desipramine and alprazolam

desipramine has been researched along with alprazolam in 33 studies

Research

Studies (33)

TimeframeStudies, this research(%)All Research%
pre-199010 (30.30)18.7374
1990's11 (33.33)18.2507
2000's7 (21.21)29.6817
2010's4 (12.12)24.3611
2020's1 (3.03)2.80

Authors

AuthorsStudies
Carrupt, PA; Crivori, P; Cruciani, G; Testa, B1
Topliss, JG; Yoshida, F1
Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY2
Lombardo, F; Obach, RS; Waters, NJ1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Campillo, NE; Guerra, A; Páez, JA1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Cannizzaro, C; Cannizzaro, G; Flugy, A; Gagliano, M; Novara, V1
Edwards, JH; Fawcett, J; Fogg, L; Kravitz, HM1
Edwards, J; Fawcett, J; Fogg, L; Kravitz, HM1
De Souza, EB; Grigoriadis, DE; Pearsall, D1
Buchanan, RA; Fleming, JA; Gibson, RE; Keller, FD; Remick, RA1
Cagiano, R; Cuomo, V; De Salvia, MA; Maselli, MA; Racagni, G; Renna, G1
Edwards, JH; Fawcett, J; Jeffriess, H; Kravitz, HM1
Aberg-Wistedt, A; Bertilsson, L; Lidén, A; Otani, K; Spina, E1
Cohen, BS; Dillon, D; Fyer, AJ; Gorman, JM; Klein, DF; Liebowitz, MR1
McCormick, WO1
Rosenbaum, JF; Tesar, GE1
Baiguerra, G; Kostowski, W; Valzelli, L1
Buchanan, RA; Fleming, JA; Hamilton, P; Keller, FD; Loomer, F; Miles, JE; Remick, RA1
Cannizzaro, C; Cannizzaro, E; Cannizzaro, G; Gagliano, M; Mineo, A; Sabatino, M1
Court, MH; Duan, SX; Greenblatt, DJ; Harmatz, JS; Shader, RI; von Moltke, LL1
Cannizzaro, C; Cannizzaro, G; Flugy, A; Gagliand, M; Mineo, A; Sabatino, M1
Coplan, JD; Gorman, JM; Papp, LA; Tiffon, L1
Cannizzaro, C; Cannizzaro, G; Flugy, A; Gagliano, M; Sabatino, M1
Cannizzaro, C; Cannizzaro, E; Gagliano, M; Mangiapane, N1
Benazzi, F; Ciucci, G1
Commissaris, RL; Fontana, DJ; McMiller, LV1
Barbui, C; Bighelli, I; Caldwell, DM; Cipriani, A; Davies, SJ; Dawson, S; Dias, S; Furukawa, TA; Guaiana, G; Imai, H; Koesters, M; Meader, N; Pompoli, A; Robertson, L; Tajika, A1

Reviews

2 review(s) available for desipramine and alprazolam

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Pharmacological treatments in panic disorder in adults: a network meta-analysis.
    The Cochrane database of systematic reviews, 2023, 11-28, Volume: 11

    Topics: Adult; Alprazolam; Antidepressive Agents; Antidepressive Agents, Tricyclic; Benzodiazepines; Clomipramine; Clonazepam; Desipramine; Diazepam; Fluoxetine; Humans; Network Meta-Analysis; Panic Disorder; Paroxetine; Reboxetine; Selective Serotonin Reuptake Inhibitors; Serotonin and Noradrenaline Reuptake Inhibitors; Venlafaxine Hydrochloride

2023

Trials

5 trial(s) available for desipramine and alprazolam

ArticleYear
Challenging the amphetamine challenge test: report of an antidepressant treatment study.
    Journal of affective disorders, 1990, Volume: 20, Issue:2

    Topics: Adult; Alprazolam; Depressive Disorder; Desipramine; Dextroamphetamine; Double-Blind Method; Female; Humans; Male; Middle Aged; Prognosis; Psychiatric Status Rating Scales

1990
Antidepressant or antianxiety? A study of the efficacy of antidepressant medication.
    Psychiatry research, 1990, Volume: 32, Issue:2

    Topics: Adult; Alprazolam; Anxiety Disorders; Clinical Trials as Topic; Depressive Disorder; Desipramine; Drug Therapy, Combination; Female; Humans; Male; Personality Tests; Prognosis

1990
A comparison of the efficacy and safety of alprazolam and desipramine in depressed outpatients.
    Canadian journal of psychiatry. Revue canadienne de psychiatrie, 1988, Volume: 33, Issue:7

    Topics: Adult; Alprazolam; Clinical Trials as Topic; Depressive Disorder; Desipramine; Double-Blind Method; Female; Humans; Male; Random Allocation

1988
Alprazolam: an antidepressant? Alprazolam, desipramine, and an alprazolam-desipramine combination in the treatment of adult depressed outpatients.
    Journal of clinical psychopharmacology, 1987, Volume: 7, Issue:5

    Topics: Adolescent; Adult; Alprazolam; Clinical Trials as Topic; Depressive Disorder; Desipramine; Double-Blind Method; Drug Combinations; Female; Humans; Male; Middle Aged; Time Factors

1987
A comparison of the safety and efficacy of alprazolam and desipramine in moderately severe depression.
    Canadian journal of psychiatry. Revue canadienne de psychiatrie, 1985, Volume: 30, Issue:8

    Topics: Adult; Alprazolam; Antidepressive Agents; Benzodiazepines; Depressive Disorder; Desipramine; Humans

1985

Other Studies

26 other study(ies) available for desipramine and alprazolam

ArticleYear
Predicting blood-brain barrier permeation from three-dimensional molecular structure.
    Journal of medicinal chemistry, 2000, Jun-01, Volume: 43, Issue:11

    Topics: Blood-Brain Barrier; Databases, Factual; Models, Chemical; Molecular Conformation; Multivariate Analysis; Permeability; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds.
    Journal of medicinal chemistry, 2001, Jul-19, Volume: 44, Issue:15

    Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water

2001
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data.
    Journal of medicinal chemistry, 2002, Jun-20, Volume: 45, Issue:13

    Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding

2002
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
    Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5

    Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution

2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
    European journal of medicinal chemistry, 2010, Volume: 45, Issue:3

    Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical

2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
    Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6

    Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics

2010
Antidepressant and anxiolytic effects of alprazolam versus the conventional antidepressant desipramine and the anxiolytic diazepam in the forced swim test in rats.
    European journal of pharmacology, 1992, Apr-22, Volume: 214, Issue:2-3

    Topics: Alprazolam; Animals; Anti-Anxiety Agents; Antidepressive Agents; Buspirone; Depression; Desipramine; Diazepam; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A; Receptors, Serotonin; Swimming

1992
Effects of chronic antidepressant and benzodiazepine treatment on corticotropin-releasing-factor receptors in rat brain and pituitary.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 1989, Volume: 2, Issue:1

    Topics: Alprazolam; Animals; Anti-Anxiety Agents; Antidepressive Agents; Benzodiazepines; Brain; Desipramine; Diazepam; Imipramine; Male; Pituitary Gland, Anterior; Rats; Rats, Inbred Strains; Receptors, Corticotropin-Releasing Hormone; Receptors, Neurotransmitter; Receptors, Serotonin

1989
Ultrasonic vocalization in response to unavoidable aversive stimuli in rats: effects of benzodiazepines.
    Life sciences, 1988, Volume: 43, Issue:6

    Topics: Alprazolam; Animals; Benzodiazepines; Desipramine; Diazepam; Electroshock; Flumazenil; Haloperidol; Male; Rats; Rats, Inbred Strains; Ultrasonics; Vocalization, Animal

1988
Alprazolam does not inhibit the metabolism of nortriptyline in depressed patients or inhibit the metabolism of desipramine in human liver microsomes.
    Therapeutic drug monitoring, 1988, Volume: 10, Issue:2

    Topics: Adult; Alprazolam; Depressive Disorder; Desipramine; Drug Interactions; Female; Humans; Hydroxylation; In Vitro Techniques; Male; Microsomes, Liver; Middle Aged; Nortriptyline

1988
Antipanic drug effects during lactate infusion in lactate-refractory panic patients.
    Psychiatry research, 1987, Volume: 21, Issue:3

    Topics: Adult; Agoraphobia; Alprazolam; Clonidine; Desipramine; Fear; Female; Fluoxetine; Humans; Imipramine; Lactates; Lactic Acid; Male; Panic; Phobic Disorders; Psychological Tests; Psychotropic Drugs

1987
Alprazolam and desipramine in moderately severe depression.
    Canadian journal of psychiatry. Revue canadienne de psychiatrie, 1986, Volume: 31, Issue:4

    Topics: Alprazolam; Benzodiazepines; Depressive Disorder; Desipramine; Humans

1986
Successful use of clonazepam in patients with treatment-resistant panic disorder.
    The Journal of nervous and mental disease, 1986, Volume: 174, Issue:8

    Topics: Adult; Agoraphobia; Alprazolam; Anxiety Disorders; Benzodiazepines; Benzodiazepinones; Clonazepam; Desipramine; Fear; Female; Humans; Imipramine; Male; Middle Aged; Panic; Phenelzine; Propranolol; Psychiatric Status Rating Scales

1986
Effect of chronic administration of alprazolam and adinazolam on clonidine- or apomorphine-induced aggression in laboratory rodents.
    Neuropharmacology, 1986, Volume: 25, Issue:7

    Topics: Aggression; Alprazolam; Animals; Anti-Anxiety Agents; Apomorphine; Benzodiazepines; Clonidine; Desipramine; Diazepam; Drug Interactions; Male; Mice; Rats; Rats, Inbred Strains

1986
Effects of desipramine and alprazolam on forced swimming behaviour of adult rats exposed to prenatal diazepam.
    European journal of pharmacology, 1995, Feb-06, Volume: 273, Issue:3

    Topics: Alprazolam; Animals; Behavior, Animal; Depression; Desipramine; Diazepam; Electroencephalography; Electrophysiology; Female; Hippocampus; Injections; Locus Coeruleus; Male; Motor Activity; Picrotoxin; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Receptors, GABA; Swimming

1995
Inhibition of alprazolam and desipramine hydroxylation in vitro by paroxetine and fluvoxamine: comparison with other selective serotonin reuptake inhibitor antidepressants.
    Journal of clinical psychopharmacology, 1995, Volume: 15, Issue:2

    Topics: Alprazolam; Biotransformation; Culture Techniques; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Desipramine; Dose-Response Relationship, Drug; Fluvoxamine; Humans; Hydroxylation; Microsomes, Liver; Mixed Function Oxygenases; Paroxetine; Selective Serotonin Reuptake Inhibitors

1995
NMDA-GABA interactions in an animal model of behaviour: a gating mechanism from motivation toward psychotic-like symptoms.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 1994, Volume: 4, Issue:2

    Topics: Alprazolam; Animals; Behavior, Animal; Desipramine; Disease Models, Animal; Dizocilpine Maleate; gamma-Aminobutyric Acid; Kindling, Neurologic; Male; Motivation; Motor Activity; Muscimol; N-Methylaspartate; Pentylenetetrazole; Psychotic Disorders; Rats; Rats, Wistar; Swimming

1994
Augmentation strategies with tricyclic or fluoxetine treatment in seven partially responsive panic disorder patients.
    The Journal of clinical psychiatry, 1994, Volume: 55, Issue:2

    Topics: Adult; Alprazolam; Antidepressive Agents, Tricyclic; Desipramine; Drug Therapy, Combination; Female; Fluoxetine; Humans; Imipramine; Lorazepam; Male; Panic Disorder; Retrospective Studies; Treatment Outcome

1994
Effects of desipramine and alprazolam in the forced swim test in rats after long-lasting termination of chronic exposure to picrotoxin and pentylenetetrazol.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 1993, Volume: 3, Issue:4

    Topics: Alprazolam; Animals; Chlordiazepoxide; Desipramine; GABA-A Receptor Antagonists; Male; Motor Activity; Pentylenetetrazole; Picrotoxin; Psychomotor Performance; Rats; Substance Withdrawal Syndrome; Swimming

1993
Behavioural responsiveness to picrotoxin and desipramine in adult rats prenatally exposed to different benzodiazepine receptor agonists.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 1995, Volume: 5, Issue:4

    Topics: Adrenergic Uptake Inhibitors; Alprazolam; Animals; Behavior, Animal; Desipramine; Diazepam; Female; GABA Antagonists; GABA Modulators; GABA-A Receptor Agonists; Hypnotics and Sedatives; Male; Picrotoxin; Pregnancy; Prenatal Exposure Delayed Effects; Pyridines; Rats; Rats, Wistar; Seizures; Zolpidem

1995
Neuropathy associated with tricyclic antidepressants.
    International journal of geriatric psychiatry, 1997, Volume: 12, Issue:8

    Topics: Alprazolam; Antidepressive Agents, Tricyclic; Desipramine; Female; Humans; Middle Aged; Nortriptyline; Peripheral Nervous System Diseases; Thyroxine

1997
Depletion of brain norepinephrine: differential influence on anxiolyic treatment effects.
    Psychopharmacology, 1999, Volume: 143, Issue:2

    Topics: Alprazolam; Animals; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Benzylamines; Biogenic Monoamines; Brain Chemistry; Conflict, Psychological; Desipramine; Dose-Response Relationship, Drug; Female; Hypnotics and Sedatives; Monoamine Oxidase Inhibitors; Norepinephrine; Phenelzine; Phenobarbital; Rats; Rats, Sprague-Dawley; Sympathomimetics

1999