desipramine and buspirone

desipramine has been researched along with buspirone in 36 studies

Research

Studies (36)

TimeframeStudies, this research(%)All Research%
pre-19902 (5.56)18.7374
1990's10 (27.78)18.2507
2000's9 (25.00)29.6817
2010's14 (38.89)24.3611
2020's1 (2.78)2.80

Authors

AuthorsStudies
Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET1
Adkison, KK; Humphreys, JE; Mahar Doan, KM; Polli, JW; Serabjit-Singh, CJ; Shampine, LJ; Webster, LO; Wring, SA1
Johans, C; Kinnunen, PK; Söderlund, T; Suomalainen, P1
He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Sun, Y; Yan, Z1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM1
Ahman, M; Holmén, AG; Wan, H1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ1
Glen, RC; Lowe, R; Mitchell, JB1
Ekins, S; Williams, AJ; Xu, JJ1
Sen, S; Sinha, N1
Chang, G; Di, L; Huang, Y; Lin, Z; Liston, TE; Scott, DO; Troutman, MD; Umland, JP1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Dalvie, D; Loi, CM; Smith, DA1
Bellman, K; Knegtel, RM; Settimo, L1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Jones, LH; Nadanaciva, S; Rana, P; Will, Y1
Cannizzaro, C; Cannizzaro, G; Flugy, A; Gagliano, M; Novara, V1
Kostowski, W; Pałejko, W; Płaźnik, A; Stefański, R1
Cervo, L; Grignaschi, G; Samanin, R1
Giordano, J; Rogers, LW1
Barry, S; Brown, I; Dinan, TG; Mobayed, M; Yatham, LN1
Carli, M; Prontera, C; Samanin, R1
Detke, MJ; Lucki, I; Wieland, S1
Joffe, RT; Schuller, DR1
Goodman, WK; McDougle, CJ; Price, LH1
Ishibashi, Y; Ishima, T; Nakagawa, Y; Takashima, T; Yoshii, T1
Bergeron, R; Blier, P; de Montigny, C1
Cassella, JV; Coverdale, S; Hoffman, DC; Kehne, JH; McCloskey, TC1
Baez, S; Jimenez, V; John, E; Lechin, F; Lechin, ME; Orozco, B; Pardey-Maldonado, B; van der Dijs, B1
Ferris, CF; King, JA; Messenger, T1
Akindipe, TO; Ipser, JC; Sager, C; Stein, DJ; Wilson, D1
Llorente, J; Miguelez, C; Morera-Herreras, T; Ruiz-Ortega, JA; Sagarduy, A; Ugedo, L1
Lin, CC; Lin, YW; Liu, YP; Tung, CS1

Reviews

3 review(s) available for desipramine and buspirone

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
The pharmacotherapy of obsessive-compulsive disorder.
    Pharmacopsychiatry, 1993, Volume: 26 Suppl 1

    Topics: 1-Naphthylamine; Buspirone; Clomipramine; Desipramine; Fluoxetine; Fluvoxamine; Humans; Obsessive-Compulsive Disorder; Selective Serotonin Reuptake Inhibitors; Sertraline

1993
Pharmacotherapy for anxiety and comorbid alcohol use disorders.
    The Cochrane database of systematic reviews, 2015, Jan-20, Volume: 1

    Topics: Alcohol-Related Disorders; Anxiety; Anxiety Disorders; Buspirone; Comorbidity; Desipramine; Humans; Paroxetine; Phobia, Social; Publication Bias; Randomized Controlled Trials as Topic; Selective Serotonin Reuptake Inhibitors; Sertraline; Stress Disorders, Post-Traumatic

2015

Trials

2 trial(s) available for desipramine and buspirone

ArticleYear
An open study of buspirone augmentation of serotonin reuptake inhibitors in refractory depression.
    The Journal of clinical psychiatry, 1993, Volume: 54, Issue:7

    Topics: Adult; Ambulatory Care; Buspirone; Depressive Disorder; Desipramine; Drug Therapy, Combination; Female; Fluoxetine; Fluvoxamine; Humans; Male; Middle Aged; Selective Serotonin Reuptake Inhibitors

1993
Enhancement of noradrenergic neural transmission: an effective therapy of myasthenia gravis: a report on 52 consecutive patients.
    Journal of medicine, 2000, Volume: 31, Issue:5-6

    Topics: Adolescent; Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Adrenergic Uptake Inhibitors; Adult; Aged; Benzhydryl Compounds; Buspirone; Desipramine; Drug Therapy, Combination; Electromyography; Epinephrine; Female; Humans; Hydroxamic Acids; Male; Middle Aged; Modafinil; Myasthenia Gravis; Neuroprotective Agents; Neurotransmitter Agents; Norepinephrine; Phenylalanine; Platelet Aggregation; Propranolol; Serotonin; Serotonin Receptor Agonists; Sympathetic Nervous System; Tyrosine

2000

Other Studies

31 other study(ies) available for desipramine and buspirone

ArticleYear
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:3

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium

1985
Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs.
    The Journal of pharmacology and experimental therapeutics, 2002, Volume: 303, Issue:3

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Cell Line; Cell Membrane Permeability; Central Nervous System Agents; Dogs; Drug Delivery Systems; Permeability; Pharmaceutical Preparations

2002
Surface activity profiling of drugs applied to the prediction of blood-brain barrier permeability.
    Journal of medicinal chemistry, 2004, Mar-25, Volume: 47, Issue:7

    Topics: Blood-Brain Barrier; Lipid Bilayers; Micelles; Permeability; Pharmaceutical Preparations; Structure-Activity Relationship; Surface Properties

2004
First-principle, structure-based prediction of hepatic metabolic clearance values in human.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:4

    Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metabolic Clearance Rate; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship; Sensitivity and Specificity; Software

2009
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
    Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19

    Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship

2008
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs.
    Journal of medicinal chemistry, 2009, Mar-26, Volume: 52, Issue:6

    Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry

2009
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
    Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3

    Topics:

2008
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes

2010
Predicting phospholipidosis using machine learning.
    Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5

    Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:2

    Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship

2011
Species independence in brain tissue binding using brain homogenates.
    Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:7

    Topics: Animals; Brain; Dogs; Guinea Pigs; Humans; Macaca fascicularis; Mice; Rats; Species Specificity

2011
FDA-approved drug labeling for the study of drug-induced liver injury.
    Drug discovery today, 2011, Volume: 16, Issue:15-16

    Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration

2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
    Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10

    Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection

2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
Which metabolites circulate?
    Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:5

    Topics: Humans; Metabolic Clearance Rate; Pharmaceutical Preparations

2013
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
    Pharmaceutical research, 2014, Volume: 31, Issue:4

    Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation

2014
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships.
    Bioorganic & medicinal chemistry letters, 2016, 08-15, Volume: 26, Issue:16

    Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone

2016
Antidepressant and anxiolytic effects of alprazolam versus the conventional antidepressant desipramine and the anxiolytic diazepam in the forced swim test in rats.
    European journal of pharmacology, 1992, Apr-22, Volume: 214, Issue:2-3

    Topics: Alprazolam; Animals; Anti-Anxiety Agents; Antidepressive Agents; Buspirone; Depression; Desipramine; Diazepam; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A; Receptors, Serotonin; Swimming

1992
Serotonergic mechanisms in the nucleus accumbens affected by chronic desipramine treatment.
    Pharmacology, biochemistry, and behavior, 1991, Volume: 39, Issue:1

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Buspirone; Chromans; Desipramine; Dose-Response Relationship, Drug; Methysergide; Microinjections; Nucleus Accumbens; Pindolol; Quipazine; Rats; Serotonin; Serotonin Antagonists; Tetrahydronaphthalenes

1991
Alpha 2-adrenoceptor blockade prevents the effect of desipramine in the forced swimming test.
    European journal of pharmacology, 1990, Jan-17, Volume: 175, Issue:3

    Topics: Adrenergic alpha-Antagonists; Animals; Buspirone; Depression; Desipramine; Dioxanes; Hydroxydopamines; Idazoxan; Locus Coeruleus; Male; Motor Activity; Oxidopamine; Rats; Swimming

1990
Effects of systemically administered monoamine reuptake blocking agents on patterns of buspirone-induced analgesia in rats.
    Life sciences, 1990, Volume: 47, Issue:11

    Topics: Amitriptyline; Analgesia; Animals; Brain Chemistry; Buspirone; Desipramine; Dopamine; Drug Interactions; Female; Neurotransmitter Uptake Inhibitors; Norepinephrine; Piperazines; Rats; Serotonin; Spinal Cord

1990
A pilot study of a neuroendocrine test battery in posttraumatic stress disorder.
    Biological psychiatry, 1990, Oct-15, Volume: 28, Issue:8

    Topics: Adult; Buspirone; Desipramine; Dexamethasone; Female; Growth Hormone; Humans; Hydrocortisone; Middle Aged; Pilot Projects; Prolactin; Psychiatric Status Rating Scales; Stress Disorders, Post-Traumatic

1990
Effect of 5-HT1A agonists on stress-induced deficit in open field locomotor activity of rats: evidence that this model identifies anxiolytic-like activity.
    Neuropharmacology, 1989, Volume: 28, Issue:5

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Buspirone; Desipramine; Diazepam; Male; Models, Biological; Motor Activity; Pyrazoles; Rats; Receptors, Serotonin; Stress, Psychological; Tetrahydronaphthalenes

1989
Blockade of the antidepressant-like effects of 8-OH-DPAT, buspirone and desipramine in the rat forced swim test by 5HT1A receptor antagonists.
    Psychopharmacology, 1995, Volume: 119, Issue:1

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antidepressive Agents; Behavior, Animal; Buspirone; Desipramine; Dose-Response Relationship, Drug; Locomotion; Male; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Antagonists; Time Factors

1995
Involvement of GABA(B) receptor systems in action of antidepressants: baclofen but not bicuculline attenuates the effects of antidepressants on the forced swim test in rats.
    Brain research, 1996, Feb-19, Volume: 709, Issue:2

    Topics: Animals; Antidepressive Agents; Baclofen; Bicuculline; Buspirone; Desipramine; Dose-Response Relationship, Drug; GABA Agonists; GABA Antagonists; Male; Mianserin; Motor Activity; Muscimol; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, GABA-B; Swimming; Volition

1996
Selective activation of postsynaptic 5-HT1A receptors induces rapid antidepressant response.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 1997, Volume: 16, Issue:5

    Topics: Adult; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Buspirone; Depressive Disorder; Desipramine; Drug Synergism; Female; Fluvoxamine; Humans; Male; Pindolol; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Selective Serotonin Reuptake Inhibitors; Serotonin Receptor Agonists; Trimipramine

1997
Effects of the CRF(1) receptor antagonist, CP 154,526, in the separation-induced vocalization anxiolytic test in rat pups.
    Neuropharmacology, 2000, Jun-08, Volume: 39, Issue:8

    Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Antipsychotic Agents; Anxiety; Behavior, Animal; Buspirone; Clozapine; Desipramine; Diazepam; Dose-Response Relationship, Drug; Female; Haloperidol; Injections, Intraperitoneal; Male; Pyrimidines; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Corticotropin-Releasing Hormone; Social Isolation; Stress, Psychological; Vocalization, Animal; Zimeldine

2000
Seed finding in golden hamsters: a potential animal model for screening anxiolytic drugs.
    Neuropsychobiology, 2002, Volume: 45, Issue:3

    Topics: Adrenergic alpha-Agonists; Animals; Anti-Anxiety Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Anxiety; Appetitive Behavior; Behavior, Animal; Buspirone; Chlordiazepoxide; Clozapine; Cricetinae; Desipramine; Drug Evaluation, Preclinical; Fasting; Fluoxetine; Injections, Intraperitoneal; Male; Mesocricetus; Models, Animal; Stress, Psychological; Yohimbine

2002
Buspirone requires the intact nigrostriatal pathway to reduce the activity of the subthalamic nucleus via 5-HT1A receptors.
    Experimental neurology, 2016, Volume: 277

    Topics: Action Potentials; Adrenergic Agents; Adrenergic Uptake Inhibitors; Animals; Buspirone; Desipramine; Disease Models, Animal; Dopamine Agents; Dyskinesia, Drug-Induced; Female; Levodopa; Male; Neurons; Neurotoxicity Syndromes; Oxidopamine; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; Serotonin Receptor Agonists; Subthalamic Nucleus

2016
Time-Dependent Effects of Buspirone versus Desipramine on the 5-Choice Serial Reaction Time Task in Rats Reared in Social Isolation: Implication of Early Life Experience and Motoric Impulsivity.
    Journal of integrative neuroscience, 2023, Jun-27, Volume: 22, Issue:4

    Topics: Animals; Buspirone; Desipramine; Impulsive Behavior; Rats; Reaction Time; Serotonin; Social Isolation

2023