deoxyuridine has been researched along with deoxycytidine in 144 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 68 (47.22) | 18.7374 |
| 1990's | 26 (18.06) | 18.2507 |
| 2000's | 25 (17.36) | 29.6817 |
| 2010's | 23 (15.97) | 24.3611 |
| 2020's | 2 (1.39) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, MS; Prusoff, WH; Schinazi, RF | 1 |
| Chawla, RR; Hampton, A; Kappler, F | 3 |
| Harano, A; Hatano, A; Nakagomi, Y; Naramoto, Y; Takigawa, Y; Toda, K; Yamada, H | 1 |
| Schreiber, C; Waxman, S | 1 |
| Hackstadt, T; Mallavia, LP | 1 |
| Hayakawa, H; Sekiguchi, M | 1 |
| Abbott, MT; Hsu, CA; Shaffer, PM | 1 |
| Roberts, D; Warmath, EV | 1 |
| Baker, PN; Bradshaw, TK; Burke, DC; Morser, J | 1 |
| Cooper, GM; Greer, S; Schildkraut, I | 1 |
| De Clercq, E; Shugar, D | 1 |
| Smirnov, AD; Vladimirov, VG | 1 |
| Rima, BK; Takahashi, I | 1 |
| Martenet, AC | 1 |
| Lin, TS; Prusoff, WH | 2 |
| Higa, E; Meyer, JS | 1 |
| Eckstein, F; Hobbs, J; Thelander, L | 1 |
| Bechynĕ, M; Buric, L; Dientsbier, Z; Foltýnová, V; Kovaríková, H; Mostecký, H | 1 |
| Anghileri, LJ; Heidbreder, M | 1 |
| Brun, G; Goodgame, DM; Skapski, AC | 1 |
| Buric, L; Dienstbier, Z | 1 |
| Bäck, R; Linna, TJ | 1 |
| Ratliff, RL; Walters, RA | 1 |
| Ache, HJ; Wong, S | 1 |
| Ames, BN; Hu, CC; Wagner, JR | 1 |
| Montgomery, JA; Riordan, JM; Secrist, JA; Tiwari, KN | 1 |
| Cadet, J; Gaboriau, F; Ulrich, J; Viari, A; Vigny, P; Voituriez, L | 1 |
| Mukai, F; Segal, A; Solomon, JJ | 1 |
| Kaysen, J; Kufe, D; Spriggs, D | 1 |
| Hüttermann, J; Schaefer, A | 1 |
| Heinemann, V; Plunkett, W | 1 |
| Segal, A; Solomon, JJ | 1 |
| Balzarini, J; De Clercq, E; Herdewijn, P; Vanderhaeghe, H | 1 |
| Cadet, J; Gaboriau, F; Moysan, A; Vigny, P; Voituriez, L | 1 |
| Kalman, TI; Yalowich, JC | 1 |
| Bianchi, V; Pontis, E; Reichard, P | 1 |
| Cory, JG; Ohmstede, CA | 1 |
| Balzarini, J | 1 |
| Ayers, O; Malinowski, N; Moyer, JD | 1 |
| Ayala, F; Santoianni, P | 1 |
| Jato, J; Windheuser, JJ | 1 |
| Chan, TS; Green, H; Meuth, M | 1 |
| Goodman, JI | 1 |
| Bloch, A; McPartland, RP; Wang, MC; Weinfeld, H | 1 |
| Harrap, KR; Tattersall, MH | 1 |
| Anderson, S; Bryan, AM; Davis, GC; Olafsson, PG | 1 |
| Fuchs, JA; Neuhard, J | 1 |
| Cooper, GM; Greer, S | 1 |
| Hudson, JB | 1 |
| Bagwell, CB; Fox, LM; Greer, SB; Mekras, JA | 1 |
| Balzarini, J; De Clercq, E; Duggan, MJ; Dyer, RL; Jones, AS; Rahim, SG; Walker, RT | 1 |
| Cheng, YC; Fox, JJ; Huang, ES; Mar, EC; Patel, PC; Watanabe, KA | 1 |
| Böhmer, FD; Graetz, H; Grosse, R; Langen, P; Lehmann, W | 1 |
| Balzarini, J; Buchele, A; De Clercq, E; Keppeler, K; Kiefer, G | 1 |
| DuFrain, RJ | 1 |
| Bover, L; Cabral, S; Leis, S; Mordoh, J; Nembrot, M | 1 |
| Gao, YS; Lin, TS; Mancini, WR | 1 |
| Balzarini, J; De Clercq, E | 1 |
| Balzarini, J; De Clercq, E; Hunston, RN; Jones, AS; McGuigan, C; Walker, RT | 1 |
| Renis, HE | 1 |
| Boehm, TL; Drahovsky, D; Kreis, W | 1 |
| Kumar, A; Nakatsugawa, S; Sugahara, T | 1 |
| Cox, EC; Erlich, HA | 1 |
| Katz, DJ; Townsend, LB; Wise, DS | 1 |
| Deveski, WB; Dudman, NP; Tattersall, MH | 1 |
| Blehová, Z; Dienstbier, Z; Masopust, J; Sámal, M | 1 |
| Bøyum, A; Løvhaug, D; Nordlie, EM; Seeberg, E | 1 |
| Cunningham, RP; Hatahet, Z; Kow, YW; Purmal, AA; Wallace, SS | 1 |
| Andersen, PS; Hammer, K; Martinussen, J | 1 |
| Plunkett, W; Xu, YZ | 1 |
| Cory, AH; Cory, JG; Robins, MJ; Samano, V | 1 |
| Decker-Samuelian, K; Singh, US; Solomon, JJ | 1 |
| Ashida, N; Awano, H; Kira, T; Machida, H; Matsuda, A; Miyashita, T; Shigeta, S; Shuto, S | 1 |
| Johansson, M; Karlsson, A | 1 |
| Chen, FX; Dande, P; Gold, B; Hashimoto, H; Liang, G; Nelson, MG; Roberts, C; Switzer, C | 1 |
| Cho, MJ; Cory, JG; Kang, SH; Mitchell, BS; Sinhababu, AK; Thakker, DR | 1 |
| Elfarra, AA; Selzer, RR | 1 |
| Focher, F; Priori, G; Spadari, S; Tondelli, L; Verri, A | 1 |
| Essigmann, JM; Kreutzer, DA; Morningstar, ML | 1 |
| Gowans, B; Hunting, DJ; Tremblay, S; Wagner, JR | 1 |
| Kanaori, K; Makino, K; Nakamura, T; Suzuki, T; Tajima, K | 1 |
| Fukada, S; Iwamoto-Tanaka, N; Kasai, H | 1 |
| Fujikawa, K; Kamiya, H; Kasai, H | 1 |
| Inanami, O; Kuwabara, M; Matsuda, A; Ogawa, A; Sasaki, T; Shuto, S; Tanaka, M | 1 |
| Barlow, T; Dipple, A | 1 |
| Solomon, JJ | 1 |
| Kainosho, M; Nonaka, K; Ono, A; Ono, AM; Oogo, Y | 1 |
| Calebiro, D; Hemminki, K; Koskinen, M | 1 |
| Fukuoka, M; Kudoh, S; Masuda, N; Matsui, K; Myobudani, H; Nakagawa, K; Negoro, S; Nemoto, S; Nihira, S; Nogami, T; Ogawa, K; Okuda, T; Takeda, K; Takifuji, N; Yamada, M; Yamamoto, N | 1 |
| Eriksson, S; Wang, L | 1 |
| Evans, VJ; Price, FM; Rotherham, J | 2 |
| Hüttermann, J; Kraft, G; Schaefer, A | 2 |
| Barnes, TW; Turner, DH | 1 |
| Brouwer, J; de Ruijter, M; Lugtenburg, J; Ouwerkerk, N; Raap, J; Steenweg, M; van Boom, JH | 1 |
| Cadet, J; Gasparutto, D; Muller, E | 1 |
| Balzarini, J; De Clercq, E; Khalili, P; Knaus, EE; Naimi, E; Wiebe, LI; Zhou, A | 1 |
| Jefferies, MW; King, RW; Zecher, M | 1 |
| Hayashi, H; Matsumoto, N; Nakamura, A; Sawai, H; Shinozuka, K | 1 |
| ROTHERHAM, J; SCHNEIDER, WC | 1 |
| Di Noia, JM; Neuberger, MS | 1 |
| Banken, L; Bellibas, SE; Brivet, B; Bush, ED; Chamorey, E; Kircher, C; Milano, G; Nave, S; Patel, I; Renée, N | 1 |
| Kanatani, K; Okamoto, A; Saito, I | 1 |
| Clivio, P; Peyrane, F | 1 |
| Clarke, SJ; Li, KM; Rivory, LP | 1 |
| Klarskov, K; Rivière, J; Wagner, JR | 1 |
| Ahmed, S; McLaughlin, LW; Sun, Z | 1 |
| Clarke, SJ; Hoskins, J; Li, KM; Rivory, LP; Sharma, R | 1 |
| Cao, H; Wang, Y | 1 |
| Kraatz, HB; Li, X; Long, Y; Schatte, G; Song, H | 1 |
| Ochi, Y; Okamoto, A; Saito, I; Tainaka, K | 1 |
| Adler, A; Forster, N; Göringer, HU; Homann, M | 1 |
| Cheng, C; Shang, P; Wang, H; Zhao, Y; Zheng, H | 1 |
| Iams, TA; McKee, EE; Morris, GW; Slepchenko, KG | 1 |
| Saada, A | 1 |
| Champavier, Y; Guilloton, M; Lucas, R; Teste, K; Zerrouki, R | 1 |
| Al Meani, SA; Clausen, AR; Piskur, J | 1 |
| Brown, T; El-Sagheer, AH; Hansen, AS; Schofield, CJ; Thalhammer, A | 1 |
| Benyumov, A; Gurvich, VJ; Kirstein, MN; Lis, LG; Williams, BW | 1 |
| Andersen, NK; Døssing, H; Jensen, F; Nielsen, P; Vester, B | 1 |
| Beijnen, JH; Benhadji, KA; Callies, S; Garcia-Ribas, I; Jansen, RS; Koolen, SL; Kronemeijer, RH; Langenberg, MH; Nol, A; Schellens, JH; Slapak, CA; Voest, EE; Witteveen, PO | 1 |
| McCann, KA; McKee, EE; Williams, DW | 1 |
| Dantzig, AH; Durland-Busbice, S; Heinz-Taheny, K; Iversen, PW; Pratt, SE; Shepard, RL | 1 |
| Dantzig, AH; Donoho, GP; Durland-Busbice, S; Perkins, EJ; Pratt, SE; Shepard, RL; Starling, JJ; Wickremsinhe, ER | 1 |
| Aguilar, M; Awad, AM; McNary, J; Samuels, ER | 1 |
| Chou, A; Foti, SB; Moll, AD; Roskams, AJ | 1 |
| Chan, PC; Chang, WY; Chen, CL; Kuo, WT; Lin, CY; Liu, RS; Shen, CC; Wang, HE; Wu, CY | 1 |
| Benhadji, KA; Makiuchi, T; Nokihara, H; Sekiguchi, R; Slapak, CA; Tamura, T; Uenaka, K; Yamada, Y; Yamamoto, N | 1 |
| Lee, LB; Ruterbories, KJ; Schmalz, CA; Torchia, J; Wickremsinhe, ER | 1 |
| Aguirre, E; Benhadji, KA; Callies, S; Garcia, M; Gil-Martín, M; Llombart, A; Morales, S; Oaknin, A; Salazar, R; Wickremsinhe, ER | 1 |
| Baay, M; Burrows, N; Deschoolmeester, V; Lardon, F; Laukens, K; Meijnders, P; Pauwels, B; Pauwels, P; Peeters, M; Van den Weyngaert, D; Van Gestel, D; Vermorken, JB; Vu, TN; Williams, KJ; Wouters, A | 1 |
| Drohat, AC; Maiti, A | 1 |
| Chomicz, L; Jian, Y; Li, L; Lin, G | 1 |
| Benhadji, KA; Callies, S; Cohen, RB; Faivre, SJ; Horn, CL; Myrand, SP; Olszanski, AJ; Ouyang, H; Raymond, E; Riess, H; Wang, X; Weigang-Köhler, K; Wickremsinhe, ER | 1 |
| Adam, T; Friedecký, D; Koberna, K; Liboska, R; Ligasová, A; Mičová, K; Oždian, T; Rosenberg, I | 1 |
| Abramov, M; Eremeeva, E; Herdewijn, P; Margamuljana, L; Marlière, P; Pezo, V; Rozenski, J | 1 |
| Abramov, M; Eremeeva, E; Herdewijn, P; Margamuljana, L | 1 |
| Hari, Y; Ito, Y; Matsuo, M; Osawa, T | 1 |
| Manska, S; Octaviano, R; Rossetto, CC | 1 |
| Baginska, P; Czyz, J; Gackowski, D; Gawronski, M; Jachalska, A; Kruszewski, M; Labejszo, A; Olinski, R; Rozalski, R; Sadowska, A; Siomek-Gorecka, A; Skalska-Bugala, A; Starczak, M; Szpila, A; Szpotan, J; Szukalska, A; Szukalski, Ł; Wasilow, A; Zarakowska, E | 1 |
4 review(s) available for deoxyuridine and deoxycytidine
| Article | Year |
|---|---|
[Biological dosimetry in ionizing radiation exposure (a review of the literature)].
Topics: Animals; Bone Marrow; Chromosome Aberrations; Deoxycytidine; Deoxyuridine; DNA; Humans; Leukocytes; Lymphopenia; Mast Cells; Radiation Effects; Radiation Injuries; Radiometry; Time Factors | 1978 |
Pyrimidines and their nucleosides.
Topics: Antiviral Agents; Carbohydrates; Chemical Phenomena; Chemistry; Cytarabine; Deoxycytidine; Deoxyuridine; Pyrimidine Nucleosides; Pyrimidines; Trifluridine | 1980 |
Cyclic adducts and intermediates induced by simple epoxides.
Topics: Alkylation; Deamination; Deoxyadenosines; Deoxycytidine; Deoxyuridine; DNA Adducts; Epoxy Compounds; Humans; Hydrogen-Ion Concentration; Hydrolysis; Models, Chemical | 1999 |
Mechanisms for enzymatic cleavage of the N-glycosidic bond in DNA.
Topics: Animals; Deoxycytidine; Deoxyuridine; DNA; DNA Glycosylases; Humans; Hydrolysis; Purines | 2014 |
6 trial(s) available for deoxyuridine and deoxycytidine
| Article | Year |
|---|---|
Phase I trial of oral 2'-deoxy-2'-methylidenecytidine: on a daily x 14-day schedule.
Topics: Adenocarcinoma; Aged; Antineoplastic Agents; Carcinoma, Squamous Cell; Chromatography, High Pressure Liquid; Colorectal Neoplasms; Deoxycytidine; Deoxyuridine; Dose-Response Relationship, Drug; Female; Humans; Lung Neoplasms; Male; Maximum Tolerated Dose; Middle Aged; Time Factors | 2000 |
Single ascending dose tolerability, pharmacokinetic-pharmacodynamic study of dihydropyrimidine dehydrogenase inhibitor Ro 09-4889.
Topics: Administration, Oral; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Capecitabine; Deoxycytidine; Deoxyuridine; Dihydrouracil Dehydrogenase (NADP); Dose-Response Relationship, Drug; Double-Blind Method; Drug Synergism; Enzyme Inhibitors; Fluorouracil; Humans; Leukocytes, Mononuclear; Male; Models, Chemical; Placebos; Time Factors; Uracil | 2004 |
Phase I study of Oral gemcitabine prodrug (LY2334737) alone and in combination with erlotinib in patients with advanced solid tumors.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Deoxycytidine; Deoxyuridine; Erlotinib Hydrochloride; Female; Gemcitabine; Humans; Male; Middle Aged; Neoplasm Staging; Neoplasms; Prodrugs; Quinazolines; Treatment Outcome; Young Adult | 2011 |
Phase I study of oral gemcitabine prodrug (LY2334737) in Japanese patients with advanced solid tumors.
Topics: Administration, Oral; Adult; Aged; Carboxylesterase; Deoxycytidine; Deoxyuridine; Disease-Free Survival; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Gemcitabine; Humans; Male; Middle Aged; Neoplasm Metastasis; Neoplasms; Polymorphism, Single Nucleotide; Prodrugs | 2013 |
Phase 1 dose escalation and pharmacokinetic evaluation of oral gemcitabine prodrug (LY2334737) in combination with docetaxel in patients with advanced solid tumors.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Deoxycytidine; Deoxyuridine; Docetaxel; Dose-Response Relationship, Drug; Female; Gemcitabine; Humans; Male; Middle Aged; Neoplasms; Prodrugs; Taxoids; Treatment Outcome | 2014 |
Phase I dose escalation and pharmacokinetic evaluation of two different schedules of LY2334737, an oral gemcitabine prodrug, in patients with advanced solid tumors.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Deoxycytidine; Deoxyuridine; Disease Progression; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Gemcitabine; Humans; Male; Middle Aged; Neoplasms; Prodrugs | 2015 |
134 other study(ies) available for deoxyuridine and deoxycytidine
| Article | Year |
|---|---|
Synthesis and biological activities of some uronic acids, uronates, uronamides, and urononitriles of pyrimidine nucleosides.
Topics: Animals; Cell Division; Cells, Cultured; Chick Embryo; Pyrimidine Nucleosides; Sarcoma 180; Simplexvirus; Streptococcus; Structure-Activity Relationship; Substrate Specificity; Thymidine Kinase; Thymidylate Synthase; Uronic Acids; Virus Replication | 1978 |
Design of species- or isozyme-specific enzyme inhibitors. 2. Differences between a bacterial and a mammalian thymidine kinase in the effect of thymidine substituents on affinity for the thymidine site.
Topics: Animals; Binding Sites; Cricetinae; Cytoplasm; Escherichia coli; Kinetics; Species Specificity; Structure-Activity Relationship; Thymidine; Thymidine Kinase | 1979 |
Design of species- or isozyme-specific enzyme inhibitors. 1. Effect of thymidine substituents on affinity for the thymidine site of hamster cytoplasmic thymidine kinase.
Topics: Animals; Cricetinae; Cytoplasm; Deoxycytidine; Deoxyuridine; Humans; In Vitro Techniques; Isoenzymes; Kidney; Kinetics; Methods; Mitochondria; Structure-Activity Relationship; Substrate Specificity; Thymidine; Thymidine Kinase; Thymine Nucleotides | 1979 |
Species- or isozyme-specific enzyme inhibitors. 5. Differential effects of thymidine substituents on affinity for rat thymidine kinase isozymes.
Topics: Animals; Cytoplasm; In Vitro Techniques; Isoenzymes; Kinetics; Mitochondria; Pyrimidine Nucleosides; Rats; Thymidine; Thymidine Kinase; Tissue Distribution | 1982 |
Kinetic parameters and recognition of thymidine analogues with varying functional groups by thymidine phosphorylase.
Topics: Kinetics; Molecular Structure; Structure-Activity Relationship; Substrate Specificity; Thymidine; Thymidine Phosphorylase | 2008 |
Varying effects of deoxynucleosides on the incorporation of thymidine into the DNA of monolayer and suspension cultures.
Topics: Animals; Ascites; Bone Marrow; Bone Marrow Cells; Cell Survival; Cells, Cultured; Deoxycytidine; Deoxyuridine; DNA; HeLa Cells; Hydrogen-Ion Concentration; Leukemia L1210; Lymphocytes; Neoplasms, Experimental; Thymidine | 1977 |
Deoxypyrimidine nucleoside metabolism in varicella-zoster virus-infected cells.
Topics: Cell Line; Cytidine; Deoxycytidine; Deoxyribonucleosides; Deoxyuridine; Enzyme Induction; Herpesvirus 3, Human; Humans; Hydrogen-Ion Concentration; Molecular Weight; Thymidine; Thymidine Kinase | 1978 |
Repair of deaminated cytosine residues of DNA: biological significance of the absence of uracil from DNA.
Topics: Bacillus subtilis; Bacteriophages; Deamination; Deoxycytidine; Deoxyuracil Nucleotides; Deoxyuridine; DNA; DNA Repair; Mutation; N-Glycosyl Hydrolases | 1978 |
Metabolism of pyrimidine deoxyribonucleosides in Neurospora crassa.
Topics: Autoradiography; Carbon Radioisotopes; Cell-Free System; Chromatography, Paper; Deoxycytidine; Deoxyribonucleosides; Deoxyuridine; Mixed Function Oxygenases; Models, Chemical; Mutation; Neurospora; Neurospora crassa; Pyrimidines; Thymidine; Thymine; Uracil | 1975 |
Methotrexate inhibition of CCRF-CEM cultures of human lymphoblasts.
Topics: Cell Division; Cell Line; Deoxycytidine; Deoxyuridine; DNA, Neoplasm; Floxuridine; Folic Acid Antagonists; Humans; Hypoxanthines; Leucovorin; Leukemia, Lymphoid; Methotrexate; Purines; Thymidine | 1975 |
The effect of 5-bromodeoxyuridine on interferon production in human cells.
Topics: Bromodeoxyuridine; Cell Division; Cell Line; Deoxycytidine; Deoxyuridine; DNA; Floxuridine; Humans; Idoxuridine; Interferons; Thymidine | 1979 |
Selective inhibition of the replication of herpes simplex virus by 5-halogenated analogues of deoxycytidine.
Topics: Animals; Carcinoma, Squamous Cell; Cells; Cells, Cultured; Cricetinae; Deoxycytidine; Deoxyuridine; Depression, Chemical; Herpesviridae; Humans; Kidney; Simplexvirus; Virus Replication | 1975 |
Antiviral activity of 5-ethyl pyrimidine deoxynucleosides.
Topics: Animals; Antiviral Agents; Cells, Cultured; Chemical Phenomena; Chemistry; Cytopathogenic Effect, Viral; Deoxycytidine; Deoxyuridine; DNA, Neoplasm; DNA, Viral; Pyrimidine Nucleotides; Rabbits; Simplexvirus; Time Factors; Vaccinia virus; Vesicular stomatitis Indiana virus | 1975 |
Metabolism of pyrimidine bases and nucleosides in Bacillus subtilis.
Topics: Bacillus subtilis; Cytidine; Cytidine Deaminase; Cytosine; Deoxycytidine; Deoxyuridine; DNA, Bacterial; Mutation; Nucleoside Deaminases; Pentosyltransferases; Phosphotransferases; Pyrimidine Nucleosides; Pyrimidines; Uracil; Uridine | 1977 |
Experiences with iododeoxycytidine in the treatment of ocular herpes simplex infections.
Topics: Animals; Bromodeoxycytidine; Deoxycytidine; Deoxyuridine; Humans; Idoxuridine; Keratitis, Dendritic; Rabbits | 1979 |
A novel synthesis and biological activity of several 5-halo-5'-amino analogues of deoxyribopyrimidine nucleosides.
Topics: Animals; Antineoplastic Agents; Antiviral Agents; Cell Division; Cell Line; Cell Survival; Cells, Cultured; Deoxycytidine; Deoxyuridine; Sarcoma 180; Structure-Activity Relationship | 1978 |
S-phase fractions of cells in lymph nodes and malignant lymphomas.
Topics: Cell Cycle; Deoxycytidine; Deoxyuridine; Humans; Interphase; Lymph Nodes; Lymphoma; Lymphoma, Non-Hodgkin; Radionuclide Imaging | 1979 |
The active site of ribonucleoside diphosphate reductase.
Topics: Azides; Binding Sites; Deoxycytidine; Deoxyuridine; Molecular Weight; Ribonucleoside Diphosphate Reductase; Ribonucleotide Reductases | 1977 |
Deoxypyrimidineuria in the course of chemotherapy in M. Hodgkin.
Topics: Cyclophosphamide; Deoxycytidine; Deoxyuridine; Drug Therapy, Combination; Female; Hodgkin Disease; Humans; Male; Prednisone; Procarbazine; Sex Factors; Splenectomy; Thymidine; Vinblastine; Vincristine | 1976 |
131I-deoxyuridine and 131I-deoxycytidine accumulation by tumors.
Topics: Animals; Deoxycytidine; Deoxyuridine; Iodine Radioisotopes; Mice; Mice, Inbred C3H; Neoplasms; Neoplasms, Experimental; Radionuclide Imaging | 1976 |
Reaction of ribonucleosides and deoxynucleosides with copper(II) acetate.
Topics: Acetates; Chemical Phenomena; Chemistry; Copper; Cytidine; Deoxycytidine; Deoxyribonucleosides; Deoxyuridine; Ribonucleosides; Spectrum Analysis; Thymidine; Uridine | 1975 |
Urine excretion of nucleosides in Hodgkin's disease treated by combined chemotherapy.
Topics: Cyclophosphamide; Deoxycytidine; Deoxyribonucleosides; Deoxyuridine; Drug Therapy, Combination; Hodgkin Disease; Humans; Prednisolone; Thymidine; Time Factors; Vinblastine | 1975 |
Preferential incorporation of 3H-deoxycytidine into chicken bursal cells. Comparison of radiolabelled nucleosides as lymphoid cell markers in chickens and mice.
Topics: Animals; Bursa of Fabricius; Chickens; Deoxycytidine; Deoxyuridine; DNA; Female; Intestinal Mucosa; Lymph Nodes; Mice; Spleen; Thymidine; Thymus Gland | 1975 |
Lack of specific correlation of the deoxycytidine triphosphate pool level with rate of DNA synthesis.
Topics: Cell Line; Cytidine; Cytosine Nucleotides; Deoxycytidine; Deoxyribonucleotides; Deoxyuridine; DNA Replication; Thymidine | 1975 |
On the preparation of 80Br- or 82Br-biomolecules via excitation labelling methods.
Topics: Bromine; Deoxycytidine; Deoxyuridine; Guanosine; Isotope Labeling; Phenylalanine; Radioisotopes; Tyrosine | 1976 |
Endogenous oxidative damage of deoxycytidine in DNA.
Topics: Animals; Brain Chemistry; Chromatography, High Pressure Liquid; Deoxycytidine; Deoxyuridine; DNA; DNA Damage; Humans; Kidney; Leukocytes; Liver; Male; Oxidation-Reduction; Rats; Rats, Inbred F344 | 1992 |
Synthesis and biological activity of 2'-deoxy-4'-thio pyrimidine nucleosides.
Topics: Animals; Antineoplastic Agents; Antiviral Agents; Carcinoma, Squamous Cell; Chemical Phenomena; Chemistry; Cytomegalovirus; Deoxycytidine; Deoxyuridine; Humans; Leukemia L1210; Leukemia, T-Cell; Mice; Simplexvirus; Thionucleosides; Thiouridine; Thymidine; Tumor Cells, Cultured | 1991 |
Identification of the two cis-syn [2 + 2] cycloadducts resulting from the photoreaction of 3-carbethoxypsoralen with 2'-deoxycytidine and 2'-deoxyuridine.
Topics: Deoxycytidine; Deoxyuridine; Furocoumarins; Photochemistry; Photochemotherapy; Ultraviolet Rays | 1990 |
In vitro reactions of glycidol with pyrimidine bases in calf thymus DNA.
Topics: 1-Propanol; Animals; Cattle; Chromatography, High Pressure Liquid; Deoxycytidine; Deoxyuridine; DNA; Epoxy Compounds; Ethers, Cyclic; Hydrogen-Ion Concentration; Propanols; Pyrimidines; Thymidine; Thymus Gland | 1990 |
Incorporation of 5-fluorodeoxycytidine and metabolites into nucleic acids of human MCF-7 breast carcinoma cells.
Topics: Azacitidine; Breast Neoplasms; Cell Line; Cell Survival; Decitabine; Deoxycytidine; Deoxyuridine; DNA, Neoplasm; Floxuridine; Humans; Methylation; RNA, Neoplasm; Tetrahydrouridine | 1986 |
Heavy-ion-induced free radical formation in solid DNA-constituents: quantitative and structural aspects.
Topics: Adenosine; Cytosine; Deoxycytidine; Deoxyuridine; DNA; Dose-Response Relationship, Radiation; Electron Spin Resonance Spectroscopy; Energy Transfer; Free Radicals; Ions; Particle Accelerators; Thymine | 1989 |
Modulation of deoxynucleotide metabolism by the deoxycytidylate deaminase inhibitor 3,4,5,6-tetrahydrodeoxyuridine.
Topics: Cell Line; Cytarabine; Cytidine Diphosphate; DCMP Deaminase; Deoxycytidine; Deoxycytidine Kinase; Deoxycytosine Nucleotides; Deoxyuridine; Hydroxyurea; Kinetics; Nucleotide Deaminases; Ribonucleotide Reductases; T-Lymphocytes; Tetrahydrouridine; Thymine Nucleotides | 1989 |
DNA adducts of propylene oxide and acrylonitrile epoxide: hydrolytic deamination of 3-alkyl-dCyd to 3-alkyl-dUrd.
Topics: Acrylonitrile; Animals; Carcinogens; Cattle; Chemical Phenomena; Chemistry; Deamination; Deoxycytidine; Deoxyuridine; DNA; Epoxy Compounds; Ethers, Cyclic; Ethylene Oxide; Hydrogen-Ion Concentration; Nitriles | 1989 |
Synthesis and antiviral activity of the carbocyclic analogues of (E)-5-(2-halovinyl)-2'-deoxyuridines and (E)-5-(2-halovinyl)-2'-deoxycytidines.
Topics: Animals; Antineoplastic Agents; Antiviral Agents; Bromodeoxyuridine; Cell Division; Cell Line; Cyclopentanes; Cytopathogenic Effect, Viral; Deoxycytidine; Deoxyuridine; Herpes Simplex; Humans; Mice; Mice, Hairless; Rabbits; Rats; Simplexvirus; Vaccinia virus; Vesicular stomatitis Indiana virus; Virus Cultivation | 1985 |
Chemical structure of 3-carbethoxypsoralen-DNA photoadducts.
Topics: Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Deoxycytidine; Deoxyuridine; DNA; Furocoumarins; Light; Photochemistry; Spectrometry, Fluorescence; Stereoisomerism; Thymidine | 1986 |
Rapid determination of thymidylate synthase activity and its inhibition in intact L1210 leukemia cells in vitro.
Topics: Animals; Cells, Cultured; Deoxycytidine; Deoxyuridine; Dose-Response Relationship, Drug; Floxuridine; Leukemia L1210; Methotrexate; Methyltransferases; Mice; Thymidylate Synthase; Tritium | 1985 |
Regulation of pyrimidine deoxyribonucleotide metabolism by substrate cycles in dCMP deaminase-deficient V79 hamster cells.
Topics: Animals; Cell Division; Cell Line; Cricetinae; Cytidine Diphosphate; DCMP Deaminase; Deoxycytidine; Deoxycytidine Monophosphate; Deoxycytosine Nucleotides; Deoxyribonucleotides; Deoxyuridine; DNA; Nucleotide Deaminases; Pyrimidines; Thymidine; Thymidine Monophosphate; Thymine Nucleotides; Uridine Diphosphate | 1987 |
Enhancement of the anticancer activity of bis(2-chloroethyl)nitrosourea in mice by coadministration of 2'-deoxyuridine, 2'-deoxycytidine, or thymidine.
Topics: Animals; Carmustine; Deoxycytidine; Deoxyribonucleosides; Deoxyuridine; Drug Synergism; Leukemia L1210; Melanoma, Experimental; Mice; Ribonucleosides; Thymidine | 1987 |
Effect of the dialdehyde derivative of 5'-deoxyinosine on pyrimidine deoxyribonucleoside metabolism in L1210 cells.
Topics: Animals; Cells, Cultured; DCMP Deaminase; Deoxycytidine; Deoxyuridine; Inosine; Leukemia L1210; Mice; Thymidylate Synthase | 1985 |
Role of thymidylate synthetase in the cytostatic activity of pyrimidine nucleoside analogues.
Topics: Animals; Antineoplastic Agents; Arabinofuranosyluracil; Cytarabine; Deoxycytidine; Deoxyuridine; Leukemia L1210; Mice; Pyrimidine Nucleosides; Thymidylate Synthase | 1985 |
Salvage of circulating pyrimidine nucleosides by tissues of the mouse.
Topics: Animals; Cytidine; Deoxycytidine; Deoxyuridine; Half-Life; Male; Metabolic Clearance Rate; Mice; Pyrimidine Nucleosides; Thymidine; Tissue Distribution; Uracil; Uridine | 1985 |
Nucleic acids enzymes in human hair roots.
Topics: Acid Phosphatase; Aminohydrolases; Deoxycytidine; Deoxyribonucleases; Deoxyribonucleosides; Deoxyuridine; DNA; Hair; Humans; Keratins; Nucleic Acids; Nucleoproteins; Nucleosides; Nucleotides; Pentosyltransferases; Phosphoric Diester Hydrolases; Purines; Ribonucleases; RNA; Uric Acid; Xanthine Oxidase | 1973 |
5-Fluorouracil and derivatives in cancer chemotherapy. 3. In vivo enhancement of antitumor activity of 5-fluorouracil (FU) and 5-fluoro-2'-deoxyuridine (FUDR).
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Chromatography, Thin Layer; Deoxycytidine; Deoxyuridine; Dialysis; Drug Synergism; Drug Therapy, Combination; Floxuridine; Fluorouracil; Leukemia L1210; Mice; Mice, Inbred Strains; Neoplasm Transplantation; Neoplasms, Experimental; Transplantation, Homologous | 1973 |
Pyrimidine excretion by cultured fibroblasts: effect of mutational deficiency in pyrimidine salvage enzymes.
Topics: Animals; Carbon Radioisotopes; Cell Line; Cells, Cultured; Chromatography, Thin Layer; Deoxycytidine; Deoxyuridine; Fibroblasts; Mice; Mice, Inbred Strains; Mutation; Phosphotransferases; Pyrimidines; Thymidine; Thymidine Kinase; Uracil | 1974 |
A comparison of the utilization of thymine and thymidine for the synthesis of DNA-thymine in Novikoff hepatoma cells.
Topics: Alkylating Agents; Carcinoma, Hepatocellular; Cells, Cultured; Deoxyadenosines; Deoxycytidine; Deoxyribonucleosides; Deoxyuridine; DNA, Neoplasm; Guanosine; Kinetics; Liver Neoplasms; Mesylates; Neoplasms, Experimental; Thymidine; Thymine; Tritium | 1974 |
Cytidine 5'-triphosphate synthetase as a target for inhibition by the antitumor agent 3-deazauridine.
Topics: Animals; Cells, Cultured; Cytidine; Cytosine Nucleotides; Deoxycytidine; Deoxyuridine; Enzyme Inhibitors; Leukemia L1210; Ligases; Liver; Mice; Thymidine; Uracil Nucleotides; Uridine | 1974 |
Changes in the deoxyribonucleoside triphosphate pools of mouse 5178Y lymphoma cells following exposure to methotrexate or 5-fluorouracil.
Topics: Adenosine Triphosphate; Animals; Cell Line; Cells, Cultured; Deoxyadenosines; Deoxycytidine; Deoxyribonucleotides; Deoxyuridine; DNA, Neoplasm; Fluorouracil; Guanosine; Leukemia, Experimental; Leukemia, Lymphoid; Methotrexate; Mice; Phosphates; Thymidine; Tritium | 1973 |
A comparative study of the relative ease of thermolytic depurination vs. depyrimidination in 2'-deoxynucleosides.
Topics: Calorimetry; Chemical Phenomena; Chemistry; Chromatography, Ion Exchange; Deoxyadenosines; Deoxycytidine; Deoxyribonucleosides; Deoxyuridine; Dimethyl Sulfoxide; Guanosine; Hot Temperature; Magnetic Resonance Spectroscopy; Molecular Conformation; Purine Nucleosides; Pyrimidine Nucleosides; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Temperature; Thermodynamics; Thymidine | 1974 |
A mutant of Escherichia coli defective in ribonucleosidediphosphate reductase. 1. Isolation of the mutant as a deoxyuridine auxotroph.
Topics: Alcohol Oxidoreductases; Aminohydrolases; Culture Media; Deoxycytidine; Deoxyribonucleotides; Deoxyuridine; Escherichia coli; Genetics, Microbial; Mutation; Phenotype; Ribonucleotides; Thymidine; Thymidylate Synthase; Thymine Nucleotides; Trimethoprim; Uracil Nucleotides | 1973 |
The effect of inhibition of cytidine deaminase by tetrahydrouridine on the utilization of deoxycytidine and 5-bromodeoxycytidine for deoxyribonucleic acid synthesis.
Topics: Adenocarcinoma; Aminohydrolases; Animals; Bone Marrow; Bromine; Cytidine; Deoxycytidine; Deoxyribonucleosides; Deoxyuridine; DNA; DNA, Neoplasm; Female; Fluorine; Intestine, Small; Lymphoma; Male; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Neoplasms, Experimental; Spleen; Testis; Tritium; Uridine | 1973 |
The problem of host DNA synthesis in murine cytomegalovirus-infected cells.
Topics: Animals; Cell Line; Cell Nucleus; Cytomegalovirus; Cytoplasm; Deoxycytidine; Deoxyribonucleosides; Deoxyuridine; DNA; Mice; Phosphates; Thymidine; Uridine | 1980 |
Capacity of deoxycytidine to selectively antagonize cytotoxicity of 5-halogenated analogs of deoxycytidine without loss of antiherpetic activity.
Topics: Animals; Antiviral Agents; Cell Cycle; Cytidine Deaminase; Deoxycytidine; Deoxyuridine; DNA, Viral; Herpes Simplex; Kinetics; Mice; Simplexvirus; Virus Replication | 1982 |
Synthesis and biological properties of 2'-deoxy-5-vinyluridine and 2'deoxy-5-vinylcytidine.
Topics: Animals; Antiviral Agents; Deoxycytidine; Deoxyuridine; Drug Evaluation, Preclinical; Herpesviridae Infections; Leukemia L1210; Mice; Structure-Activity Relationship | 1982 |
Effects of certain nucleoside analogues on human cytomegalovirus replication in vitro.
Topics: Antiviral Agents; Cytomegalovirus; Deoxycytidine; Deoxyuridine; DNA, Viral; Humans; Nucleosides; Protein Biosynthesis; Viral Proteins; Virus Replication | 1984 |
Is ribonucleotide reductase in Ehrlich ascites mammary tumour cells the target of a growth inhibitor purified from bovine mammary gland?
Topics: Animals; Carcinoma, Ehrlich Tumor; Cattle; Cells, Cultured; Cytidine; Deoxycytidine; Deoxyuridine; Electrophoresis, Polyacrylamide Gel; Epidermal Growth Factor; Female; Growth Inhibitors; Hydroxyurea; Insulin; Mammary Glands, Animal; Mice; Nucleosides; Ribonucleotide Reductases; Uracil; Uridine | 1984 |
Antitumor cell and antimetabolic effects of 5-ethyl-2'-deoxyuridine and 5'-substituted 5-ethyl-2'-deoxyuridine derivatives.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Division; Cell Survival; Cells, Cultured; Deoxycytidine; Deoxyuridine; DNA, Neoplasm; Leukemia L1210; Mice; Thymidine Kinase | 1984 |
Probing sister chromatid exchange formation with halogenated pyrimidines.
Topics: Animals; Bone Marrow; Bromodeoxycytidine; Bromodeoxyuridine; Deoxycytidine; Deoxyuridine; Humans; Idoxuridine; Lymphocytes; Mice; Models, Genetic; Pyrimidines; Rabbits; Sister Chromatid Exchange | 1984 |
Dipyridamole inhibits reversion by thymidine of methotrexate effect and increases drug uptake in Sarcoma 180 cells.
Topics: Animals; Biological Transport; Deoxycytidine; Deoxyuridine; Dipyridamole; DNA Replication; Drug Antagonism; Kinetics; Methotrexate; Mice; Sarcoma 180; Thymidine; Thymine Nucleotides | 1984 |
Synthesis and biological activity of various 3'-azido and 3'-amino analogues of 5-substituted pyrimidine deoxyribonucleosides.
Topics: Animals; Antineoplastic Agents; Deoxycytidine; Deoxycytidine Kinase; Deoxyuridine; Leukemia L1210; Mice; Sarcoma 180; Thymidine Kinase | 1983 |
Strategies for the measurement of the inhibitory effects of thymidine analogs on the activity of thymidylate synthase in intact murine leukemia L1210 cells.
Topics: Animals; Deoxycytidine; Deoxyuridine; DNA; Leukemia L1210; Methyltransferases; Mice; Thymidine; Thymidylate Synthase | 1984 |
Synthesis and biological properties of some cyclic phosphotriesters derived from 2'-deoxy-5-fluorouridine.
Topics: Animals; Antimetabolites, Antineoplastic; Bromodeoxyuridine; Deoxycytidine; Deoxyuridine; Drug Resistance; Indicators and Reagents; Leukemia L1210; Mice; Organophosphorus Compounds; Structure-Activity Relationship; Thymidine; Thymidine Monophosphate | 1984 |
Inhibition of thymidylate synthase by hydroxyurea in rapidly proliferating P815 mastocytoma cells.
Topics: Animals; Deoxycytidine; Deoxyuridine; DNA, Neoplasm; Hydroxyurea; Mast-Cell Sarcoma; Methyltransferases; Mice; Thymidine; Thymidylate Synthase | 1982 |
Purine nucleoside analogues inhibit the repair of radiation-induced potentially lethal damage in mammalian cells in culture.
Topics: Animals; Cells, Cultured; Cricetinae; Cricetulus; Deoxycytidine; Deoxyguanosine; Deoxyuridine; Dideoxynucleosides; DNA Repair; Dose-Response Relationship, Drug; Purine Nucleosides; Thymidine; Vidarabine | 1982 |
Interaction of an Escherichia coli mutator gene with a deoxyribonucleotide effector.
Topics: Culture Media; Deoxycytidine; Deoxyuridine; Escherichia coli; Genes; Mutation; Thymidine | 1980 |
Synthesis of pyridazine analogues of the naturally occurring nucleosides cytidine, uridine, deoxycytidine, and deoxyuridine.
Topics: Animals; Antineoplastic Agents; Chemical Phenomena; Chemistry; Cytidine; Deoxycytidine; Deoxyuridine; Hydrolysis; In Vitro Techniques; Leukemia L1210; Magnetic Resonance Spectroscopy; Mice; Pyridazines; Pyrimidine Nucleosides; Uridine | 1982 |
Radioimmunoassays of plasma thymidine, uridine, deoxyuridine, and cytidine/deoxycytidine.
Topics: Animals; Cytidine; Deoxycytidine; Deoxyuridine; Immune Sera; Radioimmunoassay; Thymidine; Uridine | 1981 |
Individual changes of DNA catabolite excretion in the course of antitumor therapy of Hodgkin's disease.
Topics: Cyclophosphamide; Deoxycytidine; Deoxyuridine; Hodgkin Disease; Humans; Prednisone; Procarbazine; Thymidine | 1980 |
Identification of cytidine deaminase as inhibitor of granulocyte-macrophage colony formation.
Topics: Animals; Azacitidine; Bone Marrow Cells; Cell Division; Cytarabine; Cytidine Deaminase; Deoxycytidine; Deoxyuridine; DNA; Female; Granulocytes; Hematopoietic Stem Cells; Macrophages; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Thymidine | 1994 |
New substrates for old enzymes. 5-Hydroxy-2'-deoxycytidine and 5-hydroxy-2'-deoxyuridine are substrates for Escherichia coli endonuclease III and formamidopyrimidine DNA N-glycosylase, while 5-hydroxy-2'-deoxyuridine is a substrate for uracil DNA N-glycos
Topics: Base Sequence; Deoxycytidine; Deoxyribonuclease (Pyrimidine Dimer); Deoxyuridine; DNA Glycosylases; DNA Repair; DNA-Formamidopyrimidine Glycosylase; Endodeoxyribonucleases; Escherichia coli; Escherichia coli Proteins; Molecular Sequence Data; N-Glycosyl Hydrolases; Oligodeoxyribonucleotides; Substrate Specificity; Uracil-DNA Glycosidase | 1994 |
Nucleotide metabolism in Lactococcus lactis: salvage pathways of exogenous pyrimidines.
Topics: Cytidine; Deoxycytidine; Deoxyuridine; Enzymes; Escherichia coli; Kinetics; Lactococcus lactis; Pyrimidines; Species Specificity; Uracil; Uridine | 1994 |
Regulation of thymidine kinase and thymidylate synthase in intact human lymphoblast CCRF-CEM cells.
Topics: Aphidicolin; Carbon Radioisotopes; Cell Cycle; Cytarabine; Deoxycytidine; Deoxyuridine; DNA Replication; DNA, Neoplasm; Hydroxyurea; Kinetics; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Thymidine Kinase; Thymidylate Synthase; Time Factors; Tritium; Tumor Cells, Cultured | 1993 |
2'-Deoxy-2'-methylene derivatives of adenosine, guanosine, tubercidin, cytidine and uridine as inhibitors of L1210 cell growth in culture.
Topics: Animals; Cell Cycle; Cell Division; Deoxyadenosines; Deoxycytidine; Deoxyguanosine; Deoxyuridine; Leukemia L1210; Ribonucleotide Reductases; Tubercidin; Tumor Cells, Cultured | 1994 |
Reaction of epichlorohydrin with 2'-deoxynucleosides: characterization of adducts.
Topics: Chromatography, High Pressure Liquid; Deoxyadenosines; Deoxycytidine; Deoxyguanosine; Deoxyribonucleosides; Deoxyuridine; DNA Adducts; Environmental Pollution; Epichlorohydrin; Humans; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Structure; Occupational Exposure; Thymidine | 1996 |
Synthesis and antiviral activity of 5-substituted (2'S)-2'-deoxy-2'-C-methylcytidines and -uridines.
Topics: Animals; Antineoplastic Agents; Antiviral Agents; Deoxycytidine; Deoxyuridine; Herpesvirus 1, Human; Herpesvirus 3, Human; Humans; Male; Mice; Mice, Inbred ICR; Structure-Activity Relationship; Tumor Cells, Cultured | 1996 |
Cloning of the cDNA and chromosome localization of the gene for human thymidine kinase 2.
Topics: Amino Acid Sequence; Base Sequence; Chromosome Mapping; Cloning, Molecular; Deoxycytidine; Deoxycytidine Kinase; Deoxyuridine; DNA, Complementary; Humans; Molecular Sequence Data; Phosphotransferases (Alcohol Group Acceptor); Polymerase Chain Reaction; Sequence Alignment; Thymidine; Thymidine Kinase | 1997 |
Regioselective effect of zwitterionic DNA substitutions on DNA alkylation: evidence for a strong side chain orientational preference.
Topics: Circular Dichroism; Computer Simulation; Deoxycytidine; Deoxyuridine; DNA; DNA Methylation; Ions; Isomerism; Methylnitrosourea; Models, Molecular; Nucleic Acid Conformation; Sulfuric Acid Esters | 1997 |
Cellular delivery of nucleoside diphosphates: a prodrug approach.
Topics: Animals; Antineoplastic Agents; Azides; Cell Division; Cell Line; CHO Cells; Cricetinae; Cytidine Diphosphate; Deoxycytidine; Deoxycytidine Kinase; Deoxyuracil Nucleotides; Deoxyuridine; Dideoxynucleotides; Hydrolysis; Permeability; Phosphorylation; Prodrugs; Ribonucleotide Reductases; Tumor Cells, Cultured; Uridine Monophosphate | 1997 |
Chemical modification of deoxycytidine at different sites yields adducts of different stabilities: characterization of N3- and O2-deoxycytidine and N3-deoxyuridine adducts of butadiene monoxide.
Topics: Carcinogens; Deoxycytidine; Deoxyuridine; Epoxy Compounds; Kinetics; Magnetic Resonance Spectroscopy; Spectrometry, Mass, Fast Atom Bombardment; Spectrophotometry, Ultraviolet | 1997 |
Relaxed enantioselectivity of human mitochondrial thymidine kinase and chemotherapeutic uses of L-nucleoside analogues.
Topics: Binding, Competitive; Bromodeoxyuridine; Cyclopentanes; Cytosol; Deoxycytidine; Deoxycytidine Kinase; Deoxyuridine; HeLa Cells; Humans; Mitochondria; Phosphorylation; Stereoisomerism; Substrate Specificity; Thymidine; Thymidine Kinase | 1997 |
Synthesis of oligonucleotides containing two putatively mutagenic DNA lesions: 5-hydroxy-2'-deoxyuridine and 5-hydroxy-2'-deoxycytidine.
Topics: Chromatography, High Pressure Liquid; Deoxycytidine; Deoxyuridine; Gas Chromatography-Mass Spectrometry; Mutagenesis; Oligonucleotides; Organophosphorus Compounds | 1997 |
Incorporation of two deoxycytidine oxidation products into cellular DNA.
Topics: Animals; Deoxycytidine; Deoxyuridine; DNA; DNA Damage; DNA Repair; HeLa Cells; Humans; Jurkat Cells; Leukemia L1210; Mice; Oxidation-Reduction | 1997 |
Intermediate in reaction of 2'-deoxycytidine with nitrous acid.
Topics: Chromatography, High Pressure Liquid; Deoxycytidine; Deoxyuridine; Indicators and Reagents; Kinetics; Mutagens; Nitroso Compounds; Nitrous Acid | 1997 |
DNA modifications by the mutagen glyoxal: adduction to G and C, deamination of C and GC and GA cross-linking.
Topics: Cytosine; Deamination; Deoxycytidine; Deoxyguanosine; Deoxyuridine; DNA Adducts; Glyoxal; Guanine; Single-Strand Specific DNA and RNA Endonucleases; Thymidine | 1998 |
The mutations induced by oxidatively damaged nucleotides, 5-formyl-dUTP and 5-hydroxy-dCTP,in Escherichia coli.
Topics: Bacterial Proteins; Deoxyadenine Nucleotides; Deoxycytidine; Deoxycytosine Nucleotides; Deoxyguanine Nucleotides; Deoxyuracil Nucleotides; Deoxyuridine; DNA Mutational Analysis; DNA Repair; Escherichia coli; Escherichia coli Proteins; Genome, Bacterial; Lac Repressors; Models, Genetic; Mutagenesis; Nucleic Acid Hybridization; Oxidants; Point Mutation; Repressor Proteins; Sequence Analysis, DNA; Thymine Nucleotides | 1998 |
Nucleosides and nucleotides. 176. 2'-Deoxy-2'-hydroxylaminocytidine: a new antitumor nucleoside that inhibits DNA synthesis although it has a ribonucleoside structure.
Topics: Animals; Antimetabolites, Antineoplastic; Deoxycytidine; Deoxyuridine; DNA Replication; Electron Spin Resonance Spectroscopy; Humans; Hydroxylamines; Mice; Phosphorylation; Tumor Cells, Cultured | 1998 |
Formation of deaminated products in styrene oxide reactions with deoxycytidine.
Topics: Amides; Chromatography, High Pressure Liquid; Circular Dichroism; Deoxycytidine; Deoxyuridine; DNA Adducts; Epoxy Compounds; Hydrogen Bonding; Mutagens; Spectrophotometry, Ultraviolet; Stereoisomerism | 1999 |
Preparation of 2'-deoxyribonucleosides with an identically 2H/13C-labeled sugar residue.
Topics: Carbon Isotopes; Deoxyadenosines; Deoxycytidine; Deoxyguanosine; Deoxyribonucleosides; Deoxyuridine; Deuterium; Glucose; Isotope Labeling; Nuclear Magnetic Resonance, Biomolecular; Oligodeoxyribonucleotides; Ribose | 1999 |
Styrene oxide-induced 2'-deoxycytidine adducts: implications for the mutagenicity of styrene oxide.
Topics: Animals; Chromatography, High Pressure Liquid; Deamination; Deoxycytidine; Deoxyuridine; DNA Adducts; DNA Damage; Epoxy Compounds; Mass Spectrometry; Mutagens; Salmon; Spectrophotometry, Ultraviolet | 2000 |
Cloning and characterization of full-length mouse thymidine kinase 2: the N-terminal sequence directs import of the precursor protein into mitochondria.
Topics: Amino Acid Sequence; Animals; Base Sequence; Blotting, Northern; Chromatography, Affinity; Chromatography, Gel; Cloning, Molecular; Deoxycytidine; Deoxyuridine; DNA, Complementary; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Gene Library; Humans; Kinetics; Mice; Mitochondria; Mitochondria, Liver; Molecular Sequence Data; Phosphorylation; Protein Biosynthesis; Rats; Recombinant Proteins; RNA, Messenger; Sequence Analysis, Protein; Thymidine; Thymidine Kinase; Tissue Distribution | 2000 |
Some aspects of the role of vitamin B12 in nucleic acid synthesis in a neoplastic C3H mouse cell strain. I. Growth studies.
Topics: Adenine; Adenosine; Animals; Cell Division; Cytidine; Deoxyadenosines; Deoxycytidine; Deoxyuridine; DNA, Neoplasm; Folic Acid; Guanine; Mice; Nucleic Acid Precursors; Nucleosides; Pyrimidines; Thymidine; Tumor Cells, Cultured; Uridine; Vitamin B 12 | 1970 |
Some aspects of the role of vitamin B12 in nucleic acid synthesis in a neoplastic C3H mouse cell strain. II. Incorporation of precursors.
Topics: Adenine; Animals; Carbon Radioisotopes; Cytidine; Deoxycytidine; Deoxyuridine; DNA, Neoplasm; Mice; Nucleic Acid Precursors; Nucleosides; Thymidine; Tumor Cells, Cultured; Uridine; Vitamin B 12 | 1970 |
Direct radiation action of heavy ions on DNA as studied by ESR-spectroscopy.
Topics: Adenosine; Cytosine; Deoxycytidine; Deoxyuridine; DNA; Dose-Response Relationship, Radiation; Electron Spin Resonance Spectroscopy; Free Radicals; Linear Energy Transfer; Neon; Radiation, Ionizing; Radiobiology; Temperature; Thymine; Uranium; X-Rays | 1992 |
Free radicals induced in solid DNA by heavy ion bombardment.
Topics: Adenosine; Cytosine; Deoxycytidine; Deoxyuridine; DNA; Dose-Response Relationship, Radiation; Electron Spin Resonance Spectroscopy; Free Radicals; Heavy Ions; Linear Energy Transfer; Nucleosides; Radiochemistry; Thymine; X-Rays | 1989 |
C5-(1-propynyl)-2'-deoxy-pyrimidines enhance mismatch penalties of DNA:RNA duplex formation.
Topics: Base Pair Mismatch; Deoxycytidine; Deoxyuridine; DNA; Nucleic Acid Heteroduplexes; Nucleic Acid Hybridization; Oligodeoxyribonucleotides; Pyrimidines; RNA; Thermodynamics; Thionucleotides | 2001 |
One-pot two-step enzymatic coupling of pyrimidine bases to 2-deoxy-D-ribose-5-phosphate. A new strategy in the synthesis of stable isotope labeled deoxynucleosides.
Topics: Catalysis; Deoxycytidine; Deoxyribonucleosides; Deoxyuridine; Dihydroxyacetone Phosphate; Escherichia coli; Isotope Labeling; Magnetic Resonance Spectroscopy; Molecular Structure; Organisms, Genetically Modified; Phosphotransferases; Pyrimidines; Ribosemonophosphates; Saccharomyces cerevisiae; Thymidine; Thymidine Phosphorylase; Triose-Phosphate Isomerase; Uracil | 2002 |
Chemical synthesis and biochemical properties of oligonucleotides that contain the (5'S,5S,6S)-5',6-cyclo-5-hydroxy-5,6-dihydro-2'-deoxyuridine DNA lesion.
Topics: Chromatography, High Pressure Liquid; Deoxycytidine; Deoxyuridine; DNA; DNA Damage; DNA Repair; DNA-Directed DNA Polymerase; Electrophoresis, Polyacrylamide Gel; Gas Chromatography-Mass Spectrometry; Hydrolases; Nucleic Acid Denaturation; Oligonucleotides; Organophosphorus Compounds; Piperidines | 2002 |
Synthesis of 3'- and 5'-nitrooxy pyrimidine nucleoside nitrate esters: "nitric oxide donor" agents for evaluation as anticancer and antiviral agents.
Topics: Animals; Antineoplastic Agents; Antiviral Agents; Cell Line; Chlorocebus aethiops; Deoxycytidine; Deoxyuridine; Drug Screening Assays, Antitumor; Humans; Hydrolysis; In Vitro Techniques; Nitric Oxide; Nitric Oxide Donors; Nitro Compounds; Pyrimidine Nucleosides; Rats; Structure-Activity Relationship; Tumor Cells, Cultured | 2003 |
Inhibition of the replication of a hepatitis C virus-like RNA template by interferon and 3'-deoxycytidine.
Topics: Antiviral Agents; Cell Line; Deoxyadenosines; Deoxycytidine; Deoxyguanosine; Deoxyuridine; Dose-Response Relationship, Drug; Drug Design; Drug Evaluation, Preclinical; Genes, Reporter; HeLa Cells; Hepacivirus; Hepatocytes; Humans; Interferon-alpha; Interferon-beta; Kidney; Luciferases; Recombinant Fusion Proteins; Ribavirin; RNA, Viral; Templates, Genetic; Virus Replication | 2002 |
Stereospecific synthesis of alpha-anomeric pyrimidine nucleoside.
Topics: Deoxycytidine; Deoxyribonucleosides; Deoxyuridine; Molecular Structure; Pyrimidine Nucleosides; Stereoisomerism | 2000 |
Deoxycytidine, deoxyuridine and 5-methyldeoxycytidine in rat urine.
Topics: Animals; Body Fluids; Deoxycytidine; Deoxyuridine; Nucleosides; Nucleotides; Rats | 1960 |
Immunoglobulin gene conversion in chicken DT40 cells largely proceeds through an abasic site intermediate generated by excision of the uracil produced by AID-mediated deoxycytidine deamination.
Topics: Animals; Antibody Diversity; Base Pair Mismatch; Cell Line, Tumor; Chickens; Cytidine Deaminase; Deamination; Deoxycytidine; Deoxyuridine; DNA Glycosylases; Enzyme Inhibitors; Gene Conversion; Genes, Immunoglobulin; Immunoglobulin Variable Region; Somatic Hypermutation, Immunoglobulin; Uracil-DNA Glycosidase | 2004 |
Pyrene-labeled base-discriminating fluorescent DNA probes for homogeneous SNP typing.
Topics: Amides; Deoxycytidine; Deoxyuridine; DNA Probes; Fluorescent Dyes; Humans; Models, Molecular; Polymorphism, Single Nucleotide; Pyrenes; Spectrometry, Fluorescence | 2004 |
beta-Selective synthesis of 2'-deoxy-5,6-dihydro-4-thiouridine, a precursor of the unstable nucleoside product of ionising radiation damage 2'-deoxy-5,6-dihydrocytidine.
Topics: Deoxycytidine; Deoxyuridine; Magnetic Resonance Spectroscopy; Radiation, Ionizing; Spectrometry, Mass, Electrospray Ionization; Thiouridine | 2005 |
Rapid quantitation of plasma 2'-deoxyuridine by high-performance liquid chromatography/atmospheric pressure chemical ionization mass spectrometry and its application to pharmacodynamic studies in cancer patients.
Topics: Atmospheric Pressure; Capecitabine; Chromatography, High Pressure Liquid; Deoxycytidine; Deoxyuridine; Drug Stability; Fluorouracil; Humans; Mass Spectrometry; Neoplasms; Reproducibility of Results; Sensitivity and Specificity | 2005 |
Oxidation of 5-hydroxypyrimidine nucleosides to 5-hydroxyhydantoin and its alpha-hydroxy-ketone isomer.
Topics: Chromatography, High Pressure Liquid; Deoxycytidine; Deoxyuridine; Hydantoins; Hydrogen-Ion Concentration; Indicators and Reagents; Isomerism; Ketones; Kinetics; Magnetic Resonance Spectroscopy; Mass Spectrometry; Nucleosides; Oxidation-Reduction; Stereoisomerism | 2005 |
Syntheses of pyridine C-nucleosides as analogues of the natural nucleosides dC and dU.
Topics: Deoxycytidine; Deoxyuridine; Hydrogen Bonding; Nucleic Acid Conformation; Nucleosides; Pyridines; Stereoisomerism | 2006 |
Altered deoxyuridine and thymidine in plasma following capecitabine treatment in colorectal cancer patients.
Topics: Antimetabolites, Antineoplastic; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Deoxyuridine; Female; Fluorouracil; Humans; Male; Thymidine | 2007 |
Collisionally activated dissociation of protonated 2'-deoxycytidine, 2'-deoxyuridine, and their oxidatively damaged derivatives.
Topics: Chromatography, High Pressure Liquid; Deoxycytidine; Deoxyuridine; Magnetic Resonance Spectroscopy; Oxidation-Reduction; Protons; Pyrimidines; Spectrometry, Mass, Electrospray Ionization | 2006 |
Ferrocene-modified pyrimidine nucleosides: synthesis, structure and electrochemistry.
Topics: Crystallography, X-Ray; Deoxycytidine; Deoxyuridine; DNA; Electrochemistry; Electrons; Ferrous Compounds; Metallocenes; Molecular Structure; Oligonucleotides; Oxidation-Reduction; Pyrimidine Nucleosides | 2006 |
SNPs typing by base-discriminating fluorescence DNA probe.
Topics: Deoxycytidine; Deoxyuridine; DNA Probes; Fluorescent Dyes; Genes, BRCA1; Humans; Nucleic Acid Hybridization; Polymerase Chain Reaction; Polymorphism, Single Nucleotide; Pyrimidine Nucleosides | 2005 |
Post-SELEX chemical optimization of a trypanosome-specific RNA aptamer.
Topics: Animals; Aptamers, Nucleotide; Binding Sites; Deoxycytidine; Deoxyuridine; Electrophoresis, Polyacrylamide Gel; Lysosomes; Polyethylene Glycols; Ribonucleases; RNA; SELEX Aptamer Technique; Spectrum Analysis; Temperature; Time Factors; Trypanosomiasis, African | 2008 |
Study on disulfur-backboned nucleic acids: part 3. Efficient synthesis of 3',5'-dithio-2'-deoxyuridine and deoxycytidine.
Topics: Deoxycytidine; Deoxyuridine; Magnetic Resonance Spectroscopy; Molecular Structure; Nucleic Acids | 2008 |
Origin of pyrimidine deoxyribonucleotide pools in perfused rat heart: implications for 3'-azido-3'-deoxythymidine-dependent cardiotoxicity.
Topics: Animals; Chromatography, High Pressure Liquid; Cytidine; Cytidine Triphosphate; Deoxyadenine Nucleotides; Deoxycytidine; Deoxycytosine Nucleotides; Deoxyguanine Nucleotides; Deoxyuridine; Heart; In Vitro Techniques; Male; Perfusion; Phosphorylation; Pyrimidine Nucleotides; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Inhibitors; Thymine Nucleotides; Uracil; Uridine; Uridine Monophosphate; Uridine Triphosphate; Zidovudine | 2009 |
Fishing in the (deoxyribonucleotide) pool.
Topics: Animals; Antimetabolites; Cytidine; Cytidine Triphosphate; Deoxyadenine Nucleotides; Deoxycytidine; Deoxycytosine Nucleotides; Deoxyguanine Nucleotides; Deoxyuridine; Heart; Humans; Mitochondria; Mitochondrial Diseases; Models, Biological; Phosphorylation; Pyrimidine Nucleotides; Rats; Thymine Nucleotides; Uracil; Uridine; Uridine Monophosphate; Uridine Triphosphate; Zidovudine | 2009 |
Chelation-controlled regioselective alkylation of pyrimidine 2'-deoxynucleosides.
Topics: Alkylation; Chelating Agents; Crown Ethers; Deoxycytidine; Deoxyuridine; Electric Impedance; Pyrimidine Nucleosides; Solvents; Stereoisomerism; Substrate Specificity; Thymidine | 2010 |
Pasteurella multocida thymidine kinase 1 efficiently activates pyrimidine nucleoside analogs.
Topics: Antimetabolites, Antineoplastic; Deoxycytidine; Deoxyuridine; Escherichia coli; Gemcitabine; Microbial Sensitivity Tests; Pasteurella multocida; Pyrimidine Nucleosides; Thymidine Kinase; Zidovudine | 2010 |
Improved synthesis of 5-hydroxymethyl-2'-deoxycytidine phosphoramidite using a 2'-deoxyuridine to 2'-deoxycytidine conversion without temporary protecting groups.
Topics: Deoxycytidine; Deoxyuridine; Electrophoresis, Capillary; Humans; Oligonucleotides; Organophosphorus Compounds; Spectrometry, Mass, Electrospray Ionization | 2011 |
Combinatorial pharmacologic effects of gemcitabine and its metabolite dFdU.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Combinatorial Chemistry Techniques; Deoxycytidine; Deoxyuridine; Embryo, Nonmammalian; Embryonic Development; Floxuridine; Gemcitabine; Humans; Tumor Stem Cell Assay; Zebrafish | 2011 |
Duplex and triplex formation of mixed pyrimidine oligonucleotides with stacking of phenyl-triazole moieties in the major groove.
Topics: Base Sequence; Circular Dichroism; Deoxycytidine; Deoxyuridine; DNA, Complementary; Models, Molecular; Molecular Structure; Nucleic Acid Conformation; Nucleosides; Nucleotides; Oligonucleotides; Pyrimidines; RNA, Complementary; Triazoles | 2011 |
Metabolism of deoxypyrimidines and deoxypyrimidine antiviral analogs in isolated brain mitochondria.
Topics: Animals; Brain; Chromatography, High Pressure Liquid; Deoxycytidine; Deoxyuridine; Dose-Response Relationship, Drug; Kinetics; Male; Mitochondria; Nucleotidases; Phosphorylation; Pyrimidine Nucleosides; Rats; Rats, Sprague-Dawley; Stavudine; Thymidine; Time Factors; Tritium; Zidovudine | 2012 |
Human carboxylesterase-2 hydrolyzes the prodrug of gemcitabine (LY2334737) and confers prodrug sensitivity to cancer cells.
Topics: Antimetabolites, Antineoplastic; Blotting, Western; Bystander Effect; Carboxylesterase; Deoxycytidine; Deoxyuridine; Female; Gemcitabine; Humans; Hydrolysis; Molecular Structure; Neoplasms; Prodrugs; Recombinant Proteins; RNA, Small Interfering; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2013 |
Efficacy of low-dose oral metronomic dosing of the prodrug of gemcitabine, LY2334737, in human tumor xenografts.
Topics: Administration, Metronomic; Administration, Oral; Animals; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Deoxycytidine; Deoxyuridine; Disease Models, Animal; Dose-Response Relationship, Drug; Gemcitabine; Gene Expression; HCT116 Cells; Humans; Lung Neoplasms; Mice; Prodrugs; Valproic Acid; Xenograft Model Antitumor Assays | 2013 |
Effective synthesis of 3'-deoxy-3'-azido nucleosides for antiviral and antisense ribonucleic guanidine (RNG) applications.
Topics: Azides; Deoxycytidine; Deoxyuridine; Nucleic Acid Conformation; Oligodeoxyribonucleotides; RNA, Antisense | 2013 |
HDAC inhibitors dysregulate neural stem cell activity in the postnatal mouse brain.
Topics: Age Factors; Animals; Animals, Newborn; Brain; Bromodeoxycytidine; Cell Differentiation; Cells, Cultured; Deoxycytidine; Deoxyuridine; Dose-Response Relationship, Drug; Gene Expression Regulation, Developmental; Histone Deacetylase 1; Histone Deacetylase 2; Histone Deacetylase Inhibitors; Mice; Nerve Tissue Proteins; Neural Stem Cells; Neurogenesis; Proliferating Cell Nuclear Antigen; SOXB1 Transcription Factors; Valproic Acid | 2013 |
Evaluation of (131/123)I-5-iodo-2'-deoxycytidine as a novel proliferation probe in a tumor mouse model.
Topics: Animals; Bromodeoxycytidine; Cell Line, Tumor; Deoxycytidine; Deoxyuridine; Female; Iodine Radioisotopes; Isotope Labeling; Metabolic Clearance Rate; Mice; Molecular Probe Techniques; Organ Specificity; Radionuclide Imaging; Radiopharmaceuticals; Sarcoma; Tissue Distribution | 2013 |
High sensitive assay employing column switching chromatography to enable simultaneous quantification of an amide prodrug of gemcitabine (LY2334737), gemcitabine, and its metabolite dFdU in human plasma by LC-MS/MS.
Topics: Antimetabolites, Antineoplastic; Chromatography, Liquid; Deoxycytidine; Deoxyuridine; Floxuridine; Gemcitabine; Humans; Prodrugs; Sensitivity and Specificity; Tandem Mass Spectrometry | 2013 |
The radiosensitising effect of gemcitabine and its main metabolite dFdU under low oxygen conditions is in vitro not dependent on functional HIF-1 protein.
Topics: Breast Neoplasms; Cell Cycle; Cell Hypoxia; Cell Line, Tumor; Deoxycytidine; Deoxyuridine; Female; Gemcitabine; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; In Vitro Techniques; Radiation-Sensitizing Agents | 2014 |
Reactivity of damaged pyrimidines: formation of a Schiff base intermediate at the glycosidic bond of saturated dihydrouridine.
Topics: Catalysis; Deoxycytidine; Deoxyribose; Deoxyuridine; DNA Glycosylases; Glycosylation; Hydrogen-Ion Concentration; Hydrogenation; Isomerism; Magnetic Resonance Spectroscopy; Palladium; Pyrimidines; Schiff Bases; Tandem Mass Spectrometry; Thymidine | 2015 |
Dr Jekyll and Mr Hyde: a strange case of 5-ethynyl-2'-deoxyuridine and 5-ethynyl-2'-deoxycytidine.
Topics: Antibodies; Bromodeoxyuridine; Cell Death; Cell Line, Tumor; Cell Nucleus; Cytidine Deaminase; Deoxycytidine; Deoxyuridine; DNA; DNA Replication; Humans; Metabolome; RNA, Small Interfering | 2016 |
Chemical Morphing of DNA Containing Four Noncanonical Bases.
Topics: Deoxycytidine; Deoxyguanine Nucleotides; Deoxyuridine; DNA; Escherichia coli; Polymerase Chain Reaction; Trimethoprim; Trimethoprim Resistance; Tubercidin | 2016 |
Base-Modified Nucleic Acids as a Powerful Tool for Synthetic Biology and Biotechnology.
Topics: Base Sequence; Biotechnology; Bromodeoxycytidine; Deoxyadenosines; Deoxycytidine; Deoxyuridine; DNA; Gene Library; Nucleic Acids; Polymerase Chain Reaction; Synthetic Biology; Taq Polymerase | 2017 |
Triplex- and Duplex-Forming Abilities of Oligonucleotides Containing 2'-Deoxy-5-trifluoromethyluridine and 2'-Deoxy-5-trifluoromethylcytidine.
Topics: Base Pairing; Deoxycytidine; Deoxyuridine; DNA; Kinetics; Nucleic Acid Denaturation; Oligonucleotides; RNA; Ultraviolet Rays | 2017 |
5-Ethynyl-2'-deoxycytidine and 5-ethynyl-2'-deoxyuridine are differentially incorporated in cells infected with HSV-1, HCMV, and KSHV viruses.
Topics: Biological Transport; Cell Line; Cytomegalovirus; Deoxycytidine; Deoxyuridine; Fibroblasts; Herpesvirus 1, Human; Herpesvirus 8, Human; Humans; Retinal Pigment Epithelium | 2020 |
Diagnostic and Prognostic Power of Active DNA Demethylation Pathway Intermediates in Acute Myelogenous Leukemia and Myelodysplastic Syndromes.
Topics: Deoxycytidine; Deoxyuridine; DNA; DNA Demethylation; Humans; Leukemia, Myeloid, Acute; Myelodysplastic Syndromes; Prognosis | 2022 |