deracoxib and melarsomine

A 5-year-old female spayed Labrador Retriever dog was referred to the Louisiana State University Veterinary Teaching Hospital for treatment of pneumothorax. Thoracic radiographs and computed tomography showed spontaneous pneumothorax, thoracic lymphadenopathy, pulmonary hypertension, and multifocal pulmonary bulla lesions. At surgery, numerous adult nematodes protruded from the parenchyma of the left caudal and accessory lung lobes and pulmonary arteries. On histopathology, multiple adult filarid nematodes were observed within the pulmonary blood vessels. Broad foci of necrosis of the pulmonary parenchyma were present. The tunica intima of the pulmonary arteries was markedly thickened by intimal fibrosis and medial hypertrophy. The final diagnosis was severe Dirofilaria immitis infection that resulted in pulmonary vascular lesions and focally extensive infarcts of the pulmonary parenchyma with bulla formation and rupture causing spontaneous pneumothorax. The dog received antibiotic and steroid therapy, as well as adulticide treatment, and recovered.

Topics: Animals; Anthelmintics; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Arsenicals; Dirofilaria immitis; Dirofilariasis; Dog Diseases; Dogs; Female; Pneumothorax; Sulfonamides; Triazines