desipramine and amiloride

desipramine has been researched along with amiloride in 18 studies

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19902 (11.11)18.7374
1990's2 (11.11)18.2507
2000's8 (44.44)29.6817
2010's6 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Conway, SJ; Ganapathy, V; George, RL; Huang, W; Leibach, FH; Wang, H; Wu, X1
Topliss, JG; Yoshida, F1
Faller, B; Wohnsland, F1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM1
Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S1
Campillo, NE; Guerra, A; Páez, JA1
Avdeef, A; Tam, KY1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Michael-Hepp, J; Schömig, E; Schönfeld, CL1
Boullin, DJ; O'Brien, RA1
Gerber, SH; Haass, M; Hagl, S; Heyer, C; Krüger, C; Kübler, W1
Levi, R; Smith, NC1
Cristòfol, RM; Gassó, S; Rodríguez-Farré, E; Sanfeliu, C; Suñol, C1
Maekawa, M; Murayama, T; Nomura, Y1
D'Amico, M; Martire, M; Samengo, I1
Calhau, C; Faria, A; Lemos, C; Martel, F; Meireles, M; Monteiro, R1

Reviews

1 review(s) available for desipramine and amiloride

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Other Studies

17 other study(ies) available for desipramine and amiloride

ArticleYear
Structural and functional characteristics and tissue distribution pattern of rat OCTN1, an organic cation transporter, cloned from placenta.
    Biochimica et biophysica acta, 2000, Jun-01, Volume: 1466, Issue:1-2

    Topics: Amino Acid Sequence; Animals; Base Sequence; Carnitine; Carrier Proteins; Cloning, Molecular; DNA, Complementary; Humans; Membrane Proteins; Membrane Transport Proteins; Molecular Sequence Data; Organic Cation Transport Proteins; Placenta; Rats; RNA, Messenger; Solute Carrier Proteins; Structure-Activity Relationship; Symporters; Tetraethylammonium; Tissue Distribution

2000
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
High-throughput permeability pH profile and high-throughput alkane/water log P with artificial membranes.
    Journal of medicinal chemistry, 2001, Mar-15, Volume: 44, Issue:6

    Topics: Alkanes; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Membranes, Artificial; Octanols; Permeability; Pharmaceutical Preparations; Solubility; Water

2001
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
    Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11

    Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship

2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
    Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19

    Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship

2008
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
    Bioorganic & medicinal chemistry, 2009, Oct-01, Volume: 17, Issue:19

    Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship

2009
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
    European journal of medicinal chemistry, 2010, Volume: 45, Issue:3

    Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical

2010
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability?
    Journal of medicinal chemistry, 2010, May-13, Volume: 53, Issue:9

    Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological; Permeability; Porosity; Regression Analysis

2010
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
Inhibition of neuronal noradrenaline transport (uptake1) and desipramine binding by amiloride and ethylisopropylamiloride.
    Naunyn-Schmiedeberg's archives of pharmacology, 1989, Volume: 340, Issue:5

    Topics: Amiloride; Animals; Anti-Arrhythmia Agents; Desipramine; Hydrogen-Ion Concentration; Kinetics; Neurons; Norepinephrine; Pheochromocytoma; Sodium; Synaptic Transmission; Tritium

1989
Accumulation, storage and release of adrenergic neuron blocking agents and related drugs by human platelets.
    Biochemical pharmacology, 1972, Jul-01, Volume: 21, Issue:13

    Topics: Amiloride; Binding Sites; Blood Platelets; Carbon Isotopes; Cocaine; Desipramine; Dextroamphetamine; Ethylmaleimide; Guanethidine; Guanidines; Humans; Iodoacetates; Isoquinolines; Ouabain; Parasympatholytics; Quinidine; Reserpine; Serotonin; Tritium

1972
Influence of Bretschneider's cardioplegia on norepinephrine release from isolated perfused guinea-pig hearts.
    Journal of molecular and cellular cardiology, 1999, Volume: 31, Issue:1

    Topics: Adrenergic Uptake Inhibitors; Amiloride; Animals; Desipramine; Dose-Response Relationship, Drug; Fever; Glucose; Guinea Pigs; Heart Arrest, Induced; Hypothermia; Ion Exchange; Mannitol; Myocardial Ischemia; Myocardium; Norepinephrine; Perfusion; Potassium Chloride; Procaine; Reperfusion; Temperature; Time Factors

1999
LLC-PK(1) cells stably expressing the human norepinephrine transporter: A functional model of carrier-mediated norepinephrine release in protracted myocardial ischemia.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 291, Issue:2

    Topics: 1-Methyl-4-phenylpyridinium; Amiloride; Animals; Biological Transport, Active; Desipramine; Drug Interactions; Gramicidin; Humans; Imidazoline Receptors; LLC-PK1 Cells; Mazindol; Models, Biological; Myocardial Ischemia; Nigericin; Norepinephrine; Receptors, Drug; Sodium; Swine; Time Factors

1999
Pharmacological characterization of the effects of methylmercury and mercuric chloride on spontaneous noradrenaline release from rat hippocampal slices.
    Life sciences, 2000, Volume: 67, Issue:10

    Topics: Adrenergic Uptake Inhibitors; Amiloride; Animals; Caffeine; Calcium; Calcium Channel Blockers; Chelating Agents; Chromatography, High Pressure Liquid; Cobalt; Desipramine; Egtazic Acid; Enzyme Inhibitors; Hippocampus; Male; Mercuric Chloride; Methylmercury Compounds; Norepinephrine; omega-Conotoxin GVIA; Rats; Rats, Wistar; Reserpine; Ruthenium Red; Sodium Channel Blockers; Sodium-Calcium Exchanger; Synapses; Tetrodotoxin; Thapsigargin

2000
Involvement of noradrenaline transporters in S-nitrosocysteine-stimulated noradrenaline release from rat brain slices: existence of functional Na(+)-independent transporter activity.
    Neurochemistry international, 2001, Volume: 38, Issue:4

    Topics: Adrenergic Uptake Inhibitors; Amiloride; Animals; Biological Transport; Brain; Carrier Proteins; Central Nervous System Stimulants; Cerebral Cortex; Cysteine; Desipramine; Diethylamines; Hippocampus; In Vitro Techniques; Male; Nitroso Compounds; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Ouabain; Potassium Chloride; Rats; Rats, Wistar; Reserpine; S-Nitrosothiols; Sodium; Symporters; Thiophenes; Tritium

2001
Effects of extracellular pH reductions on [(3)H]D-aspartate and [(3)H]noradrenaline release by presynaptic nerve terminals isolated from rat cerebral cortex.
    Journal of neural transmission (Vienna, Austria : 1996), 2010, Volume: 117, Issue:1

    Topics: Amiloride; Animals; Aspartic Acid; Calcium; Central Nervous System Agents; Cerebral Cortex; D-Aspartic Acid; Desipramine; Extracellular Space; Hydrogen-Ion Concentration; Male; Neurons; Norepinephrine; Presynaptic Terminals; Rats; Rats, Wistar; Synaptosomes; Time Factors; Tritium

2010
Thiamine is a substrate of organic cation transporters in Caco-2 cells.
    European journal of pharmacology, 2012, May-05, Volume: 682, Issue:1-3

    Topics: Amiloride; Amprolium; Biological Transport; Caco-2 Cells; Desipramine; Enzyme Inhibitors; Fluoxetine; Humans; Hydrogen-Ion Concentration; Organic Cation Transport Proteins; Oxythiamine; Phosphoric Monoester Hydrolases; Protein Binding; Serotonin; Sodium Chloride; Thiamine

2012