Compounds > demethoxyviridin

Page last updated: 2024-09-03

demethoxyviridin and wortmannin

demethoxyviridin has been researched along with wortmannin in 8 studies

Compound Research Comparison

Studies (demethoxyviridin)	Trials (demethoxyviridin)	Recent Studies (post-2010) (demethoxyviridin)	Studies (wortmannin)	Trials (wortmannin)	Recent Studies (post-2010) (wortmannin)
15	0	3	4,066	2	726

Protein Interaction Comparison

Protein	Taxonomy	demethoxyviridin (IC50)	wortmannin (IC50)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)		0.0465
Myosin light chain kinase, smooth muscle	Gallus gallus (chicken)		0.26
Metabotropic glutamate receptor 1	Rattus norvegicus (Norway rat)		0.0085
Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)		0.2368
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)		0.1309
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)		0.0493
Serine/threonine-protein kinase mTOR	Homo sapiens (human)		0.04
Phosphatidylinositol 4-kinase alpha	Homo sapiens (human)		0.28
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)		0.0492
Serine/threonine-protein kinase PLK1	Homo sapiens (human)		0.4433
Myosin light chain kinase, smooth muscle	Homo sapiens (human)		2.3567
Phosphoinositide 3-kinase regulatory subunit 5	Homo sapiens (human)		0.019
Serine/threonine-protein kinase PLK3	Homo sapiens (human)		0.1057
Phosphatidylinositol 4-kinase beta	Homo sapiens (human)		0.44

Research

Studies (8)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	6 (75.00)	18.2507
2000's	2 (25.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Blois, J; Clardy, J; Josephson, L; Pupo, MT; Smith, A; Weissleder, R; Yuan, H	1
Bonser, RW; Garland, LG; Hodson, HF; Randall, RW; Spacey, GD; Tateson, JE; Thompson, NT	1
Cross, MJ; Hodgkin, MN; Kerr, DJ; Stewart, A; Wakelam, MJ	1
Ballou, LM; Edelmann, HM; Parker, PJ; Petritsch, C; Woscholski, R	1
Kodaki, T; McKinnon, M; Parker, PJ; Waterfield, MD; Woscholski, R	1
Auer, M; Baumruker, T; Harrer, NE; Pendl, GG; Prieschl, EE; Thumb, W	1
Brunton, VG; Cross, MJ; Hill, R; Hodgkin, MN; Kerr, DJ; MacAully, G; Plumb, JA; Stewart, A; Wakelam, MJ; Workman, P	1
Badwey, JA; Cook, JA; Giner, JL; Kehbein, KA; Smith, MC; Vlahos, CJ	1

Other Studies

8 other study(ies) available for demethoxyviridin and wortmannin

Article	Year
A stabilized demethoxyviridin derivative inhibits PI3 kinase. Bioorganic & medicinal chemistry letters, 2009, Aug-01, Volume: 19, Issue:15 Topics: Amines; Androstadienes; Androstenes; Animals; Chemistry, Pharmaceutical; Drug Design; Enzyme Inhibitors; Esters; Glucosides; Glycine; Inhibitory Concentration 50; Models, Chemical; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Sulfonamides; Wortmannin	2009
Demethoxyviridin and wortmannin block phospholipase C and D activation in the human neutrophil. British journal of pharmacology, 1991, Volume: 103, Issue:1 Topics: Androstadienes; Androstenes; Anti-Inflammatory Agents, Non-Steroidal; Diglycerides; Female; GTP-Binding Proteins; Humans; In Vitro Techniques; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phospholipase D; Receptors, Formyl Peptide; Receptors, Immunologic; Second Messenger Systems; Tetradecanoylphorbol Acetate; Type C Phospholipases; Wortmannin	1991
Wortmannin and its structural analogue demethoxyviridin inhibit stimulated phospholipase A2 activity in Swiss 3T3 cells. Wortmannin is not a specific inhibitor of phosphatidylinositol 3-kinase. The Journal of biological chemistry, 1995, Oct-27, Volume: 270, Issue:43 Topics: 3T3 Cells; Androstadienes; Androstenes; Animals; Bombesin; Dose-Response Relationship, Drug; Enzyme Activation; Mice; Phosphatidylinositol 3-Kinases; Phosphatidylinositol Phosphates; Phosphodiesterase Inhibitors; Phospholipase D; Phospholipases; Phospholipases A; Phospholipases A2; Phosphotransferases (Alcohol Group Acceptor); Type C Phospholipases; Wortmannin	1995
Selective inhibition of p70 S6 kinase activation by phosphatidylinositol 3-kinase inhibitors. European journal of biochemistry, 1995, Jun-01, Volume: 230, Issue:2 Topics: 3T3 Cells; Androstadienes; Androstenes; Animals; Enzyme Activation; Epidermal Growth Factor; Mice; Phosphatidylinositol 3-Kinases; Phosphatidylinositol Phosphates; Phosphotransferases (Alcohol Group Acceptor); Platelet-Derived Growth Factor; Protein Serine-Threonine Kinases; Ribosomal Protein S6 Kinases; Signal Transduction; Wortmannin	1995
A comparison of demethoxyviridin and wortmannin as inhibitors of phosphatidylinositol 3-kinase. FEBS letters, 1994, Apr-04, Volume: 342, Issue:2 Topics: Androstadienes; Androstenes; Animals; Baculoviridae; Binding Sites; Gene Expression; Genetic Vectors; In Vitro Techniques; Insecta; Mammals; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Saccharomyces cerevisiae; Schizosaccharomyces; Wortmannin	1994
Effects of phosphatidylinositol-3-kinase inhibitors on degranulation and gene induction in allergically triggered mouse mast cells. International archives of allergy and immunology, 1997, Volume: 112, Issue:4 Topics: Allergens; Androstadienes; Androstenes; Animals; Cell Degranulation; Cell Line; Dinitrobenzenes; Gene Expression Regulation; Immunoglobulin E; Leukotriene Antagonists; Leukotrienes; Mast Cells; Mice; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Transcriptional Activation; Tumor Necrosis Factor-alpha; Wortmannin	1997
Inhibition of phospholipid signalling and proliferation of Swiss 3T3 cells by the wortmannin analogue demethoxyviridin. Biochimica et biophysica acta, 1997, Nov-28, Volume: 1362, Issue:1 Topics: 3T3 Cells; Androstadienes; Androstenes; Animals; Bombesin; Cell Division; Enzyme Inhibitors; Insulin; Mice; Phosphatidylinositols; Phosphoinositide-3 Kinase Inhibitors; Phospholipases; Phospholipids; Phosphorylation; Receptor Protein-Tyrosine Kinases; Signal Transduction; Tyrosine; Wortmannin	1997
Synthesis of fluorescent derivatives of wortmannin and demethoxyviridin as probes for phosphatidylinositol 3-kinase. Bioorganic & medicinal chemistry letters, 2006, May-01, Volume: 16, Issue:9 Topics: Androstadienes; Androstenes; Enzyme Inhibitors; Fluorescent Dyes; Molecular Conformation; Molecular Probe Techniques; Phosphoinositide-3 Kinase Inhibitors; Stereoisomerism; Structure-Activity Relationship; Wortmannin	2006