deoxyuridine has been researched along with folic acid in 122 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 100 (81.97) | 18.7374 |
| 1990's | 17 (13.93) | 18.2507 |
| 2000's | 4 (3.28) | 29.6817 |
| 2010's | 1 (0.82) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lietman, PS; Rogers, HJ | 1 |
| Ganeshaguru, K; Hoffbrand, AV | 1 |
| Chanarin, I | 3 |
| Saunders, JE; Wickramasinghe, SN | 2 |
| Van Der Weyden, MB | 1 |
| Burman, JF; Mollin, DL; Sladden, RA; Sourial, NA | 1 |
| Marquet, J; Zittoun, J; Zittoun, R | 1 |
| Hansen, OP | 1 |
| Bacon, B; Goodman, A; Hines, JD | 1 |
| Sauer, H; Wilmanns, W | 1 |
| Chanarin, I; Laundy, M; Reid, C; Reynolds, EH; Taguchi, H | 1 |
| Bonney, RJ; Maley, F | 1 |
| Cheng, FW; Shane, B; Stokstad, EL | 1 |
| Goldman, ID; Rape, TJ; Seither, RL | 2 |
| Bunni, M; Freisheim, JH; Galivan, J; Priest, DG; Rhee, M; Whiteley, JM | 1 |
| Brumley, J; Hayman, RJ; Rose, IS; van der Weyden, MB | 1 |
| Cravo, ML; Mason, JB; Rosenberg, IH; Selhub, J | 1 |
| Sakamoto, S | 2 |
| Alarcòn, GS; Baggott, JE; Everson, MP; Hardin, JM; Hine, RJ; Koopman, WJ; Krumdieck, CL; Morgan, SL | 1 |
| Butterworth, CE; Cole, P; Hatch, KD; Sauberlich, HE; Soong, SJ; Tamura, T | 1 |
| Gill, DS; Latham, J; Wickramasinghe, SN | 1 |
| Matthews, JH; Shiels, S; Wickramasinghe, SN | 1 |
| Ghitis, J; Schreiber, C; Waxman, S | 1 |
| Das, KC; Garewal, G; Narang, A | 1 |
| James, SJ; Yin, L | 1 |
| Goldman, ID; Mikulecky, DC; Rape, TJ; Seither, RL; Trent, DF | 1 |
| Andersen, K; Gimsing, P; Hippe, E; Melgaard, B; Vilstrup, H | 1 |
| Das, KC; Herbert, V | 1 |
| Chanarin, I; Deacon, R; Lumb, M; Muir, M; Perry, J | 1 |
| Alison, DL; Calvert, AH; Harrap, KR; Jackman, AL | 1 |
| Galivan, J; Nimec, Z; Rhee, M | 1 |
| Bassendine, MF; Curtin, NJ; Harris, AL; James, OF | 1 |
| Reidy, JA | 2 |
| Abels, J; Ermens, AA; Lindemans, J | 1 |
| Abels, J; Ermens, AA; Kroes, AC; Lindemans, J; Schoester, M; van Lom, K | 1 |
| Matthews, JH; Wickramasinghe, SN | 2 |
| Herbert, V | 1 |
| Iwata, N; Maekawa, T; Omine, M; Yamauchi, H | 1 |
| Iwata, N; Karasawa, M; Katahira, H; Maekawa, T; Omine, M; Sugita, Y; Tokue, Y; Tsukamoto, N; Yamauchi, H; Yatabe, H | 1 |
| Karasawa, M; Maekawa, T; Omine, M; Yatabe, H | 1 |
| Johnson, HL; Kretsch, MJ; Sauberlich, HE; Skala, JH; Taylor, PC | 1 |
| Allegra, CJ; Chabner, BA; Drake, JC; Fine, RL | 1 |
| Abels, J; Kroes, AC; Lindemans, J; Schoester, M | 1 |
| Herbert, V; Kanazawa, S | 1 |
| Milman, G; Osborne, C; Shane, B; Sussman, DJ | 1 |
| Amos, RJ; Bingham, RM; Cole, PV; Petty, AC; Sweeney, B | 1 |
| Allen, SM; Blundell, EL; Matthews, JH; Middleton, AM; Morris, JE; Wickramasinghe, SN | 1 |
| Amess, JA; Amos, RJ; Hinds, CJ; Mollin, DL | 2 |
| Catovsky, D; Das, KC; Hoffbrand, V; Tripp, E | 1 |
| Greenspan, EM; Schreiber, C; Waxman, S | 1 |
| Cooper, M; Koutts, J; Van der Weyden, MB | 1 |
| DaCosta, M; Kamen, B; Rothenberg, SP | 1 |
| Dodsworth, H; Hulme, B; Rault, RM; Wickramasinghe, SN | 1 |
| Cooper, M; Firkin, BG; Van der Weyden, MB | 1 |
| Brewer, CF; Santi, DV | 1 |
| Brenner, L; Herbert, V; Tisman, G | 1 |
| Hoffbrand, AV; Houlihan, CM; Scott, JM; Tripp, E | 1 |
| Auletta, AE; Davis, J; Gery, AM; Mead, JA; Mishra, L; Parmar, A | 1 |
| Hillcoat, BL; Kawai, M | 1 |
| Crawford, EJ; Friedkin, M; Livingston, D | 1 |
| Borsa, J; Whitmore, GF | 1 |
| Roscoe, DH; Tucker, RG | 1 |
| Mead, JA; Mishra, LC | 1 |
| Green, R; Metz, J; Sive, J | 1 |
| Firkin, BG; Rother, M; Van der Weyden, MB | 1 |
| Bertino, JR; Chabner, BA; Chello, PL | 1 |
| Hammond, D; Hyman, CB; Lampkin, BC; Pyesmany, A | 1 |
| Bertino, JR; Hryniuk, WM | 1 |
| Kammen, HO | 1 |
| Corcino, J; Herbert, V; Waxman, S | 1 |
| Das, KC; Hoffbrand, AV | 1 |
| Evans, VJ; Otani, TT; Price, FM; Rotherham, J | 1 |
| Joseph, LB; Simon, GT; Singh, AD; Singh, SP; Von Essen, CF | 1 |
| Herbert, V; Kelly, A; Metz, J; Swett, VC; Waxman, S | 1 |
| Herbert, V; Waxman, S | 1 |
| Besserer, JA; Boritzki, TJ; Elslager, EF; Fry, DW; Jackson, RC; Leopold, WR; Sloan, BJ | 1 |
| Kano, Y; Kubota, T; Miura, Y; Sakamoto, S; Sakuraya, K; Taguchi, H; Takaku, F | 1 |
| Abdalla, SH; Weatherall, DJ; Wickramasinghe, SN | 1 |
| Akinyanju, OO; Grange, A; Litwinczuk, RA; Wickramasinghe, SN | 1 |
| Calvert, AH; Harrap, KR; Jackman, AL; Taylor, GA | 1 |
| Abels, J; Kroes, AC; Lindemans, J | 1 |
| Campbell, CL; Fonda, S; Hillman, RS; Steinberg, SE | 1 |
| Brøndum Nielsen, K; Friis, B; Hippe, E; Hjelt, K; Tommerup, N | 1 |
| Calvert, AH; Jackman, AL; Jackson, RC | 1 |
| Deacon, R; Lumb, MJ; Perry, J | 1 |
| Chanarin, I; Hewlett, AM; Lewis, JD; Lumb, M; Nunn, JF; Skacel, PO | 1 |
| Lindenbaum, J | 1 |
| Hoffbrand, AV; Jackson, BF; Taheri, MR; Wickremasinghe, RG | 1 |
| Bruckner, H; Waxman, S | 1 |
| Nauss, KM; Newberne, PM | 1 |
| Wickramasinghe, SN | 1 |
| Hida, K; Kano, Y; Sakamoto, S; Suda, K; Takaku, F | 1 |
| Schreiber, C; Waxman, S | 1 |
| Chanarin, I; Deacon, R; Lumb, M; Perry, J | 3 |
| McKenna, B; Scott, JM; Weir, DG | 1 |
| Das, KC; Herbert, V; Manusselis, C | 1 |
| Goodman, AM; Harris, JW; Kiraly, D | 1 |
| Fernandes-Costa, F; Metz, J; Miller, H | 1 |
| Armstrong, J; Rennie, JS; Whitehead, CC | 1 |
| Erlichman, C; Mandelbaum, S; Mitrovski, B; Pressacco, J | 1 |
| Arza, B; Barceló, MJ; Cadafalch, J; García-Die, F; Parellada, MM; Remacha, A | 1 |
| Matsuda, A; Nomura, Y; Ueno, Y | 1 |
| Sage, CR; Stout, TJ; Stroud, RM | 1 |
| Liu, Y; Santi, DV | 1 |
| Zittoun, J; Zittoun, R | 1 |
| Aherne, GW; Benstead, J; Clarke, SJ; Farrugia, DC; Jackman, AL; Pritchard, DM | 1 |
| Evans, VJ; Price, FM; Rotherham, J | 1 |
| Bacherikov, VA; Chao, TC; Chen, CM; Chen, KT; Huang, YL; Lee, YJ; Li, WW; Lin, CF; Su, TL | 1 |
| ANSFIELD, FJ | 1 |
| Burren, KA; Chitty, LS; Copp, AJ; Doudney, K; Dunlevy, LP; Greene, ND; Scott, R; Stanier, P; Stojilkovic-Mikic, T | 1 |
| Clarke, SJ; Li, KM; Rivory, LP | 1 |
| Field, MS; Finkelstein, JL; Martiniova, L; Perry, CA; Stover, PJ | 1 |
9 review(s) available for deoxyuridine and folic acid
| Article | Year |
|---|---|
Isotopes in megaloblastic anaemia.
Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Antibodies; Cobalt Radioisotopes; Deoxyuridine; Folic Acid; Humans; Intestinal Absorption; Intrinsic Factor; Isotope Labeling; Protein Binding; Radioimmunoassay; Transcobalamins; Vitamin B 12 | 1977 |
Cobalamin-folate interrelations: a critical review.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Anemia, Megaloblastic; Animals; Central Nervous System; Deoxyuridine; Disease Models, Animal; Drug Interactions; Enzyme Activation; Folic Acid; Folic Acid Deficiency; Histidine; Humans; Liver; Methionine; Methylmalonyl-CoA Mutase; Nitrous Oxide; Oxidation-Reduction; Pteroylpolyglutamic Acids; Purines; Serine; Tetrahydrofolates; Thymidylate Synthase; Vitamin B 12; Vitamin B 12 Deficiency | 1985 |
Making sense of laboratory tests of folate status: folate requirements to sustain normality.
Topics: Age Factors; Anemia; Deoxyuridine; Erythropoiesis; Folic Acid; Folic Acid Deficiency; Humans; Nutritional Requirements | 1987 |
Cobalamins and nitrous oxide: a review.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Bone Marrow; Cobamides; Deoxyuridine; Ethanolamine Ammonia-Lyase; Folic Acid; Humans; Liver; Methylmalonyl-CoA Mutase; Nitrous Oxide; Pteroylpolyglutamic Acids; Vitamin B 12 | 1980 |
Vitamin B12, folate and nitrous oxide.
Topics: Anemia, Megaloblastic; Animals; Deoxyuridine; Folic Acid; Formates; Hematopoiesis; Humans; Methylation; Nitrous Oxide; Vitamin B 12 | 1982 |
Nitrous oxide and the cobalamins.
Topics: Anesthesia, Inhalation; Animals; Chemical Phenomena; Chemistry; Coenzymes; Deoxyuridine; Folic Acid; Humans; Liver; Methylation; Nervous System; Nitrous Oxide; Pteroylpolyglutamic Acids; Rats; Vitamin B 12 | 1980 |
Effects of dietary folate, vitamin B12 and methionine/choline deficiency on immune function.
Topics: Animals; Antibody Formation; Choline Deficiency; Deoxyuridine; Drug Interactions; Folic Acid; Folic Acid Deficiency; Humans; Hypersensitivity, Delayed; Immunity; Lymphocyte Activation; Lymphocytes; Lymphoid Tissue; Methionine; Vitamin B 12; Vitamin B 12 Deficiency | 1981 |
The deoxyuridine suppression test: a review of its clinical and research applications.
Topics: Alcoholism; Anemia, Hemolytic; Anticonvulsants; Bone Marrow Cells; Bone Marrow Diseases; Cells; Deoxyuridine; Erythrocytes, Abnormal; Female; Fluorouracil; Folic Acid; Folic Acid Deficiency; Formyltetrahydrofolates; Homocysteine; Humans; Hypothyroidism; Lymphocyte Activation; Methionine; Pregnancy; Pregnancy Complications; Statistics as Topic; Tetrahydrofolates; Vitamin B 12; Vitamin B 12 Deficiency | 1981 |
Modern clinical testing strategies in cobalamin and folate deficiency.
Topics: Deoxyuridine; Folic Acid; Folic Acid Deficiency; Humans; Vitamin B 12; Vitamin B 12 Deficiency | 1999 |
2 trial(s) available for deoxyuridine and folic acid
| Article | Year |
|---|---|
Evaluation of the deoxyuridine suppression test by using whole blood samples from folic acid-supplemented subjects.
Topics: Adult; Deoxyuridine; DNA; Erythrocytes; Female; Folic Acid; Humans; Male; Middle Aged; Nutritional Status; Random Allocation; Thymidine; Uterine Cervical Dysplasia; Vitamin B 12 | 1990 |
Pemetrexed pharmacokinetics and pharmacodynamics in a phase I/II study of doublet chemotherapy with vinorelbine: implications for further optimisation of pemetrexed schedules.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Carcinoma, Non-Small-Cell Lung; Deoxyuridine; Dietary Supplements; Dose-Response Relationship, Drug; Female; Folic Acid; Glutamates; Guanine; Homocysteine; Humans; Lung Neoplasms; Male; Methylmalonic Acid; Middle Aged; Pemetrexed; Thymidine; Thymidylate Synthase; Vinblastine; Vinorelbine; Vitamin B 12 | 2007 |
111 other study(ies) available for deoxyuridine and folic acid
| Article | Year |
|---|---|
The in vitro effect of trimethoprim on blastogenic transformation of human peripheral blood lymphocytes.
Topics: Autoradiography; Cells, Cultured; Concanavalin A; Deoxyuridine; Folic Acid; Formates; Humans; In Vitro Techniques; Leucine; Leucovorin; Lymphocyte Activation; Lymphocytes; Thymidine; Time Factors; Trimethoprim; Uridine | 1977 |
The effect of deoxyuridine, vitamin B12, folate and alcohol on the uptake of thymidine and on the deoxynucleoside triphosphate concentrations in normal and megaloblastic cells.
Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Bone Marrow; Cells, Cultured; Deoxyadenine Nucleotides; Deoxyuridine; DNA; Ethanol; Folic Acid; Humans; Leucovorin; Lymphocytes; Tetrahydrofolates; Thymidine; Thymine Nucleotides; Vitamin B 12 | 1978 |
Results of three years' experience with the deoxyuridine suppression test.
Topics: Alcoholism; Anemia, Hemolytic; Anemia, Hypochromic; Anticonvulsants; Azathioprine; Deoxyuridine; Epilepsy; Erythrocytes; Erythrocytes, Abnormal; Erythropoiesis; Evaluation Studies as Topic; Folic Acid; Folic Acid Antagonists; Folic Acid Deficiency; Humans; Mercaptopurine; Sulfamethoxazole; Thioguanine; Trimethoprim; Vitamin B 12 Deficiency | 1977 |
Deoxyuridine metabolism in human megaloblastic marrow cells.
Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Bone Marrow; Deoxyuridine; DNA; Folic Acid; Folic Acid Deficiency; Humans; Methotrexate; Thymidine; Thymidylate Synthase; Vitamin B 12; Vitamin B 12 Deficiency | 1979 |
Inherited lack of transcobalamin II in serum and megaloblastic anaemia: a further patient.
Topics: Adult; Anemia, Macrocytic; Anemia, Megaloblastic; Blood Proteins; Bone Marrow; Deoxyuridine; Folic Acid; Humans; Intestinal Absorption; Male; Transcobalamins; Vitamin B 12; Vitamin B 12 Deficiency | 1979 |
Effect of folate and cobalamin compounds on the deoxyuridine suppression test in vitamin B12 and folate deficiency.
Topics: Deoxyuridine; Folic Acid; Folic Acid Deficiency; Humans; Methotrexate; Thymidine; Vitamin B 12; Vitamin B 12 Deficiency | 1978 |
Bone marrow studies in myelomatosis.
Topics: Adult; Aged; Bone Marrow; Deoxyuridine; Female; Folic Acid; Formiminoglutamic Acid; Glomerular Filtration Rate; Humans; Iron; Male; Middle Aged; Multiple Myeloma; Plasma Cells; Vitamin B 12 | 1978 |
Deoxyuridine suppression studies in bone marrow in primary refractory sideroblastic anemia.
Topics: Adult; Aged; Anemia, Sideroblastic; Bone Marrow; Deoxyuridine; Female; Folic Acid; Humans; Iron; Liver Function Tests; Male; Middle Aged; Vitamin B 12 | 1978 |
Cobalamin dependent methionine synthesis and methyl-folate-trap in human vitamin B12 deficiency.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Bone Marrow; Bone Marrow Cells; Deoxyuridine; Folic Acid; Humans; Methotrexate; Methyltransferases; Tetrahydrofolates; Thymidine; Vitamin B 12 Deficiency | 1977 |
The effect of anticonvulsant drugs on thymidine and deoxyribosenucleic acid synthesis by human marrow cells.
Topics: Anticonvulsants; Bone Marrow; Bone Marrow Cells; Deoxyuridine; DNA; Folic Acid; Humans; Phenytoin; Thymidine; Vitamin B 12 | 1977 |
Letter: deoxyuridine suppression test.
Topics: Bone Marrow; Bone Marrow Cells; Deoxyuridine; Diagnosis, Differential; Folic Acid; Folic Acid Deficiency; Humans; In Vitro Techniques; Vitamin B 12 Deficiency | 1975 |
Effect of methotrexate on thymidylate synthetase in cultured parenchymal cells isolated from regenerating rat liver.
Topics: Animals; Cells, Cultured; Cycloheximide; Dactinomycin; Deoxyuridine; Dose-Response Relationship, Drug; Folic Acid; Liver; Liver Regeneration; Methotrexate; Methyltransferases; Protein Biosynthesis; Puromycin; Rats; Stimulation, Chemical; Tetrahydrofolate Dehydrogenase; Thymidine Kinase; Thymidylate Synthase | 1975 |
The anti-folate effect of methionine on bone marrow of normal and vitamin B12 deficient rats.
Topics: Animals; Bone Marrow; Deoxyuridine; DNA; Folic Acid; Folic Acid Antagonists; Homocysteine; Liver; Male; Methionine; Methionine Adenosyltransferase; Rats; Thymidine; Vitamin B 12; Vitamin B 12 Deficiency | 1975 |
Interconversion of tetrahydrofolate cofactors to dihydrofolate induced by trimetrexate after suppression of thymidylate synthase by fluorodeoxyuridine in L1210 leukemia cells.
Topics: Animals; Computer Simulation; Deoxyuridine; DNA; Enzyme Reactivators; Floxuridine; Folic Acid; Folic Acid Antagonists; Leucovorin; Leukemia L1210; Mice; Purines; Tetrahydrofolates; Thermodynamics; Thymidylate Synthase; Time Factors; Trimetrexate; Tumor Cells, Cultured | 1992 |
The effect of methotrexate on the folate coenzyme pools in human hepatoma cells in culture.
Topics: Carbon Radioisotopes; Carcinoma, Hepatocellular; Deoxyuridine; Folic Acid; Glycine; Humans; Kinetics; Liver Neoplasms; Methotrexate; Tritium; Tumor Cells, Cultured | 1991 |
Folate-deficient human lymphoblasts: changes in deoxynucleotide metabolism and thymidylate cycle activities.
Topics: Deoxyadenine Nucleotides; Deoxycytosine Nucleotides; Deoxyguanine Nucleotides; Deoxyuridine; Dose-Response Relationship, Drug; Folic Acid; Folic Acid Deficiency; Humans; Lymphocyte Activation; Lymphocytes; Nucleotides; Thymidine; Thymidylate Synthase; Thymine Nucleotides | 1991 |
Use of the deoxyuridine suppression test to evaluate localized folate deficiency in rat colonic epithelium.
Topics: Animals; Cells, Cultured; Colon; Deoxyuridine; DNA; Epithelium; Fluorouracil; Folic Acid; Male; Rats; Rats, Inbred Strains; Thymidine | 1991 |
[Megaloblastic anemia].
Topics: Adult; Aged; Anemia, Megaloblastic; Bone Marrow; Deoxyuridine; DNA; Female; Folic Acid; Humans; Male; Methylmalonic Acid; Middle Aged; Schilling Test; Vitamin B 12 | 1991 |
Methotrexate therapy in rheumatoid arthritis patients diminishes lectin-induced mononuclear cell proliferation.
Topics: Arthritis, Rheumatoid; Cell Division; Cells, Cultured; Culture Media; Deoxyuridine; DNA; Female; Folic Acid; Humans; Lectins; Leukocytes, Mononuclear; Male; Methotrexate; Middle Aged; Phytohemagglutinins; Thymidine; Tritium | 1990 |
Effects of phenytoin sodium on doubling time, deoxyuridine suppression, 3H-methotrexate uptake and 57Co-cyanocobalamin uptake in HL60 cells.
Topics: Cell Division; Cell Survival; Cobalt Radioisotopes; Deoxyuridine; Folic Acid; Humans; Methotrexate; Phenytoin; Tritium; Tumor Cells, Cultured; Vitamin B 12 | 1990 |
The effects of folate deficiency on thymidylate synthetase activity, deoxyuridine suppression, cell size and doubling time in a cultured human myeloid cell line.
Topics: Cell Division; Cell Survival; Deoxyuridine; Folic Acid; Folic Acid Deficiency; Humans; Interphase; Leukemia, Promyelocytic, Acute; Thymidylate Synthase; Tumor Cells, Cultured | 1990 |
[Clinical diagnosis and therapy of megaloblastic anemia].
Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Bone Marrow Cells; Deoxyuridine; DNA; Folic Acid; Folic Acid Deficiency; Humans; Schilling Test; Vitamin B 12; Vitamin B 12 Deficiency | 1990 |
Phosphate-induced phosphoribosylpyrophosphate elevations to assess deranged folate and purine nucleotide metabolism.
Topics: Cell Line; Deoxyuridine; Erythrocytes; Folic Acid; Humans; Leucovorin; Leukemia, Myeloid, Acute; Male; Methotrexate; Pentosephosphates; Phosphates; Phosphoribosyl Pyrophosphate; Purines; Stimulation, Chemical | 1987 |
Infantile tremor syndrome: a vitamin B12 deficiency syndrome in infants.
Topics: Anemia, Megaloblastic; Bone Marrow; Deoxyuridine; Developmental Disabilities; Erythrocytes; Female; Folic Acid; Humans; Infant; Iron; Male; Syndrome; Transcobalamins; Tremor; Vitamin B 12; Vitamin B 12 Deficiency | 1988 |
Further studies on the pharmacologic effects of the 7-hydroxy catabolite of methotrexate in the L1210 murine leukemia cell.
Topics: Animals; Deoxyuridine; Folic Acid; Folic Acid Antagonists; Formates; Leucovorin; Leukemia L1210; Methotrexate; Mice; Polyglutamic Acid; Tumor Cells, Cultured | 1989 |
Diet-induced DNA damage and altered nucleotide metabolism in lymphocytes from methyl-donor-deficient rats.
Topics: Animals; Choline; Choline Deficiency; Deoxyuridine; Diet; DNA Damage; DNA Replication; Folic Acid; Folic Acid Deficiency; Liver; Lymphocytes; Male; Methionine; NAD; Nucleotides; Rats; Rats, Inbred F344; Reference Values; RNA; Spleen; Thymidine | 1989 |
Folate-pool interconversions and inhibition of biosynthetic processes after exposure of L1210 leukemia cells to antifolates. Experimental and network thermodynamic analyses of the role of dihydrofolate polyglutamylates in antifolate action in cells.
Topics: Animals; Computer Simulation; Deoxyuridine; Floxuridine; Folic Acid; Folic Acid Antagonists; Formates; Leukemia L1210; Methotrexate; Mice; Purines; Pyrimidines; Quinazolines; Tetrahydrofolates; Thermodynamics; Thymidylate Synthase; Trimetrexate | 1989 |
Vitamin B-12 and folate function in chronic alcoholic men with peripheral neuropathy and encephalopathy.
Topics: Adult; Alcoholism; Deoxyuridine; Folic Acid; Folic Acid Deficiency; Formiminoglutamic Acid; Hematologic Tests; Hepatic Encephalopathy; Humans; Liver Function Tests; Male; Middle Aged; Neurologic Examination; Peripheral Nervous System Diseases; Vitamin B 12; Vitamin B 12 Deficiency | 1989 |
In vitro DNA synthesis by megaloblastic bone marrow: effect of folates and cobalamins on thymidine incorporation and de novo thymidylate synthesis.
Topics: Adolescent; Adult; Aged; Bone Marrow; Deoxyuridine; DNA; Erythrocytes, Abnormal; Female; Folic Acid; Humans; Male; Megaloblasts; Middle Aged; Thymidine; Thymidine Kinase; Thymidine Monophosphate; Vitamin B 12 | 1989 |
Increased thymidylate synthase in L1210 cells possessing acquired resistance to N10-propargyl-5,8-dideazafolic acid (CB3717): development, characterization, and cross-resistance studies.
Topics: Animals; Antineoplastic Agents; Cells, Cultured; Deoxyuridine; Drug Resistance; Floxuridine; Fluorouracil; Folic Acid; Folic Acid Antagonists; Hypoxanthine; Hypoxanthines; Kinetics; Leukemia L1210; Mice; Quinazolines; Thymidylate Synthase; Tritium | 1986 |
Synergistic growth inhibition of rat hepatoma cells exposed in vitro to N10-propargyl-5,8-dideazafolate with methotrexate or the lipophilic antifolates trimetrexate or metoprine.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Cycle; Deoxyuridine; Folic Acid; Folic Acid Antagonists; Liver Neoplasms, Experimental; Methotrexate; Pyrimethamine; Quinazolines; Rats; Thymidine; Thymidylate Synthase; Trimetrexate | 1987 |
Inhibition of the growth of human hepatocellular carcinoma in vitro and in athymic mice by a quinazoline inhibitor of thymidylate synthase, CB3717.
Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Deoxyuridine; Dose-Response Relationship, Drug; Folic Acid; Humans; In Vitro Techniques; Liver Neoplasms; Mice; Mice, Nude; Neoplasm Transplantation; Quinazolines; Thymidine | 1986 |
Folate- and deoxyuridine-sensitive chromatid breakage may result from DNA repair during G2.
Topics: Aphidicolin; Chromosome Aberrations; Chromosome Fragility; Cytarabine; Deoxyuridine; Diterpenes; DNA Repair; Folic Acid; Humans; In Vitro Techniques; Interphase; Lymphocytes; Uracil | 1987 |
Moderate antiproliferative effect of the antifolate CB3717 in the BN myeloid leukaemia model.
Topics: Animals; Antineoplastic Agents; Deoxyuridine; DNA; Fluorouracil; Folic Acid; Folic Acid Antagonists; Leukemia, Myeloid, Acute; Quinazolines; Rats; Thymidine Monophosphate; Thymidylate Synthase | 1988 |
Effect of cobalamin inactivation on folate metabolism of leukemic cells.
Topics: Bone Marrow; Cell Line; Deoxyuridine; Female; Folic Acid; Humans; Leukemia; Male; Methotrexate; Nitrous Oxide; Tumor Cells, Cultured; Vitamin B 12 | 1988 |
The deoxyuridine suppression test performed on phytohaemagglutinin-stimulated peripheral blood cells fails to reflect in vivo vitamin B12 or folate deficiency.
Topics: Aged; Blood Cells; Deoxyuridine; Female; Folic Acid; Folic Acid Deficiency; Humans; Leucovorin; Male; Osmolar Concentration; Phytohemagglutinins; Vitamin B 12 Deficiency | 1988 |
[Folate status in vitamin B12-deficient megaloblastic bone marrow cells: enhanced sensitivity to methotrexate and increased rescue effects of folates].
Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Deoxyuridine; DNA; Female; Folic Acid; Humans; Male; Methotrexate; Vitamin B 12 Deficiency | 1988 |
[Relative sensitivity of acute leukemia cells to methotrexate in vitro and the rescue effects of folates].
Topics: Deoxyuridine; Drug Screening Assays, Antitumor; Folic Acid; Humans; Leukemia, Myeloid, Acute; Methotrexate; Tumor Cells, Cultured | 1987 |
Growth and DNA synthesis of folate- and methionine-depleted L1210 mouse leukemia cells in culture.
Topics: Animals; Cell Division; Cells, Cultured; Deoxyuridine; DNA; Folic Acid; Leucovorin; Leukemia L1210; Methionine; Mice | 1987 |
Folate requirement and metabolism in nonpregnant women.
Topics: Adult; Deoxyuridine; Diet; FIGLU Test; Folic Acid; Hematocrit; Hemoglobins; Humans; Lymphocytes; Male; Neutrophils; Nutritional Requirements | 1987 |
The effect of methotrexate on intracellular folate pools in human MCF-7 breast cancer cells. Evidence for direct inhibition of purine synthesis.
Topics: Breast Neoplasms; Cell Division; Cell Line; Chromatography, High Pressure Liquid; Deoxyuridine; Female; Folic Acid; Formyltetrahydrofolates; Humans; Methotrexate; Purines; Time Factors | 1986 |
Acquired folate deficiency in phytohaemagglutinin-stimulated human lymphocytes.
Topics: Cells, Cultured; Culture Media; Deoxyuridine; Dose-Response Relationship, Drug; Folic Acid; Folic Acid Deficiency; Humans; Lymphocyte Activation; Lymphocytes; Phytohemagglutinins; Thymidine | 1986 |
Enhanced therapeutic effect of methotrexate in experimental rat leukemia after inactivation of cobalamin (vitamin B12) by nitrous oxide.
Topics: Animals; Blood Cell Count; Deoxyuridine; Drug Administration Schedule; Drug Synergism; Folic Acid; Leukemia, Experimental; Male; Methotrexate; Nitrous Oxide; Rats; Thymine Nucleotides; Vitamin B 12 | 1986 |
Detection of folate deficiency in alcoholism using the peripheral blood lymphocyte deoxyuridine suppression test.
Topics: Adult; Alcoholism; Cell Nucleus; Deoxyuridine; DNA Replication; Erythrocytes; Folic Acid; Folic Acid Deficiency; Humans; Lymphocytes; Middle Aged; Predictive Value of Tests | 1986 |
Deoxyuridine increases folate-sensitive fragile site expression in human lymphocytes.
Topics: Chromosome Fragile Sites; Chromosome Fragility; Deoxyuracil Nucleotides; Deoxyuridine; DNA; Folic Acid; Humans; In Vitro Techniques; Lymphocytes | 1987 |
In situ autoradiographic detection of folylpolyglutamate synthetase activity.
Topics: Animals; Autoradiography; Cell Line; Cricetinae; Deoxyuridine; DNA; Folic Acid; Peptide Synthases; Thymidylate Synthase | 1986 |
Toxicity of bone marrow in dentists exposed to nitrous oxide.
Topics: Anesthesia, Dental; Bone Marrow; Dentists; Deoxyuridine; DNA; Folic Acid; Humans; In Vitro Techniques; Male; Nitrous Oxide; Occupational Diseases; Vitamin B 12 | 1985 |
Importance of low serum vitamin B12 and red cell folate concentrations in elderly hospital inpatients.
Topics: Aged; Bone Marrow; Deoxyuridine; Erythrocytes; Folic Acid; Folic Acid Deficiency; Hemoglobins; Humans; Leukocyte Count; Neutrophils; Serum Albumin; Thyroxine; Vitamin B 12; Vitamin B 12 Deficiency | 1985 |
Investigations into the effect of nitrous oxide anaesthesia on folate metabolism in patients receiving intensive care.
Topics: Adolescent; Adult; Aged; Anesthesia; Bone Marrow; Child; Critical Care; Deoxyuridine; Erythrocytes; Female; Folic Acid; Folic Acid Deficiency; Humans; Male; Middle Aged; Nitrous Oxide; Vitamin B 12 | 1985 |
Transport of methotrexate into normal haemopoietic cells and into leukaemic cells and its effects on DNA synthesis.
Topics: Bone Marrow; Bone Marrow Cells; Carbon Radioisotopes; Culture Techniques; Cyclic AMP; Dactinomycin; Deoxyuridine; DNA; Folic Acid; Humans; Lectins; Leukemia, Lymphoid; Leukemia, Myeloid; Lymphocyte Activation; Methotrexate; Mitosis; Phosphodiesterase Inhibitors; Puromycin; RNA; Theophylline; Thymidine; Tritium | 1973 |
The role of folic acid binding proteins (FABP) in the cellular uptake of folates.
Topics: Animals; Blood; Carrier Proteins; Cell Division; Culture Media; Deoxyuridine; DNA; Female; Folic Acid; HeLa Cells; Humans; Kinetics; Lactoglobulins; Lymphocytes; Milk; Protein Binding; Tetrahydrofolates; Thymidine; Tritium | 1974 |
Effect ot trimethoprim on folate metabolism in human bone marrow.
Topics: Adult; Anemia, Macrocytic; Anti-Infective Agents; Bone Marrow; Culture Techniques; Deoxyuridine; Depression, Chemical; DNA; Drug Synergism; Female; Folic Acid; Folic Acid Antagonists; Folic Acid Deficiency; Humans; Male; Middle Aged; Pyrimidines; Thymidine; Thymine; Trimethoprim; Tritium; Vitamin B 12 Deficiency | 1973 |
DNA synthesis in chronic myelogenous leukemia cells: comparison of results in cells containing folate binding factor to replicating cells without binder.
Topics: Anemia, Hypochromic; Binding Sites; Bone Marrow Cells; Cells, Cultured; Deoxyuridine; DNA; DNA Replication; Folic Acid; Folic Acid Antagonists; Humans; Leukemia, Myeloid; Leukocytes; Lymphoma, Large B-Cell, Diffuse; Methotrexate; RNA; Thymidine; Tritium; Tuberculosis, Lymph Node; Uridine | 1972 |
Observations on the incidence and cause of macrocytosis in patients on azathioprine therapy following renal transplantation.
Topics: Anemia, Hypochromic; Azathioprine; Blood Cell Count; Bone Marrow; Bone Marrow Cells; Bone Marrow Examination; Cadaver; Deoxyuridine; DNA; Erythrocytes; Erythrocytes, Abnormal; Female; Folic Acid; Hematocrit; Humans; Kidney Function Tests; Kidney Transplantation; Liver Function Tests; Male; Time Factors; Transplantation, Homologous; Tritium; Vitamin B 12 | 1974 |
Defective DNA synthesis in human megaloblastic bone marrow: effects of hydroxy-B 12 5'-deoxyadenosyl-B 12 and methyl-B 12 .
Topics: Anemia, Macrocytic; Anemia, Pernicious; Bone Marrow; Bone Marrow Cells; Cells, Cultured; Deoxyuridine; DNA; Folic Acid; Humans; Thymidine; Thymine Nucleotides; Tritium; Vitamin B 12; Vitamin B 12 Deficiency | 1973 |
Model studies of thymidylate synthetase. Intramolecular catalysis of 5-hydrogen exchange and 5-hydroxymethylation of 1-substituted uracils.
Topics: Acetals; Carbon Isotopes; Catalysis; Chromatography, Paper; Chromatography, Thin Layer; Deoxyuridine; Deuterium; Ethers, Cyclic; Folic Acid; Hydrogen; Kinetics; Magnetic Resonance Spectroscopy; Methylation; Methyltransferases; Models, Chemical; Protons; Pyrimidinones; Ribonucleosides; Spectrophotometry, Ultraviolet; Tetrahydrofolates; Thymidylate Synthase; Tritium; Uracil; Uridine | 1973 |
The dU suppression test using 125 I-UdR to define biochemical megaloblastosis.
Topics: Anemia, Macrocytic; Bone Marrow; Deoxyuridine; DNA; Folic Acid; Folic Acid Deficiency; Humans; In Vitro Techniques; Iodine Isotopes; Methods; Thymidine; Thymine; Tritium; Vitamin B 12; Vitamin B 12 Deficiency | 1973 |
Studies on the uptake of synthetic conjugated folates by human marrow cells.
Topics: Anemia, Macrocytic; Biological Transport; Bone Marrow; Bone Marrow Cells; Coenzymes; Deoxyuridine; DNA; Folic Acid; Glutamates; Humans; Lymphocytes; Pyrimidines; Structure-Activity Relationship; Thymidine; Tritium | 1973 |
The effect of folate and folate analogs upon dihydrofolate reductase and DNA synthesis in kidneys of normal mice.
Topics: Animals; Biological Transport; Carbon Radioisotopes; Chromatography, DEAE-Cellulose; Deoxyuridine; DNA; Folic Acid; Folic Acid Antagonists; Isotope Labeling; Kidney; Male; Methotrexate; Mice; Mice, Inbred Strains; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Thymidine; Time Factors; Tritium; Ultracentrifugation; Ultrafiltration; Xanthopterin | 1974 |
Interaction of thymidylate synthetase and dihydrofolate reductase enzymes in vitro and in vivo.
Topics: Animals; Cells, Cultured; Deoxyuridine; DNA, Neoplasm; Drug Interactions; Folic Acid; Leukemia L1210; Methotrexate; Methyltransferases; Mice; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase; Tritium | 1974 |
Studies with tetrahydrohomofolate and thymidylate synthetase from amethopterin-resistant mouse leukemia cells.
Topics: Animals; Carbon Isotopes; Chemical Precipitation; Chromatography, Gel; Deoxyuridine; Drug Stability; Escherichia coli; Folic Acid; Leukemia L1210; Ligases; Methotrexate; Mice; Nucleotides; Spleen; Splenic Neoplasms; Tetrahydrofolate Dehydrogenase | 1968 |
Studies relating to the mode of action of methotrexate. 3. Inhibition of thymidylate synthetase in tissue culture cells and in cell-free systems.
Topics: Animals; Carcinoma, Ehrlich Tumor; Cell-Free System; Chromatography, Ion Exchange; Cricetinae; Culture Techniques; Deoxyuridine; DNA; Embryo, Mammalian; Escherichia coli; Folic Acid; Histocytochemistry; Kinetics; L Cells; Leucovorin; Methotrexate; Mice; Nucleotides; RNA; Thymidine; Transferases; Tritium | 1969 |
The biosynthesis of 5-hydroxymethyldeoxyuridylic acid in bacteriophage-infected Bacillus subtilis.
Topics: Aminohydrolases; Bacillus subtilis; Bacteriophages; Chromatography, Paper; Cytosine Nucleotides; Deoxyuridine; DNA, Viral; Folic Acid; Hexoses; In Vitro Techniques; Ligases; Spectrophotometry; Thymine | 1966 |
On the biochemical mechanism of action of tetrahydrohomofolic acid.
Topics: Animals; Carbon Isotopes; Cell Line; Deoxyuridine; Depression, Chemical; DNA; Drug Resistance; Folic Acid; Formates; Leukemia L1210; Male; Mice; Orotic Acid; Spleen; Tetrahydrofolate Dehydrogenase; Tetrahydrofolates; Thymine; Tritium | 1972 |
Effect of trimethoprim on folate-dependent DNA synthesis in human bone marrow.
Topics: Anti-Infective Agents; Bone Marrow; Culture Techniques; Deoxyuridine; DNA; Ethanol; Folic Acid; Folic Acid Antagonists; Humans; Methotrexate; Pyrimidines; Thymidine; Trimethoprim; Tritium | 1972 |
The metabolic significance of reduced serum B 12 in folate deficiency.
Topics: Anemia, Macrocytic; Bone Marrow; Culture Techniques; Deoxyuridine; DNA; Folic Acid; Folic Acid Deficiency; Humans; Nutritional Physiological Phenomena; Reticulocytes; Thymine; Vitamin B 12; Vitamin B 12 Deficiency | 1972 |
Antitumor activity of a folate-cleaving enzyme, carboxypeptidase G 1 .
Topics: Animals; Antineoplastic Agents; Carboxypeptidases; Carcinoma 256, Walker; Cell Division; Cell Line; Cells, Cultured; Clone Cells; Deoxyuridine; Depression, Chemical; DNA, Neoplasm; Female; Folic Acid; Folic Acid Deficiency; Humans; Injections, Intraperitoneal; Leukemia L1210; Liver; Lymphoma; Male; Mice; Mice, Inbred AKR; Mice, Inbred DBA; Mice, Inbred Strains; Neoplasms, Experimental; Rats; Sarcoma 180; Thymidine; Time Factors; Tritium | 1972 |
Congenital familial megaloblastic anemia.
Topics: Anemia, Macrocytic; Bone Marrow; Cobalt Isotopes; Deoxyuridine; Female; Folic Acid; Hemoglobins; Humans; In Vitro Techniques; Infant; Infant, Newborn; Methods; Orotic Acid; Phosphates; Thymidine; Vitamin B 12 | 1971 |
Treatment of leukemia with large doses of methotrexate and folinic acid: clinical-biochemical correlates.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Deoxyuridine; DNA, Neoplasm; Female; Folic Acid; Humans; Leukemia; Leukemia, Lymphoid; Male; Methotrexate; Middle Aged; Tetrahydrofolate Dehydrogenase; Thymidine; Tritium | 1969 |
A rapid assay for thymidylate synthetase.
Topics: Bacteriophages; Buffers; Deoxyuridine; Escherichia coli; Folic Acid; Formaldehyde; Ligases; Magnesium; Nucleotides; Spectrophotometry; Tritium | 1966 |
Mechanism of triamterene-induced megaloblastosis.
Topics: Adult; Alcoholism; Anemia, Macrocytic; Bone Marrow; Bone Marrow Examination; Deoxyuridine; DNA; Erythrocytes; Female; Folic Acid; Folic Acid Antagonists; Humans; Liver Cirrhosis; Pregnancy; Thymine; Triamterene; Tritium; Vitamin B 12 | 1970 |
Lymphocyte transformation in megaloblastic anaemia: morphology and DNA synthesis.
Topics: Anemia, Macrocytic; Anemia, Pernicious; Chromosomes; Culture Techniques; Deoxyuridine; DNA; Folic Acid; Folic Acid Deficiency; Humans; Lectins; Lymphocyte Activation; Lymphocytes; Thymidine; Tritium; Vitamin B 12; Vitamin B 12 Deficiency | 1970 |
Some aspects of the role of vitamin B 12 and folic acid in DNA-thymidine sy nthesis in a neoplastic C3H mouse cell strain.
Topics: Adenine; Animals; Carbon Isotopes; Cell Line; Chromatography, Paper; Culture Media; Culture Techniques; Deoxyuridine; DNA, Neoplasm; Folic Acid; Formates; Hydroxocobalamin; Mice; Neoplasms; Stimulation, Chemical; Thymidine; Vitamin B 12 | 1971 |
Sequential chemotherapy and radiation therapy of buccal mucosa carcinoma in South India. Methods and preliminary results.
Topics: Adult; Aged; Antineoplastic Agents; Carcinoma, Squamous Cell; Cheek; Cobalt Isotopes; Deoxyuridine; Female; Fluorouracil; Folic Acid; Humans; India; Leukocyte Count; Male; Methotrexate; Middle Aged; Mouth Mucosa; Mouth Neoplasms; Radioisotope Teletherapy; Radiotherapy Dosage | 1968 |
Deranged DNA synthesis by bone marrow from vitamin B-12-deficient humans.
Topics: Anemia, Macrocytic; Bone Marrow; Bone Marrow Cells; Deoxyuridine; DNA; Female; Folic Acid; Folic Acid Deficiency; Humans; In Vitro Techniques; Methionine; Methotrexate; Thymine; Tritium; Uridine; Vitamin B 12; Vitamin B 12 Deficiency | 1968 |
Mechanism of pyrimethamine-induced megaloblastosis in human bone marrow.
Topics: Anemia, Macrocytic; Bone Marrow; Bone Marrow Diseases; Chorioretinitis; Culture Techniques; Deoxyuridine; DNA; Erythrocytes; Female; Fluorouracil; Folic Acid; Folic Acid Antagonists; Humans; Methotrexate; Middle Aged; Nucleotides; Oxidation-Reduction; Pyrimethamine; Thymidine; Tritium | 1969 |
Incidence and pathogenesis of acute megaloblastic bone-marrow change in patients receiving intensive care.
Topics: Adolescent; Adult; Aged; Anemia, Macrocytic; Anemia, Megaloblastic; Anesthesia; Bone Marrow; Child; Deoxyuridine; DNA; Female; Folic Acid; Folic Acid Deficiency; Hematopoiesis; Humans; Intensive Care Units; Male; Middle Aged; Nitrous Oxide; Vitamin B 12 | 1982 |
Biochemical pharmacology of the lipophilic antifolate, trimetrexate.
Topics: Animals; Cell Line; Culture Techniques; Deoxyuridine; Drug Resistance; Folic Acid; Folic Acid Antagonists; Humans; Kinetics; Leucovorin; Leukemia L1210; Lymphocytes; Methotrexate; Mice; Mice, Inbred Strains; Quinazolines; Ribonucleotides; Thymidine; Trimetrexate | 1984 |
Effects of leucovorin and methylcobalamin with N2O anesthesia.
Topics: Bone Marrow; Deoxyuridine; DNA; Folic Acid; Humans; Leucovorin; Nitrous Oxide; Thymidine; Time Factors; Vitamin B 12 | 1984 |
The deoxyuridine suppression test in severe anaemia following Plasmodium falciparum malaria.
Topics: Anemia; Bone Marrow; Child, Preschool; Deoxyuridine; DNA; Erythropoiesis; Folic Acid; Humans; Infant; Malaria; Plasmodium falciparum; Vitamin B 12 | 1984 |
Folate levels and deoxyuridine suppression tests in protein-energy malnutrition.
Topics: Bone Marrow; Child, Preschool; Deoxyuridine; DNA; Erythrocytes; Erythropoiesis; Folic Acid; Humans; Infant; Kwashiorkor; Protein-Energy Malnutrition; Thymidine; Vitamin B 12 | 1983 |
Modulation of anti-metabolite effects. Effects of thymidine on the efficacy of the quinazoline-based thymidylate synthetase inhibitor, CB3717.
Topics: Animals; Antimetabolites, Antineoplastic; Cells, Cultured; Deoxyuridine; Folic Acid; Leukemia L1210; Male; Methyltransferases; Mice; Mice, Inbred DBA; Quinazolines; Thymidine; Thymidylate Synthase | 1984 |
Synergistic growth inhibiting effect of nitrous oxide and cycloleucine in experimental rat leukaemia.
Topics: Amino Acids; Animals; Cycloleucine; Deoxyuridine; Drug Synergism; Folic Acid; Leukemia, Experimental; Leukocyte Count; Liver; Male; Nitrous Oxide; Organ Size; Rats; Rats, Inbred BN; S-Adenosylmethionine; Spleen; Vitamin B 12 | 1984 |
Cellular abnormalities of folate deficiency.
Topics: Cell Division; Cell Line; Cells, Cultured; Deoxyuridine; DNA; Flow Cytometry; Folic Acid; Folic Acid Deficiency; Leukemia, Erythroblastic, Acute | 1983 |
Folic acid metabolism in a patient with fragile X.
Topics: Deoxyuridine; Folic Acid; Formiminoglutamic Acid; Fragile X Syndrome; Humans; Infant; Sex Chromosome Aberrations; Thymidylate Synthase; Vitamin B 12 | 1983 |
Biochemical effects of a quinazoline inhibitor of thymidylate synthetase, N-(4-(N-(( 2-amino-4-hydroxy-6-quinazolinyl)methyl)prop-2-ynylamino) benzoyl)-L-glutamic acid (CB3717), on human lymphoblastoid cells.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Cell Line; Deoxyribonucleotides; Deoxyuridine; Folic Acid; Folic Acid Antagonists; Humans; Kinetics; Lymphocytes; Methotrexate; Methyltransferases; Quinazolines; Ribonucleotides; Thymidylate Synthase | 1983 |
Studies on the haemopoietic toxicity of nitrous oxide in man.
Topics: Anesthesia, General; Bone Marrow; Deoxyuridine; Folic Acid; Hematopoiesis; Humans; Megaloblasts; Methionine; Neutrophils; Nitrous Oxide; Platelet Count; Time Factors; Vitamin B 12 | 1983 |
Status of laboratory testing in the diagnosis of megaloblastic anemia.
Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Autoantibodies; Deoxyuridine; Erythrocyte Indices; Folic Acid; Humans; Intrinsic Factor; Reagent Kits, Diagnostic; Schilling Test; Vitamin B 12 | 1983 |
The effect of folate analogues and vitamin B12 on provision of thymine nucleotides for DNA synthesis in megaloblastic anemia.
Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Bone Marrow; Deoxyuridine; DNA; Folic Acid; Folic Acid Deficiency; Humans; Leucovorin; Tetrahydrofolates; Thymine Nucleotides; Vitamin B 12; Vitamin B 12 Deficiency | 1982 |
The enhancement of 5-fluorouracil anti-metabolic activity by leucovorin, menadione and alpha-tocopherol.
Topics: Animals; Antimetabolites; Cell Count; Cell Division; Cell Line; Deoxyuridine; DNA, Neoplasm; Dose-Response Relationship, Drug; Drug Interactions; Fluorouracil; Folic Acid; Leucovorin; Leukemia, Erythroblastic, Acute; Mice; Vitamin E; Vitamin K | 1982 |
5-Methyltetrahydrofolate related enzymes and DNA polymerase alpha activities in bone marrow cells from patients with vitamin B12 deficient megaloblastic anemia.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; 5,10-Methylenetetrahydrofolate Reductase (FADH2); Adult; Aged; Alcohol Oxidoreductases; Anemia, Macrocytic; Anemia, Megaloblastic; Bone Marrow; Bone Marrow Cells; Deoxyuridine; DNA Polymerase II; DNA-Directed DNA Polymerase; Female; Folic Acid; Humans; Hydroxocobalamin; Leucovorin; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Tetrahydrofolates; Thymidine; Vitamin B 12; Vitamin B 12 Deficiency | 1982 |
Evaluation of X-methyl folate preparations as possible folic acid antagonists.
Topics: Cell Differentiation; Cell Line; Deoxyuridine; Folic Acid; Folic Acid Antagonists; Folic Acid Deficiency; Humans | 1982 |
The effect of folate analogues on the thymidine utilization by human and rat marrow cells and the effect on the deoxyuridine suppression test.
Topics: Anemia, Megaloblastic; Animals; Bone Marrow; Deoxyuridine; Folic Acid; Humans; Male; Rats; Rats, Inbred Strains; Thymidine; Vitamin B 12 | 1981 |
The induction of functional vitamin B-12 deficiency in rats by exposure to nitrous oxide.
Topics: Animals; Bone Marrow; Deoxyuridine; Disease Models, Animal; DNA; Female; Folic Acid; Formyltetrahydrofolates; Nitrous Oxide; Rats; Thymidine; Vitamin B 12; Vitamin B 12 Deficiency | 1980 |
In vitro DNA synthesis by bone marrow cells and PHA-stimulated lymphocytes. Suppression by nonradioactive thymidine of the incorporation of 3H-deoxyuridine into DNA: enhancement of incorporation when inadequate vitamin B12 or folate is corrected.
Topics: Bone Marrow; Cells, Cultured; Deoxyuridine; DNA; Folic Acid; Folic Acid Deficiency; Humans; Lymphocytes; Phytohemagglutinins; Thymidine; Vitamin B 12; Vitamin B 12 Deficiency | 1980 |
Impaired deoxyuridine utilization in the B12-inactivated rat and its correction by folate analogues.
Topics: Animals; Deoxyuridine; DNA; Folic Acid; Male; Nitrous Oxide; Rats; Vitamin B 12 | 1980 |
Studies in B12-deficient monkeys with combined system disease. I. B12-deficient patterns in bone marrow deoxyuridine suppression tests without morphologic or functional abnormalities.
Topics: Animals; Bone Marrow Cells; Deoxyuridine; Erythrocyte Volume; Folic Acid; Iron; Macaca mulatta; Male; Nervous System Diseases; Syndrome; Vitamin B 12; Vitamin B 12 Deficiency | 1980 |
Marrow cells from patients with untreated pernicious anaemia cannot use tetrahydrofolate normally.
Topics: Anemia, Megaloblastic; Anemia, Pernicious; Bone Marrow; Bone Marrow Cells; Deoxyuridine; Folic Acid; Formyltetrahydrofolates; Humans; Hydroxocobalamin; Methylation; Tetrahydrofolates | 1980 |
Synthesis of DNA as shown by the deoxyuridine suppression test is normal in the vitamin B12-deficient fruit bat (Rosettus Aegyptiacus).
Topics: Animals; Bone Marrow; Cells, Cultured; Chiroptera; Deoxyuridine; DNA; Folic Acid; Lymphocytes; Methotrexate; Thymidine; Vitamin B 12; Vitamin B 12 Deficiency | 1980 |
Biochemical responses of broiler chicks to folate deficiency.
Topics: Animals; Bone Marrow; Chickens; Deoxyuridine; DNA; Erythrocytes; Folic Acid; Folic Acid Deficiency; Liver; Male; Nutritional Status; Phosphoribosyl Pyrophosphate; Tetrahydrofolate Dehydrogenase | 1993 |
Biochemical effects of folate-based inhibitors of thymidylate synthase in MGH-U1 cells.
Topics: Cell Survival; Deoxyuracil Nucleotides; Deoxyuridine; Folic Acid; Folic Acid Antagonists; Glutamates; Humans; In Vitro Techniques; Indoles; Isoindoles; Quinazolines; Structure-Activity Relationship; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured; Urinary Bladder Neoplasms | 1994 |
The deoxyuridine suppression test in HIV-1 positive patients: the role of azydothymidine (AZT).
Topics: Anemia, Megaloblastic; Bone Marrow; Cells, Cultured; Deoxyuridine; Folic Acid; HIV Infections; HIV-1; Humans; Intestinal Absorption; Methotrexate; Vitamin B 12; Vitamin B 12 Deficiency; Zidovudine | 1996 |
Site-specific introduction of functional groups into phosphodiester oligodeoxynucleotides and their thermal stability and nuclease-resistance properties.
Topics: Animals; Deoxyuridine; Esters; Folic Acid; Heating; Molecular Structure; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Palmitic Acid; Phosphodiesterase I; Phosphoric Diester Hydrolases; Ribonuclease H; RNA; Single-Strand Specific DNA and RNA Endonucleases | 1997 |
The additivity of substrate fragments in enzyme-ligand binding.
Topics: Crystallography, X-Ray; Deoxyuracil Nucleotides; Deoxyuridine; Escherichia coli; Folic Acid; Models, Molecular; Mutagenesis, Site-Directed; Phosphates; Protein Conformation; Quinazolines; Recombinant Proteins; Ribose; Structure-Activity Relationship; Thymidylate Synthase; Uridine | 1998 |
A continuous spectrophotometric assay for thymidine and deoxycytidine kinases.
Topics: Deoxycytidine Kinase; Deoxycytidine Monophosphate; Deoxyuracil Nucleotides; Deoxyuridine; Folic Acid; Herpesvirus 1, Human; Hydrogen-Ion Concentration; Kinetics; Methylation; Spectrophotometry; Tetrahydrofolates; Thymidine Kinase; Thymidylate Synthase | 1998 |
Balb/c mice as a preclinical model for raltitrexed-induced gastrointestinal toxicity.
Topics: Animals; Antimetabolites, Antineoplastic; Deoxyuridine; Diarrhea; Digestive System; Dose-Response Relationship, Drug; Folic Acid; Intestinal Mucosa; Intestine, Large; Intestine, Small; Male; Maximum Tolerated Dose; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Quinazolines; Thiophenes; Thymidine; Thymidylate Synthase; Weight Loss | 2000 |
Some aspects of the role of vitamin B12 in nucleic acid synthesis in a neoplastic C3H mouse cell strain. I. Growth studies.
Topics: Adenine; Adenosine; Animals; Cell Division; Cytidine; Deoxyadenosines; Deoxycytidine; Deoxyuridine; DNA, Neoplasm; Folic Acid; Guanine; Mice; Nucleic Acid Precursors; Nucleosides; Pyrimidines; Thymidine; Tumor Cells, Cultured; Uridine; Vitamin B 12 | 1970 |
Non-classical antifolates, 5-(N-phenylpyrrolidin-3-yl)-2,4,6-triaminopyrimidines and 2,4-Diamino-6(5H)-oxopyrimidines, synthesis and antitumor studies.
Topics: Antineoplastic Agents; Cell Survival; Deoxyuridine; Drug Screening Assays, Antitumor; Folic Acid; Folic Acid Antagonists; Humans; Leucovorin; Methotrexate; Pyrimidines; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Tritium; Tumor Cells, Cultured | 2003 |
Ineffectiveness of 5-fluoro-2'-deoxyuridine in man after failure of 5-fluorouracil.
Topics: Deoxyuridine; Floxuridine; Fluorouracil; Folic Acid; Humans | 1963 |
Abnormal folate metabolism in foetuses affected by neural tube defects.
Topics: Anencephaly; Animals; Antimetabolites; Deoxyuridine; Female; Ferredoxin-NADP Reductase; Fetal Diseases; Fetus; Fibroblasts; Folic Acid; Genotype; Humans; Methylation; Mice; Neural Tube Defects; NIH 3T3 Cells; Polymorphism, Genetic; Pregnancy; S-Adenosylhomocysteine; S-Adenosylmethionine; Spinal Dysraphism | 2007 |
Maternal dietary uridine causes, and deoxyuridine prevents, neural tube closure defects in a mouse model of folate-responsive neural tube defects.
Topics: Animals; Deoxyuridine; Disease Models, Animal; Female; Folic Acid; Folic Acid Deficiency; Glycine Hydroxymethyltransferase; HeLa Cells; Humans; Maternal Nutritional Physiological Phenomena; Mice; Neural Tube; Neural Tube Defects; Pregnancy; Thymidine; Uracil; Uridine | 2015 |