desipramine and baclofen

desipramine has been researched along with baclofen in 18 studies

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19906 (33.33)18.7374
1990's6 (33.33)18.2507
2000's3 (16.67)29.6817
2010's3 (16.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
de Graaf, JS; Dijcks, FA; Ruigt, GS1
Malinowska, B; Molderings, G; Schlicker, E; Schneider, D1
Kostowski, W; Płaznik, A; Stefański, R1
Barbaccia, ML; Costa, E; Szekely, AM1
Borsini, F; Giuliani, S; Meli, A2
Hilakivi, I; Hilakivi, LA; Loikas, P; Taira, T1
Håkanson, R; Kannisto, P; Owman, C; Schmidt, G; Wahlestedt, C1
Goodwin, WB; Guyenet, PG; Huangfu, D1
Ishibashi, Y; Ishima, T; Nakagawa, Y; Takashima, T; Yoshii, T1
Ishibashi, Y; Ishima, T; Nakagawa, Y; Takashima, T; Tsuji, M1
Asahi, Y; Yonehara, N1
Enna, SJ; McCarson, KE; Sands, SA1
Biswas, K; Castell, DO; Chan, BS; Chey, WD; Davis-Karim, A; Dunbar, KB; Fernando, RS; Gellad, ZF; Genta, RM; Ghaferi, AA; Huang, GD; Hunter, JG; Jackson, CS; Jones, KM; Kaz, AM; Kim, AW; Kim, T; Lagoo-Deenadayalan, S; Laine, L; Lee, R; Lieberman, D; Lo, WK; Mashimo, H; Melton, SD; Murthy, UK; Paski, SC; Pearl, JP; Pham, TH; Provenzale, D; Rubenstein, JH; Sanchez, VM; Serpi, T; Smith, BR; Souza, RF; Spechler, SJ; Tatum, RP; von Rosenvinge, EC; Wallen, JM; Warren, SR1

Reviews

1 review(s) available for desipramine and baclofen

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Trials

1 trial(s) available for desipramine and baclofen

ArticleYear
Randomized Trial of Medical versus Surgical Treatment for Refractory Heartburn.
    The New England journal of medicine, 2019, 10-17, Volume: 381, Issue:16

    Topics: Adult; Baclofen; Desipramine; Drug Resistance; Drug Therapy, Combination; Female; Fundoplication; Gastroesophageal Reflux; Heartburn; Humans; Male; Middle Aged; Muscle Relaxants, Central; Omeprazole; Proton Pump Inhibitors; Quality of Life; Surveys and Questionnaires; Veterans

2019

Other Studies

16 other study(ies) available for desipramine and baclofen

ArticleYear
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:3

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium

1985
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
    Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19

    Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship

2008
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Antidepressants affect amine modulation of neurotransmission in the rat hippocampal slice--I. Delayed effects.
    Neuropharmacology, 1991, Volume: 30, Issue:11

    Topics: Adaptation, Physiological; Animals; Baclofen; Biogenic Amines; Desipramine; Electric Stimulation; Hippocampus; In Vitro Techniques; Isoproterenol; Male; Mianserin; Rats; Rats, Inbred Strains; Serotonin; Synaptic Transmission; Time Factors

1991
Noradrenaline release in the rat vena cava is inhibited by gamma-aminobutyric acid via GABAB receptors but not affected by histamine.
    British journal of pharmacology, 1991, Volume: 104, Issue:2

    Topics: Animals; Baclofen; Bicuculline; Corticosterone; Desipramine; Electric Stimulation; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Histamine; In Vitro Techniques; Male; Muscimol; Norepinephrine; Organophosphorus Compounds; Rats; Rats, Inbred Strains; Receptors, GABA-A; Vena Cava, Inferior; Yohimbine

1991
GABAergic mechanisms in the nucleus accumbens septi regulating rat motor activity: the effect of chronic treatment with desipramine.
    Pharmacology, biochemistry, and behavior, 1990, Volume: 36, Issue:3

    Topics: Adaptation, Physiological; Animals; Baclofen; Desipramine; Male; Motor Activity; Muscimol; Nucleus Accumbens; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Septal Nuclei

1990
Effect of a protracted antidepressant treatment on signal transduction and [3H](-)-baclofen binding at GABAB receptors.
    The Journal of pharmacology and experimental therapeutics, 1987, Volume: 243, Issue:1

    Topics: Adenylyl Cyclases; Animals; Anthracenes; Baclofen; Cerebral Cortex; Colforsin; Desipramine; Drug Administration Schedule; Imipramine; Injections, Intraperitoneal; Kinetics; Male; Maprotiline; Rats; Rats, Inbred Strains; Receptors, GABA-A

1987
Functional evidence for altered activity of GABAergic receptors following chronic desipramine treatment in rats.
    The Journal of pharmacy and pharmacology, 1986, Volume: 38, Issue:12

    Topics: Analgesics; Animals; Baclofen; Desipramine; Isoxazoles; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A

1986
Neonatal treatment with monoamine uptake inhibitors alters later response in behavioural 'despair' test to beta and GABA-B receptor agonists.
    Pharmacology & toxicology, 1988, Volume: 63, Issue:1

    Topics: Albuterol; Animals; Animals, Newborn; Antidepressive Agents; Baclofen; Behavior, Animal; Desipramine; gamma-Aminobutyric Acid; Male; Nomifensine; Rats; Rats, Inbred Strains; Time Factors; Zimeldine

1988
GABA suppresses stimulation-induced release of [3H]-noradrenaline from sympathetic nerve fibres in bovine ovarian follicles.
    Journal of autonomic pharmacology, 1987, Volume: 7, Issue:4

    Topics: Animals; Baclofen; Bicuculline; Cattle; Desipramine; Electric Stimulation; Female; gamma-Aminobutyric Acid; Hydroxydopamines; In Vitro Techniques; Muscimol; Norepinephrine; Normetanephrine; Ovarian Follicle; Oxidopamine; Potassium Chloride; Sympathectomy, Chemical; Sympathetic Nervous System

1987
Functional responses to baclofen and 4,5,6,7-tetrahydroisoxazolo (5,4-c) pyridin-3-ol (THIP) in rats repeatedly treated with desipramine.
    Pharmacology, biochemistry, and behavior, 1988, Volume: 29, Issue:1

    Topics: Analgesics; Animals; Baclofen; Behavior, Animal; Body Temperature; Desipramine; Isoxazoles; Male; Oxazoles; Rats; Rats, Inbred Strains

1988
Sympatholytic effect of tricyclic antidepressants: site and mechanism of action in anesthetized rats.
    The American journal of physiology, 1995, Volume: 268, Issue:6 Pt 2

    Topics: Adrenergic alpha-Antagonists; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Baclofen; Blood Pressure; Brain Mapping; Desipramine; Dioxanes; Fluoxetine; gamma-Aminobutyric Acid; Idazoxan; Imidazoles; Male; Medulla Oblongata; Microinjections; Nordefrin; Oxidopamine; Rats; Rats, Sprague-Dawley; Splanchnic Nerves; Sympatholytics; Time Factors

1995
Involvement of GABA(B) receptor systems in action of antidepressants: baclofen but not bicuculline attenuates the effects of antidepressants on the forced swim test in rats.
    Brain research, 1996, Feb-19, Volume: 709, Issue:2

    Topics: Animals; Antidepressive Agents; Baclofen; Bicuculline; Buspirone; Desipramine; Dose-Response Relationship, Drug; GABA Agonists; GABA Antagonists; Male; Mianserin; Motor Activity; Muscimol; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, GABA-B; Swimming; Volition

1996
Involvement of GABAB receptor systems in action of antidepressants. II: Baclofen attenuates the effect of desipramine whereas muscimol has no effect in learned helplessness paradigm in rats.
    Brain research, 1996, Jul-29, Volume: 728, Issue:2

    Topics: Animals; Antidepressive Agents; Baclofen; Behavior, Animal; Desipramine; Dose-Response Relationship, Drug; Helplessness, Learned; Male; Muscimol; Rats; Rats, Wistar

1996
Involvement of GABAergic systems in manifestation of pharmacological activity of desipramine.
    Japanese journal of pharmacology, 2001, Volume: 86, Issue:3

    Topics: Animals; Antidepressive Agents, Tricyclic; Baclofen; Desipramine; Freund's Adjuvant; GABA Antagonists; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Male; Membrane Potentials; Muscimol; Picrotoxin; Rats; Rats, Sprague-Dawley; Reaction Time

2001
Relationship between the antinociceptive response to desipramine and changes in GABAB receptor function and subunit expression in the dorsal horn of the rat spinal cord.
    Biochemical pharmacology, 2004, Feb-15, Volume: 67, Issue:4

    Topics: Analgesics; Animals; Antidepressive Agents, Tricyclic; Baclofen; Desipramine; gamma-Aminobutyric Acid; Gene Expression; Guanosine 5'-O-(3-Thiotriphosphate); Male; Posterior Horn Cells; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, GABA-B; Spinal Cord

2004