Compounds > desipramine

desipramine and acetylcysteine

desipramine has been researched along with acetylcysteine in 12 studies

Research

Studies (12)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (8.33)	18.7374
1990's	0 (0.00)	18.2507
2000's	6 (50.00)	29.6817
2010's	4 (33.33)	24.3611
2020's	1 (8.33)	2.80

Authors

Authors	Studies
Lombardo, F; Obach, RS; Waters, NJ	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Jollow, DJ; Keiser, H; Mitchell, JR; Potter, WZ; Thorgeirsson, SS	1
Kohama, T; Koishi, R; Serizawa, N; Yoshimura, C	1
Choi, HK; Hong, JT; Lee, YM; Lee, YS; Oh, S; Yoo, HS; Yoo, JM; Yun, YP	1
Calvaruso, G; Carlisi, D; Giuliano, M; Pellerito, O; Portanova, P; Tesoriere, G; Vento, R	1
Du, W; Li, P; Miao, YX; Wang, CB; Xing, YX	1
Dias, IH; Fell, S; Griffiths, HR; Lip, GY; Mistry, J; Polidori, MC; Reis, A; Spickett, CM	1
Ghashghaeinia, M; Giustarini, D; Köberle, M; Lang, F; Pan, X; Rossi, R; Wieder, T	1

Reviews

1 review(s) available for desipramine and acetylcysteine

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Other Studies

11 other study(ies) available for desipramine and acetylcysteine

Article	Year
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
Acetaminophen-induced hepatic injury: protective role of glutathione in man and rationale for therapy. Clinical pharmacology and therapeutics, 1974, Volume: 16, Issue:4 Topics: Acetaminophen; Acetylcysteine; Adult; Amobarbital; Animals; Chemical and Drug Induced Liver Injury; Chromatography, Paper; Cysteamine; Cytochrome P-450 Enzyme System; Desipramine; Dimercaprol; Dose-Response Relationship, Drug; Enzyme Induction; Female; Glutathione; Humans; Indicators and Reagents; Liver; Male; Mass Spectrometry; Methyltransferases; Mice; Microsomes, Liver; Phenobarbital; Protein Binding; Proteins; Sulfhydryl Compounds; Time Factors; Tritium	1974
Leustroducsin B activates nuclear factor-kappaB via the acidic sphingomyelinase pathway in human bone marrow-derived stromal cell line KM-102. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, 2002, Volume: 22, Issue:3 Topics: Acetylcysteine; Antioxidants; Bone Marrow Cells; Bridged-Ring Compounds; Cell Line; Clone Cells; Desipramine; Genes, Reporter; Humans; Interleukin-11; Interleukin-8; Lactones; Mutagenesis, Site-Directed; NF-kappa B; Norbornanes; Organophosphorus Compounds; Perhexiline; Phosphodiesterase Inhibitors; Point Mutation; Promoter Regions, Genetic; Protein Processing, Post-Translational; Pyrones; Signal Transduction; Sphingomyelin Phosphodiesterase; Stromal Cells; Thiocarbamates; Thiones; Transcriptional Activation	2002
Protection of LLC-PK1 cells against hydrogen peroxide-induced cell death by modulation of ceramide level. Archives of pharmacal research, 2005, Volume: 28, Issue:3 Topics: Acetylcysteine; Animals; Cell Death; Ceramides; Desipramine; Glutathione; Glutathione S-Transferase pi; Glutathione Transferase; Hydrogen Peroxide; Isoenzymes; LLC-PK1 Cells; Oxidative Stress; Sphingolipids; Sphingomyelin Phosphodiesterase; Swine	2005
Anandamide-induced apoptosis in Chang liver cells involves ceramide and JNK/AP-1 pathway. International journal of molecular medicine, 2006, Volume: 17, Issue:5 Topics: Acetylcysteine; Apoptosis; Apoptosis Regulatory Proteins; Arachidonic Acids; Bcl-2-Like Protein 11; Blotting, Western; Caspases; Cell Line; Cell Line, Tumor; Cell Survival; Ceramides; Desipramine; Dose-Response Relationship, Drug; Endocannabinoids; Enzyme Activation; Enzyme Inhibitors; Fas Ligand Protein; Free Radical Scavengers; Humans; JNK Mitogen-Activated Protein Kinases; Liver; Membrane Glycoproteins; Membrane Potentials; Membrane Proteins; Mitochondrial Membranes; Polyunsaturated Alkamides; Proto-Oncogene Proteins; Signal Transduction; Transcription Factor AP-1; Tumor Necrosis Factors	2006
Involvement of ROS/ASMase/JNK signalling pathway in inhibiting UVA-induced apoptosis of HaCaT cells by polypeptide from Chlamys farreri. Free radical research, 2008, Volume: 42, Issue:1 Topics: Acetylcysteine; Animals; Anthracenes; Antioxidants; Apoptosis; Cell Line; Desipramine; Dose-Response Relationship, Drug; Enzyme Activation; Free Radical Scavengers; Humans; JNK Mitogen-Activated Protein Kinases; Keratinocytes; Pectinidae; Peptides; Phosphorylation; Protein Kinase Inhibitors; Reactive Oxygen Species; Signal Transduction; Sphingomyelin Phosphodiesterase; Ultraviolet Rays	2008
Oxidized LDL lipids increase β-amyloid production by SH-SY5Y cells through glutathione depletion and lipid raft formation. Free radical biology & medicine, 2014, Volume: 75 Topics: Acetylcysteine; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Cell Line, Tumor; Cell Survival; Cholesterol, LDL; Desipramine; Enzyme Activation; Enzyme Inhibitors; Free Radical Scavengers; Glutathione; Glutathione Disulfide; Humans; Hydroxycholesterols; Lipid Metabolism; Lipoproteins, LDL; Membrane Microdomains; Oxidation-Reduction; Sphingomyelin Phosphodiesterase	2014
Desipramine induces eryptosis in human erythrocytes, an effect blunted by nitric oxide donor sodium nitroprusside and N-acetyl-L-cysteine but enhanced by Calcium depletion. Cell cycle (Georgetown, Tex.), 2023, Volume: 22, Issue:17 Topics: Acetylcysteine; Annexins; Calcium; Cell Size; Ceramides; Desipramine; Eryptosis; Erythrocytes; Glutathione; Humans; Nitric Oxide Donors; Nitroprusside; Oxidative Stress; Phosphatidylserines; Reactive Oxygen Species	2023