desipramine and 2-hydroxydesipramine

desipramine has been researched along with 2-hydroxydesipramine in 63 studies

Research

Studies (63)

Timeframe	Studies, this research(%)	All Research%
pre-1990	34 (53.97)	18.7374
1990's	23 (36.51)	18.2507
2000's	5 (7.94)	29.6817
2010's	1 (1.59)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Baldessarini, RJ; Biederman, J; Flood, JG; McDermott, SP; Puopolo, PR; Wilens, TE	1
Barnhill, JG	1
Argenti, D; D'mello, A	1
Danis, M; Dukes, GE; Hak, LJ; Han, YH; Hermann, DJ; Hussey, EK; Krol, TF; Powell, JR	1
Baldessarini, RJ; Biederman, J; Flood, JG; Puopolo, PR; Wilens, TE	2
Cooper, TB; Roose, SP; Suckow, RF	1
Foglia, JP; Perel, JM; Sorisio, D	1
Brøsen, K; Gram, LF; Kragh-Sørensen, P	1
Cooper, TB; Johnson, MH; Nelson, LD; Ribner, HS; Stern, SL; Suckow, RF	1
Cooper, T; Dell, RB; Hein, K; Puig-Antich, J; Ramakrishnan, R	1
Chiba, M; Fujita, S; Suzuki, T	1
Dumont, E; Henthorn, TK; Spina, E; von Bahr, C	1
Bupp, SJ; Preskorn, SH; Weller, EB; Weller, RA	1
Burton, ME; Kenney, JT; Kolodner, RM; Orsulak, PJ	1
Brøsen, K; Gram, LF	1
Atillasoy, E; Jatlow, PI; Mazure, C; Nelson, JC	1
Abrahamsson, T; Carlsson, L	1
Dahlqvist, R; Dumont, E; Spina, E; Steiner, E	1
Cooper, TB; Suckow, RF	1
Jatlow, PI; Mazure, C; Nelson, JC	1
Bech, P; Bertilsson, L; Brøsen, K; Gram, LF; Klysner, R; Otton, SV	1
Jatlow, PI; Nelson, JC	1
Arena, A; Pisani, F; Spina, E	1
Bech, P; Brøsen, K; Gram, LF; Klysner, R	1
Brøsen, K; Gram, LF; Otton, SV	1
Dubbin, JD; Kutcher, SP; Reid, K; Shulman, KI	1
Reed, KL; Stancer, HC	1
Kutcher, SP; Reed, K; Shulman, KI	1
Amsterdam, JD; Brunswick, DJ; Potter, L; Rickels, K; Winokur, A	1
Bock, J; Bowers, MB; Jatlow, PI; Nelson, JC; Quinlan, DM	1
Bock, JL; Gray, S; Jatlow, PI; Nelson, JC	1
DeVane, CL; Jusko, WJ; Sutfin, TA	1
Amsterdam, JD; Brunswick, DJ; Kaplan, MJ; Potter, L	1
Cooke, RG; Persad, E; Reed, KL; Stancer, HC; Warsh, JJ	1
Birgersson, C; Ericsson, O; Mellström, B; Sjöqvist, F; Spina, E; Steiner, E; von Bahr, C	1
Chang, WH; Lane, EA; Potter, WZ; Rudorfer, MV; Zhang, MD	1
Jatlow, PI; Nelson, JC; Price, LH	1
Barkai, AI; Cooper, TB; Suckow, RF	1
Bock, JL; Jatlow, PI; Nelson, JC	1
Bjerre, M; Gram, LF; Kragh-Sørensen, P; Kvinesdal, B; Molin, J; Pedersen, OL; Reisby, N	1
Cutler, NR; Kitanaka, I; Potter, WZ; Ross, RJ; Zavadil, AP	1
Calil, HM; Goodwin, FK; Jusko, WJ; Potter, WZ; Rapoport, J; Sutfin, TA; Zavadil, AP	1
Kramer, PA; McCauley, T; Wong, SH	1
Mahajan, S; Sundaram, K	1
DeVane, CL; Jusko, WJ; Savett, M	1
Beauchamp, G; Elie, R; Lavoie, PA	1
Brøsen, K; Madsen, H; Nielsen, KK	1
Villarreal, G	1
Cotreau-Bibbo, MM; Duan, SX; Greenblatt, DJ; Harmatz, JS; Shader, RI; von Moltke, LL	1
Miescke, KJ; Musa, MN	1
Baker, GB; Coutts, RT; Daneshtalab, M; Su, P	1
Alm, C; Dahl, ML; Ingelman-Sundberg, M; Iselius, L; Johansson, I; Lee, D; Sjöqvist, F; Svensson, JO	1
Avenoso, A; Campo, GM; Caputi, AP; Perucca, E; Spina, E	1
Cooper, TB; Johnson, MH; Nelson, LD; Stern, SL; Suckow, RF	1
Chan, K; Chen, AG; Chen, CN; Chiu, H; Lee, S; Wing, YK	1
Kim, JH; Tluczek, L; Van Dort, ME; Wieland, DM	1
Hirokane, G; Morita, S; Shimoda, K; Someya, T; Takahashi, S; Yokono, A	1
Fotteler, B; Jorga, KM; Modi, M; Rabbia, M	1
Anttila, M; Björklund, H; De Bruyn, S; Hänninen, J; Laine, K; Rouru, J; Scheinin, H	1
Burczynski, ME; Connolly, SM; Fatato, P; Guico-Pabia, C; Isler, JA; Jiang, Q; Nichols, AI; Patroneva, A; Paul, J; Pedersen, R	1
Ahmed, S; Fatato, P; Isler, JA; Jiang, Q; Nichols, AI; Patroneva, A; Paul, J; Pedersen, RD; Shenouda, M	1
Abell, M; Behrle, JA; Chen, Y; Frick, G; Madelyn, A; Nichols, AI; Paul, J	1

Trials

11 trial(s) available for desipramine and 2-hydroxydesipramine

Article	Year
Comparison of verapamil, diltiazem, and labetalol on the bioavailability and metabolism of imipramine. Journal of clinical pharmacology, 1992, Volume: 32, Issue:2 Topics: Administration, Oral; Adolescent; Adult; Antidepressive Agents, Tricyclic; Biological Availability; Desipramine; Diltiazem; Drug Administration Schedule; Drug Interactions; Humans; Imipramine; Labetalol; Male; Verapamil	1992
2-Hydroxydesipramine and desipramine plasma levels and electrocardiographic effects in depressed younger adults. Journal of clinical psychopharmacology, 1991, Volume: 11, Issue:2 Topics: Adult; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Depressive Disorder; Desipramine; Electrocardiography; Female; Heart Block; Humans; Male; Middle Aged; Psychiatric Status Rating Scales; Risk Factors; Single-Blind Method	1991
Steady-state concentrations of imipramine and its metabolites in relation to the sparteine/debrisoquine polymorphism. European journal of clinical pharmacology, 1986, Volume: 30, Issue:6 Topics: Adult; Aged; Aged, 80 and over; Clinical Trials as Topic; Debrisoquin; Depression; Desipramine; Female; Humans; Hydroxylation; Imipramine; Isoquinolines; Kinetics; Male; Middle Aged; Phenotype; Polymorphism, Genetic; Sparteine	1986
The analysis and disposition of imipramine and its active metabolites in man. Psychopharmacology, 1984, Volume: 82, Issue:4 Topics: Administration, Oral; Biotransformation; Chromatography, High Pressure Liquid; Desipramine; Humans; Imipramine; Injections, Intramuscular; Kinetics; Male	1984
Desipramine plasma levels and treatment response in panic disorder. Canadian journal of psychiatry. Revue canadienne de psychiatrie, 1995, Volume: 40, Issue:2 Topics: Desipramine; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Panic Disorder; Treatment Outcome	1995
Phenobarbital induces the 2-hydroxylation of desipramine. Therapeutic drug monitoring, 1996, Volume: 18, Issue:1 Topics: Adult; Anticonvulsants; Antidepressive Agents, Tricyclic; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Debrisoquin; Desipramine; Enzyme Induction; Epilepsy; Half-Life; Humans; Hydroxylation; Male; Mixed Function Oxygenases; Phenobarbital; Phenotype; Polymorphism, Genetic	1996
Effect of tolcapone on the haemodynamic effects and tolerability of desipramine. European neurology, 2000, Volume: 44, Issue:2 Topics: Adult; Antiparkinson Agents; Benzophenones; Cross-Over Studies; Desipramine; Double-Blind Method; Drug Interactions; Drug Tolerance; Female; Hemodynamics; Humans; Levodopa; Male; Nitrophenols; Parkinson Disease; Tolcapone	2000
Effect of the novel anxiolytic drug deramciclane on cytochrome P(450) 2D6 activity as measured by desipramine pharmacokinetics. European journal of clinical pharmacology, 2004, Volume: 59, Issue:12 Topics: Adult; Analysis of Variance; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Area Under Curve; Camphanes; Cytochrome P-450 CYP2D6; Desipramine; Double-Blind Method; Drug Interactions; Female; Half-Life; Humans; Male; Middle Aged	2004
An assessment of drug-drug interactions: the effect of desvenlafaxine and duloxetine on the pharmacokinetics of the CYP2D6 probe desipramine in healthy subjects. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:12 Topics: Adult; Antidepressive Agents; Area Under Curve; Biotransformation; Cross-Over Studies; Cyclohexanols; Cytochrome P-450 CYP2D6; Desipramine; Desvenlafaxine Succinate; Drug Interactions; Duloxetine Hydrochloride; Female; Humans; Male; Middle Aged; Thiophenes	2008
The effects of desvenlafaxine and paroxetine on the pharmacokinetics of the cytochrome P450 2D6 substrate desipramine in healthy adults. Journal of clinical pharmacology, 2009, Volume: 49, Issue:2 Topics: Adult; Antidepressive Agents; Area Under Curve; Cross-Over Studies; Cyclohexanols; Cytochrome P-450 CYP2D6 Inhibitors; Desipramine; Desvenlafaxine Succinate; Drug Interactions; Enzyme Inhibitors; Female; Genotype; Humans; Least-Squares Analysis; Male; Middle Aged; Paroxetine; United States; Young Adult	2009
Effects of desvenlafaxine on the pharmacokinetics of desipramine in healthy adults. International clinical psychopharmacology, 2013, Volume: 28, Issue:2 Topics: Adolescent; Adult; Antidepressive Agents; Antidepressive Agents, Tricyclic; Biological Availability; Cyclohexanols; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Desipramine; Desvenlafaxine Succinate; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Female; Half-Life; Humans; Male; Metabolic Clearance Rate; Metabolic Detoxication, Phase I; Middle Aged; Neurotransmitter Uptake Inhibitors; Polymorphism, Genetic; Young Adult	2013

Other Studies

52 other study(ies) available for desipramine and 2-hydroxydesipramine

Article	Year
Fluoxetine inhibits desipramine metabolism. Archives of general psychiatry, 1992, Volume: 49, Issue:9 Topics: Attention Deficit Disorder with Hyperactivity; Depressive Disorder; Desipramine; Drug Interactions; Drug Therapy, Combination; Fluoxetine; Humans; Retrospective Studies	1992
Plasma desipramine levels and ECG changes in depressed young adults. Journal of clinical psychopharmacology, 1992, Volume: 12, Issue:2 Topics: Adult; Alcoholism; Depressive Disorder; Desipramine; Dose-Response Relationship, Drug; Electrocardiography; Female; Heart Rate; Humans; Male; Middle Aged	1992
Chelation with ferric ions may prevent extraction of 2-hydroxydesipramine from whole blood. Clinical chemistry, 1992, Volume: 38, Issue:6 Topics: Chelating Agents; Desipramine; Erythrocytes; Ferric Compounds; Humans	1992
Developmental changes in serum concentrations of desipramine and 2-hydroxydesipramine during treatment with desipramine. Journal of the American Academy of Child and Adolescent Psychiatry, 1992, Volume: 31, Issue:4 Topics: Adolescent; Adult; Age Factors; Aged; Child; Depressive Disorder; Desipramine; Dose-Response Relationship, Drug; Female; Humans; Male; Metabolic Clearance Rate; Middle Aged	1992
Effect of fluoxetine on plasma desipramine and 2-hydroxydesipramine. Biological psychiatry, 1992, Jan-15, Volume: 31, Issue:2 Topics: Aged; Depressive Disorder; Desipramine; Drug Therapy, Combination; Female; Fluoxetine; Humans	1992
Determination of imipramine, desipramine and their hydroxy metabolites by reversed-phase chromatography with ultraviolet and coulometric detection. Journal of chromatography, 1991, Dec-06, Volume: 572, Issue:1-2 Topics: Chromatography, High Pressure Liquid; Desipramine; Electrochemistry; Humans; Imipramine; Reproducibility of Results; Spectrophotometry, Ultraviolet	1991
Extremely slow metabolism of amitriptyline but normal metabolism of imipramine and desipramine in an extensive metabolizer of sparteine, debrisoquine, and mephenytoin. Therapeutic drug monitoring, 1991, Volume: 13, Issue:2 Topics: Administration, Oral; Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Chromatography, Thin Layer; Debrisoquin; Desipramine; Drug Interactions; Humans; Imipramine; Male; Mephenytoin; Phenotype; Quinidine; Sparteine	1991
Model for the kinetics of imipramine and its metabolites in adolescents. Therapeutic drug monitoring, 1990, Volume: 12, Issue:5 Topics: Adolescent; Desipramine; Female; Humans; Imipramine; Male; Models, Biological; Models, Theoretical	1990
Kinetic properties of the metabolism of imipramine and desipramine in isolated rat hepatocytes. Biochemical pharmacology, 1990, Jan-15, Volume: 39, Issue:2 Topics: Animals; Cells, Cultured; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Desipramine; Dose-Response Relationship, Drug; Imipramine; Kinetics; Liver; Male; Rats; Rats, Inbred Strains	1990
In vitro inhibition of a polymorphic human liver P-450 isozyme by narcotic analgesics. Anesthesiology, 1989, Volume: 70, Issue:2 Topics: Analgesics, Opioid; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Desipramine; Humans; Hydroxylation; In Vitro Techniques; Microsomes, Liver; Mixed Function Oxygenases; Polymorphism, Genetic	1989
Plasma levels of imipramine and metabolites in 68 hospitalized children. Journal of the American Academy of Child and Adolescent Psychiatry, 1989, Volume: 28, Issue:3 Topics: Adolescent; Child; Depressive Disorder; Desipramine; Female; Humans; Imipramine; Male; Psychiatric Department, Hospital	1989
Determination of serum desipramine and 2-hydroxydesipramine for pharmacokinetic applications by HPLC with ultraviolet detection. Clinical chemistry, 1989, Volume: 35, Issue:10 Topics: Alkalies; Amitriptyline; Chromatography, High Pressure Liquid; Desipramine; Humans; Microchemistry; Spectrometry, Fluorescence; Time Factors	1989
Quinidine inhibits the 2-hydroxylation of imipramine and desipramine but not the demethylation of imipramine. European journal of clinical pharmacology, 1989, Volume: 37, Issue:2 Topics: Adult; Dealkylation; Desipramine; Drug Interactions; Female; Half-Life; Humans; Hydroxylation; Imipramine; Male; Phenotype; Quinidine; Sparteine	1989
Hydroxydesipramine in the elderly. Journal of clinical psychopharmacology, 1988, Volume: 8, Issue:6 Topics: Administration, Oral; Aged; Aged, 80 and over; Depressive Disorder; Desipramine; Female; Humans; Male; Metabolic Clearance Rate; Middle Aged	1988
Characterization of the inhibitory effect of some antidepressant drugs on the outward transport of norepinephrine in the ischemic myocardium. The Journal of pharmacology and experimental therapeutics, 1988, Volume: 247, Issue:2 Topics: Animals; Antidepressive Agents; Biological Transport, Active; Chromatography, High Pressure Liquid; Clonidine; Coronary Disease; Desipramine; Fluoxetine; Heart; Isomerism; Lidocaine; Male; Maprotiline; Myocardium; Norepinephrine; Rats; Rats, Inbred Strains	1988
Inhibition of desipramine 2-hydroxylation by quinidine and quinine. Clinical pharmacology and therapeutics, 1988, Volume: 43, Issue:5 Topics: Adult; Desipramine; Drug Interactions; Female; Humans; Hydroxylation; Male; Quinidine; Quinine	1988
Isolation and identification of the glucuronide conjugate of 2-hydroxydesipramine by preparative liquid chromatography. Journal of chromatography, 1988, Jun-03, Volume: 427, Issue:2 Topics: Chromatography, High Pressure Liquid; Desipramine; Humans; Indicators and Reagents; Mass Spectrometry; Spectrophotometry, Ultraviolet	1988
Antidepressant activity of 2-hydroxydesipramine. Clinical pharmacology and therapeutics, 1988, Volume: 44, Issue:3 Topics: Adult; Aged; Antidepressive Agents, Tricyclic; Depressive Disorder; Desipramine; Female; Humans; Male; Middle Aged; Prospective Studies; Time Factors	1988
Nonlinear desipramine kinetics: prevalence and importance. Clinical pharmacology and therapeutics, 1987, Volume: 41, Issue:6 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Depressive Disorder; Desipramine; Dose-Response Relationship, Drug; Female; Humans; Kinetics; Male; Middle Aged	1987
Urinary desipramine hydroxylation index and steady-state plasma concentrations of imipramine and desipramine. Therapeutic drug monitoring, 1987, Volume: 9, Issue:2 Topics: Adult; Desipramine; Female; Humans; Hydroxylation; Imipramine; Male; Middle Aged	1987
Steady-state levels of imipramine and its metabolites: significance of dose-dependent kinetics. European journal of clinical pharmacology, 1986, Volume: 30, Issue:1 Topics: Adult; Aged; Biotransformation; Desipramine; Dose-Response Relationship, Drug; Female; Humans; Imipramine; Kinetics; Male; Middle Aged; Phenotype; Time Factors	1986
Imipramine demethylation and hydroxylation: impact of the sparteine oxidation phenotype. Clinical pharmacology and therapeutics, 1986, Volume: 40, Issue:5 Topics: Adult; Desipramine; Female; Humans; Hydroxylation; Imipramine; Kinetics; Male; Methylation; Oxidation-Reduction; Phenotype; Sparteine	1986
Electrocardiogram changes and therapeutic desipramine and 2-hydroxy-desipramine concentrations in elderly depressives. The British journal of psychiatry : the journal of mental science, 1986, Volume: 148 Topics: Aged; Depressive Disorder; Desipramine; Electrocardiography; Female; Humans; Male; Middle Aged; Time Factors	1986
Desipramine and 2-hydroxydesipramine in human breast milk and the nursing infant's serum. The American journal of psychiatry, 1986, Volume: 143, Issue:12 Topics: Adult; Breast Feeding; Depressive Disorder; Desipramine; Female; Humans; Infant, Newborn; Kinetics; Milk, Human	1986
Desipramine plasma concentration and therapeutic response in elderly depressives: a naturalistic pilot study. Canadian journal of psychiatry. Revue canadienne de psychiatrie, 1986, Volume: 31, Issue:8 Topics: Aged; Aged, 80 and over; Depressive Disorder; Desipramine; Dexamethasone; Female; Humans; Hydrocortisone; Male; Middle Aged	1986
Desipramine and 2-hydroxydesipramine plasma levels in endogenous depressed patients. Lack of correlation with therapeutic response. Archives of general psychiatry, 1985, Volume: 42, Issue:4 Topics: Adolescent; Adult; Depressive Disorder; Desipramine; Female; Humans; Male; Middle Aged; Psychiatric Status Rating Scales	1985
Major adverse reactions during desipramine treatment: relationship to plasma drug concentrations, concomitant antipsychotic treatment, and patient characteristics. Archives of general psychiatry, 1982, Volume: 39, Issue:9 Topics: Adult; Age Factors; Aged; Antipsychotic Agents; Constipation; Delirium; Depressive Disorder; Desipramine; Drug Interactions; Drug Therapy, Combination; Female; Humans; Hypotension, Orthostatic; Male; Middle Aged; Mood Disorders; Urination Disorders	1982
Desipramine hydroxylation: variability and effect of antipsychotic drugs. Clinical pharmacology and therapeutics, 1983, Volume: 33, Issue:3 Topics: Adult; Aged; Antipsychotic Agents; Chromatography, Gas; Chromatography, High Pressure Liquid; Desipramine; Drug Interactions; Female; Humans; Hydroxylation; Male; Middle Aged; Perphenazine	1983
Cimetidine-induced alterations in desipramine plasma concentrations. Psychopharmacology, 1984, Volume: 83, Issue:4 Topics: Adult; Biotransformation; Cimetidine; Desipramine; Humans; Middle Aged	1984
The nonlinear kinetics of desipramine and 2-hydroxydesipramine in plasma. Clinical pharmacology and therapeutics, 1984, Volume: 36, Issue:3 Topics: Administration, Oral; Adolescent; Adult; Aged; Amitriptyline; Chromatography, High Pressure Liquid; Depressive Disorder; Desipramine; Dose-Response Relationship, Drug; Female; Humans; Kinetics; Male; Middle Aged; Nortriptyline; Random Allocation	1984
Phenotypic consistency in hydroxylation of desmethylimipramine and debrisoquine in healthy subjects and in human liver microsomes. Clinical pharmacology and therapeutics, 1984, Volume: 36, Issue:5 Topics: Adult; Chromatography, High Pressure Liquid; Debrisoquin; Desipramine; Female; Humans; Hydroxylation; Isoquinolines; Kinetics; Male; Microsomes, Liver; Middle Aged; Phenotype	1984
Desipramine pharmacokinetics in Chinese and Caucasian volunteers. British journal of clinical pharmacology, 1984, Volume: 17, Issue:4 Topics: Adult; Asian People; Desipramine; Female; Half-Life; Humans; Hydroxylation; Kinetics; Male; Middle Aged; White People	1984
Effects of desipramine on clinical liver function tests. The American journal of psychiatry, 1984, Volume: 141, Issue:6 Topics: Adult; Aged; Chemical and Drug Induced Liver Injury; Depressive Disorder; Desipramine; Dose-Response Relationship, Drug; Female; Humans; Liver; Liver Function Tests; Male; Middle Aged	1984
Imipramine and its metabolites: relationship to cerebral catecholamines in rats in vivo. The Journal of pharmacology and experimental therapeutics, 1984, Volume: 230, Issue:2 Topics: Animals; Brain; Desipramine; Dopamine; Imipramine; Injections, Intraventricular; Kinetics; Male; Norepinephrine; Rats; Rats, Inbred Strains; Time Factors; Tissue Distribution	1984
Clinical implications of 2-hydroxydesipramine plasma concentrations. Clinical pharmacology and therapeutics, 1983, Volume: 33, Issue:2 Topics: Depressive Disorder; Desipramine; Drug Evaluation; Humans; Middle Aged; Regression Analysis	1983
Imipramine metabolites in blood of patients during therapy and after overdose. Clinical pharmacology and therapeutics, 1983, Volume: 33, Issue:3 Topics: Adult; Aged; Chromatography, Thin Layer; Desipramine; Dose-Response Relationship, Drug; Female; Humans; Imipramine; Kinetics; Male; Middle Aged	1983
Altered hydroxydesipramine concentrations in elderly depressed patients. Clinical pharmacology and therapeutics, 1982, Volume: 31, Issue:1 Topics: Adult; Aged; Aging; Depression; Desipramine; Female; Humans; Kidney; Male; Middle Aged	1982
Active metabolites of imipramine and desipramine in man. Clinical pharmacology and therapeutics, 1982, Volume: 31, Issue:3 Topics: Adolescent; Adult; Aged; Biotransformation; Child; Desipramine; Double-Blind Method; Enuresis; Female; Humans; Imipramine; Male; Middle Aged	1982
Determination of 2-hydroxydesipramine by high-performance liquid chromatography. Journal of chromatography, 1981, Nov-13, Volume: 226, Issue:1 Topics: Antidepressive Agents, Tricyclic; Chromatography, High Pressure Liquid; Desipramine; Humans	1981
Theoretical studies on tricyclic antidepressants: III. Analysis of stereospecificity. Physiological chemistry and physics, 1981, Volume: 13, Issue:5 Topics: Antidepressive Agents, Tricyclic; Computers; Desipramine; Molecular Conformation; Structure-Activity Relationship	1981
Desipramine and 2-hydroxy-desipramine pharmacokinetics in normal volunteers. European journal of clinical pharmacology, 1981, Volume: 19, Issue:1 Topics: Adult; Desipramine; Humans; Kinetics; Male	1981
Differential effect of desipramine and 2-hydroxydesipramine on depolarization-induced calcium uptake in synaptosomes from rat limbic sites. Canadian journal of physiology and pharmacology, 1995, Volume: 73, Issue:5 Topics: Animals; Antidepressive Agents, Tricyclic; Calcium; Desipramine; Dose-Response Relationship, Drug; Hippocampus; Male; Rats; Rats, Sprague-Dawley; Synaptosomes	1995
Imipramine metabolism in relation to the sparteine and mephenytoin oxidation polymorphisms--a population study. British journal of clinical pharmacology, 1995, Volume: 39, Issue:4 Topics: Adult; Chromatography, High Pressure Liquid; Cohort Studies; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Denmark; Desipramine; Female; Genotype; Heterozygote; Homozygote; Humans; Hydroxylation; Imipramine; Male; Mephenytoin; Middle Aged; Mixed Function Oxygenases; Oxidation-Reduction; Oxidoreductases; Polymerase Chain Reaction; Polymorphism, Genetic; Smoking; Sparteine	1995
Inhibition of desipramine hydroxylation in vitro by serotonin-reuptake-inhibitor antidepressants, and by quinidine and ketoconazole: a model system to predict drug interactions in vivo. The Journal of pharmacology and experimental therapeutics, 1994, Volume: 268, Issue:3 Topics: Animals; Antidepressive Agents; Biotransformation; Desipramine; Drug Interactions; Haplorhini; Humans; Hydroxylation; In Vitro Techniques; Ketoconazole; Male; Mice; Microsomes, Liver; Quinidine; Rats; Selective Serotonin Reuptake Inhibitors; Species Specificity	1994
Pharmacogenetics of desipramine metabolism. International journal of clinical pharmacology and therapeutics, 1994, Volume: 32, Issue:3 Topics: Adolescent; Adult; Antidepressive Agents, Tricyclic; Chromatography, High Pressure Liquid; Depressive Disorder; Desipramine; Energy Metabolism; Female; Genotype; Humans; Male; Mathematics; Middle Aged; Pharmacogenetics; Statistics as Topic	1994
Analysis of imipramine and three metabolites produced by isozyme CYP2D6 expressed in a human cell line. Xenobiotica; the fate of foreign compounds in biological systems, 1993, Volume: 23, Issue:11 Topics: Catalysis; Cell Line; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Desipramine; Humans; Imipramine; Isoenzymes; Methylation; Mixed Function Oxygenases; Oxidation-Reduction; Recombinant Proteins; Substrate Specificity	1993
Electrocardiographic effects of desipramine and 2-hydroxydesipramine in children, adolescents, and adults treated with desipramine. Journal of the American Academy of Child and Adolescent Psychiatry, 1993, Volume: 32, Issue:4 Topics: Adolescent; Adult; Antidepressive Agents, Tricyclic; Attention Deficit Disorder with Hyperactivity; Child; Depressive Disorder; Desipramine; Electrocardiography; Female; Heart Rate; Humans; Male; Metabolic Clearance Rate; Risk Factors	1993
Polymorphic 2-hydroxylation of desipramine. A population and family study. European journal of clinical pharmacology, 1993, Volume: 44, Issue:5 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antidepressive Agents, Tricyclic; Child; Debrisoquin; Desipramine; Female; Genetic Linkage; Genotype; Humans; Hydroxylation; Male; Middle Aged; Phenotype; Polymorphism, Genetic; Sweden	1993
2-Hydroxydesipramine and desipramine plasma levels: how are they related to antidepressant response? International clinical psychopharmacology, 1996, Volume: 11, Issue:4 Topics: Adult; Antidepressive Agents, Tricyclic; Depressive Disorder; Desipramine; Female; Humans; Male; Middle Aged; Psychiatric Status Rating Scales	1996
Simultaneous determination of imipramine, desipramine and their 2- and 10-hydroxylated metabolites in human plasma and urine by high-performance liquid chromatography. Journal of chromatography. B, Biomedical sciences and applications, 1997, May-23, Volume: 693, Issue:1 Topics: Adult; Antidepressive Agents, Tricyclic; Chromatography, High Pressure Liquid; Desipramine; Female; Humans; Imipramine; Male; Middle Aged; Sensitivity and Specificity	1997
Synthesis of 11C-labeled desipramine and its metabolite 2-hydroxydesipramine: potential radiotracers for PET studies of the norepinephrine transporter. Nuclear medicine and biology, 1997, Volume: 24, Issue:8 Topics: Carbon Radioisotopes; Carrier Proteins; Desipramine; Isotope Labeling; Norepinephrine Plasma Membrane Transport Proteins; Radiopharmaceuticals; Symporters; Tomography, Emission-Computed	1997
Metabolism of desipramine in Japanese psychiatric patients: the impact of CYP2D6 genotype on the hydroxylation of desipramine. Pharmacology & toxicology, 2000, Volume: 86, Issue:6 Topics: Adult; Aged; Aged, 80 and over; Antidepressive Agents, Tricyclic; Asian People; Cytochrome P-450 CYP2D6; Depressive Disorder; Desipramine; Female; Genotype; Humans; Hydroxylation; Japan; Male; Middle Aged	2000