demeclocycline and camphorated-parachlorophenol

The aim of this study was to evaluate the time required by four different root canal medications coupled with the temporary filling material Cavit (ESPE, Seefeld, Germany) to prevent penetration of bacteria into the root canal. There were 145 roots prepared in a standardized manner. Four groups with 15 samples each were dressed with calcium hydroxide (Ca(OH)(2)), a 5% chlorhexidine gel (CHX), a chloromono-campherphenolic compound (ChKM), and Ledermix (LM), respectively, and sealed with Cavit. Four control groups contained identical medications but the roots were left unsealed. The 25 remaining roots served as additional controls. A standard setup for bacterial leakage studies was chosen with Staphylococcus epidermidis as test strain. Cavit application resulted in a significantly better seal compared with the unsealed groups. In the Cavit-sealed groups, all groups differed significantly from one another except for the CHX and the ChKM groups. The Ca(OH)(2) medicated roots provided the longest protection (median of 36 days), followed by the Ledermix-group (27 days) and the CHX (18 days) or ChKM groups (19 days). It may be concluded that Cavit-sealed and medicated root canals do not provide adequate protection against bacterial leakage for more than 1 month.

Topics: Anti-Infective Agents, Local; Calcium Hydroxide; Calcium Sulfate; Camphor; Chlorophenols; Cuspid; Demeclocycline; Dental Cements; Dental Leakage; Drug Combinations; Humans; Polyvinyls; Root Canal Filling Materials; Root Canal Irrigants; Staphylococcus epidermidis; Triamcinolone Acetonide; Zinc Oxide

The effects of different intracanal medicaments and zinc oxide-eugenol based root canal sealers on an experimentally induced apical periodontitis were studied histologically in mesial roots of lower molars of Wistar rats. After root canal instrumentation each canal was filled either with an intracanal medicament twice for 3 days each time or with a sealer for 21 days. The intracanal medicament chlorophenol caused periapical tissue damage. P-chloroxylenol-camphor lead to periapical improvement as did 5% sodium-hypochlorite. 12% sodium-hypochlorite gave tissue damage. After intracanal medication with an aqueous suspension of calcium hydroxide periapical repair was clearly visible. A combination of a corticoid and an antibiotic appeared to induce damage of the periapical tissues. The root canal sealers Endomethasone and N2 essentially impaired periapical repair. The results were acceptable for Aptal-Zink-Harz root canal fillings after 21 days as well as after 56 days.

Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Calcium Hydroxide; Camphor; Chlorophenols; Demeclocycline; Dexamethasone; Drug Combinations; Eugenol; Female; Formaldehyde; Hydrocortisone; Periapical Periodontitis; Periapical Tissue; Rats; Rats, Wistar; Root Canal Filling Materials; Root Canal Irrigants; Sodium Hypochlorite; Thymol; Triamcinolone Acetonide; Zinc Oxide; Zinc Oxide-Eugenol Cement