Compounds > desethylamiodarone
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desethylamiodarone and ketoconazole

desethylamiodarone has been researched along with ketoconazole in 4 studies

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (50.00)29.6817
2010's2 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bigler, L; Follath, F; Ha, HR; Kozlik, P; Stieger, B1
Brocks, DR; El-Kadi, AO; Shayeganpour, A1
Endo, S; Fukami, T; Nakajima, M; Toyoda, Y; Yokoi, T1
Bryant, MS; Guo, L; Ning, B; Ren, Z; Wu, Q; Xuan, J1

Other Studies

4 other study(ies) available for desethylamiodarone and ketoconazole

ArticleYear
Metabolism of amiodarone (Part III): identification of rabbit cytochrome P450 isoforms involved in the hydroxylation of mono-N-desethylamiodarone.
    Xenobiotica; the fate of foreign compounds in biological systems, 2001, Volume: 31, Issue:5

    Topics: Amiodarone; Animals; Anti-Anxiety Agents; Anti-Arrhythmia Agents; Aryl Hydrocarbon Hydroxylases; Benzoflavones; Chromatography, High Pressure Liquid; Cimetidine; Cyclosporine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ketoconazole; Kinetics; Microsomes, Liver; Midazolam; Models, Chemical; Oxidoreductases, N-Demethylating; Protein Isoforms; Quinidine; Rabbits; Rifampin; Time Factors

2001
Determination of the enzyme(s) involved in the metabolism of amiodarone in liver and intestine of rat: the contribution of cytochrome P450 3A isoforms.
    Drug metabolism and disposition: the biological fate of chemicals, 2006, Volume: 34, Issue:1

    Topics: Administration, Oral; Amiodarone; Animals; Area Under Curve; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Half-Life; Injections, Intravenous; Intestinal Mucosa; Intestines; Isoenzymes; Ketoconazole; Liver; Male; Microsomes, Liver; Rats; Rats, Sprague-Dawley

2006
Stimulation of human monocytic THP-1 cells by metabolic activation of hepatotoxic drugs.
    Drug metabolism and pharmacokinetics, 2012, Volume: 27, Issue:6

    Topics: Albendazole; Amiodarone; B7-2 Antigen; Biotransformation; Cell Line, Tumor; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP3A; Humans; Intercellular Adhesion Molecule-1; Interleukin-8; Ketoconazole; Leukemia, Myeloid; Microsomes, Liver; Monocytes; RNA, Messenger; Tumor Necrosis Factor-alpha; Up-Regulation

2012
The role of CYP 3A4 and 1A1 in amiodarone-induced hepatocellular toxicity.
    Toxicology letters, 2016, Jun-24, Volume: 253

    Topics: Activation, Metabolic; Amiodarone; Anti-Arrhythmia Agents; Benzoflavones; Cell Survival; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dose-Response Relationship, Drug; Hep G2 Cells; Hepatocytes; Humans; Ketoconazole; Time Factors; Transfection

2016