desipramine and amantadine

desipramine has been researched along with amantadine in 42 studies

Research

Studies (42)

Timeframe	Studies, this research(%)	All Research%
pre-1990	11 (26.19)	18.7374
1990's	9 (21.43)	18.2507
2000's	10 (23.81)	29.6817
2010's	10 (23.81)	24.3611
2020's	2 (4.76)	2.80

Authors

Authors	Studies
Giacomini, KM; Schaner, ME; Zhang, L	1
Topliss, JG; Yoshida, F	1
Adkison, KK; Humphreys, JE; Mahar Doan, KM; Polli, JW; Serabjit-Singh, CJ; Shampine, LJ; Webster, LO; Wring, SA	1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY	1
Bleich, S; Gulbins, E; Kornhuber, J; Reichel, M; Terfloth, L; Tripal, P; Wiltfang, J	1
Lombardo, F; Obach, RS; Waters, NJ	1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM	1
Ahman, M; Holmén, AG; Wan, H	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Glen, RC; Lowe, R; Mitchell, JB	1
Gozalbes, R; Pineda-Lucena, A	1
Chang, G; Di, L; Huang, Y; Lin, Z; Liston, TE; Scott, DO; Troutman, MD; Umland, JP	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Bellman, K; Knegtel, RM; Settimo, L	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Jones, LH; Nadanaciva, S; Rana, P; Will, Y	1
Brea, JM; Companys-Alemany, J; Griñán-Ferré, C; Johnson, JW; Kurnikova, MG; Loza, MI; Pallàs, M; Patel, DS; Pérez, B; Phillips, MB; Soto, D; Sureda, FX; Turcu, AL; Vázquez, S	1
Badia, A; Garcia-Sevilla, JA; Laporte, J	1
Brown, BS; Haertzen, CC; Jaffe, JH; Kolar, AF; Michaelson, BS; Weddington, WW	1
Falcione, J; Kosten, TR; Morgan, CM; Schottenfeld, RS	1
Kosten, TR; Ziedonis, DM	1
Brown, BS; Haertzen, CA; Hess, JM; Jaffe, JH; Kolar, AF; Mahaffey, JR; Weddington, WW	1
Kosten, TR; Morgan, CH; Schottenfeld, RS	1
Brown, BS; Haertzen, CA; Hess, JM; Weddington, WW	1
Brown, BS; Haertzen, CA; Hess, JM; Kolar, AF; Mahaffey, JR; Weddington, WW	1
Berman, ML; Tennant, F	1
Consolo, S; Garattini, S; Ladinsky, H	1
Beyer, J; Philippu, A	1
Kadzielawa, K	1
Tolosa, E	1
Cohen, G; Heikkila, RE	1
Papeschi, R; Randrup, A	1
Baran, L; Maj, J; Sowińska, H	1
De Carolis, AS; Del Basso, P; Longo, VG; Ziegler, H	1
Kosten, T; Leal, J; Ziedonis, D	1
Browning, RG; Merigian, KS	1
Balster, RL; Harvey, SA; Nicholson, KL; Wiley, JL	1
Duggan, C; Ferriter, M; Huband, N; Khalifa, N; Lieb, K; Stoffers, J; Völlm, BA	1
Cheung, NH; Gibbon, S; Khalifa, NR; McCarthy, L; Völlm, BA	1

Reviews

4 review(s) available for desipramine and amantadine

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Parkinson's disease; modern treatment. Minnesota medicine, 1973, Volume: 56, Issue:6 Topics: Amantadine; Amphetamine; Antidepressive Agents; Antiparkinson Agents; Aromatic Amino Acid Decarboxylase Inhibitors; Catechol O-Methyltransferase Inhibitors; Desipramine; Dihydroxyphenylalanine; Dose-Response Relationship, Drug; Drug Combinations; Drug Incompatibility; Drug Synergism; Humans; Imipramine; Monoamine Oxidase Inhibitors; Parasympatholytics; Parkinson Disease	1973
Pharmacological interventions for antisocial personality disorder. The Cochrane database of systematic reviews, 2010, Aug-04, Issue:8 Topics: Adult; Aggression; Alcohol-Related Disorders; Amantadine; Antisocial Personality Disorder; Anxiety; Bromocriptine; Desipramine; Female; Humans; Male; Nortriptyline; Phenytoin; Psychotropic Drugs; Randomized Controlled Trials as Topic	2010
Pharmacological interventions for antisocial personality disorder. The Cochrane database of systematic reviews, 2020, 09-03, Volume: 9 Topics: Adult; Aggression; Alcohol-Related Disorders; Amantadine; Antisocial Personality Disorder; Anxiety; Bromocriptine; Desipramine; Female; Humans; Male; Middle Aged; Nortriptyline; Phenytoin; Placebos; Psychotropic Drugs; Randomized Controlled Trials as Topic	2020

Trials

8 trial(s) available for desipramine and amantadine

Article	Year
Treatment of cocaine dependence in methadone maintenance clients: a pilot study comparing the efficacy of desipramine and amantadine. The International journal of the addictions, 1992, Volume: 27, Issue:7 Topics: Adolescent; Adult; Amantadine; Baltimore; Cocaine; Desipramine; Female; Follow-Up Studies; Humans; Male; Methadone; Middle Aged; Opioid-Related Disorders; Pilot Projects; Placebos; Research Design; Substance Abuse Treatment Centers; Substance Withdrawal Syndrome; Substance-Related Disorders; United States	1992
Pharmacotherapy for cocaine-abusing methadone-maintained patients using amantadine or desipramine. Archives of general psychiatry, 1992, Volume: 49, Issue:11 Topics: Adult; Amantadine; Cocaine; Desipramine; Double-Blind Method; Female; Humans; Male; Methadone; Opioid-Related Disorders; Placebos; Substance Abuse Detection; Substance-Related Disorders; Treatment Outcome	1992
Depression as a prognostic factor for pharmacological treatment of cocaine dependence. Psychopharmacology bulletin, 1991, Volume: 27, Issue:3 Topics: Adult; Amantadine; Cocaine; Depression; Desipramine; Female; Humans; Male; Prognosis; Psychiatric Status Rating Scales; Substance-Related Disorders	1991
Comparison of amantadine and desipramine combined with psychotherapy for treatment of cocaine dependence. The American journal of drug and alcohol abuse, 1991, Volume: 17, Issue:2 Topics: Adult; Amantadine; Cocaine; Combined Modality Therapy; Desipramine; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Humans; Male; Psychotherapy; Single-Blind Method; Substance-Related Disorders	1991
Amantadine and desipramine in the treatment of cocaine abusing methadone maintained patients. NIDA research monograph, 1990, Volume: 105 Topics: Adult; Amantadine; Cocaine; Desipramine; Double-Blind Method; Female; Humans; Male; Methadone; Opioid-Related Disorders; Substance-Related Disorders	1990
Psychological reactions and retention by cocaine addicts during treatment according to HIV-serostatus: a matched-control study. The American journal of drug and alcohol abuse, 1991, Volume: 17, Issue:3 Topics: Adaptation, Psychological; Adult; Affect; AIDS Serodiagnosis; Amantadine; Baltimore; Cocaine; Combined Modality Therapy; Desipramine; Female; Fluoxetine; HIV Seropositivity; Humans; Male; Patient Dropouts; Psychotherapy; Sick Role; Substance-Related Disorders	1991
Comparison of amantadine and desipramine combined with psychotherapy for treatment of cocaine dependence. NIDA research monograph, 1989, Volume: 95 Topics: Amantadine; Clinical Trials as Topic; Cocaine; Combined Modality Therapy; Desipramine; Follow-Up Studies; Humans; Personality Tests; Psychotherapy; Single-Blind Method; Substance-Related Disorders	1989
Antisocial personality disorder as a prognostic factor for pharmacotherapy of cocaine dependence. Drug and alcohol dependence, 1994, Volume: 35, Issue:1 Topics: Adult; Amantadine; Antisocial Personality Disorder; Cocaine; Combined Modality Therapy; Comorbidity; Depressive Disorder; Desipramine; Double-Blind Method; Female; Follow-Up Studies; Heroin Dependence; Humans; Male; Methadone; Patient Dropouts; Substance Abuse Detection; Substance-Related Disorders	1994

Other Studies

30 other study(ies) available for desipramine and amantadine

Article	Year
Functional characterization of an organic cation transporter (hOCT1) in a transiently transfected human cell line (HeLa). The Journal of pharmacology and experimental therapeutics, 1998, Volume: 286, Issue:1 Topics: Carrier Proteins; Corticosterone; HeLa Cells; Humans; Membrane Proteins; Midazolam; Organic Cation Transporter 1; Permeability; Recombinant Proteins; Structure-Activity Relationship; Tetraethylammonium Compounds; Transfection	1998
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs. The Journal of pharmacology and experimental therapeutics, 2002, Volume: 303, Issue:3 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Cell Line; Cell Membrane Permeability; Central Nervous System Agents; Dogs; Drug Delivery Systems; Permeability; Pharmaceutical Preparations	2002
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics. Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5 Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution	2004
Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model. Journal of medicinal chemistry, 2008, Jan-24, Volume: 51, Issue:2 Topics: Algorithms; Animals; Cell Line; Cell Line, Tumor; Chemical Phenomena; Chemistry, Physical; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Molecular Conformation; Quantitative Structure-Activity Relationship; Rats; Sphingomyelin Phosphodiesterase	2008
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship	2008
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs. Journal of medicinal chemistry, 2009, Mar-26, Volume: 52, Issue:6 Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry	2009
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Predicting phospholipidosis using machine learning. Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5 Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine	2010
QSAR-based solubility model for drug-like compounds. Bioorganic & medicinal chemistry, 2010, Oct-01, Volume: 18, Issue:19 Topics: Databases, Factual; Models, Molecular; Pharmaceutical Preparations; Quantitative Structure-Activity Relationship; Solubility; Water	2010
Species independence in brain tissue binding using brain homogenates. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:7 Topics: Animals; Brain; Dogs; Guinea Pigs; Humans; Macaca fascicularis; Mice; Rats; Species Specificity	2011
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds. Pharmaceutical research, 2014, Volume: 31, Issue:4 Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation	2014
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships. Bioorganic & medicinal chemistry letters, 2016, 08-15, Volume: 26, Issue:16 Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone	2016
Design, synthesis, and in vitro and in vivo characterization of new memantine analogs for Alzheimer's disease. European journal of medicinal chemistry, 2022, Jun-05, Volume: 236 Topics: Alzheimer Disease; Animals; Caenorhabditis elegans; Disease Models, Animal; Memantine; Mice; Receptors, N-Methyl-D-Aspartate	2022
Nature of neuronal uptake and noradrenaline--adrenaline effects in the isolated rat vas deferens. European journal of pharmacology, 1975, Volume: 31, Issue:2 Topics: Amantadine; Animals; Cocaine; Computers; Depression, Chemical; Desipramine; Epinephrine; Guanethidine; In Vitro Techniques; Male; Neurons; Norepinephrine; Rats; Vas Deferens	1975
Stepwise detoxification from cocaine. A promising regimen. Postgraduate medicine, 1988, Volume: 84, Issue:2 Topics: Adolescent; Adult; Amantadine; Bromocriptine; Cocaine; Desipramine; Drug Therapy, Combination; Female; Humans; Levodopa; Male; Middle Aged; Substance Withdrawal Syndrome; Substance-Related Disorders; Tryptophan; Tyrosine	1988
Effect of several dopaminergic drugs and trihexyphenidyl on cholinergic parameters in the rat striatum. The Journal of pharmacy and pharmacology, 1974, Volume: 26, Issue:4 Topics: Acetylcholine; Amantadine; Animals; Apomorphine; Choline; Corpus Striatum; Desipramine; Dextroamphetamine; Dihydroxyphenylalanine; Dopamine; Dose-Response Relationship, Drug; Female; In Vitro Techniques; Piperazines; Rats; Time Factors; Trihexyphenidyl	1974
Dopamine and noradrenaline transport into subcellular vesicles of the striatum. Naunyn-Schmiedeberg's archives of pharmacology, 1973, Volume: 278, Issue:4 Topics: Adenosine Triphosphate; Amantadine; Amphetamine; Animals; Basal Ganglia; Brain Chemistry; Carbon Isotopes; Corpus Striatum; Desipramine; Dopamine; Magnesium; Norepinephrine; Swine; Temperature	1973
Dopamine receptor in the reward system of the rat. Archives internationales de pharmacodynamie et de therapie, 1974, Volume: 209, Issue:2 Topics: Amantadine; Animals; Apomorphine; Benzyl Compounds; Cortical Synchronization; Desipramine; Dihydroxyphenylalanine; Dopamine; Electrodes, Implanted; Electroencephalography; Haloperidol; Hydrazines; Hypothalamus; Levodopa; Male; Rats; Receptors, Drug; Reward; Self Stimulation; Time Factors	1974
Evaluation of amantadine as a releasing agent or uptake blocker for H 3 -dopamine in rat brain slices. European journal of pharmacology, 1972, Volume: 20, Issue:2 Topics: Amantadine; Animals; Brain; Cerebral Cortex; Corpus Striatum; Desipramine; Dopamine; Dopamine Antagonists; In Vitro Techniques; Male; Rabbits; Rats; Serotonin Antagonists; Tritium	1972
Catalepsy, sedation and hypothermia induced by alpha-methyl-p-tyrosine in the rat. An ideal tool for screening of drugs active on central catecholaminergic receptors. Pharmakopsychiatrie, Neuro-Psychopharmakologie, 1973, Volume: 6, Issue:3 Topics: Amantadine; Animals; Apomorphine; Behavior, Animal; Body Temperature; Brain Chemistry; Catalepsy; Depression, Chemical; Desipramine; Dextroamphetamine; Dihydroxyphenylalanine; Disulfides; Dopamine; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Exploratory Behavior; Humans; Hydrazines; Hypnotics and Sedatives; Male; Methyltyrosines; Motor Activity; Norepinephrine; Posture; Rats; Receptors, Drug; Scopolamine; Time Factors	1973
The effect of amantadine on motor activity and catalepsy in rats. Psychopharmacologia, 1972, Volume: 24, Issue:2 Topics: Amantadine; Animals; Brain; Catalepsy; Catecholamines; Chlorpromazine; Cocaine; Desipramine; Dihydroxyphenylalanine; Drug Synergism; Female; Humans; Male; Methyltyrosines; Motor Activity; Nialamide; Rats; Rats, Inbred Strains; Reserpine; Spiro Compounds; Thiocarbamates	1972
Central effects of 6-hydroxydopamine. Physiology & behavior, 1971, Volume: 7, Issue:5 Topics: Amantadine; Amitriptyline; Amphetamine; Animals; Behavior, Animal; Brain; Brain Chemistry; Desipramine; Dopamine; Electroencephalography; Female; Humans; Hydroxydopamines; Imipramine; Male; Mice; Motor Activity; Norepinephrine; Rats; Seizures; Species Specificity; Stereotyped Behavior	1971
Desipramine and amantadine causing false-positive urine test for amphetamine. Annals of emergency medicine, 1993, Volume: 22, Issue:12 Topics: Adult; Amantadine; Amphetamine; Cocaine; Desipramine; False Positive Reactions; Humans; Male; Substance Abuse Detection	1993
Affinity and specificity of N-methyl- D-aspartate channel blockers affect their ability to disrupt prepulse inhibition of acoustic startle in rats. Psychopharmacology, 2003, Volume: 165, Issue:4 Topics: Acoustic Stimulation; Adrenergic Uptake Inhibitors; Alanine; Amantadine; Animals; Binding Sites; Desipramine; Dextromethorphan; Dextrorphan; Dizocilpine Maleate; Dopamine Agents; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Ibogaine; Loudness Perception; Male; Memantine; Muscarinic Antagonists; Neural Inhibition; Orphenadrine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reflex, Startle; Selective Serotonin Reuptake Inhibitors	2003