixyrazine. Acta psychiatrica Scandinavica, 1987, Volume: 75, Issue:4 Topics: Adult; Antipsychotic Agents; Clinical Trials as Topic; Depressive Disorder; Desipramine; Diazepam; Drug Therapy, Combination; Female; Humans; Imipramine; Male; Middle Aged; Phenothiazines; Random Allocation	1987
Withdrawal reactions to diazepam in combined imipramine/diazepam treatment of primary nonagitated depressed outpatients. Acta psychiatrica Scandinavica, 1988, Volume: 78, Issue:3 Topics: Clinical Trials as Topic; Depressive Disorder; Desipramine; Diazepam; Double-Blind Method; Drug Therapy, Combination; Humans; Imipramine; Random Allocation; Substance Withdrawal Syndrome	1988
[Quantitative EEG analysis of a single dose of psychotropic drugs in healthy probands]. Psychiatrie, Neurologie, und medizinische Psychologie, 1986, Volume: 38, Issue:8 Topics: Adult; Arousal; Brain; Carbamazepine; Clomipramine; Desipramine; Diazepam; Electroencephalography; Evoked Potentials; Female; Haloperidol; Humans; Imipramine; Male; Psychotropic Drugs	1986
Self-evaluations of antidepressants. Psychopharmacologia, 1974, Volume: 37, Issue:4 Topics: Amitriptyline; Antidepressive Agents; Chlordiazepoxide; Clinical Trials as Topic; Depression; Desipramine; Dextroamphetamine; Diazepam; Doxepin; Drug Evaluation; Drug Therapy, Combination; Humans; Imipramine; Methylphenidate; MMPI; Nialamide; Pargyline; Placebos; Psychiatric Status Rating Scales; Psychological Tests; Statistics as Topic; Thioridazine; Tranylcypromine	1974
[Clinical experimentation with desipramine with statistical control]. Annales medico-psychologiques, 1968, Volume: 1, Issue:1 Topics: Adult; Aged; Anorexia Nervosa; Barbiturates; Bipolar Disorder; Chlordiazepoxide; Chlorpromazine; Clinical Trials as Topic; Depression; Desipramine; Diazepam; Haloperidol; Humans; Methotrimeprazine; Middle Aged; Schizophrenia	1968
Effects of psychotropic drugs (desimipramine, chlorimipramine, sulpiride and diazepam) on the human HPA axis. Psychopharmacology, 1984, Volume: 84, Issue:1 Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Clomipramine; Desipramine; Diazepam; Humans; Hydrocortisone; Hypothalamo-Hypophyseal System; Male; Pituitary-Adrenal System; Psychotropic Drugs; Sulpiride	1984
Comparison of growth hormone stimulation induced by desimipramine, diazepam and metaclazepam in man. Psychoneuroendocrinology, 1982, Volume: 7, Issue:2-3 Topics: Adult; Anti-Anxiety Agents; Benzodiazepines; Desipramine; Diazepam; Dose-Response Relationship, Drug; Growth Hormone; Humans; Male; Time Factors	1982

Other Studies

102 other study(ies) available for desipramine and diazepam

Article	Year
Activity of aromatic substituted phenylpiperazines lacking affinity for dopamine binding sites in a preclinical test of antipsychotic efficacy. Journal of medicinal chemistry, 1989, Volume: 32, Issue:5 Topics: Animals; Antipsychotic Agents; Avoidance Learning; Dose-Response Relationship, Drug; Piperazines; Rats; Receptors, Dopamine; Receptors, Serotonin; Structure-Activity Relationship	1989
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs. Journal of medicinal chemistry, 1985, Volume: 28, Issue:3 Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium	1985
Functional group contributions to drug-receptor interactions. Journal of medicinal chemistry, 1984, Volume: 27, Issue:12 Topics: Animals; Calorimetry; Kinetics; Models, Biological; Protein Binding; Receptors, Cell Surface; Receptors, Drug; Structure-Activity Relationship	1984
Synthesis and anxiolytic activity of a series of pyrazino[1,2-a][1,4]benzodiazepine derivatives. Journal of medicinal chemistry, 1980, Volume: 23, Issue:8 Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Apomorphine; Benzodiazepines; Diazepam; Guinea Pigs; Histamine Antagonists; In Vitro Techniques; Male; Norepinephrine; Pyrazines; Rats; Receptors, Drug; Serotonin	1980
Predicting blood-brain barrier permeation from three-dimensional molecular structure. Journal of medicinal chemistry, 2000, Jun-01, Volume: 43, Issue:11 Topics: Blood-Brain Barrier; Databases, Factual; Models, Chemical; Molecular Conformation; Multivariate Analysis; Permeability; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Prediction of drug solubility from Monte Carlo simulations. Bioorganic & medicinal chemistry letters, 2000, Jun-05, Volume: 10, Issue:11 Topics: Monte Carlo Method; Pharmaceutical Preparations; Solubility	2000
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds. Journal of medicinal chemistry, 2001, Jul-19, Volume: 44, Issue:15 Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water	2001
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data. Journal of medicinal chemistry, 2002, Jun-20, Volume: 45, Issue:13 Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding	2002
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics. Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5 Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution	2004
Surface activity profiling of drugs applied to the prediction of blood-brain barrier permeability. Journal of medicinal chemistry, 2004, Mar-25, Volume: 47, Issue:7 Topics: Blood-Brain Barrier; Lipid Bilayers; Micelles; Permeability; Pharmaceutical Preparations; Structure-Activity Relationship; Surface Properties	2004
Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk). Journal of medicinal chemistry, 2005, May-05, Volume: 48, Issue:9 Topics: 1-Octanol; Alkanes; Hydrogen-Ion Concentration; Least-Squares Analysis; Mathematics; Models, Chemical; Models, Molecular; Solvents; Water	2005
New approach to measure protein binding based on a parallel artificial membrane assay and human serum albumin. Journal of medicinal chemistry, 2008, Apr-10, Volume: 51, Issue:7 Topics: Humans; Kinetics; Membranes, Artificial; Permeability; Protein Binding; Serum Albumin	2008
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
First-principle, structure-based prediction of hepatic metabolic clearance values in human. European journal of medicinal chemistry, 2009, Volume: 44, Issue:4 Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metabolic Clearance Rate; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship; Sensitivity and Specificity; Software	2009
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs. Journal of medicinal chemistry, 2009, Mar-26, Volume: 52, Issue:6 Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry	2009
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain. Bioorganic & medicinal chemistry, 2009, Oct-01, Volume: 17, Issue:19 Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship	2009
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Neural computational prediction of oral drug absorption based on CODES 2D descriptors. European journal of medicinal chemistry, 2010, Volume: 45, Issue:3 Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical	2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability? Journal of medicinal chemistry, 2010, May-13, Volume: 53, Issue:9 Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological; Permeability; Porosity; Regression Analysis	2010
Predicting phospholipidosis using machine learning. Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5 Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Cinnamides as selective small-molecule inhibitors of a cellular model of breast cancer stem cells. Bioorganic & medicinal chemistry letters, 2013, Mar-15, Volume: 23, Issue:6 Topics: Amides; Breast Neoplasms; Cell Line, Tumor; Drug Screening Assays, Antitumor; Female; Humans; Neoplastic Stem Cells; Small Molecule Libraries; Structure-Activity Relationship	2013
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
A comparison of anti-inflammatory and other compounds on the spontaneously contracting pregnant rat uterus. The Journal of pharmacy and pharmacology, 1977, Volume: 29, Issue:2 Topics: Animals; Anti-Inflammatory Agents; Chlorpromazine; Desipramine; Diazepam; Female; In Vitro Techniques; Ketamine; Muscle, Smooth; Papaverine; Pregnancy; Pregnancy, Animal; Rats; Uterine Contraction	1977
[Effect of psychotropic drugs on somatosensory evoked cortical potentials]. Acta biologica et medica Germanica, 1979, Volume: 38, Issue:4 Topics: Animals; Anti-Anxiety Agents; Desipramine; Diazepam; Evoked Potentials; Female; Haloperidol; Hexobarbital; Medazepam; Piperidines; Rats; Somatosensory Cortex	1979
Plasma corticosterone and brain catecholamines in stress: effect of psychotropic drugs. Pharmacology, biochemistry, and behavior, 1977, Volume: 6, Issue:1 Topics: Adrenal Glands; Adrenocorticotropic Hormone; Animals; Brain Chemistry; Catecholamines; Chlorpromazine; Corticosterone; Desipramine; Diazepam; Dopamine; Haloperidol; Hypothalamus; In Vitro Techniques; Male; Norepinephrine; Pargyline; Phenobarbital; Prohibitins; Psychotropic Drugs; Rats; Stress, Physiological; Telencephalon	1977
Correlation of urinary excretion of methadone metabolites with methadone metabolism and analgesia in the rat. The Journal of pharmacology and experimental therapeutics, 1978, Volume: 204, Issue:1 Topics: Analgesics; Animals; Biotransformation; Desipramine; Diazepam; Drug Interactions; Male; Methadone; Phenobarbital; Rats; Reaction Time; Time Factors; Tissue Distribution	1978
Patterns of symptom change in anxious depressed outpatients treated with different drugs. Diseases of the nervous system, 1975, Volume: 36, Issue:3 Topics: Amitriptyline; Antidepressive Agents; Anxiety; Chlordiazepoxide; Chlorpromazine; Depression; Desipramine; Diazepam; Drug Combinations; Fluphenazine; Humans; Imipramine; Mental Disorders; Nortriptyline; Perphenazine; Thioridazine; Thiothixene; Tranquilizing Agents; Trifluoperazine	1975
Antidepressant and anxiolytic effects of alprazolam versus the conventional antidepressant desipramine and the anxiolytic diazepam in the forced swim test in rats. European journal of pharmacology, 1992, Apr-22, Volume: 214, Issue:2-3 Topics: Alprazolam; Animals; Anti-Anxiety Agents; Antidepressive Agents; Buspirone; Depression; Desipramine; Diazepam; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A; Receptors, Serotonin; Swimming	1992
Effects of anxiolytic and antidepressant drugs on long-lasting behavioural deficits resulting from one short stress experience in male rats. Psychopharmacology, 1992, Volume: 109, Issue:4 Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Behavior, Animal; Desipramine; Diazepam; Electroshock; Fluvoxamine; Male; Motor Activity; Noise; Piperazines; Rats; Rats, Wistar; Serotonin Receptor Agonists; Stress, Psychological	1992
Involvement of prefrontal dopamine neurones in behavioural blockade induced by controllable vs uncontrollable negative events in rats. Behavioural brain research, 1990, Feb-12, Volume: 37, Issue:1 Topics: Animals; Arousal; Avoidance Learning; Desipramine; Diazepam; Dopamine; Drinking; Electroshock; Fear; Frontal Lobe; Helplessness, Learned; Male; Motor Activity; Neurons; Rats; Rats, Inbred Strains; Receptors, Dopamine	1990
The stability of several compounds in formalin fixed tissues and formalin-blood solutions. Forensic science international, 1990, Volume: 44, Issue:2-3 Topics: Carbon Monoxide; Carboxyhemoglobin; Cyanides; Desipramine; Diazepam; Drug Stability; Embalming; Fixatives; Formaldehyde; Humans; Liver; Phenobarbital; Phenytoin; Postmortem Changes	1990
Effects of chronic antidepressant and benzodiazepine treatment on corticotropin-releasing-factor receptors in rat brain and pituitary. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 1989, Volume: 2, Issue:1 Topics: Alprazolam; Animals; Anti-Anxiety Agents; Antidepressive Agents; Benzodiazepines; Brain; Desipramine; Diazepam; Imipramine; Male; Pituitary Gland, Anterior; Rats; Rats, Inbred Strains; Receptors, Corticotropin-Releasing Hormone; Receptors, Neurotransmitter; Receptors, Serotonin	1989
Effect of 5-HT1A agonists on stress-induced deficit in open field locomotor activity of rats: evidence that this model identifies anxiolytic-like activity. Neuropharmacology, 1989, Volume: 28, Issue:5 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Buspirone; Desipramine; Diazepam; Male; Models, Biological; Motor Activity; Pyrazoles; Rats; Receptors, Serotonin; Stress, Psychological; Tetrahydronaphthalenes	1989
Restraint stress-induced changes in saccharin preference: the effect of antidepressive treatment and diazepam. Pharmacology, biochemistry, and behavior, 1989, Volume: 33, Issue:4 Topics: Animals; Citalopram; Desipramine; Diazepam; Dose-Response Relationship, Drug; Electroshock; Food Preferences; Male; Rats; Rats, Inbred Strains; Restraint, Physical; Saccharin; Stress, Physiological; Time Factors	1989
Drug interactions between imipramine and benzodiazepines in rats. Journal of pharmaceutical sciences, 1988, Volume: 77, Issue:1 Topics: Animals; Anti-Anxiety Agents; Blood Proteins; Brain; Chromatography, High Pressure Liquid; Desipramine; Diazepam; Drug Interactions; Hypothermia; Imipramine; Liver; Male; Oxazepam; Protein Binding; Rats; Rats, Inbred Strains; Stress, Physiological	1988
Behavioral effects of histamine H1 antagonists: comparison with other drugs and modification by haloperidol. The Journal of pharmacology and experimental therapeutics, 1988, Volume: 245, Issue:2 Topics: Animals; Bupropion; Cocaine; Conditioning, Operant; Cyproheptadine; Desipramine; Diazepam; Dose-Response Relationship, Drug; Electroshock; Haloperidol; Histamine H1 Antagonists; Male; Propiophenones; Saimiri	1988
Brain neurotransmitter systems mediating behavioral deficits produced by inescapable shock treatment in rats. Brain research, 1988, Apr-26, Volume: 447, Issue:1 Topics: Alanine; Amphetamine; Animals; Antidepressive Agents; Atropine; Brain; Desipramine; Diazepam; Electroshock; Escape Reaction; Male; Motor Activity; Neurotransmitter Agents; Physostigmine; Rats; Rats, Inbred Strains; Valproic Acid	1988
Ultrasonic vocalization in response to unavoidable aversive stimuli in rats: effects of benzodiazepines. Life sciences, 1988, Volume: 43, Issue:6 Topics: Alprazolam; Animals; Benzodiazepines; Desipramine; Diazepam; Electroshock; Flumazenil; Haloperidol; Male; Rats; Rats, Inbred Strains; Ultrasonics; Vocalization, Animal	1988
The effects of chronic antidepressant treatment in an animal model of anxiety. Psychopharmacology, 1988, Volume: 95, Issue:3 Topics: Amitriptyline; Animals; Antidepressive Agents; Anxiety; Desipramine; Diazepam; Disease Models, Animal; Flumazenil; Male; Rats; Time Factors	1988
Interactions of brotizolam and diazepam with some psychotropic drugs on motor performance in mice. Arzneimittel-Forschung, 1986, Volume: 36, Issue:3A Topics: Animals; Azepines; Desipramine; Diazepam; Drug Interactions; Ethanol; Female; Hexobarbital; Hypnotics and Sedatives; Mice; Psychomotor Performance; Psychotropic Drugs; Reflex; Time Factors	1986
Effect of chronic administration of alprazolam and adinazolam on clonidine- or apomorphine-induced aggression in laboratory rodents. Neuropharmacology, 1986, Volume: 25, Issue:7 Topics: Aggression; Alprazolam; Animals; Anti-Anxiety Agents; Apomorphine; Benzodiazepines; Clonidine; Desipramine; Diazepam; Drug Interactions; Male; Mice; Rats; Rats, Inbred Strains	1986
Pharmacological investigations with benzoctamine (Tacitin), a new psycho-active agent. Archives internationales de pharmacodynamie et de therapie, 1973, Volume: 201, Issue:1 Topics: Adjuvants, Anesthesia; Aggression; Animals; Anthracenes; Cats; Central Nervous System; Chlordiazepoxide; Chlorpromazine; Desipramine; Diazepam; Dogs; Haplorhini; Hemodynamics; Humans; Imipramine; Mice; Motor Neurons; Muscle Contraction; Rabbits; Rats; Reflex; Respiration; Seizures	1973
[Effect of psychotropic drugs on the K + -dependent phosphatase activity in guinea pig brain microsomes]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1972, Volume: 68, Issue:1 Topics: Amitriptyline; Animals; Antidepressive Agents; Brain; Chlordiazepoxide; Chlorpromazine; Desipramine; Diazepam; Guinea Pigs; Histamine; Hydroxyzine; Imipramine; Meprobamate; Microsomes; Morphine; Nialamide; Phenelzine; Phenobarbital; Phenoxybenzamine; Phosphoric Monoester Hydrolases; Pilocarpine; Potassium; Procaine; Reserpine; Tranquilizing Agents	1972
Stress and the hormonal regulation of the immune response in mice. Psychotherapy and psychosomatics, 1974, Volume: 23, Issue:1-6 Topics: Acceleration; Adrenal Cortex Hormones; Adrenal Glands; Adrenalectomy; Adrenocorticotropic Hormone; Anesthesia; Animals; Antibody Formation; Antibody-Producing Cells; B-Lymphocytes; Cells, Cultured; Chromium Radioisotopes; Corticosterone; Crowding; Desipramine; Diazepam; Ethyl Ethers; Growth Hormone; Hemolytic Plaque Technique; Hypophysectomy; Immunosuppression Therapy; Macrophages; Mice; Pituitary Gland; Stress, Physiological; T-Lymphocytes	1974
Uptake of the putative neurotransmitter, glycine, into the rabbit retina. Investigative ophthalmology, 1972, Volume: 11, Issue:4 Topics: Alanine; Aminobutyrates; Animals; Aspartic Acid; Desipramine; Diazepam; Dinitrophenols; Glutamates; Glutethimide; Glycine; Haloperidol; Lysine; Meprobamate; Neurons; Neurotransmitter Agents; Ouabain; Phenytoin; Rabbits; Retina; Synaptic Transmission; Temperature	1972
Effect of central stimulants and depressants on mouse brain acetylcholine and choline levels. European journal of pharmacology, 1972, Volume: 18, Issue:2 Topics: Acetylcholine; Amphetamine; Animals; Atropine; Brain Chemistry; Central Nervous System Stimulants; Chlorpromazine; Choline; Depression, Chemical; Desipramine; Diazepam; Haloperidol; Ketones; Male; Mice; Pentobarbital; Pentylenetetrazole; Physostigmine; Reserpine; Stimulation, Chemical; Tranquilizing Agents; Tremorine	1972
The "on-off" side effect of L-DOPA. Advances in neurology, 1974, Volume: 5 Topics: Age Factors; Amitriptyline; Aromatic Amino Acid Decarboxylase Inhibitors; Athetosis; Carbidopa; Catechol O-Methyltransferase Inhibitors; Chlordiazepoxide; Chorea; Desipramine; Diazepam; Dietary Proteins; Enzyme Inhibitors; Female; Humans; Imipramine; Levodopa; Male; Middle Aged; Movement Disorders; Parkinson Disease; Physical Exertion; Picolinic Acids; Prochlorperazine; Sex Factors; Stress, Psychological	1974
Treatment of the depressed outpatient. Postgraduate medicine, 1974, Volume: 55, Issue:3 Topics: Adolescent; Adult; Aged; Amitriptyline; Antidepressive Agents; Anxiety; Child; Chlordiazepoxide; Depression; Desipramine; Diazepam; Humans; Hydroxyzine; Imipramine; Lithium; Methylphenidate; Outpatient Clinics, Hospital; Suicide; Tranylcypromine	1974
Desipramine poisoning. JAMA, 1972, May-08, Volume: 220, Issue:6 Topics: Desipramine; Diazepam; Gastric Lavage; Humans; Infant; Lidocaine; Male; Paraldehyde; Poisoning; Potassium Chloride; Respiration, Artificial	1972
The use of psychopharmacological drugs in the aged. Geriatrics, 1971, Volume: 26, Issue:6 Topics: Affective Symptoms; Aged; Antidepressive Agents; Anxiety; Barbiturates; Butyrophenones; Dementia; Desipramine; Dextroamphetamine; Diazepam; Humans; Imipramine; Isocarboxazid; Mental Disorders; Monoamine Oxidase Inhibitors; Nortriptyline; Phenelzine; Phenothiazines; Phytotherapy; Piperazines; Plants, Medicinal; Rauwolfia; Thiothixene; Tranquilizing Agents; Tranylcypromine; Xanthenes	1971
Detection of some psychotherapeutic drugs and their metabolites in urine. Clinical toxicology, 1971, Volume: 4, Issue:2 Topics: Amitriptyline; Amphetamine; Analgesics; Antidepressive Agents; Chlordiazepoxide; Chlorpromazine; Chromatography, Thin Layer; Desipramine; Diazepam; Fluphenazine; Haloperidol; Humans; Imipramine; Indicators and Reagents; Methadone; Perphenazine; Solvents; Thioridazine; Tranquilizing Agents; Trifluoperazine	1971
Pharmacology-toxicology. Science (New York, N.Y.), 1970, May-22, Volume: 168, Issue:3934 Topics: Antidepressive Agents; Blood Pressure; Brain; Contraceptives, Oral; Cytochromes; Desipramine; Diazepam; Endoplasmic Reticulum; Histamine; Lidocaine; Liver; Methylphenidate; Methyltyrosines; National Institutes of Health (U.S.); Norepinephrine; Norethindrone; Nortriptyline; Oxyphenbutazone; Pharmaceutical Preparations; Phenobarbital; Placenta; Progesterone; Smoking; United States	1970
[Parenteral treatment of depressive diseases]. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1970, Oct-10, Volume: 44, Issue:40 Topics: Antidepressive Agents; Bipolar Disorder; Dementia; Depression; Depressive Disorder, Major; Desipramine; Diazepam; Drug Synergism; Humans; Infusions, Parenteral; Neurotic Disorders; Schizophrenia; Trifluoperazine	1970
Unexpected failure of a satisfactory anti-depressive drug routine to control hostile expression in psychiatric out-patients. Diseases of the nervous system, 1970, Volume: 31 Topics: Adjustment Disorders; Ambulatory Care; Antidepressive Agents; Anxiety; Bipolar Disorder; Chlordiazepoxide; Desipramine; Diazepam; Hostility; Humans; Meprobamate; Psychological Tests; Thioridazine; Tranquilizing Agents	1970
The effect of antidepressants and "tranquilizers" on the response of mice to ethanol. British journal of pharmacology, 1968, Volume: 34, Issue:2 Topics: Accidents, Traffic; Amitriptyline; Animals; Antidepressive Agents; Chlorpromazine; Coma; Desipramine; Diazepam; Dibenzazepines; Drug Synergism; Ethanol; Humans; Imipramine; Methylphenidate; Mice; Nortriptyline; Phenelzine; Phenobarbital; Reflex; Substance-Related Disorders; Thioridazine; Tranquilizing Agents; Trifluoperazine	1968
Effects of centrally active drugs on four models of experimentally-induced aggregession in rodents. Life sciences, 1969, Jul-01, Volume: 8, Issue:13 Topics: Acridines; Aggression; Animals; Antidepressive Agents; Azepines; Chlordiazepoxide; Desipramine; Diazepam; Electrocoagulation; Electroshock; Ethers, Cyclic; Humans; Imipramine; Mice; Models, Biological; Rats; Rotation; Social Isolation; Thioridazine; Tranquilizing Agents	1969
[The influence of psychopharmacologic agents on the acitvity of retinal neurons]. Vision research, 1969, Volume: 9, Issue:4 Topics: Action Potentials; Amitriptyline; Animals; Cats; Chlorpromazine; Chlorprothixene; Desipramine; Diazepam; Neurons; Optic Nerve; Retina; Tranquilizing Agents	1969
[The influence of psychopharmacologic agents on visual evoked potentials in the cat]. Vision research, 1969, Volume: 9, Issue:4 Topics: Amitriptyline; Animals; Cats; Cerebral Cortex; Chlorpromazine; Chlorprothixene; Desipramine; Diazepam; Evoked Potentials; Haloperidol; Tranquilizing Agents; Vision, Ocular; Visual Cortex	1969
Suppression of histamine-induced adrenocorticotropic hormone release by antihistamines and antidepressants. The Journal of pharmacology and experimental therapeutics, 1982, Volume: 222, Issue:3 Topics: Adrenocorticotropic Hormone; Amitriptyline; Animals; Antidepressive Agents; Desipramine; Diazepam; Doxepin; Histamine; Histamine H1 Antagonists; Imipramine; Iprindole; Male; Mianserin; Radioimmunoassay; Rats; Rats, Inbred Strains; Receptors, Histamine; Stimulation, Chemical	1982
[Ataractic treatment in psychiatry and general medicine. Survey of drugs, 4]. Fortschritte der Medizin, 1983, Jul-07, Volume: 101, Issue:25 Topics: Azepines; Chemical Phenomena; Chemistry; Clozapine; Desipramine; Diazepam; Dibenzazepines; Family Practice; Humans; Mental Disorders; Phenothiazines; Tranquilizing Agents	1983
Drug-specific EEG frequency spectra and their time courses produced in the cat by antidepressants and a benzodiazepine. Electroencephalography and clinical neurophysiology, 1981, Volume: 52, Issue:1 Topics: Animals; Antidepressive Agents, Tricyclic; Brain; Cats; Desipramine; Diazepam; Dose-Response Relationship, Drug; Doxepin; Electroencephalography; Female; Imipramine	1981
An increase in sensitivity of rat cingulate cortical neurones to substance P occurs following withdrawal of chronic administration of antidepressant drugs. British journal of pharmacology, 1984, Volume: 81, Issue:4 Topics: Action Potentials; Animals; Antidepressive Agents; Clomipramine; Desipramine; Diazepam; Drug Resistance; Fluphenazine; Gyrus Cinguli; Male; Neurons; Rats; Substance P; Time Factors; Trimipramine; Zimeldine	1984
Role of imipramine & desipramine in counteracting diazepam induced changes of adenosinetriphosphatase & cholinesterase of human fetal brain. Indian journal of experimental biology, 1981, Volume: 19, Issue:8 Topics: Adenosine Triphosphatases; Brain; Cholinesterases; Desipramine; Diazepam; Female; Fetus; Gestational Age; Humans; Imipramine; Pregnancy	1981
Effects of chronic administration of antidepressants on mouse-killing behavior (muricide) in olfactory bulbectomized rats. Pharmacology, biochemistry, and behavior, 1984, Volume: 21, Issue:2 Topics: Aggression; Amitriptyline; Amygdala; Animals; Antidepressive Agents; Chlorpromazine; Clomipramine; Desipramine; Diazepam; Humans; Injections; Male; Microinjections; Olfactory Bulb; Rats; Rats, Inbred Strains; Time Factors	1984
Inhibition of foot intake in the rat. Neurochemical research, 1982, Volume: 7, Issue:3 Topics: Animals; Antidepressive Agents; Appetite Depressants; Desipramine; Diazepam; Eating; Haloperidol; Imipramine; Male; Nomifensine; Rats; Rats, Inbred Strains	1982
Effects of desipramine and alprazolam on forced swimming behaviour of adult rats exposed to prenatal diazepam. European journal of pharmacology, 1995, Feb-06, Volume: 273, Issue:3 Topics: Alprazolam; Animals; Behavior, Animal; Depression; Desipramine; Diazepam; Electroencephalography; Electrophysiology; Female; Hippocampus; Injections; Locus Coeruleus; Male; Motor Activity; Picrotoxin; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Receptors, GABA; Swimming	1995
Stress-induced norepinephrine release in the rat prefrontal cortex measured by microdialysis. The American journal of physiology, 1994, Volume: 267, Issue:6 Pt 2 Topics: alpha-Methyltyrosine; Animals; Calcium; Carbolines; Desipramine; Diazepam; Electric Stimulation; Isotonic Solutions; Locus Coeruleus; Male; Methamphetamine; Methyltyrosines; Microdialysis; Norepinephrine; Potassium; Prefrontal Cortex; Rats; Rats, Wistar; Restraint, Physical; Ringer's Solution; Stress, Physiological; Tetrodotoxin	1994
Selective serotonin re-uptake inhibitors decrease schedule-induced polydipsia in rats: a potential model for obsessive compulsive disorder. Psychopharmacology, 1993, Volume: 112, Issue:2-3 Topics: Animals; Clomipramine; Conditioning, Operant; Desipramine; Diazepam; Disease Models, Animal; Drinking Behavior; Fluoxetine; Haloperidol; Male; Obsessive-Compulsive Disorder; Rats; Rats, Wistar; Reinforcement Schedule; Selective Serotonin Reuptake Inhibitors	1993
Effects of diazepam and desipramine in the forced swimming test: influence of previous experience with the situation. European journal of pharmacology, 1993, May-19, Volume: 236, Issue:2 Topics: Animals; Behavior, Animal; Desipramine; Diazepam; Injections, Intraperitoneal; Male; Physical Exertion; Rats; Rats, Sprague-Dawley; Swimming	1993
The contribution of lysosomal trapping in the uptake of desipramine and chloroquine by different tissues. Pharmacology & toxicology, 1995, Volume: 77, Issue:6 Topics: Adipose Tissue; Animals; Brain; Chloroquine; Desipramine; Diaphragm; Diazepam; In Vitro Techniques; Kidney; Liver; Lung; Lysosomes; Male; Microtomy; Muscle, Skeletal; Myocardium; Rats; Rats, Sprague-Dawley; Thiopental; Tissue Distribution	1995
Behavioural responsiveness to picrotoxin and desipramine in adult rats prenatally exposed to different benzodiazepine receptor agonists. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 1995, Volume: 5, Issue:4 Topics: Adrenergic Uptake Inhibitors; Alprazolam; Animals; Behavior, Animal; Desipramine; Diazepam; Female; GABA Antagonists; GABA Modulators; GABA-A Receptor Agonists; Hypnotics and Sedatives; Male; Picrotoxin; Pregnancy; Prenatal Exposure Delayed Effects; Pyridines; Rats; Rats, Wistar; Seizures; Zolpidem	1995
Effects of proposed treatments for cocaine addiction on hemodynamic responsiveness to cocaine in conscious rats. The Journal of pharmacology and experimental therapeutics, 1997, Volume: 283, Issue:2 Topics: Animals; Bromocriptine; Buprenorphine; Cocaine; Desipramine; Diazepam; Dizocilpine Maleate; Hemodynamics; Male; Piperazines; Rats; Rats, Sprague-Dawley; Substance-Related Disorders	1997
In vitro effect of central nervous system active drugs on the ATPase-ADPase activity and acetylcholinesterase activity from cerebral cortex of adult rats. General pharmacology, 1998, Volume: 31, Issue:4 Topics: Acetylcholinesterase; Adenosine Triphosphatases; Amitriptyline; Animals; Apyrase; Central Nervous System Agents; Cerebral Cortex; Desipramine; Diazepam; Hydrolases; Imipramine; In Vitro Techniques; Lithium; Rats; Synaptosomes	1998
Effects of psychoactive drugs on temporal discrimination in rats. Behavioural pharmacology, 1997, Volume: 8, Issue:4 Topics: Animals; Atropine; Clomipramine; Desipramine; Diazepam; Discrimination Learning; Discrimination, Psychological; Haloperidol; Male; Nicotine; Psychotropic Drugs; Rats; Rats, Wistar; Scopolamine	1997
Benzodiazepine withdrawal facilitates the subsequent onset of escape failures and anhedonia: influence of different antidepressant drugs. Brain research, 1999, Feb-20, Volume: 819, Issue:1-2 Topics: Amphetamine; Animals; Anti-Anxiety Agents; Antidepressive Agents; Avoidance Learning; Conditioning, Classical; Cues; Desipramine; Diazepam; Electroshock; Escape Reaction; Fluoxetine; Male; Odorants; Phenelzine; Rats; Sexual Behavior, Animal; Substance Withdrawal Syndrome; Time Factors	1999
Effects of the CRF(1) receptor antagonist, CP 154,526, in the separation-induced vocalization anxiolytic test in rat pups. Neuropharmacology, 2000, Jun-08, Volume: 39, Issue:8 Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Antipsychotic Agents; Anxiety; Behavior, Animal; Buspirone; Clozapine; Desipramine; Diazepam; Dose-Response Relationship, Drug; Female; Haloperidol; Injections, Intraperitoneal; Male; Pyrimidines; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Corticotropin-Releasing Hormone; Social Isolation; Stress, Psychological; Vocalization, Animal; Zimeldine	2000
Dual effects of intravenous anesthetics on the function of norepinephrine transporters. Anesthesiology, 2000, Volume: 93, Issue:5 Topics: Adrenal Medulla; Adrenergic Uptake Inhibitors; Anesthetics, Dissociative; Anesthetics, Intravenous; Animals; Carrier Proteins; Cattle; Cell Membrane; Cells, Cultured; Desipramine; Diazepam; Drug Administration Schedule; Ketamine; Kinetics; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Propofol; RNA, Messenger; Symporters; Thiamylal; Tritium	2000
Antidepressant activity of memory-enhancing drugs in the reduction of submissive behavior model. European journal of pharmacology, 2002, Apr-05, Volume: 440, Issue:1 Topics: Animals; Antidepressive Agents; Competitive Behavior; Desipramine; Diazepam; Dioxoles; Dose-Response Relationship, Drug; Fluoxetine; Injections, Intraperitoneal; Male; Maze Learning; Models, Animal; Nootropic Agents; Piperidines; Piracetam; Pyrrolidinones; Rats; Rats, Sprague-Dawley	2002
Tail-swing behavior: a novel animal model for anxiety. Methods and findings in experimental and clinical pharmacology, 2003, Volume: 25, Issue:5 Topics: Animals; Anxiety; Behavior, Animal; Desipramine; Diazepam; Disease Models, Animal; Haloperidol; Immobilization; Male; Mice; Muscle Tonus; Muscle, Skeletal; Nitrazepam; Psychotropic Drugs; Tail	2003
Effects of selective serotonin reuptake inhibitors on immobility time in the tail suspension test in streptozotocin-induced diabetic mice. Pharmacology, biochemistry, and behavior, 2003, Volume: 75, Issue:2 Topics: Adrenergic Uptake Inhibitors; Animals; Anti-Anxiety Agents; Blood Glucose; Body Weight; Desipramine; Diabetes Mellitus, Experimental; Diazepam; Dose-Response Relationship, Drug; Fluoxetine; Fluvoxamine; Hindlimb Suspension; Male; Mice; Mice, Inbred ICR; Motor Activity; Selective Serotonin Reuptake Inhibitors	2003
[DRUGS ACTING ON THE NERVOUS SYSTEM. (2). WITH SPECIAL REFERENCE TO TRANQUILIZERS AND ANTIDEPRESSIVE AGENTS]. [Chiryo] [Therapy], 1963, Volume: 45 Topics: Amides; Amitriptyline; Antidepressive Agents; Benactyzine; Chemical Phenomena; Chemistry; Chlordiazepoxide; Desipramine; Diazepam; Haloperidol; Humans; Hydroxyzine; Hypnotics and Sedatives; Imipramine; Isocarboxazid; Meprobamate; Methylphenidate; Monoamine Oxidase Inhibitors; Nervous System; Nialamide; Pharmacology; Phenelzine; Piperidines; Tranquilizing Agents; Tranylcypromine; Tryptamines	1963
'Compulsive' lever-pressing in rats is attenuated by the serotonin re-uptake inhibitors paroxetine and fluvoxamine but not by the tricyclic antidepressant desipramine or the anxiolytic diazepam. Behavioural pharmacology, 2004, Volume: 15, Issue:3 Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Compulsive Behavior; Conditioning, Operant; Desipramine; Diazepam; Dose-Response Relationship, Drug; Extinction, Psychological; Fluvoxamine; Male; Paroxetine; Rats; Rats, Wistar; Reward; Selective Serotonin Reuptake Inhibitors	2004
Antianxiety and antidepressant-like effects of AC-5216, a novel mitochondrial benzodiazepine receptor ligand. British journal of pharmacology, 2004, Volume: 142, Issue:7 Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Behavior, Animal; Brain; Cell Line, Tumor; Desipramine; Diazepam; Electroencephalography; Humans; In Vitro Techniques; Isoindoles; Ligands; Male; Mice; Mitochondria; Piperazines; Purines; Pyrimidines; Radioligand Assay; Rats; Rats, Wistar; Receptors, GABA-A; Serotonin 5-HT1 Receptor Agonists	2004
Antidepressants attenuate both the enhanced ethanol intake and ethanol-induced anxiolytic effects in diazepam withdrawn rats. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2005, Volume: 15, Issue:1 Topics: Alcohol Drinking; Analysis of Variance; Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Behavior, Animal; Central Nervous System Depressants; Choice Behavior; Desipramine; Diazepam; Dose-Response Relationship, Drug; Drinking; Drug Administration Schedule; Drug Interactions; Ethanol; Fluoxetine; Male; Maze Learning; Rats; Rats, Wistar; Substance Withdrawal Syndrome; Time Factors	2005
Reinforced spatial alternation as an animal model of obsessive-compulsive disorder (OCD): investigation of 5-HT2C and 5-HT1D receptor involvement in OCD pathophysiology. Biological psychiatry, 2005, May-15, Volume: 57, Issue:10 Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Desipramine; Diazepam; Disease Models, Animal; Fluoxetine; Indoles; Male; Maze Learning; Obsessive-Compulsive Disorder; Piperazines; Piperidines; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1D; Receptor, Serotonin, 5-HT2C; Reinforcement, Psychology; Selective Serotonin Reuptake Inhibitors; Serotonin Receptor Agonists; Tryptamines	2005
The comparison of immobility time in experimental rat swimming models. Life sciences, 2006, Sep-27, Volume: 79, Issue:18 Topics: Animals; Blood Glucose; Corticosterone; Desipramine; Diazepam; Glycogen; Immobilization; Liver; Male; Models, Biological; Rats; Rats, Wistar; Stress, Psychological; Swimming; Time Factors	2006
Pharmacological and genetic influences on hole-board behaviors in mice. Pharmacology, biochemistry, and behavior, 2006, Volume: 85, Issue:1 Topics: Animals; Desipramine; Diazepam; Exploratory Behavior; Female; Fluoxetine; Male; Methamphetamine; Mice; Mice, Inbred Strains; Pentylenetetrazole; Piperazines; Selective Serotonin Reuptake Inhibitors	2006
Evaluation of the repeated open-space swim model of depression in the mouse. Pharmacology, biochemistry, and behavior, 2008, Volume: 91, Issue:1 Topics: Adaptation, Psychological; Animals; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Cell Proliferation; Chronic Disease; Depression; Desipramine; Diazepam; Disease Models, Animal; Fluoxetine; Food Preferences; Haloperidol; Hindlimb Suspension; Hypnotics and Sedatives; Male; Mice; Motor Activity; Neurons; Swimming	2008
The triple reuptake inhibitor DOV216,303 exhibits limited antidepressant-like properties in the differential reinforcement of low-rate 72-second responding assay, likely due to dopamine reuptake inhibition. Journal of psychopharmacology (Oxford, England), 2011, Volume: 25, Issue:10 Topics: Animals; Antidepressive Agents; Aza Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bupropion; Desipramine; Diazepam; Dopamine Uptake Inhibitors; Fluvoxamine; Haloperidol; Imipramine; Male; Piperazines; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology	2011
Sex differences in baseline and drug-induced behavioural responses in classical behavioural tests. Progress in neuro-psychopharmacology & biological psychiatry, 2012, Jun-01, Volume: 37, Issue:2 Topics: Adrenergic Uptake Inhibitors; Amphetamine; Animals; Anti-Anxiety Agents; Behavior, Animal; Central Nervous System Stimulants; Desipramine; Diazepam; Female; Male; Motor Activity; Rats; Rats, Sprague-Dawley; Sex Characteristics	2012
The effects of isolated and enriched housing conditions on baseline and drug-induced behavioural responses in the male rat. Behavioural brain research, 2012, Oct-01, Volume: 234, Issue:2 Topics: Amphetamine; Analysis of Variance; Animals; Anti-Anxiety Agents; Behavior, Animal; Body Weight; Central Nervous System Agents; Desipramine; Diazepam; Dose-Response Relationship, Drug; Environment; Exploratory Behavior; Locomotion; Male; Maze Learning; Rats; Rats, Sprague-Dawley; Social Isolation; Swimming	2012
A depressive phenotype induced by Bacille Calmette Guérin in 'susceptible' animals: sensitivity to antidepressants. Psychopharmacology, 2013, Volume: 226, Issue:3 Topics: Animals; Antidepressive Agents; BCG Vaccine; Chronic Disease; Depression; Desipramine; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Fluoxetine; Inflammation; Male; Mice; Motor Activity; Phenotype	2013
Lipid raft integrity affects GABAA receptor, but not NMDA receptor modulation by psychopharmacological compounds. The international journal of neuropsychopharmacology, 2013, Volume: 16, Issue:6 Topics: Animals; Anti-Anxiety Agents; Caveolin 1; Cells, Cultured; Desipramine; Diazepam; Dose-Response Relationship, Drug; Electric Stimulation; Embryo, Mammalian; gamma-Aminobutyric Acid; Hippocampus; Humans; Membrane Microdomains; Membrane Proteins; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Rats; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate	2013
Maerua angolensis stem bark extract reverses anxiety and related behaviours in zebrafish-Involvement of GABAergic and 5-HT systems. Journal of ethnopharmacology, 2017, Jul-31, Volume: 207 Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Capparaceae; Desipramine; Diazepam; Disease Models, Animal; gamma-Aminobutyric Acid; Locomotion; Motor Activity; Plant Bark; Receptors, GABA-A; Serotonin; Stress, Psychological; Zebrafish	2017