desipramine and debrisoquin

desipramine has been researched along with debrisoquin in 23 studies

Research

Studies (23)

Timeframe	Studies, this research(%)	All Research%
pre-1990	12 (52.17)	18.7374
1990's	7 (30.43)	18.2507
2000's	2 (8.70)	29.6817
2010's	2 (8.70)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Mottram, DR; Wadhwani, D	1
Dahl, ML; Ingelman-Sundberg, M; Johansson, I; Palmertz, MP; Sjöqvist, F	1
Ayesh, R; Cholerton, S; Dawling, S; Hayler, A; Idle, JR; Oates, NS; Smith, RL; Widdop, B	1
Brøsen, K; Gram, LF; Kragh-Sørensen, P	1
Dahlqvist, R; Dumont, E; Spina, E; Steiner, E	1
Aberg-Wistedt, A; Bertilsson, L; Dumont, E; Lundström, J	1
Bertilsson, L; Sjöqvist, F	1
Bech, P; Bertilsson, L; Brøsen, K; Gram, LF; Klysner, R; Otton, SV	1
Spina, E; Steiner, E	1
Birgersson, C; Jörnvall, H; Morgan, ET; von Bahr, C	1
Ericsson, O; Sjöqvist, F; Spina, E; Steiner, E	1
Lane, EA; Potter, WZ; Rudorfer, MV	1
Antonaccio, MJ	1
Birgersson, C; Ericsson, O; Mellström, B; Sjöqvist, F; Spina, E; Steiner, E; von Bahr, C	1
Aberg-Wistedt, A; Bertilsson, L	1
Chiba, K; Echizen, H; Ishizaki, T; Kikuchi, Y; Koyama, E	1
Alm, C; Dahl, ML; Ingelman-Sundberg, M; Iselius, L; Johansson, I; Lee, D; Sjöqvist, F; Svensson, JO	1
Bluhm, RE; Branch, RA; Shelton, R; Wilkinson, GR	1
Avenoso, A; Campo, GM; Caputi, AP; Perucca, E; Spina, E	1
Dorne, JL; Renwick, AG; Slob, W; Walton, K	1

Reviews

2 review(s) available for desipramine and debrisoquin

Article	Year
Inhibition of desipramine 2-hydroxylation by quinidine and quinine in rapid and slow debrisoquine hydroxylators. Psychopharmacology series, 1989, Volume: 7 Topics: Debrisoquin; Depression, Chemical; Desipramine; Humans; Hydroxylation; Isoquinolines; Phenotype; Quinidine; Quinine	1989
Slow hydroxylation of tricyclic antidepressants--relationship to polymorphic drug oxidation. Progress in clinical and biological research, 1986, Volume: 214 Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Debrisoquin; Desipramine; Female; Humans; Hydroxylation; Kinetics; Male; Middle Aged; Nortriptyline; Phenotype; Polymorphism, Genetic; Smoking; Twins, Dizygotic; Twins, Monozygotic	1986

Trials

2 trial(s) available for desipramine and debrisoquin

Article	Year
Steady-state concentrations of imipramine and its metabolites in relation to the sparteine/debrisoquine polymorphism. European journal of clinical pharmacology, 1986, Volume: 30, Issue:6 Topics: Adult; Aged; Aged, 80 and over; Clinical Trials as Topic; Debrisoquin; Depression; Desipramine; Female; Humans; Hydroxylation; Imipramine; Isoquinolines; Kinetics; Male; Middle Aged; Phenotype; Polymorphism, Genetic; Sparteine	1986
Phenobarbital induces the 2-hydroxylation of desipramine. Therapeutic drug monitoring, 1996, Volume: 18, Issue:1 Topics: Adult; Anticonvulsants; Antidepressive Agents, Tricyclic; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Debrisoquin; Desipramine; Enzyme Induction; Epilepsy; Half-Life; Humans; Hydroxylation; Male; Mixed Function Oxygenases; Phenobarbital; Phenotype; Polymorphism, Genetic	1996

Article

Year

Steady-state concentrations of imipramine and its metabolites in relation to the sparteine/debrisoquine polymorphism.

European journal of clinical pharmacology, 1986, Volume: 30, Issue:6

Topics: Adult; Aged; Aged, 80 and over; Clinical Trials as Topic; Debrisoquin; Depression; Desipramine; Female; Humans; Hydroxylation; Imipramine; Isoquinolines; Kinetics; Male; Middle Aged; Phenotype; Polymorphism, Genetic; Sparteine

1986

Phenobarbital induces the 2-hydroxylation of desipramine.

Therapeutic drug monitoring, 1996, Volume: 18, Issue:1

Topics: Adult; Anticonvulsants; Antidepressive Agents, Tricyclic; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Debrisoquin; Desipramine; Enzyme Induction; Epilepsy; Half-Life; Humans; Hydroxylation; Male; Mixed Function Oxygenases; Phenobarbital; Phenotype; Polymorphism, Genetic

1996

Other Studies

19 other study(ies) available for desipramine and debrisoquin

Article	Year
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
The sympathomimetic activity of fenfluramine hydrochloride on rat vas deferens. British journal of pharmacology, 1977, Volume: 59, Issue:4 Topics: Animals; Debrisoquin; Desipramine; Drug Interactions; Fenfluramine; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Nerve Endings; Rats; Reserpine; Sympathomimetics; Time Factors; Tyramine; Vas Deferens	1977
Analysis of the CYP2D6 gene in relation to debrisoquin and desipramine hydroxylation in a Swedish population. Clinical pharmacology and therapeutics, 1992, Volume: 51, Issue:1 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alleles; Child; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Debrisoquin; Deoxyribonucleases, Type II Site-Specific; Desipramine; DNA; Female; Gene Amplification; Humans; Hydroxylation; Male; Middle Aged; Mixed Function Oxygenases; Phenotype; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length	1992
Comparative effects of the diastereoisomers, quinine and quinidine in producing phenocopy debrisoquine poor metabolisers (PMs) in healthy volunteers. Chirality, 1991, Volume: 3, Issue:1 Topics: Adult; Debrisoquin; Desipramine; Female; Humans; Male; Metabolic Clearance Rate; Molecular Structure; Nortriptyline; Phenotype; Quinidine; Quinine; Reference Values; Stereoisomerism	1991
Extremely slow metabolism of amitriptyline but normal metabolism of imipramine and desipramine in an extensive metabolizer of sparteine, debrisoquine, and mephenytoin. Therapeutic drug monitoring, 1991, Volume: 13, Issue:2 Topics: Administration, Oral; Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Chromatography, Thin Layer; Debrisoquin; Desipramine; Drug Interactions; Humans; Imipramine; Male; Mephenytoin; Phenotype; Quinidine; Sparteine	1991
Rapid conjugation in an extremely rapid hydroxylator of debrisoquine: a case report supporting a coregulation of certain phase I and II metabolic reactions. Therapeutic drug monitoring, 1988, Volume: 10, Issue:2 Topics: Adult; Antidepressive Agents; Debrisoquin; Desipramine; Female; Glucuronates; Humans; Hydroxylation; In Vitro Techniques; Isoniazid; Isoquinolines; Oxazepam; Zimeldine	1988
Differences in the inhibitory effect of cimetidine on desipramine metabolism between rapid and slow debrisoquin hydroxylators. Clinical pharmacology and therapeutics, 1987, Volume: 42, Issue:3 Topics: Adult; Cimetidine; Debrisoquin; Desipramine; Half-Life; Humans; Hydroxylation; Isoquinolines; Kinetics; Metabolic Clearance Rate	1987
Purification of a desmethylimipramine and debrisoquine hydroxylating cytochrome P-450 from human liver. Biochemical pharmacology, 1986, Sep-15, Volume: 35, Issue:18 Topics: Cytochrome P-450 Enzyme System; Debrisoquin; Desipramine; Electrophoresis, Polyacrylamide Gel; Humans; Isoquinolines; Liver; Microsomes, Liver	1986
Hydroxylation of desmethylimipramine: dependence on the debrisoquin hydroxylation phenotype. Clinical pharmacology and therapeutics, 1987, Volume: 41, Issue:3 Topics: Adult; Debrisoquin; Desipramine; Female; Half-Life; Humans; Hydroxylation; Isoquinolines; Kinetics; Male; Metabolic Clearance Rate; Middle Aged; Phenotype	1987
Interethnic dissociation between debrisoquine and desipramine hydroxylation. Journal of clinical psychopharmacology, 1985, Volume: 5, Issue:2 Topics: Adult; China; Debrisoquin; Desipramine; Ethnicity; Female; Humans; Hydroxylation; Isoquinolines; Kinetics; Male; Metabolic Clearance Rate; Middle Aged; Molecular Biology; Phenotype; United States; White People	1985
Paradoxical vagal tachycardia in ganglion-blocked anesthetized dogs. European journal of pharmacology, 1974, Volume: 28, Issue:1 Topics: Adrenergic beta-Antagonists; Anesthesia; Animals; Atropine; Blood Pressure; Bretylium Compounds; Chlorisondamine; Debrisoquin; Desipramine; Dogs; Drug Interactions; Electric Stimulation; Female; Ganglionic Blockers; Guanethidine; Heart Rate; Hexamethonium Compounds; Male; Mecamylamine; Methylphenidate; Oxprenolol; Reserpine; Vagus Nerve	1974
Phenotypic consistency in hydroxylation of desmethylimipramine and debrisoquine in healthy subjects and in human liver microsomes. Clinical pharmacology and therapeutics, 1984, Volume: 36, Issue:5 Topics: Adult; Chromatography, High Pressure Liquid; Debrisoquin; Desipramine; Female; Humans; Hydroxylation; Isoquinolines; Kinetics; Male; Microsomes, Liver; Middle Aged; Phenotype	1984
The debrisoquine hydroxylation test predicts steady-state plasma levels of desipramine. British journal of clinical pharmacology, 1983, Volume: 15, Issue:3 Topics: Debrisoquin; Depression; Desipramine; Humans; Hydroxylation	1983
Simultaneous high-performance liquid chromatography-electrochemical detection determination of imipramine, desipramine, their 2-hydroxylated metabolites, and imipramine N-oxide in human plasma and urine: preliminary application to oxidation pharmacogeneti Therapeutic drug monitoring, 1993, Volume: 15, Issue:3 Topics: Arylsulfatases; Calibration; Chromatography, High Pressure Liquid; Debrisoquin; Desipramine; Electrochemistry; Glucuronidase; Humans; Hydroxylation; Imipramine; Male; Oxidation-Reduction; Phenotype; Psychotropic Drugs; Sensitivity and Specificity; Sparteine; Time Factors; Tranquilizing Agents	1993
Polymorphic 2-hydroxylation of desipramine. A population and family study. European journal of clinical pharmacology, 1993, Volume: 44, Issue:5 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antidepressive Agents, Tricyclic; Child; Debrisoquin; Desipramine; Female; Genetic Linkage; Genotype; Humans; Hydroxylation; Male; Middle Aged; Phenotype; Polymorphism, Genetic; Sweden	1993
Genetically determined drug-metabolizing activity and desipramine-associated cardiotoxicity: a case report. Clinical pharmacology and therapeutics, 1993, Volume: 53, Issue:1 Topics: Acetylation; Debrisoquin; Depressive Disorder; Desipramine; Electrocardiography; Family; Genetic Testing; Heart Diseases; Humans; Male; Middle Aged	1993
Human variability in polymorphic CYP2D6 metabolism: is the kinetic default uncertainty factor adequate? Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2002, Volume: 40, Issue:11 Topics: Adult; Aged; Aging; Benzhydryl Compounds; Cresols; Cyclohexanols; Cytochrome P-450 CYP2D6; Debrisoquin; Desipramine; Encainide; Ethnicity; Genetic Variation; Humans; Hydroxylation; Infant; Infant, Newborn; Kidney Diseases; Kinetics; Liver Diseases; Metabolic Clearance Rate; Metoprolol; Phenylpropanolamine; Polymorphism, Genetic; Propafenone; Substrate Specificity; Tolterodine Tartrate; Venlafaxine Hydrochloride	2002