desacetyl-alacepril has been researched along with captopril in 9 studies
*Captopril: A potent and specific inhibitor of PEPTIDYL-DIPEPTIDASE A. It blocks the conversion of ANGIOTENSIN I to ANGIOTENSIN II, a vasoconstrictor and important regulator of arterial blood pressure. Captopril acts to suppress the RENIN-ANGIOTENSIN SYSTEM and inhibits pressure responses to exogenous angiotensin. [MeSH]
*Captopril: A potent and specific inhibitor of PEPTIDYL-DIPEPTIDASE A. It blocks the conversion of ANGIOTENSIN I to ANGIOTENSIN II, a vasoconstrictor and important regulator of arterial blood pressure. Captopril acts to suppress the RENIN-ANGIOTENSIN SYSTEM and inhibits pressure responses to exogenous angiotensin. [MeSH]
| Studies (desacetyl-alacepril) | Trials (desacetyl-alacepril) | Recent Studies (post-2010) (desacetyl-alacepril) | Studies (captopril) | Trials (captopril) | Recent Studies (post-2010) (captopril) |
|---|---|---|---|---|---|
| 9 | 0 | 0 | 10,320 | 1,514 | 890 |
| Protein | Taxonomy | desacetyl-alacepril (IC50) | captopril (IC50) |
|---|---|---|---|
| Leukotriene A-4 hydrolase | Homo sapiens (human) | 3.6 | |
| Angiotensin-converting enzyme | Homo sapiens (human) | 0.084 | |
| Angiotensin-converting enzyme | Oryctolagus cuniculus (rabbit) | 0.0173 | |
| Succinyl-diaminopimelate desuccinylase | Haemophilus influenzae Rd KW20 | 3.3 | |
| Angiotensin-converting enzyme | Rattus norvegicus (Norway rat) | 0.1004 | |
| Beta-lactamase | Pseudomonas aeruginosa | 5 | |
| Angiotensin-converting enzyme 2 | Homo sapiens (human) | 0.011 | |
| Beta-lactamase class B VIM-2 | Pseudomonas aeruginosa | 3.5 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (66.67) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hashimoto, M; Hosoki, K; Matsumoto, K; Miyazaki, H; Nambu, K; Takeyama, K | 1 |
| Fujii, T; Hashimoto, M; Matsumoto, K; Miyazaki, H; Nambu, K; Takeyama, K | 1 |
| Amejima, H; Fujii, T; Hashimoto, M; Matsumoto, K; Miyazaki, H; Yoshida, K | 1 |
| Fujitani, B; Ito, T; Kadokawa, T; Matsuno, Y; Taira, N | 1 |
| Hori, H; Ito, T; Kadokawa, T; Matsuno, Y; Nakamura, H; Oka, M | 1 |
| Hosoki, K; Ikeno, A; Kadokawa, T; Minato, H; Takeyama, K | 1 |
| Mori, A; Noda, Y; Packer, L | 1 |
| Hirano, K; Iguchi, K; Katagiri, Y; Kiho, T; Kubota, M; Sugiyama, T; Usui, S | 1 |
| Katada, K; Kuroda, M; Manabe, H; Naito, Y; Nakabe, N; Shimozawa, M; Uchiyama, K; Yoshida, N; Yoshikawa, T | 1 |
9 other study(ies) available for desacetyl-alacepril and captopril
| Article | Year |
|---|---|
Tissue levels, tissue angiotensin converting enzyme inhibition and antihypertensive effect of the novel antihypertensive agent alacepril in renal hypertensive rats.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Aorta; Blood Pressure; Captopril; Hypertension, Renovascular; Kidney; Lung; Male; Rats; Rats, Inbred Strains | 1986 |
Metabolism of protein conjugate of desacetyl-alacepril and its effect on angiotensin converting enzyme in renal hypertensive rats.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Aorta; Captopril; Feces; Hypertension, Renovascular; Kidney; Lung; Male; Protein Binding; Rats; Rats, Inbred Strains | 1986 |
Disposition and metabolism of the novel antihypertensive agent alacepril in rats.
Topics: Administration, Oral; Animals; Antihypertensive Agents; Bile; Captopril; Feces; Gas Chromatography-Mass Spectrometry; In Vitro Techniques; Injections, Intravenous; Intestine, Small; Kidney; Liver; Lung; Male; Rats; Rats, Inbred Strains; Time Factors | 1986 |
General pharmacology of the novel angiotensin converting enzyme inhibitor alacepril. 1st communication: Effects on cardiovascular, visceral and renal functions and on blood.
Topics: Animals; Antihypertensive Agents; Autonomic Nervous System; Blood Coagulation; Blood Pressure; Captopril; Cats; Digestive System; Dogs; Female; Guinea Pigs; Heart Rate; Hemodynamics; In Vitro Techniques; Kidney; Male; Mice; Muscle, Smooth; Muscle, Smooth, Vascular; Nictitating Membrane; Platelet Aggregation; Rabbits; Rats | 1986 |
General pharmacology of the novel angiotensin converting enzyme inhibitor alacepril. 2nd communication: Effects on central nervous and sensory systems and on the other functions.
Topics: Animals; Anticonvulsants; Antihypertensive Agents; Behavior, Animal; Body Temperature; Capillary Permeability; Captopril; Cats; Central Nervous System; Female; Male; Mice; Neuromuscular Junction; Rabbits; Rats; Reflex; Sensation; Sleep | 1986 |
Antihypertensive mechanism of alacepril: effect on norepinephrine-induced vasoconstrictive response in vitro and in vivo.
Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Blood Pressure; Captopril; Hypertension; In Vitro Techniques; Male; Mesenteric Arteries; Norepinephrine; Rats; Rats, Inbred Strains; Vasoconstriction | 1986 |
Free radical scavenging properties of alacepril metabolites and lisinopril.
Topics: Angiotensin-Converting Enzyme Inhibitors; Captopril; Dose-Response Relationship, Drug; Electron Spin Resonance Spectroscopy; Free Radical Scavengers; Lisinopril; Nitric Oxide; Superoxides | 1997 |
Sialic acid 9-O-acetylesterase catalyzes the hydrolyzing reaction from alacepril to deacetylalacepril.
Topics: Acetyltransferases; Amino Acid Sequence; Animals; Antihypertensive Agents; Captopril; Chromatography, Liquid; Hydrolysis; Liver; Male; Mass Spectrometry; Molecular Sequence Data; Molecular Weight; Rats; Rats, Sprague-Dawley; Sequence Analysis, Protein; Substrate Specificity | 2003 |
The inhibitory effect of alacepril, an angiotensin-converting enzyme inhibitor, on endothelial inflammatory response induced by oxysterol and TNF-alpha.
Topics: Angiotensin-Converting Enzyme Inhibitors; Captopril; Cell Adhesion; Dose-Response Relationship, Drug; Enalapril; Endothelium, Vascular; Inflammation; Intercellular Adhesion Molecule-1; Ketocholesterols; Monocytes; Reactive Oxygen Species; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1 | 2004 |