desipramine and caffeine

desipramine has been researched along with caffeine in 68 studies

Research

Studies (68)

Timeframe	Studies, this research(%)	All Research%
pre-1990	12 (17.65)	18.7374
1990's	1 (1.47)	18.2507
2000's	22 (32.35)	29.6817
2010's	32 (47.06)	24.3611
2020's	1 (1.47)	2.80

Authors

Authors	Studies
Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET	1
Carrupt, PA; Crivori, P; Cruciani, G; Testa, B	1
Duffy, EM; Jorgensen, WL	1
Topliss, JG; Yoshida, F	1
Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA	1
Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL	1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY	2
Akamatsu, M; Fujikawa, M; Nakao, K; Shimizu, R	1
Lombardo, F; Obach, RS; Waters, NJ	1
Alimuddin, M; Bulloch, D; Dahl, R; Grant, D; Lee, N; Peacock, M	1
He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Sun, Y; Yan, Z	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Ahman, M; Holmén, AG; Wan, H	1
Andrisano, V; Barril, X; Bartolini, M; Carreiras, Mdo C; de los Ríos, C; García, AG; Huertas, O; León, R; López, B; López, MG; Luque, FJ; Marco-Contelles, J; Rodríguez-Franco, MI; Samadi, A; Villarroya, M	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Andrisano, V; Arce, MP; Badia, A; Bartolini, M; Camps, P; Clos, MV; Dafni, T; Formosa, X; Galdeano, C; Gómez, E; Huertas, O; Isambert, N; Lavilla, R; Luque, FJ; Mancini, F; Muñoz-Torrero, D; Ramírez, L; Rodríguez-Franco, MI	1
Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S	1
Arce, MP; Conde, S; García, AG; González-Muñoz, GC; López, B; López, MG; Pérez, C; Rodríguez-Franco, MI; Villarroya, M	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Campillo, NE; Guerra, A; Páez, JA	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Avdeef, A; Tam, KY	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Glen, RC; Lowe, R; Mitchell, JB	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Akamatsu, M	1
Sen, S; Sinha, N	1
Arce, MP; Conde, S; del Barrio, L; Egea, J; García, AG; González-Muñoz, GC; León, R; López, B; López, MG; Martín-de-Saavedra, MD; Pérez, C; Rodríguez-Franco, MI; Romero, A; Villarroya, M	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Chen, ZF; Huang, SL; Huang, ZS; Liang, H; Qin, JK; Tang, H; Zhao, HT; Zhao, LZ; Zhong, SM	1
Brea, J; Cadavid, MI; Campillo, NE; Ceballos, P; Gil, C; Loza, MI; Martínez, A; Moro, MA; Pérez, C; Pérez, DI; Perez-Castillo, A; Redondo, M; Val, C; Zarruk, JG	1
Andrisano, V; Bolognesi, ML; Carloni, P; Cavalli, A; Chiriano, G; De Simone, A; Legname, G; Mancini, F; Martinez, A; Perez, DI; Roberti, M	1
Alonso-Gil, S; Campillo, NE; Castro, A; Encinas, A; Gil, C; Martinez, A; Morales-Garcia, JA; Palomo, V; Perez, C; Perez, DI; Perez-Castillo, A; Soteras, I	1
Chen, ZF; Liang, H; Tang, H; Wang, ZY; Zhao, HT; Zhong, SM	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Alonso-Gil, S; Chavarría, C; Gil, C; Morales Garcia, JA; Pérez, C; Perez, DI; Pérez-Castillo, A; Porcal, W; Souza, JM	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Bello, ML; Gil, C; Kraemer, BC; Lecourtois, M; Liachko, NF; Martinez, A; Miguel, L; Perez, C; Perez, DI; Redondo, M; Salado, IG	1
Cahlíková, L; Chlebek, J; Hošt'álková, A; Opletal, L; Pérez, DI; Šafratová, M; Štěpánková, Š	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Chen, W; Huangli, Y; Qin, J; Shen, Y; Tang, H; Wang, L; Wei, S	1
Arce, MP; Conde, S; Egea, J; Gil, C; León, R; López, MG; Monjas, L; Pérez, C; Rodríguez-Franco, MI; Villarroya, M	1
Campillo, NE; Geiger, L; Gil, C; González, S; Li, L; Martinez, A; Morales, AV; Perez, DI; Salado, IG; Sebastián-Pérez, V; Zaldivar-Diez, J	1
Campillo, NE; Cañada, FJ; Canales, A; Carvalho, I; Chierrito, TPC; Martinez, A; Martínez-Gonzalez, L; Pedersoli-Mantoani, S; Perez, C; Pérez, DI; Roca, C; Sebastian-Pérez, V	1
Alcaro, S; Bagetta, D; Borges, F; Cagide, F; Oliveira, PJ; Ortuso, F; Pérez, C; Reis, J; Rodríguez-Franco, MI; Teixeira, J; Uriarte, E; Valencia, ME	1
Chaikuad, A; de Lago, E; Gil, C; Gomez-Almeria, M; Gonzalo-Consuegra, C; Knapp, S; Lietha, D; Martín-Requero, A; Martinez, A; Martínez-González, L; Monti, B; Nozal, V; Palomo, V; Pérez-Cuevas, E; Petralla, S; Ramírez, D; Santana, P	1
Blum, JJ; Rothstein, TL	1
Doggett, NS; Spencer, PS	1
Morgan, HE; Rannels, SR; Whitfield, CF	1
Mlejnkova, M; Rysánek, K; Spánkova, H; Synek, P	1
Mennear, JH; Rudzik, AD	1
Blum, JJ	1
Bouttier, D; Julou, L; Sigwald, J; Thomas, J	1
Babbini, M; Cestari, A; De Marchi, F; Graziani, G	1
Phillis, JW	1
Jones, RS; Olpe, HR; Steinmann, MW	1
Esser, MJ; Reid, AR; Sawynok, J	1
Cristòfol, RM; Gassó, S; Rodríguez-Farré, E; Sanfeliu, C; Suñol, C	1
METYS, J; METYSOVA, J	1
Caboche, J; Girault, JA; Hervé, D; Pagès, C; Valjent, E	1
Avdeef, A; Nielsen, PE	1
Johal, MS; Patel, R; Selassie, CR; Zwang, TJ	1
Alova, LH; Nikolov, RP; Pechlivanova, DM; Petkov, VV; Tchekalarova, JD; Yakimova, KS	1
Doogue, MP; Jensen, BP; Patel, F; Polasek, TM; Sorich, MJ; Wiese, MD	1
Bohner, LO; Costa, AP; De Lima, TC; Lino-de-Oliveira, C; Santos, EC; Silva, CF; Vieira, C	1

Reviews

1 review(s) available for desipramine and caffeine

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Other Studies

67 other study(ies) available for desipramine and caffeine

Article	Year
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs. Journal of medicinal chemistry, 1985, Volume: 28, Issue:3 Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium	1985
Predicting blood-brain barrier permeation from three-dimensional molecular structure. Journal of medicinal chemistry, 2000, Jun-01, Volume: 43, Issue:11 Topics: Blood-Brain Barrier; Databases, Factual; Models, Chemical; Molecular Conformation; Multivariate Analysis; Permeability; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Prediction of drug solubility from Monte Carlo simulations. Bioorganic & medicinal chemistry letters, 2000, Jun-05, Volume: 10, Issue:11 Topics: Monte Carlo Method; Pharmaceutical Preparations; Solubility	2000
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds. Journal of medicinal chemistry, 2001, Jul-19, Volume: 44, Issue:15 Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water	2001
Cheminformatic models to predict binding affinities to human serum albumin. Journal of medicinal chemistry, 2001, Dec-06, Volume: 44, Issue:25 Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids	2001
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data. Journal of medicinal chemistry, 2002, Jun-20, Volume: 45, Issue:13 Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding	2002
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics. Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5 Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution	2004
QSAR study on permeability of hydrophobic compounds with artificial membranes. Bioorganic & medicinal chemistry, 2007, Jun-01, Volume: 15, Issue:11 Topics: Biological Transport; Caco-2 Cells; Drug Evaluation, Preclinical; Humans; Hydrophobic and Hydrophilic Interactions; Membranes, Artificial; Permeability; Pharmaceutical Preparations; Quantitative Structure-Activity Relationship	2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Determination of log D via automated microfluidic liquid-liquid extraction. Journal of medicinal chemistry, 2008, Aug-28, Volume: 51, Issue:16 Topics: Automation; Biopharmaceutics; Microfluidic Analytical Techniques; Pharmacokinetics	2008
First-principle, structure-based prediction of hepatic metabolic clearance values in human. European journal of medicinal chemistry, 2009, Volume: 44, Issue:4 Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metabolic Clearance Rate; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship; Sensitivity and Specificity; Software	2009
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs. Journal of medicinal chemistry, 2009, Mar-26, Volume: 52, Issue:6 Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry	2009
Tacripyrines, the first tacrine-dihydropyridine hybrids, as multitarget-directed ligands for the treatment of Alzheimer's disease. Journal of medicinal chemistry, 2009, May-14, Volume: 52, Issue:9 Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Blood-Brain Barrier; Butyrylcholinesterase; Calcium; Calcium Channel Blockers; Catalytic Domain; Cell Death; Cell Line, Tumor; Cholinesterase Inhibitors; Cytosol; Dihydropyridines; Humans; Hydrogen Peroxide; Kinetics; Ligands; Models, Molecular; Peptide Fragments; Permeability; Tacrine	2009
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Pyrano[3,2-c]quinoline-6-chlorotacrine hybrids as a novel family of acetylcholinesterase- and beta-amyloid-directed anti-Alzheimer compounds. Journal of medicinal chemistry, 2009, Sep-10, Volume: 52, Issue:17 Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Binding Sites; Blood-Brain Barrier; Butyrylcholinesterase; Cattle; Cholinesterase Inhibitors; Drug Design; Humans; Isomerism; Membranes, Artificial; Mice; Models, Molecular; Molecular Conformation; Permeability; Protein Binding; Tacrine	2009
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain. Bioorganic & medicinal chemistry, 2009, Oct-01, Volume: 17, Issue:19 Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship	2009
Neuroprotective and cholinergic properties of multifunctional glutamic acid derivatives for the treatment of Alzheimer's disease. Journal of medicinal chemistry, 2009, Nov-26, Volume: 52, Issue:22 Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Blood-Brain Barrier; Catalytic Domain; Cattle; Cell Death; Cell Line, Tumor; Cell Survival; Cholinergic Agents; Cholinesterase Inhibitors; Esters; Glutamic Acid; Humans; Hydrophobic and Hydrophilic Interactions; Neuroprotective Agents; Permeability; Piperidines; Protein Binding	2009
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Neural computational prediction of oral drug absorption based on CODES 2D descriptors. European journal of medicinal chemistry, 2010, Volume: 45, Issue:3 Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical	2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability? Journal of medicinal chemistry, 2010, May-13, Volume: 53, Issue:9 Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological; Permeability; Porosity; Regression Analysis	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
Predicting phospholipidosis using machine learning. Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5 Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
Importance of physicochemical properties for the design of new pesticides. Journal of agricultural and food chemistry, 2011, Apr-13, Volume: 59, Issue:7 Topics: Anabasine; Animals; Biological Availability; Cell Membrane Permeability; Chemical Phenomena; Drug Design; Humans; Imidazoles; Insecticides; Neonicotinoids; Nitro Compounds; Pesticides; Quantitative Structure-Activity Relationship; Receptors, Nicotinic	2011
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model. European journal of medicinal chemistry, 2011, Volume: 46, Issue:2 Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship	2011
N-acylaminophenothiazines: neuroprotective agents displaying multifunctional activities for a potential treatment of Alzheimer's disease. European journal of medicinal chemistry, 2011, Volume: 46, Issue:6 Topics: Alzheimer Disease; Amyloid beta-Peptides; Antineoplastic Agents; Butyrylcholinesterase; Calcium; Cell Death; Cell Survival; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Humans; Molecular Structure; Okadaic Acid; Peptide Fragments; Phenothiazines; Stereoisomerism; Structure-Activity Relationship; Tumor Cells, Cultured	2011
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
Hybrids of oxoisoaporphine-tacrine congeners: novel acetylcholinesterase and acetylcholinesterase-induced β-amyloid aggregation inhibitors. European journal of medicinal chemistry, 2011, Volume: 46, Issue:10 Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Animals; Aporphines; Blood-Brain Barrier; Butyrylcholinesterase; Cholinesterase Inhibitors; Electrophorus; Horses; Humans; Models, Biological; Tacrine	2011
Neuroprotective efficacy of quinazoline type phosphodiesterase 7 inhibitors in cellular cultures and experimental stroke model. European journal of medicinal chemistry, 2012, Volume: 47, Issue:1 Topics: Animals; Blood-Brain Barrier; Cells, Cultured; Cyclic Nucleotide Phosphodiesterases, Type 7; Disease Models, Animal; Enzyme Inhibitors; Infarction, Middle Cerebral Artery; Male; Mice; Neuroprotective Agents; Permeability; Quinazolines; Stroke	2012
A small chemical library of 2-aminoimidazole derivatives as BACE-1 inhibitors: Structure-based design, synthesis, and biological evaluation. European journal of medicinal chemistry, 2012, Volume: 48 Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Cell Survival; Chickens; Humans; Imidazoles; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Models, Molecular; Neurons; Small Molecule Libraries; Spectrometry, Mass, Electrospray Ionization; Spectroscopy, Fourier Transform Infrared; Structure-Activity Relationship	2012
5-imino-1,2,4-thiadiazoles: first small molecules as substrate competitive inhibitors of glycogen synthase kinase 3. Journal of medicinal chemistry, 2012, Feb-23, Volume: 55, Issue:4 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Astrocytes; Blood-Brain Barrier; Cell Death; Cell Differentiation; Cell Membrane Permeability; Cells, Cultured; Glycogen Synthase Kinase 3; Hippocampus; Humans; Imines; In Vitro Techniques; Lipopolysaccharides; Membranes, Artificial; Microglia; Models, Molecular; Neural Stem Cells; Neurogenesis; Neurons; Neuroprotective Agents; Nitrites; Protein Binding; Rats; Structure-Activity Relationship; Substrate Specificity; Swine; Thiadiazoles	2012
Novel oxoisoaporphine-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation. Bioorganic & medicinal chemistry letters, 2012, Mar-15, Volume: 22, Issue:6 Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Aporphines; Binding Sites; Blood-Brain Barrier; Butyrylcholinesterase; Cholinesterase Inhibitors; Humans; Membranes, Artificial; Models, Molecular; Molecular Structure; Permeability; Protein Binding	2012
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
Microwave-assisted synthesis of hydroxyphenyl nitrones with protective action against oxidative stress. European journal of medicinal chemistry, 2012, Volume: 58 Topics: Anti-Inflammatory Agents; Antioxidants; Blood-Brain Barrier; Cell Survival; Dose-Response Relationship, Drug; Humans; Microwaves; Molecular Structure; Neuroblastoma; Neuroprotective Agents; Nitrogen Oxides; Oxidative Stress; Oxidopamine; Peroxynitrous Acid; Structure-Activity Relationship; Tyrosine	2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Protein kinase CK-1 inhibitors as new potential drugs for amyotrophic lateral sclerosis. Journal of medicinal chemistry, 2014, Mar-27, Volume: 57, Issue:6 Topics: Amyotrophic Lateral Sclerosis; Animals; Animals, Genetically Modified; Benzothiazoles; Blood-Brain Barrier; Casein Kinase I; Cell Membrane Permeability; Cells, Cultured; DNA-Binding Proteins; Drosophila; Drug Design; Drug Discovery; HEK293 Cells; Heterocyclic Compounds; High-Throughput Screening Assays; Humans; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; Neurons; Neurotoxicity Syndromes; Phosphorylation; Protein Kinase Inhibitors; Substrate Specificity	2014
In Vitro Inhibitory Effects of 8-O-Demethylmaritidine and Undulatine on Acetylcholinesterase and Their Predicted Penetration across the Blood-Brain Barrier. Journal of natural products, 2015, Jun-26, Volume: 78, Issue:6 Topics: Acetylcholinesterase; Alzheimer Disease; Amaryllidaceae Alkaloids; Biological Transport; Blood-Brain Barrier; Cholinesterase Inhibitors; Humans; In Vitro Techniques; Molecular Structure	2015
Multitarget-directed oxoisoaporphine derivatives: Anti-acetylcholinesterase, anti-β-amyloid aggregation and enhanced autophagy activity against Alzheimer's disease. Bioorganic & medicinal chemistry, 2016, 11-15, Volume: 24, Issue:22 Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Aporphines; Autophagy; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Humans; Molecular Structure; Protein Aggregates; Structure-Activity Relationship; Tumor Cells, Cultured	2016
Enzymatic and solid-phase synthesis of new donepezil-based L- and d-glutamic acid derivatives and their pharmacological evaluation in models related to Alzheimer's disease and cerebral ischemia. European journal of medicinal chemistry, 2017, Apr-21, Volume: 130 Topics: Alzheimer Disease; Animals; Brain Ischemia; Calcium Channel Blockers; Cholinesterase Inhibitors; Donepezil; Glutamates; Hippocampus; Humans; Indans; Neuroprotective Agents; Piperidines; Rats; Solid-Phase Synthesis Techniques	2017
Leucine rich repeat kinase 2 (LRRK2) inhibitors based on indolinone scaffold: Potential pro-neurogenic agents. European journal of medicinal chemistry, 2017, Sep-29, Volume: 138 Topics: Animals; Cell Differentiation; Cell Proliferation; Dose-Response Relationship, Drug; Humans; Indoles; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Mice; Mice, Inbred C57BL; Models, Molecular; Molecular Structure; Neural Stem Cells; Neuroprotective Agents; Protein Kinase Inhibitors; Structure-Activity Relationship	2017
Chameleon-like behavior of indolylpiperidines in complex with cholinesterases targets: Potent butyrylcholinesterase inhibitors. European journal of medicinal chemistry, 2018, Feb-10, Volume: 145 Topics: Acetylcholinesterase; Butyrylcholinesterase; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Humans; Indoles; Molecular Structure; Piperidines; Structure-Activity Relationship	2018
Multi-target-directed ligands for Alzheimer's disease: Discovery of chromone-based monoamine oxidase/cholinesterase inhibitors. European journal of medicinal chemistry, 2018, Oct-05, Volume: 158 Topics: Alzheimer Disease; Blood-Brain Barrier; Cholinesterase Inhibitors; Cholinesterases; Chromones; Drug Design; Hep G2 Cells; Humans; Ligands; Molecular Docking Simulation; Molecular Targeted Therapy; Monoamine Oxidase; Monoamine Oxidase Inhibitors	2018
TDP-43 Modulation by Tau-Tubulin Kinase 1 Inhibitors: A New Avenue for Future Amyotrophic Lateral Sclerosis Therapy. Journal of medicinal chemistry, 2022, 01-27, Volume: 65, Issue:2 Topics: Amyotrophic Lateral Sclerosis; Animals; Brain; Case-Control Studies; DNA-Binding Proteins; Humans; Inflammation; Macrophages; Male; Mice; Mice, Inbred BALB C; Mice, Transgenic; Phosphorylation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Rats; Rats, Wistar; Spinal Cord; Tissue Distribution	2022
Lysosomal physiology in Tetrahymena. 3. Pharmacological studies on acid hydrolase release and the ingestion and egestion of dimethylbenzanthracene particles. The Journal of cell biology, 1974, Volume: 62, Issue:3 Topics: Acid Phosphatase; Benz(a)Anthracenes; Bucladesine; Caffeine; Carbon Radioisotopes; Colchicine; Cytochalasin B; Desipramine; Endocytosis; Epinephrine; Exocytosis; Glucosidases; Hydrolases; Isoproterenol; Lysosomes; Norepinephrine; Phenoxybenzamine; Reserpine; Ribonucleases; Serotonin; Tetrahymena; Vinblastine	1974
Pharmacological properties of centrally administered ouabain and their modification by other drugs. British journal of pharmacology, 1971, Volume: 42, Issue:2 Topics: Adenine Nucleotides; Amphetamine; Animals; Body Temperature; Caffeine; Central Nervous System; Cerebral Ventricles; Depression, Chemical; Desipramine; Dopamine; Injections; Male; Mice; Mixed Function Oxygenases; Motor Activity; Nialamide; Norepinephrine; Ouabain; Posture; Serotonin; Synaptic Transmission; Thiocarbamates	1971
Acceleration of sugar transport in avian erythrocytes by catecholamines. The Journal of biological chemistry, 1974, Jul-10, Volume: 249, Issue:13 Topics: Adenosine Triphosphate; Animals; Caffeine; Carbon Radioisotopes; Catechols; Cell Membrane; Cyclic AMP; Desipramine; Dopamine; Ephedrine; Epinephrine; Erythrocytes; Galactose; Geese; Glucose; Iproniazid; Isoproterenol; Methylglycosides; Norepinephrine; Phentolamine; Phloretin; Potassium; Propranolol; Sorbitol; Stereoisomerism	1974
Effect of drugs on the activity of thrombocytes 3,5-cyclic AMP phosphodiesterase. International journal of clinical pharmacology, therapy and toxicology, 1974, Volume: 10, Issue:1 Topics: 1-Propanol; Adenosine Diphosphate; Adenosine Monophosphate; Aminophylline; Blood Platelets; Caffeine; Chlorpromazine; Cyclic AMP; Desipramine; Dibenzothiepins; Epinephrine; Imipramine; Nortriptyline; Phosphoric Diester Hydrolases; Piperazines; Platelet Adhesiveness	1974
Potentiation of the anticonvulsant action of acetazolamide. The Journal of pharmacy and pharmacology, 1966, Volume: 18, Issue:12 Topics: Acetazolamide; Amphetamine; Animals; Anticonvulsants; Caffeine; Cocaine; Desipramine; Drug Synergism; Electric Stimulation; Electroshock; Ephedrine; Histamine H1 Antagonists; Imipramine; Isoproterenol; Male; Metaraminol; Mice; Morphine; Phenethylamines; Quaternary Ammonium Compounds; Seizures; Stress, Physiological; Tranylcypromine; Tyramine	1966
An adrenergic control system in Tetrahymena. Proceedings of the National Academy of Sciences of the United States of America, 1967, Volume: 58, Issue:1 Topics: Caffeine; Catecholamines; Desipramine; Glycogen; Hydrazines; Isoproterenol; Phenoxybenzamine; Propranolol; Reserpine; Tetrahymena; Triiodothyronine	1967
[Therapy of hypersomnia]. Revue neurologique, 1967, Volume: 116, Issue:6 Topics: Amphetamine; Animals; Antidepressive Agents; Appetite Depressants; Bemegride; Caffeine; Cats; Central Nervous System Stimulants; Chlorphentermine; Desipramine; Electroencephalography; Ephedrine; Glycolates; Humans; Hydroxybutyrates; Imipramine; Mice; Narcolepsy; Pemoline; Phentermine; Piperidines; Rabbits; Rats; Sleep Wake Disorders; Strychnine; Sympathomimetics	1967
Central nervous system activity of 1-(3-methoxypropylamino)-2-hydroxy-2-(1,4-benzodioxan-2-yl)-ethane hydrochloride. Archives internationales de pharmacodynamie et de therapie, 1967, Volume: 165, Issue:1 Topics: Animals; Anxiety; Behavior, Animal; Caffeine; Central Nervous System; Chlorpromazine; Desipramine; Drug Synergism; Electroencephalography; Humans; Methamphetamine; Phenelzine; Rats; Reserpine; Reticular Formation; Sympatholytics; Thiopental	1967
Potentiation of the action of adenosine on cerebral cortical neurones by the tricyclic antidepressants. British journal of pharmacology, 1984, Volume: 83, Issue:2 Topics: Action Potentials; Adenosine; Animals; Antidepressive Agents, Tricyclic; Caffeine; Cerebral Cortex; Clomipramine; Desipramine; Drug Synergism; Iprindole; Male; Neurons; Nortriptyline; Rats; Rats, Inbred Strains	1984
The locus coeruleus: actions of psychoactive drugs. Experientia, 1983, Mar-15, Volume: 39, Issue:3 Topics: Action Potentials; Animals; Atropine; Caffeine; Chlorpromazine; Desipramine; Haloperidol; Locus Coeruleus; Male; Neurons; Nicotine; Norepinephrine; Physostigmine; Psychotropic Drugs; Rats; Scopolamine	1983
Peripheral antinociceptive actions of desipramine and fluoxetine in an inflammatory and neuropathic pain test in the rat. Pain, 1999, Volume: 82, Issue:2 Topics: Adrenergic Uptake Inhibitors; Amitriptyline; Animals; Caffeine; Desipramine; Drug Evaluation, Preclinical; Fluoxetine; Male; Neuralgia; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists; Spinal Nerves	1999
Pharmacological characterization of the effects of methylmercury and mercuric chloride on spontaneous noradrenaline release from rat hippocampal slices. Life sciences, 2000, Volume: 67, Issue:10 Topics: Adrenergic Uptake Inhibitors; Amiloride; Animals; Caffeine; Calcium; Calcium Channel Blockers; Chelating Agents; Chromatography, High Pressure Liquid; Cobalt; Desipramine; Egtazic Acid; Enzyme Inhibitors; Hippocampus; Male; Mercuric Chloride; Methylmercury Compounds; Norepinephrine; omega-Conotoxin GVIA; Rats; Rats, Wistar; Reserpine; Ruthenium Red; Sodium Channel Blockers; Sodium-Calcium Exchanger; Synapses; Tetrodotoxin; Thapsigargin	2000
PHARMACOLOGICAL PROPERTIES OF THE DESMETHYL DERIVATIVES OF SOME ANTIDEPRESSANTS OF IMIPRAMINE TYPE. International journal of neuropharmacology, 1965, Volume: 4 Topics: Amitriptyline; Animals; Antidepressive Agents; Caffeine; Desipramine; Hypothermia; Hypothermia, Induced; Imipramine; Injections, Intraperitoneal; Mice; Nortriptyline; Pentylenetetrazole; Peptic Ulcer; Rats; Research; Reserpine; Selective Serotonin Reuptake Inhibitors; Serotonin; Strychnine; Toxicology; Tranquilizing Agents	1965
Addictive and non-addictive drugs induce distinct and specific patterns of ERK activation in mouse brain. The European journal of neuroscience, 2004, Volume: 19, Issue:7 Topics: Adrenergic Uptake Inhibitors; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Benzazepines; Brain; Caffeine; Central Nervous System Stimulants; Cocaine; Desipramine; Dopamine Antagonists; Dronabinol; Enzyme Activation; Fluoxetine; Immunohistochemistry; Male; Mice; Mitogen-Activated Protein Kinases; Morphine; Muscarinic Antagonists; Neurons; Nicotine; Nicotinic Agonists; Scopolamine; Selective Serotonin Reuptake Inhibitors	2004
PAMPA--a drug absorption in vitro model 8. Apparent filter porosity and the unstirred water layer. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2004, Volume: 22, Issue:1 Topics: Adsorption; Algorithms; Caffeine; Desipramine; Diclofenac; Filtration; Hydrogen-Ion Concentration; Lipids; Membranes, Artificial; Models, Chemical; Permeability; Piroxicam; Porosity; Water	2004
Desolvation of BSA-ligand complexes measured using the quartz crystal microbalance and dual polarization interferometer. Langmuir : the ACS journal of surfaces and colloids, 2012, Jun-26, Volume: 28, Issue:25 Topics: Adsorption; Animals; Caffeine; Cattle; Desipramine; Hydrophobic and Hydrophilic Interactions; Immobilized Proteins; Interferometry; Ligands; Quartz Crystal Microbalance Techniques; Salicylic Acid; Serum Albumin, Bovine; Solvents	2012
Effect of long-term caffeine administration on depressive-like behavior in rats exposed to chronic unpredictable stress. Behavioural pharmacology, 2012, Volume: 23, Issue:4 Topics: Administration, Oral; Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Body Temperature; Caffeine; Depressive Disorder; Desipramine; Disease Models, Animal; Dopamine; Hippocampus; Injections, Intraperitoneal; Male; Maze Learning; Motor Activity; Rats; Rats, Wistar; Serotonin; Stress, Psychological; Sucrose; Weight Gain	2012
Predicted metabolic drug clearance with increasing adult age. British journal of clinical pharmacology, 2013, Volume: 75, Issue:4 Topics: Adult; Aged; Aged, 80 and over; Aging; Caffeine; Computer Simulation; Desipramine; Female; Humans; Male; Mephenytoin; Metabolic Clearance Rate; Midazolam; Middle Aged; Models, Biological; Warfarin	2013
A proposal for refining the forced swim test in Swiss mice. Progress in neuro-psychopharmacology & biological psychiatry, 2013, Aug-01, Volume: 45 Topics: Animals; Antidepressive Agents; Apomorphine; Caffeine; Central Nervous System Stimulants; Desipramine; Disease Models, Animal; Fluoxetine; Imipramine; Immobility Response, Tonic; Male; Mice; Principal Component Analysis; Swimming; Time Factors	2013