deltorphin ii, ala(2)- has been researched along with morphine in 44 studies
| Studies (deltorphin ii, ala(2)-) | Trials (deltorphin ii, ala(2)-) | Recent Studies (post-2010) (deltorphin ii, ala(2)-) | Studies (morphine) | Trials (morphine) | Recent Studies (post-2010) (morphine) |
|---|---|---|---|---|---|
| 7 | 0 | 3 | 44,270 | 5,200 | 8,695 |
| 6 | 0 | 2 | 44,270 | 5,200 | 8,695 |
| 233 | 0 | 20 | 44,270 | 5,200 | 8,695 |
| Protein | Taxonomy | deltorphin ii, ala(2)- (IC50) | morphine (IC50) |
|---|---|---|---|
| Delta-type opioid receptor | Mus musculus (house mouse) | 0.2939 | |
| Delta-type opioid receptor | Rattus norvegicus (Norway rat) | 0.2278 | |
| Kappa-type opioid receptor | Mus musculus (house mouse) | 0.0828 | |
| Mu-type opioid receptor | Rattus norvegicus (Norway rat) | 0.0385 | |
| Kappa-type opioid receptor | Rattus norvegicus (Norway rat) | 0.0545 | |
| Mu-type opioid receptor | Homo sapiens (human) | 0.122 | |
| Delta-type opioid receptor | Homo sapiens (human) | 0.1199 | |
| Kappa-type opioid receptor | Cavia porcellus (domestic guinea pig) | 0.9308 | |
| Kappa-type opioid receptor | Homo sapiens (human) | 0.655 | |
| Mu-type opioid receptor | Mus musculus (house mouse) | 0.3305 | |
| Mu-type opioid receptor | Cavia porcellus (domestic guinea pig) | 0.202 | |
| Beta-2 adrenergic receptor | Cavia porcellus (domestic guinea pig) | 0.25 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 22 (50.00) | 18.2507 |
| 2000's | 18 (40.91) | 29.6817 |
| 2010's | 3 (6.82) | 24.3611 |
| 2020's | 1 (2.27) | 2.80 |
| Authors | Studies |
|---|---|
| Allaoa, A; Ansonoff, M; Devi, LA; Faouzi, A; Gomes, I; Gupta, A; Keresztes, AI; Le Rouzic, V; Majumdar, S; Massaly, N; Morón, JA; Pan, YX; Pintar, J; Streicher, JM; Uprety, R; Yoon, HJ; Zhang, T | 1 |
| Balboni, G; Borea, PA; Marastoni, M; Morari, M; Salvadori, S; Tomatis, R | 1 |
| Bell, GI; Chen, Y; Kong, H; Raynor, K; Reisine, T; Yasuda, K; Yu, L | 1 |
| Adapa, ID; Auh, JS; Berzetei-Gurske, IP; Brandt, SR; Craymer, K; Farrington, L; Haggart, D; Kennedy, JM; O'Brien, A; Polgar, WE; Rodriguez, L; Schwartz, RW; Toll, L; White, A | 1 |
| Erspamer, V; Maritati, M; Melchiorri, P; Negri, L | 1 |
| Haaseth, RC; Horan, P; Hruby, VJ; Matsunaga, TO; Porreca, F; Tallarida, RJ | 1 |
| Mosberg, HI; Porreca, F; Vanderah, T; Wild, KD | 1 |
| Mosberg, HI; Porreca, F; Qi, JA | 1 |
| Capasso, A; Carnuccio, R; D'Acquisto, F; Iuvone, T | 1 |
| Endoh, T; Misawa, M; Mori, T; Nagase, H; Suzuki, T; Tsuji, M | 1 |
| Tseng, LF; Xu, JY | 1 |
| Kamei, J; Misawa, M; Mizoguchi, H; Nagase, H; Suzuki, T; Yoshiike, M | 1 |
| Capasso, A; Di Giannuario, A; Domenici, MR; Loizzo, A; Pieretti, S; Sagratella, S; Sorrentino, L | 1 |
| Castro, MA; Garzón, J; Juarros, JL; Sánchez-Blázquez, P | 1 |
| García-España, A; Garzón, J; Sánchez-Blázquez, P | 1 |
| Bhargava, HN; Zhao, GM | 1 |
| Cox, BM; Noble, F | 1 |
| Bhargava, HN; Bian, JT | 1 |
| Darula, Z; Fürst, S; Gyires, K; Rónai, AZ; Tóth, G | 1 |
| Bilsky, EJ; Hruby, VJ; Inturrisi, CE; Porreca, F; Sadée, W | 1 |
| Appleyard, SM; Davis, TP; Hruby, VJ; Knapp, RJ; Lipkowski, AW; Misicka, A; Slaninova, J; Weber, SJ; Yamamura, HI | 1 |
| DeAntonio, I; DeFelipe, J; García-España, A; Garzón, J; Rodríguez, JR; Sánchez-Blázquez, P | 1 |
| Mizoguchi, H; Narita, M; Sora, I; Tseng, LF; Uhl, GR | 1 |
| Fairbanks, CA; Kitto, KF; Posthumus, IJ; Stone, LS; Wilcox, GL | 1 |
| Beslot, F; Ledent, C; Parmentier, M; Roques, BP; Valverde, O | 1 |
| Elde, RP; Hauser, KF; Houdi, AA; Maxson, W; Turbek, CS | 1 |
| Kieffer, BL; Maldonado, R; Matthes, HW; Melchiorri, P; Negri, L; Severini, C | 1 |
| Ananthan, S; Bartlett, JL; Bilsky, EJ; Wells, JL | 1 |
| Adler, MW; Cowan, A; Eisenstein, TK; Gaughan, J; Geller, EB; Meissler, JJ; Rahim, RT; Rogers, TJ | 1 |
| Capasso, A; d'Emmanuele di Villa Bianca, R; Pinto, A; Sorrentino, R | 1 |
| Adler, MW; Eisenstein, LK; Hilburger, ME; MacFarland, AS; Meissler, LJ; Peng, X; Rahim, RT; Rogers, TJ; Wan, AC | 1 |
| Chocyk, A; Labuz, D; Przewlocka, B; Toth, G; Wedzony, K | 1 |
| Aibak, H; Beaudet, A; Cahill, CM; Clarke, PB; Collier, B; Henry, JL; Hoffert, C; Mennicken, F; Morinville, A; O'Donnell, D; Pradhan, A; Rymar, VV; Sadikot, AF; Stroh, T; Vincent, JP | 1 |
| Borys, D; Hosohata, K; Navratilova, E; Nylen, A; Porreca, F; Roeske, WR; Vanderah, TW; Varga, EV; Yamamura, HI | 1 |
| Eaton, MC; Navratilova, E; Roeske, WR; Stropova, D; Vanderah, TW; Varga, EV; Yamamura, HI | 1 |
| Hall, FS; Schwasinger, E; Sora, I; Sun, HS; Terashivili, M; Tseng, LF; Uhl, GR; Wu, HE | 1 |
| Adler, MW; Cowan, A; Eisenstein, TK; Feng, P; Gaughan, J; Liu-Chen, LY; Meissler, JJ; Peng, X; Rahim, RT | 1 |
| Beaudet, A; Cahill, CM; Devi, LA; Esdaile, MJ; Gendron, L; Mennicken, F; O'Donnell, D; Pan, H; Stroh, T; Vincent, JP | 1 |
| Armstrong, SA; Cahill, CM; Holdridge, SV; Taylor, AM | 1 |
| Ashley, MD; Christie, MJ; Ingram, SL; Morgan, MM | 1 |
| Beaudry, H; Chavkin, C; Dory, Y; Gendron, L; Li, S; Proteau-Gagné, A | 1 |
| Cahill, CM; Olmstead, MC; Ong, EW; Xue, L | 1 |
| Fairbanks, CA; Kitto, KF; Messing, RO; Metcalf, MD; Schuster, DJ; Wilcox, GL | 1 |
| Beaudry, H; Delaygue, C; Gendron, L; Lavoie, C; Mercier-Blais, AA; Neugebauer, W; Parent, JL | 1 |
44 other study(ies) available for deltorphin ii, ala(2)- and morphine
| Article | Year |
|---|---|
Synthesis and Pharmacology of a Novel μ-δ Opioid Receptor Heteromer-Selective Agonist Based on the Carfentanyl Template.
Topics: Analgesics; Animals; Cell Line; Fentanyl; Humans; Male; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Pain Measurement; Rats; Rats, Long-Evans; Receptors, Opioid, delta | 2020 |
Synthesis and structure-activity relationships of deltorphin analogues.
Topics: Amino Acid Sequence; Animals; Binding, Competitive; Chemical Phenomena; Chemistry; Guinea Pigs; Male; Mice; Molecular Sequence Data; Muscle, Smooth; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid; Structure-Activity Relationship | 1991 |
Pharmacological characterization of the cloned kappa-, delta-, and mu-opioid receptors.
Topics: Analgesics; Animals; Binding Sites; Cell Line; CHO Cells; Cloning, Molecular; Cricetinae; Ligands; PC12 Cells; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Software | 1994 |
Standard binding and functional assays related to medications development division testing for potential cocaine and opiate narcotic treatment medications.
Topics: Animals; Aorta, Thoracic; Cocaine; Cyclic AMP; Electric Stimulation; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Male; Mice; Muscle, Smooth; Opioid-Related Disorders; Rats; Receptors, Dopamine; Receptors, Opioid; Receptors, Serotonin; Substance-Related Disorders | 1998 |
Long-term sensitization to the activation of cerebral delta-opioid receptors by the deltorphin Tyr-D-Ala-Phe-Glu-Val-Val-Gly-NH2 in rats exposed to morphine.
Topics: Animals; Base Sequence; Brain; Drug Administration Schedule; Male; Molecular Sequence Data; Morphine; Motor Activity; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Substance Withdrawal Syndrome | 1992 |
Antinociceptive interactions of opioid delta receptor agonists with morphine in mice: supra- and sub-additivity.
Topics: Analgesics; Animals; Drug Synergism; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Male; Mice; Mice, Inbred ICR; Morphine; Oligopeptides; Receptors, Opioid; Receptors, Opioid, delta | 1992 |
Opioid delta receptor subtypes are associated with different potassium channels.
Topics: Analgesics; Animals; Benzeneacetamides; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Glyburide; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Morphine; Oligopeptides; Potassium Channels; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Tetraethylammonium Compounds | 1991 |
Antinociceptive effects of [D-Ala2]deltorphin II, a highly selective delta agonist in vivo.
Topics: Analgesics; Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Injections, Intraventricular; Mice; Mice, Inbred ICR; Morphine; Naltrexone; Narcotic Antagonists; Oligopeptides; Receptors, Opioid; Receptors, Opioid, delta | 1990 |
Opioids inhibit the induction of nitric oxide synthase in J774 macrophages.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amino Acid Oxidoreductases; Animals; Arginine; Cell Line; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Enzyme Induction; Lipopolysaccharides; Macrophages; Mice; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Nitric Oxide; Nitric Oxide Synthase; Oligopeptides; omega-N-Methylarginine; Pyrrolidines; Receptors, Opioid | 1995 |
Effects of a highly selective nonpeptide delta opioid receptor agonist, TAN-67, on morphine-induced antinociception in mice.
Topics: Analgesics; Animals; Drug Interactions; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Subcutaneous; Male; Mice; Mice, Inbred Strains; Morphine; Naltrexone; Nociceptors; Oligopeptides; Quinolines; Receptors, Opioid, delta | 1995 |
Nitric oxide/cyclic guanosine monophosphate system in the spinal cord differentially modulates intracerebroventricularly administered morphine- and beta-endorphin-induced antinociception in the mouse.
Topics: Analgesics; Animals; Arginine; beta-Endorphin; Cyclic GMP; Dose-Response Relationship, Drug; Hemoglobins; Injections, Intraventricular; Injections, Spinal; Male; Methylene Blue; Mice; Mice, Inbred ICR; Morphine; Nitric Oxide; Oligopeptides; Spinal Cord | 1995 |
Blockade of delta-opioid receptors prevents morphine-induced place preference in mice.
Topics: Analgesics; Animals; Benzylidene Compounds; Conditioning, Operant; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Mice, Inbred Strains; Morphine; Naltrexone; Narcotic Antagonists; Oligopeptides; Receptors, Opioid, delta; Receptors, Opioid, mu | 1994 |
Dexamethasone-induced selective inhibition of the central mu opioid receptor: functional in vivo and in vitro evidence in rodents.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; beta-Endorphin; Dexamethasone; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hippocampus; In Vitro Techniques; Male; Mice; Morphine; Oligopeptides; Pain Measurement; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, mu | 1994 |
Antibodies raised against the N-terminal sequence of delta opioid receptors blocked delta-mediated supraspinal antinociception in mice.
Topics: Amino Acid Sequence; Analysis of Variance; Animals; beta-Endorphin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; GTP-Binding Proteins; Immunoglobulin G; Immunohistochemistry; Male; Mice; Mice, Inbred Strains; Molecular Sequence Data; Morphine; Narcotic Antagonists; Oligopeptides; Pain; Pain Measurement; Protein Binding; Reaction Time; Receptors, Opioid, delta | 1994 |
In vivo injection of antisense oligodeoxynucleotides to G alpha subunits and supraspinal analgesia evoked by mu and delta opioid agonists.
Topics: Analgesics, Opioid; Animals; Base Sequence; beta-Endorphin; Blotting, Western; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP-Binding Proteins; Injections, Intraventricular; Mice; Molecular Sequence Data; Morphine; Oligonucleotides, Antisense; Oligopeptides; Receptors, Opioid, delta; Receptors, Opioid, mu | 1995 |
Nitric oxide synthase inhibition attenuates tolerance to morphine but not to [D-Ala2, Glu4] deltorphin II, a delta 2-opioid receptor agonist in mice.
Topics: Analgesia; Animals; Cerebral Ventricles; Drug Tolerance; Enzyme Inhibitors; Injections, Intraperitoneal; Injections, Intraventricular; Injections, Subcutaneous; Male; Mice; Morphine; Nitric Oxide Synthase; Nitroarginine; Oligopeptides; omega-N-Methylarginine; Receptors, Opioid, delta | 1996 |
Differential desensitization of mu- and delta- opioid receptors in selected neural pathways following chronic morphine treatment.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylyl Cyclases; Aminobutyrates; Analgesics; Animals; Brain; Caudate Nucleus; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Glutamic Acid; Male; Morphine; Morphine Dependence; Naloxone; Narcotic Antagonists; Nucleus Accumbens; Oligopeptides; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Serotonin Receptor Agonists; Substance Withdrawal Syndrome; Thalamus | 1996 |
Effects of morphine-3-glucuronide on the antinociceptive activity of peptide and nonpeptide opioid receptor agonists in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Behavior, Animal; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Morphine; Morphine Derivatives; Nociceptors; Oligopeptides; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1996 |
Analysis of the role of delta opioid receptors in gastroprotection in the rat.
Topics: Analgesics; Animals; Binding Sites; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethanol; Gastric Mucosa; Ileum; Male; Mice; Mice, Inbred Strains; Morphine; Muscle, Smooth; Oligopeptides; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu; Stomach; Stomach Diseases; Vas Deferens | 1997 |
Competitive and non-competitive NMDA antagonists block the development of antinociceptive tolerance to morphine, but not to selective mu or delta opioid agonists in mice.
Topics: Analgesics, Opioid; Animals; Binding, Competitive; Dizocilpine Maleate; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Excitatory Amino Acid Antagonists; Fentanyl; Isoquinolines; Male; Mice; Mice, Inbred ICR; Morphine; Oligopeptides; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, delta; Receptors, Opioid, mu | 1996 |
[125I-Tyr1]biphalin binding to opioid receptors of rat brain and NG108-15 cell membranes.
Topics: Animals; Brain; Cell Line; Cell Membrane; Enkephalins; Iodine Radioisotopes; Morphine; Naltrexone; Narcotic Antagonists; Oligopeptides; Radioligand Assay; Rats; Receptors, Opioid | 1998 |
Transport of CSF antibodies to Galpha subunits across neural membranes requires binding to the target protein and protein kinase C activity.
Topics: Analgesics; Analgesics, Opioid; Animals; Autoantibodies; Biological Transport; Brain Chemistry; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Epitopes; GTP-Binding Protein alpha Subunits, Gi-Go; Immunoblotting; Immunoglobulin G; Injections, Intraventricular; Iodine Radioisotopes; Male; Mice; Mice, Inbred Strains; Microscopy, Immunoelectron; Morphine; Neurons; Nociceptors; Oligopeptides; Pain; Protein Kinase C; Signal Transduction | 1999 |
Absence of G-protein activation by mu-opioid receptor agonists in the spinal cord of mu-opioid receptor knockout mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Binding, Competitive; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Membranes; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mice, Knockout; Mice, Transgenic; Morphine; Oligopeptides; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord; Sulfur Radioisotopes; Tritium | 1999 |
Moxonidine, a selective imidazoline/alpha(2) adrenergic receptor agonist, synergizes with morphine and deltorphin II to inhibit substance P-induced behavior in mice.
Topics: Adrenergic alpha-2 Receptor Agonists; Aggression; Animals; Antihypertensive Agents; Drug Synergism; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Imidazoles; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Morphine; Oligopeptides; Pain; Spinal Cord; Substance P | 2000 |
Reduction of stress-induced analgesia but not of exogenous opioid effects in mice lacking CB1 receptors.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Dopamine; Electroshock; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Exploratory Behavior; Foot; Habituation, Psychophysiologic; Hot Temperature; Mice; Mice, Knockout; Models, Neurological; Morphine; Motor Activity; Nociceptors; Oligopeptides; Pain; Pain Threshold; Receptors, Cannabinoid; Receptors, Drug; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Stress, Mechanical; Stress, Physiological; Swimming; Tail; Viscera | 2000 |
Opioids intrinsically inhibit the genesis of mouse cerebellar granule neuron precursors in vitro: differential impact of mu and delta receptor activation on proliferation and neurite elongation.
Topics: Analgesics, Opioid; Animals; Antimetabolites; Apoptosis; Bromodeoxyuridine; Cell Differentiation; Cell Division; Cell Survival; Cells, Cultured; Cerebellum; DNA; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; In Vitro Techniques; Mice; Microscopy, Electron; Morphine; Naloxone; Narcotic Antagonists; Neurites; Neurons; Oligopeptides; Opioid-Related Disorders; Protein Precursors; Receptors, Opioid, delta; Receptors, Opioid, mu; Stem Cells | 2000 |
Activity of mu- and delta-opioid agonists in vas deferens from mice deficient in MOR gene.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Female; Genotype; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mice, Mutant Strains; Morphine; Muscle Contraction; Naltrexone; Narcotic Antagonists; Oligopeptides; Receptors, Opioid, delta; Receptors, Opioid, mu; Vas Deferens | 2001 |
In vivo pharmacological characterization of SoRI 9409, a nonpeptidic opioid mu-agonist/delta-antagonist that produces limited antinociceptive tolerance and attenuates morphine physical dependence.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Morphine; Morphine Dependence; Morphine Derivatives; Naloxone; Narcotic Antagonists; Oligopeptides; Pain Measurement; Receptors, Opioid, delta; Receptors, Opioid, mu | 2001 |
Administration of mu-, kappa- or delta2-receptor agonists via osmotic minipumps suppresses murine splenic antibody responses.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Antibody Formation; Depression, Chemical; Dose-Response Relationship, Drug; Female; Immunosuppressive Agents; Infusion Pumps; Mice; Mice, Inbred C3H; Morphine; Naltrexone; Neuroimmunomodulation; Oligopeptides; Osmosis; Peptide Fragments; Peptides; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Somatostatin; Spleen | 2001 |
Dexamethasone modulates hypotension induced by opioids in anaesthetised rats.
Topics: Animals; Anti-Inflammatory Agents; Blood Pressure; Cycloheximide; Dexamethasone; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Heart Rate; Hypotension; Male; Mifepristone; Morphine; Narcotics; Oligopeptides; Rats; Rats, Wistar; Receptors, Glucocorticoid; Receptors, Opioid, kappa | 2001 |
Effect of opioids on oral Salmonella infection and immune function.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Drug Implants; Female; Immunosuppressive Agents; Infusion Pumps, Implantable; Mice; Mice, Inbred C3H; Morphine; Mouth Diseases; Naltrexone; Narcotic Antagonists; Narcotics; Oligopeptides; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Salmonella Infections, Animal; Salmonella typhimurium | 2001 |
Endomorphin-2, deltorphin II and their analogs suppress formalin-induced nociception and c-Fos expression in the rat spinal cord.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Formaldehyde; Inflammation; Male; Morphine; Nociceptors; Oligopeptides; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord; Time Factors | 2003 |
Morphine-induced changes in delta opioid receptor trafficking are linked to somatosensory processing in the rat spinal cord.
Topics: Animals; Fluorescent Dyes; Guanosine 5'-O-(3-Thiotriphosphate); In Situ Hybridization; Lumbosacral Region; Male; Microscopy, Fluorescence; Morphine; Narcotics; Oligopeptides; Posterior Horn Cells; Protein Transport; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Rhizotomy; Spinal Cord; Up-Regulation | 2004 |
Antinociception depends on the presence of G protein gamma2-subunits in brain.
Topics: Analgesics; Analgesics, Opioid; Animals; Benzoxazines; Brain; Clonidine; GTP-Binding Proteins; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Morphine; Morpholines; Naphthalenes; Oligonucleotides, Antisense; Oligopeptides; Pain; Pain Measurement; Time Factors | 2005 |
Morphine promotes phosphorylation of the human delta-opioid receptor at serine 363.
Topics: Amino Acid Substitution; Animals; CHO Cells; Cricetinae; Cricetulus; Humans; Morphine; Mutation; Oligopeptides; Phosphorylation; Receptors, Opioid, delta; Serine | 2005 |
dextro- and levo-morphine attenuate opioid delta and kappa receptor agonist produced analgesia in mu-opioid receptor knockout mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Opioid; Animals; Female; Genotype; Injections, Spinal; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Morphine; Nociceptors; Oligopeptides; Pain; Pain Measurement; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Stereoisomerism | 2006 |
Effects of mu, kappa or delta opioids administered by pellet or pump on oral Salmonella infection and gastrointestinal transit.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Disease Susceptibility; Dose-Response Relationship, Drug; Drug Implants; Enkephalin, D-Penicillamine (2,5)-; Female; Gastrointestinal Transit; Infusion Pumps, Implantable; Lymph Nodes; Mice; Mice, Inbred C57BL; Morphine; Oligopeptides; Peyer's Patches; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Salmonella Infections, Animal; Salmonella typhimurium; Spleen | 2006 |
Morphine priming in rats with chronic inflammation reveals a dichotomy between antihyperalgesic and antinociceptive properties of deltorphin.
Topics: Analgesics; Analgesics, Opioid; Animals; Behavior, Animal; Chronic Disease; Dose-Response Relationship, Drug; Enkephalin, Methionine; Freund's Adjuvant; Hyperalgesia; Inflammation; Male; Morphine; Oligopeptides; Pain Threshold; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Cell Surface; Receptors, Opioid, delta; Reverse Transcriptase Polymerase Chain Reaction; Spinal Cord; Up-Regulation | 2007 |
Behavioural and morphological evidence for the involvement of glial cell activation in delta opioid receptor function: implications for the development of opioid tolerance.
Topics: Analgesics; Animals; Astrocytes; Drug Tolerance; Immunohistochemistry; Male; Morphine; Neuroglia; Oligopeptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Spinal Cord; Xanthines | 2007 |
Behavioral consequences of delta-opioid receptor activation in the periaqueductal gray of morphine tolerant rats.
Topics: Analysis of Variance; Animals; Behavior, Animal; Catheterization; Cell Membrane; Drug Tolerance; Male; Microinjections; Morphine; Motor Activity; Neurons; Oligopeptides; Pain Measurement; Pain Threshold; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta | 2009 |
Differential noxious and motor tolerance of chronic delta opioid receptor agonists in rodents.
Topics: Administration, Cutaneous; Animals; Arthritis, Experimental; Dose-Response Relationship, Drug; Drug Tolerance; Freund's Adjuvant; Hot Temperature; Hyperalgesia; Injections, Spinal; Male; Mice; Mice, Inbred C57BL; Morphine; Morphine Derivatives; Motor Activity; Oligopeptides; Pain; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta | 2009 |
Prolonged morphine treatment alters δ opioid receptor post-internalization trafficking.
Topics: Analgesics, Opioid; Animals; Benzamides; Cells, Cultured; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Ganglia, Spinal; Male; Mice, Knockout; Morphine; Naltrexone; Neurons; Oligopeptides; Piperazines; Protein Transport; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu | 2015 |
Ligand requirements for involvement of PKCε in synergistic analgesic interactions between spinal μ and δ opioid receptors.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Drug Therapy, Combination; Female; Hot Temperature; Ligands; Male; Mice, Knockout; Morphine; Morpholines; Oligopeptides; Pain; Protein Kinase C-epsilon; Protein Multimerization; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord | 2015 |
Regulation of μ and δ opioid receptor functions: involvement of cyclin-dependent kinase 5.
Topics: Analgesia; Animals; Cell-Penetrating Peptides; Cyclin-Dependent Kinase 5; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Ganglia, Spinal; Lipopeptides; Male; MAP Kinase Signaling System; Morphine; Oligopeptides; Pain Measurement; Purines; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Roscovitine | 2015 |