demecolcine has been researched along with 5-chloro-2--deoxyuridine* in 2 studies
2 other study(ies) available for demecolcine and 5-chloro-2--deoxyuridine
| Article | Year |
|---|---|
[Telomeric fusion of the chromosomes in cells with micronuclei during the subsequent incorporation into the DNA of thymidine halogenated analogs].
As was shown elsewhere among halogenated analogs of thymidine there exist strong (5-chlorodeoxyuridine, 5-ChldU) and weak (5-iododeoxyuridine, 5-IdU) inducers of dicentric chromosomes in cells with micronuclei. Since from colcemid administration to the moment of fixation two cycles of replication are passed, a study was made of the pattern of induction of dicentric chromosomes under subsequent administration of 5-ChldU and 5-IdU, and the other way round. It was shown that the pattern of induction of dicentric chromosomes was strong or weak, and depended on the fact which analog was administered in the first S-period. Topics: Animals; Cells, Cultured; Chromosomes; Cricetinae; Cricetulus; Demecolcine; Deoxyuridine; DNA; Idoxuridine; Micronuclei, Chromosome-Defective; Thymidine | 1989 |
[5-Chlorodeoxyuridine, more effectively than 5-bromodeoxyuridine, induces the formation of specific dicentric chromosomes in cells with micronuclei].
5-chlorodeoxyuridine (5-ChldU) and 5-bromodeoxyuridine (5-BrdU) were tested in respect of the formation of specific dicentric chromosomes in cells with micronuclei. It is shown that the frequency of dicentrics is higher when 5-ChldU is used. On the ground of results of this study and of the previous data it is concluded that the activity of halogenated deoxyuridines is falling with molecular weight increasing. Topics: Animals; Bromodeoxyuridine; Cell Line; Cells, Cultured; Chromosome Aberrations; Cricetinae; Cricetulus; Demecolcine; Deoxyuridine; Micronucleus Tests; Molecular Weight | 1988 |