deltorphin ii, ala(2)- has been researched along with u-50488 in 18 studies
| Studies (deltorphin ii, ala(2)-) | Trials (deltorphin ii, ala(2)-) | Recent Studies (post-2010) (deltorphin ii, ala(2)-) | Studies (u-50488) | Trials (u-50488) | Recent Studies (post-2010) (u-50488) |
|---|---|---|---|---|---|
| 6 | 0 | 2 | 1,664 | 3 | 209 |
| 233 | 0 | 20 | 1,664 | 3 | 209 |
| Protein | Taxonomy | deltorphin ii, ala(2)- (IC50) | u-50488 (IC50) |
|---|---|---|---|
| Delta-type opioid receptor | Rattus norvegicus (Norway rat) | 2.15 | |
| Kappa-type opioid receptor | Mus musculus (house mouse) | 0.0027 | |
| Mu-type opioid receptor | Rattus norvegicus (Norway rat) | 2.15 | |
| Kappa-type opioid receptor | Rattus norvegicus (Norway rat) | 0.7171 | |
| Kappa-type opioid receptor | Cavia porcellus (domestic guinea pig) | 0.0958 | |
| Kappa-type opioid receptor | Homo sapiens (human) | 0.0537 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (38.89) | 18.2507 |
| 2000's | 11 (61.11) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Adapa, ID; Auh, JS; Berzetei-Gurske, IP; Brandt, SR; Craymer, K; Farrington, L; Haggart, D; Kennedy, JM; O'Brien, A; Polgar, WE; Rodriguez, L; Schwartz, RW; Toll, L; White, A | 1 |
| Capasso, A; Carnuccio, R; D'Acquisto, F; Iuvone, T | 1 |
| Capasso, A; Di Giannuario, A; Domenici, MR; Loizzo, A; Pieretti, S; Sagratella, S; Sorrentino, L | 1 |
| Bhargava, HN; Bian, JT | 1 |
| Kampine, JP; Mizoguchi, H; Narita, M; Tseng, LF | 1 |
| Boudinot, E; Denavit-Saubié, M; Foutz, AS; Kieffer, BL; Maldonado, R; Matthes, HW; Negri, L; Roques, BP; Severini, C; Smadja, C; Valverde, O; Vonesch, JL | 1 |
| Mizoguchi, H; Narita, M; Sora, I; Tseng, LF; Uhl, GR | 1 |
| Paul, D; Ware, TD | 1 |
| Beslot, F; Ledent, C; Parmentier, M; Roques, BP; Valverde, O | 1 |
| Adler, MW; Cowan, A; Eisenstein, TK; Gaughan, J; Geller, EB; Meissler, JJ; Rahim, RT; Rogers, TJ | 1 |
| Adler, MW; Eisenstein, LK; Hilburger, ME; MacFarland, AS; Meissler, LJ; Peng, X; Rahim, RT; Rogers, TJ; Wan, AC | 1 |
| Leitermann, R; Mizoguchi, H; Nagase, H; Spaulding, A; Tseng, LF; Wu, HE | 1 |
| Fujimura, T; Ito, K; Kawamura, S; Mizoguchi, H; Murayama, K; Nakayama, D; Sakurada, C; Sakurada, S; Sakurada, T; Sato, T; Watanabe, C; Watanabe, H | 1 |
| Hall, FS; Schwasinger, E; Sora, I; Sun, HS; Terashivili, M; Tseng, LF; Uhl, GR; Wu, HE | 1 |
| Adler, MW; Cowan, A; Eisenstein, TK; Feng, P; Gaughan, J; Liu-Chen, LY; Meissler, JJ; Peng, X; Rahim, RT | 1 |
| Bidlack, JM; Parkhill, AL | 1 |
| Ishiura, Y; Komatsu, K; Nagasaka, Y; Nakamura, Y; Namiki, M; Yokoyama, O | 1 |
| Capasso, A | 1 |
18 other study(ies) available for deltorphin ii, ala(2)- and u-50488
| Article | Year |
|---|---|
Standard binding and functional assays related to medications development division testing for potential cocaine and opiate narcotic treatment medications.
Topics: Animals; Aorta, Thoracic; Cocaine; Cyclic AMP; Electric Stimulation; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Male; Mice; Muscle, Smooth; Opioid-Related Disorders; Rats; Receptors, Dopamine; Receptors, Opioid; Receptors, Serotonin; Substance-Related Disorders | 1998 |
Opioids inhibit the induction of nitric oxide synthase in J774 macrophages.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amino Acid Oxidoreductases; Animals; Arginine; Cell Line; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Enzyme Induction; Lipopolysaccharides; Macrophages; Mice; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Nitric Oxide; Nitric Oxide Synthase; Oligopeptides; omega-N-Methylarginine; Pyrrolidines; Receptors, Opioid | 1995 |
Dexamethasone-induced selective inhibition of the central mu opioid receptor: functional in vivo and in vitro evidence in rodents.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; beta-Endorphin; Dexamethasone; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hippocampus; In Vitro Techniques; Male; Mice; Morphine; Oligopeptides; Pain Measurement; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, mu | 1994 |
Effects of morphine-3-glucuronide on the antinociceptive activity of peptide and nonpeptide opioid receptor agonists in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Behavior, Animal; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Morphine; Morphine Derivatives; Nociceptors; Oligopeptides; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1996 |
The effect of pretreatment with a delta 2-opioid receptor antisense oligodeoxynucleotide on the recovery from acute antinociceptive tolerance to delta 2-opioid receptor agonist in the mouse spinal cord.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Oligopeptides; Pain Measurement; Pyrrolidines; Receptors, Opioid, delta; RNA, Antisense | 1997 |
Activity of the delta-opioid receptor is partially reduced, whereas activity of the kappa-receptor is maintained in mice lacking the mu-receptor.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Anti-Arrhythmia Agents; Benzofurans; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; GTP-Binding Proteins; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Oligopeptides; Pain Measurement; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Respiration; Signal Transduction; Vas Deferens | 1998 |
Absence of G-protein activation by mu-opioid receptor agonists in the spinal cord of mu-opioid receptor knockout mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Binding, Competitive; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Membranes; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mice, Knockout; Mice, Transgenic; Morphine; Oligopeptides; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord; Sulfur Radioisotopes; Tritium | 1999 |
Cross-tolerance between analgesia produced by xylazine and selective opioid receptor subtype treatments.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenergic alpha-Agonists; Analgesia; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Male; Mice; Oligopeptides; Receptors, Adrenergic, alpha-2; Xylazine; Yohimbine | 2000 |
Reduction of stress-induced analgesia but not of exogenous opioid effects in mice lacking CB1 receptors.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Dopamine; Electroshock; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Exploratory Behavior; Foot; Habituation, Psychophysiologic; Hot Temperature; Mice; Mice, Knockout; Models, Neurological; Morphine; Motor Activity; Nociceptors; Oligopeptides; Pain; Pain Threshold; Receptors, Cannabinoid; Receptors, Drug; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Stress, Mechanical; Stress, Physiological; Swimming; Tail; Viscera | 2000 |
Administration of mu-, kappa- or delta2-receptor agonists via osmotic minipumps suppresses murine splenic antibody responses.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Antibody Formation; Depression, Chemical; Dose-Response Relationship, Drug; Female; Immunosuppressive Agents; Infusion Pumps; Mice; Mice, Inbred C3H; Morphine; Naltrexone; Neuroimmunomodulation; Oligopeptides; Osmosis; Peptide Fragments; Peptides; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Somatostatin; Spleen | 2001 |
Effect of opioids on oral Salmonella infection and immune function.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Drug Implants; Female; Immunosuppressive Agents; Infusion Pumps, Implantable; Mice; Mice, Inbred C3H; Morphine; Mouth Diseases; Naltrexone; Narcotic Antagonists; Narcotics; Oligopeptides; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Salmonella Infections, Animal; Salmonella typhimurium | 2001 |
Buprenorphine blocks epsilon- and micro-opioid receptor-mediated antinociception in the mouse.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; beta-Endorphin; Buprenorphine; Disease Models, Animal; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Time Factors | 2003 |
A Tyr-W-MIF-1 analog containing D-Pro2 acts as a selective mu2-opioid receptor antagonist in the mouse.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Male; Mice; MSH Release-Inhibiting Hormone; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Receptors, Opioid, mu | 2005 |
dextro- and levo-morphine attenuate opioid delta and kappa receptor agonist produced analgesia in mu-opioid receptor knockout mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Opioid; Animals; Female; Genotype; Injections, Spinal; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Morphine; Nociceptors; Oligopeptides; Pain; Pain Measurement; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Stereoisomerism | 2006 |
Effects of mu, kappa or delta opioids administered by pellet or pump on oral Salmonella infection and gastrointestinal transit.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Disease Susceptibility; Dose-Response Relationship, Drug; Drug Implants; Enkephalin, D-Penicillamine (2,5)-; Female; Gastrointestinal Transit; Infusion Pumps, Implantable; Lymph Nodes; Mice; Mice, Inbred C57BL; Morphine; Oligopeptides; Peyer's Patches; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Salmonella Infections, Animal; Salmonella typhimurium; Spleen | 2006 |
Reduction of lipopolysaccharide-induced interleukin-6 production by the kappa opioid U50,488 in a mouse monocyte-like cell line.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Cell Line, Tumor; Cell Survival; Dactinomycin; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Gene Expression; Interleukin-6; Lipopolysaccharides; Mice; Monocytes; Naltrexone; Narcotic Antagonists; Oligopeptides; Receptors, Opioid, kappa; RNA Stability; Time Factors; Transcription, Genetic; Tumor Necrosis Factor-alpha | 2006 |
Effects of opioid subtypes on detrusor overactivity in rats with cerebral infarction.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Cerebral Infarction; Cerebral Ventricles; Disease Models, Animal; Drug Administration Routes; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Female; Oligopeptides; Rats; Rats, Sprague-Dawley; Treatment Outcome; Urinary Bladder, Overactive; Urodynamics | 2007 |
Comparison with naloxone of two dynorphin A analogues with K- and delta-opioid antagonist activity.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Dose-Response Relationship, Drug; Dynorphins; Guinea Pigs; Ileum; Jejunum; Male; Muscle Contraction; Naloxone; Oligopeptides; Peptides; Rabbits; Receptors, Opioid, delta; Receptors, Opioid, kappa; Structure-Activity Relationship | 2009 |