desipramine and brompheniramine

desipramine has been researched along with brompheniramine in 30 studies

Research

Studies (30)

TimeframeStudies, this research(%)All Research%
pre-199026 (86.67)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's4 (13.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET1
Högberg, T; Renyi, AL; Ross, SB; Ulff, B1
Sen, S; Sinha, N1
Bellman, K; Knegtel, RM; Settimo, L1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Jones, LH; Nadanaciva, S; Rana, P; Will, Y1
Fromm, GH; Glass, JD1
Calil, HM; Extein, I; Goodwin, FK; Potter, WZ; Zavadil, AP1
Prough, RA; Ziegler, DM1
Davis, RS; McNeill, JH1
Fuxe, K; Jonsson, G; Lidbrink, P1
Korduba, CA; Symchowicz, S; Veals, J1
Aberg-Wistedt, A; Jostell, KG; Ross, SB; Sjöquist, B1
Calil, HM; Karoum, F; Kopin, IJ; Linnoila, M; Potter, WZ1
Aberg-Wistedt, A2
Prakash, R1
Kupfer, D1
Karoum, F; Linnoila, M; Potter, WZ; Rosenthal, N1
Bratfos, O; Bratlid, T; Haug, JO; Lingjaerde, O1
Karoum, F; Linnoila, M; Potter, WZ1
Agnati, LF; Andersson, K; Eneroth, P; Fuxe, K; Ogren, SO1
Scuvée-Moreau, JJ; Svensson, TH1
Agnati, LF; Calza, L; Fuxe, K; Ogren, SO1
Holm, AC; Ogren, SO1
Calil, HM; Extein, I; Gold, PW; Goodwin, FK; Potter, WZ; Wehr, TA1
Aberg, A1
Calil, HM; Extein, I; Goodwin, FK; Muscettola, G; Potter, WZ1
Aberg-Wistedt, A; Jostell, KG; Ross, SB; Westerlund, D1
Archer, T; Fuxe, K; Hall, H; Holm, AC; Köhler, C; Ogren, SO1

Reviews

1 review(s) available for desipramine and brompheniramine

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Trials

10 trial(s) available for desipramine and brompheniramine

ArticleYear
Comparative pharmacokinetics of zimelidine and desipramine in man following acute and chronic administration.
    Psychiatry research, 1979, Volume: 1, Issue:3

    Topics: Adolescent; Adult; Affective Disorders, Psychotic; Aged; Antidepressive Agents; Brompheniramine; Desipramine; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Male; Middle Aged; Pyridines; Zimeldine

1979
Alteration of norepinephrine metabolism with desipramine and zimelidine in depressed patients.
    Archives of general psychiatry, 1982, Volume: 39, Issue:9

    Topics: Antidepressive Agents; Brain; Brompheniramine; Depressive Disorder; Desipramine; Female; Humans; Male; Methoxyhydroxyphenylglycol; Middle Aged; Norepinephrine; Normetanephrine; Pyridines; Vanilmandelic Acid; Zimeldine

1982
A double-blind study of zimelidine, a serotonin uptake inhibitor, and desipramine, a noradrenaline uptake inhibitor, in endogenous depression. I. Clinical findings.
    Acta psychiatrica Scandinavica, 1982, Volume: 66, Issue:1

    Topics: Adult; Aged; Antidepressive Agents; Bipolar Disorder; Brompheniramine; Depressive Disorder; Desipramine; Double-Blind Method; Female; Humans; Male; Middle Aged; Norepinephrine; Psychiatric Status Rating Scales; Pyridines; Serotonin; Zimeldine

1982
Evaluation of role of the biogenic amines in affective illness: a clinical strategy.
    Medical hypotheses, 1982, Volume: 9, Issue:1

    Topics: Antidepressive Agents; Biogenic Amines; Brompheniramine; Clinical Trials as Topic; Desipramine; Humans; Mood Disorders; Zimeldine

1982
Comparison between zimelidine and desipramine in endogenous depression. A cross-over study.
    Acta psychiatrica Scandinavica, 1982, Volume: 66, Issue:2

    Topics: Antidepressive Agents; Bipolar Disorder; Brompheniramine; Depressive Disorder; Desipramine; Double-Blind Method; Female; Humans; Male; Middle Aged; Norepinephrine; Pyridines; Serotonin; Zimeldine

1982
A double-blind comparison of zimelidine and desipramine in endogenous depression.
    Acta psychiatrica Scandinavica, 1983, Volume: 68, Issue:1

    Topics: Adolescent; Adult; Aged; Brompheniramine; Depressive Disorder; Desipramine; Double-Blind Method; Female; Humans; Male; Middle Aged; Psychiatric Status Rating Scales; Pyridines; Serotonin; Zimeldine

1983
Effects of antidepressant treatments on dopamine turnover in depressed patients.
    Archives of general psychiatry, 1983, Volume: 40, Issue:9

    Topics: 3,4-Dihydroxyphenylacetic Acid; Adult; Antidepressive Agents; Bipolar Disorder; Brompheniramine; Clorgyline; Depressive Disorder; Desipramine; Dopamine; Electroconvulsive Therapy; Female; Homovanillic Acid; Humans; Male; Middle Aged; Zimeldine

1983
Controlled cross-over study of a 5-HT uptake inhibiting and an NA uptake inhibiting antidepressant.
    Acta psychiatrica Scandinavica. Supplementum, 1981, Volume: 290

    Topics: Antidepressive Agents; Brompheniramine; Depressive Disorder; Desipramine; Female; Humans; Male; Norepinephrine; Psychiatric Status Rating Scales; Serotonin Antagonists; Zimeldine

1981
Crossover study of zimelidine and desipramine in depression: evidence for amine specificity [proceedings].
    Psychopharmacology bulletin, 1981, Volume: 17, Issue:1

    Topics: Brompheniramine; Clinical Trials as Topic; Depressive Disorder; Desipramine; Double-Blind Method; Humans; Pyridines; Time Factors; Zimeldine

1981
Effects of zimelidine and desipramine on serotonin and noradrenaline uptake mechanisms in relation to plasma concentrations and to therapeutic effects during treatment of depression.
    Psychopharmacology, 1981, Volume: 74, Issue:4

    Topics: Animals; Antidepressive Agents; Blood Platelets; Brompheniramine; Depressive Disorder; Desipramine; Female; Humans; In Vitro Techniques; Male; Norepinephrine; Pyridines; Rats; Serotonin; Synaptosomes; Zimeldine

1981

Other Studies

19 other study(ies) available for desipramine and brompheniramine

ArticleYear
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:3

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium

1985
Synthesis of pyridylallylamines related to zimelidine and their inhibition of neuronal monoamine uptake.
    Journal of medicinal chemistry, 1981, Volume: 24, Issue:12

    Topics: Animals; Biogenic Amines; Brain; Brompheniramine; Chemical Phenomena; Chemistry; In Vitro Techniques; Male; Mice; Molecular Conformation; Neurons; Norepinephrine; Pyridines; Serotonin; Structure-Activity Relationship; Zimeldine

1981
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:2

    Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship

2011
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
    Pharmaceutical research, 2014, Volume: 31, Issue:4

    Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation

2014
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships.
    Bioorganic & medicinal chemistry letters, 2016, 08-15, Volume: 26, Issue:16

    Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone

2016
The effect of tricyclic antidepressants on corticofugal inhibition of the spinal trigeminal nucleus.
    Electroencephalography and clinical neurophysiology, 1977, Volume: 43, Issue:5

    Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Brompheniramine; Cats; Cerebral Cortex; Clomipramine; Desipramine; Dose-Response Relationship, Drug; Drug Combinations; Imipramine; Neural Inhibition; Procyclidine; Spinal Cord; Trigeminal Nerve

1977
The relative participation of liver microsomal amine oxidase and cytochrome P-450 in N-demethylation reactions.
    Archives of biochemistry and biophysics, 1977, Apr-30, Volume: 180, Issue:2

    Topics: Amines; Aminopyrine; Aniline Compounds; Animals; Antibodies; Benzphetamine; Brompheniramine; Cricetinae; Cytochrome P-450 Enzyme System; Desipramine; Ephedrine; Male; Mesocricetus; Methamphetamine; Methimazole; Methylamines; Microsomes, Liver; Morphine Derivatives; NADPH-Ferrihemoprotein Reductase; Oxidoreductases Acting on CH-NH Group Donors; Rats; Swine

1977
The cardiac effects of cocaine and certain antihistamines and antidepressants.
    Archives internationales de pharmacodynamie et de therapie, 1973, Volume: 201, Issue:2

    Topics: Animals; Antidepressive Agents; Brompheniramine; Chlorpheniramine; Cocaine; Desipramine; Guinea Pigs; Heart; Histamine H1 Antagonists; Imipramine; Nerve Endings; Norepinephrine; Tripelennamine; Triprolidine; Tyramine

1973
The effect of imipramine-like drugs and antihistamine drugs on uptake mechanisms in the central noradrenaline and 5-hydroxytryptamine neurons.
    Neuropharmacology, 1971, Volume: 10, Issue:5

    Topics: Amitriptyline; Animals; Antidepressive Agents; Brain; Brompheniramine; Chlorpheniramine; Desipramine; Dibenzazepines; Dihydroxyphenylalanine; Histamine H1 Antagonists; Imipramine; Male; Microscopy, Fluorescence; Monoamine Oxidase Inhibitors; Neurons; Nialamide; Norepinephrine; Rats; Reflex; Reserpine; Serotonin

1971
The effect of pheniramine and its structural analogues on 5-hydroxytryptamine in rat and mouse brain.
    Life sciences, 1973, Dec-01, Volume: 13, Issue:11

    Topics: Amines; Amphetamine; Animals; Biological Transport; Brompheniramine; Chlorine; Chlorpheniramine; Chlorpromazine; Corpus Striatum; Desipramine; Fluorine; Hydroxyindoleacetic Acid; Male; Mice; Pheniramine; Promethazine; Rats; Serotonin; Structure-Activity Relationship; Synaptosomes; Time Factors

1973
A double-blind study of zimelidine, a serotonin uptake inhibitor, and desipramine, a noradrenaline uptake inhibitor, in endogenous depression. II. Biochemical findings.
    Acta psychiatrica Scandinavica, 1982, Volume: 66, Issue:1

    Topics: Adult; Aged; Animals; Antidepressive Agents; Blood Platelets; Brompheniramine; Depressive Disorder; Desipramine; Double-Blind Method; Female; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Hypothalamus; Male; Methoxyhydroxyphenylglycol; Middle Aged; Norepinephrine; Pyridines; Rats; Serotonin; Synaptosomes; Zimeldine

1982
Interaction of EEG sleep, antidepressants, and affective disease.
    The Journal of clinical psychiatry, 1982, Volume: 43, Issue:11 Pt 2

    Topics: Amitriptyline; Antidepressive Agents; Brompheniramine; Depressive Disorder; Desipramine; Electroencephalography; Humans; Sleep; Sleep, REM; Zimeldine

1982
Electroconvulsive treatment and lithium carbonate. Their effects on norepinephrine metabolism in patients with primary, major depressions.
    Archives of general psychiatry, 1983, Volume: 40, Issue:6

    Topics: Brompheniramine; Clorgyline; Depressive Disorder; Desipramine; Electroconvulsive Therapy; Female; Humans; Lithium; Lithium Carbonate; Male; Methoxyhydroxyphenylglycol; Middle Aged; Norepinephrine; Normetanephrine; Vanilmandelic Acid; Zimeldine

1983
The effects of subchronic antidepressant drug treatment on the secretion of adenohypophyseal hormones and of corticosterone in the male rat.
    Advances in biochemical psychopharmacology, 1982, Volume: 31

    Topics: Animals; Antidepressive Agents; Brompheniramine; Corticosterone; Desipramine; Male; Norepinephrine; Pituitary Hormones, Anterior; Rats; Rats, Inbred Strains; Serotonin; Synaptic Transmission; Time Factors; Zimeldine

1982
Sensitivity in vivo of central alpha 2- and opiate receptors after chronic treatment with various antidepressants.
    Journal of neural transmission, 1982, Volume: 54, Issue:1-2

    Topics: Animals; Antidepressive Agents; Brompheniramine; Chlorpromazine; Clomipramine; Clonidine; Desipramine; Evoked Potentials; Imipramine; Iprindole; Locus Coeruleus; Male; Mianserin; Morphine; Neural Inhibition; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Opioid; Zimeldine

1982
Evidence for stabilization of cortical 5HT neurotransmission by chronic treatment with antidepressant drugs: induction of a high and low affinity component in 3H-5HT binding sites.
    Acta physiologica Scandinavica, 1982, Volume: 114, Issue:3

    Topics: Animals; Antidepressive Agents; Binding Sites; Brompheniramine; Cerebral Cortex; Desipramine; Imipramine; Male; Rats; Rats, Inbred Strains; Serotonin; Synaptic Transmission; Tritium; Zimeldine

1982
Test-specific effects of the 5-HT reuptake inhibitors alaproclate and zimelidine on pain sensitivity and morphine analgesia.
    Journal of neural transmission, 1980, Volume: 47, Issue:4

    Topics: Alanine; Analgesia; Animals; Behavior, Animal; Brompheniramine; Desipramine; Dose-Response Relationship, Drug; Male; Morphine; Naloxone; p-Chloroamphetamine; Pain; Pyridines; Rats; Serotonin; Zimeldine

1980
Specific norepinephrine and serotonin uptake inhibitors in man: a crossover study with pharmacokinetic, biochemical, neuroendocrine and behavioral parameters.
    Acta psychiatrica Scandinavica. Supplementum, 1981, Volume: 290

    Topics: Adolescent; Adult; Affective Disorders, Psychotic; Aged; Behavior; Brompheniramine; Desipramine; Double-Blind Method; Female; Hormones; Humans; Kinetics; Male; Middle Aged; Norepinephrine; Serotonin; Zimeldine

1981
Studies on the role of central 5-HT neurons in avoidance learning: a behavioral and biochemical analysis.
    Advances in experimental medicine and biology, 1981, Volume: 133

    Topics: Animals; Avoidance Learning; Brain; Brompheniramine; Cerebral Cortex; Desipramine; Fenclonine; Lysergic Acid Diethylamide; Male; Neurons; p-Chloroamphetamine; Rats; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Synaptosomes; Zimeldine

1981