desethylamodiaquine has been researched along with pyrimethamine in 10 studies
| Studies (desethylamodiaquine) | Trials (desethylamodiaquine) | Recent Studies (post-2010) (desethylamodiaquine) | Studies (pyrimethamine) | Trials (pyrimethamine) | Recent Studies (post-2010) (pyrimethamine) |
|---|---|---|---|---|---|
| 96 | 14 | 37 | 5,088 | 738 | 1,047 |
| Protein | Taxonomy | desethylamodiaquine (IC50) | pyrimethamine (IC50) |
|---|---|---|---|
| Dihydrofolate reductase | Homo sapiens (human) | 3.1057 | |
| Dihydrofolate reductase | Bos taurus (cattle) | 0.1007 | |
| Beta-hexosaminidase subunit alpha | Homo sapiens (human) | 6.8333 | |
| Beta-hexosaminidase subunit beta | Homo sapiens (human) | 6.4 | |
| Dihydrofolate reductase | Escherichia coli K-12 | 4.3 | |
| Bifunctional dihydrofolate reductase-thymidylate synthase | Plasmodium falciparum K1 | 0.0609 | |
| Dihydrofolate reductase | Pneumocystis carinii | 3.25 | |
| Dihydrofolate reductase | Candida albicans | 5 | |
| Low molecular weight phosphotyrosine protein phosphatase | Homo sapiens (human) | 15.615 | |
| Dipeptidyl peptidase 4 | Homo sapiens (human) | 0.39 | |
| Bifunctional dihydrofolate reductase-thymidylate synthase | Toxoplasma gondii | 0.3217 | |
| Bifunctional dihydrofolate reductase-thymidylate synthase | Plasmodium falciparum 3D7 | 2.48 | |
| Dihydrofolate reductase | Rattus norvegicus (Norway rat) | 2.0727 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (70.00) | 29.6817 |
| 2010's | 2 (20.00) | 24.3611 |
| 2020's | 1 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bertaux, L; Bogreau, H; Bouchiba, H; Garnotel, E; Kraemer, P; Parzy, D; Pradines, B; Rogier, C; Savini, H; Simon, F | 1 |
| Masseno, V; Muriithi, S; Nzila, A | 1 |
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Arimondo, PB; Bon, C; Cadet-Daniel, V; Claes, A; Dobrescu, I; Erdmann, D; Halby, L; Hammam, E; Mairet-Khedim, M; Mecheri, S; Nardella, F; Peronet, R; Roesch, C; Scherf, A; Tafit, A; Viluma, J; Witkowski, B | 1 |
| Basco, LK; Keundjian, A; Ringwald, P; Same Ekobo, A | 1 |
| Basco, LK | 1 |
| Bell, DJ; Molyneux, ME; Nyirongo, SK; Ward, SA; Winstanley, PA | 1 |
| Stepniewska, K; White, NJ | 1 |
| Joloba, M; Kiggundu, M; Nawaz, F; Nsobya, SL; Rosenthal, PJ | 1 |
| Aubouy, A; Dahlström, S; Deloron, P; Ezinmègnon, S; Faucher, JF; Houzé, P; Houzé, S; Kendjo, E; Le Bras, J; Maïga-Ascofaré, O; Massougbodji, A; Wakpo, A | 1 |
1 trial(s) available for desethylamodiaquine and pyrimethamine
| Article | Year |
|---|---|
Selection of parasites with diminished drug susceptibility by amodiaquine-containing antimalarial regimens in Uganda.
Topics: Amino Acid Sequence; Amodiaquine; Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Artesunate; Child; Child, Preschool; Cohort Studies; Drug Combinations; Drug Resistance; Ethanolamines; Fluorenes; Humans; Infant; Malaria, Falciparum; Molecular Sequence Data; Multidrug Resistance-Associated Proteins; Plasmodium falciparum; Polymorphism, Genetic; Pyrimethamine; Sequence Alignment; Sulfadoxine; Uganda | 2009 |
9 other study(ies) available for desethylamodiaquine and pyrimethamine
| Article | Year |
|---|---|
First case of emergence of atovaquone-proguanil resistance in Plasmodium falciparum during treatment in a traveler in Comoros.
Topics: Animals; Antimalarials; Atovaquone; Comoros; Drug Resistance; France; Genotype; Humans; Malaria, Falciparum; Male; Parasitic Sensitivity Tests; Plasmodium falciparum; Proguanil; Travel; Treatment Failure | 2008 |
In vitro chemosensitization of Plasmodium falciparum to antimalarials by verapamil and probenecid.
Topics: Adjuvants, Pharmaceutic; Animals; Antimalarials; Parasitic Sensitivity Tests; Plasmodium falciparum; Probenecid; Verapamil | 2009 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
Procainamide-SAHA Fused Inhibitors of hHDAC6 Tackle Multidrug-Resistant Malaria Parasites.
Topics: Antimalarials; Dose-Response Relationship, Drug; Drug Resistance, Multiple; Histone Deacetylase 6; Histone Deacetylase Inhibitors; Hydroxamic Acids; Malaria, Falciparum; Molecular Structure; Plasmodium falciparum; Procainamide; Structure-Activity Relationship | 2021 |
Chemoresistance of Plasmodium falciparum in the urban region of Yaounde, Cameroon. Part 2: Evaluation of the efficacy of amodiaquine and sulfadoxine-pyrimethamine combination in the treatment of uncomplicated Plasmodium falciparum malaria in Yaounde, Came
Topics: Adolescent; Adult; Aged; Amodiaquine; Animals; Antimalarials; Cameroon; Child; Drug Combinations; Female; Humans; Malaria, Falciparum; Male; Middle Aged; Parasitic Sensitivity Tests; Plasmodium falciparum; Pyrimethamine; Sulfadoxine; Treatment Outcome; Urban Health | 2000 |
Molecular epidemiology of malaria in Cameroon. XV. Experimental studies on serum substitutes and supplements and alternative culture media for in vitro drug sensitivity assays using fresh isolates of Plasmodium falciparum.
Topics: Amodiaquine; Animals; Antimalarials; Cameroon; Chloroquine; Culture Media; Humans; Malaria, Falciparum; Parasitic Sensitivity Tests; Plasmodium falciparum; Pyrimethamine; Serum Albumin | 2003 |
Practical HPLC methods for the quantitative determination of common antimalarials in Africa.
Topics: Africa; Amodiaquine; Antimalarials; Chloroquine; Chromatography, High Pressure Liquid; Humans; Pyrimethamine; Reproducibility of Results; Sulfadoxine | 2007 |
Pharmacokinetic determinants of the window of selection for antimalarial drug resistance.
Topics: Algorithms; Amodiaquine; Animals; Antimalarials; Artemisinins; Chloroquine; Computer Simulation; Drug Resistance; Malaria; Mefloquine; Models, Theoretical; Pyrimethamine; Quinine | 2008 |
Plasmodium falciparum Polymorphisms associated with ex vivo drug susceptibility and clinical effectiveness of artemisinin-based combination therapies in Benin.
Topics: Amodiaquine; Antimalarials; Artemisinins; Drug Combinations; Ethanolamines; Female; Fluorenes; Humans; Inhibitory Concentration 50; Lumefantrine; Male; Mefloquine; Membrane Transport Proteins; Multidrug Resistance-Associated Proteins; Plasmodium falciparum; Polymorphism, Single Nucleotide; Protozoan Proteins; Pyrimethamine; Quinine; Sulfadoxine | 2014 |