Page last updated: 2024-09-03

deltorphin i, ala(2)- and morphine

deltorphin i, ala(2)- has been researched along with morphine in 10 studies

Compound Research Comparison

Studies
(deltorphin i, ala(2)-)
Trials
(deltorphin i, ala(2)-)
Recent Studies (post-2010)
(deltorphin i, ala(2)-)
Studies
(morphine)
Trials
(morphine)
Recent Studies (post-2010) (morphine)
1220444,2705,2008,695

Protein Interaction Comparison

ProteinTaxonomydeltorphin i, ala(2)- (IC50)morphine (IC50)
Delta-type opioid receptorMus musculus (house mouse)0.2939
Delta-type opioid receptorRattus norvegicus (Norway rat)0.2278
Kappa-type opioid receptorMus musculus (house mouse)0.0828
Mu-type opioid receptorRattus norvegicus (Norway rat)0.0385
Kappa-type opioid receptorRattus norvegicus (Norway rat)0.0545
Mu-type opioid receptorHomo sapiens (human)0.122
Delta-type opioid receptorHomo sapiens (human)0.1199
Kappa-type opioid receptorCavia porcellus (domestic guinea pig)0.9308
Kappa-type opioid receptorHomo sapiens (human)0.655
Mu-type opioid receptorMus musculus (house mouse)0.3305
Mu-type opioid receptorCavia porcellus (domestic guinea pig)0.202
Beta-2 adrenergic receptorCavia porcellus (domestic guinea pig)0.25

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (30.00)18.2507
2000's6 (60.00)29.6817
2010's1 (10.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Balboni, G; Caliendo, G; Capasso, A; Guerrini, R; Lazarus, LH; Marastoni, M; Salvadori, S; Santagada, V; Sorrentino, L; Tomatis, R1
Cridland, R; Cros, J; Gouarderes, C; Jhamandas, K; Quirion, R; Zajac, JM1
Desprat, C; Zajac, JM1
Kieffer, BL; Maldonado, R; Matthes, HW; Melchiorri, P; Negri, L; Severini, C1
Aibak, H; Beaudet, A; Cahill, CM; Clarke, PB; Collier, B; Henry, JL; Hoffert, C; Mennicken, F; Morinville, A; O'Donnell, D; Pradhan, A; Rymar, VV; Sadikot, AF; Stroh, T; Vincent, JP1
Bagley, EE; Chieng, BC; Christie, MJ; Hack, SP1
Clarke, PBS; Constantin, A; Pradhan, AAA; Siau, C1
Balboni, G; Jinsmaa, Y; Lazarus, LH; Marczak, ED; Salvadori, S1
Benaderet, TS; Bishop-Mathis, K; Dersch, CM; Partilla, JS; Prisinzano, TE; Rothman, RB; Simpson, DS; Wang, X; Xu, H1
Fairbanks, CA; Kitto, KF; Messing, RO; Metcalf, MD; Schuster, DJ; Wilcox, GL1

Other Studies

10 other study(ies) available for deltorphin i, ala(2)- and morphine

ArticleYear
Synthesis and pharmacological activity of deltorphin and dermorphin-related glycopeptides.
    Journal of medicinal chemistry, 1997, Aug-29, Volume: 40, Issue:18

    Topics: Amino Acid Sequence; Analgesics, Opioid; Animals; Binding, Competitive; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Glycopeptides; Guinea Pigs; Ileum; In Vitro Techniques; Indicators and Reagents; Jejunum; Kinetics; Male; Mice; Muscle Contraction; Muscle, Smooth; Oligopeptides; Opioid Peptides; Pain; Rabbits; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Structure-Activity Relationship; Synaptosomes

1997
Opioid and substance P receptor adaptations in the rat spinal cord following sub-chronic intrathecal treatment with morphine and naloxone.
    Neuroscience, 1993, Volume: 54, Issue:3

    Topics: Analgesics; Animals; Autoradiography; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Densitometry; Drug Tolerance; In Vitro Techniques; Injections, Spinal; Male; Morphine; Naloxone; Oligopeptides; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord; Substance P; Succinimides

1993
Differential modulation of mu- and delta-opioid antinociception by neuropeptide FF receptors in young mice.
    Neuropeptides, 1997, Volume: 31, Issue:1

    Topics: Age Factors; Analgesics, Opioid; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Mice; Mice, Inbred Strains; Morphine; Naltrexone; Narcotic Antagonists; Neuropeptides; Nociceptors; Oligopeptides; Receptors, Neuropeptide; Receptors, Opioid, delta; Receptors, Opioid, mu

1997
Activity of mu- and delta-opioid agonists in vas deferens from mice deficient in MOR gene.
    British journal of pharmacology, 2001, Volume: 132, Issue:7

    Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Female; Genotype; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mice, Mutant Strains; Morphine; Muscle Contraction; Naltrexone; Narcotic Antagonists; Oligopeptides; Receptors, Opioid, delta; Receptors, Opioid, mu; Vas Deferens

2001
Morphine-induced changes in delta opioid receptor trafficking are linked to somatosensory processing in the rat spinal cord.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004, Jun-16, Volume: 24, Issue:24

    Topics: Animals; Fluorescent Dyes; Guanosine 5'-O-(3-Thiotriphosphate); In Situ Hybridization; Lumbosacral Region; Male; Microscopy, Fluorescence; Morphine; Narcotics; Oligopeptides; Posterior Horn Cells; Protein Transport; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Rhizotomy; Spinal Cord; Up-Regulation

2004
Induction of delta-opioid receptor function in the midbrain after chronic morphine treatment.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005, Mar-23, Volume: 25, Issue:12

    Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Arrestins; beta-Arrestin 2; beta-Arrestins; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Excitatory Amino Acid Antagonists; G Protein-Coupled Inwardly-Rectifying Potassium Channels; gamma-Aminobutyric Acid; Glycine Agents; In Vitro Techniques; Isoquinolines; Male; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Knockout; Morphine; Narcotic Antagonists; Narcotics; Neurons; Oligopeptides; Patch-Clamp Techniques; Periaqueductal Gray; Protein Kinase Inhibitors; Receptors, Opioid, delta; Receptors, Opioid, mu; Strychnine; Sulfonamides; Synaptic Transmission; Time Factors; Xanthines

2005
Chronic morphine administration results in tolerance to delta opioid receptor-mediated antinociception.
    Neuroscience, 2006, Aug-25, Volume: 141, Issue:2

    Topics: Analgesics; Animals; Autoradiography; Behavior, Animal; Brain Chemistry; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Drug Tolerance; Guanosine 5'-O-(3-Thiotriphosphate); Iodine Isotopes; Male; Morphine; Motor Activity; Narcotics; Oligopeptides; Pain Measurement; Phosphorus Isotopes; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta

2006
Inhibition of the development of morphine tolerance by a potent dual mu-delta-opioid antagonist, H-Dmt-Tic-Lys-NH-CH2-Ph.
    Pharmacology, biochemistry, and behavior, 2008, Volume: 90, Issue:4

    Topics: Analgesics, Opioid; Animals; Area Under Curve; Dose-Response Relationship, Drug; Drug Tolerance; Injections, Intraventricular; Injections, Subcutaneous; Ligands; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Oligopeptides; Reaction Time; Receptors, Opioid, delta; Receptors, Opioid, mu; Somatostatin

2008
Differential effects of opioid agonists on G protein expression in CHO cells expressing cloned human opioid receptors.
    Brain research bulletin, 2008, Sep-05, Volume: 77, Issue:1

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Benzamides; Blotting, Western; CHO Cells; Cricetinae; Cricetulus; Diterpenes, Clerodane; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Etorphine; Female; Furans; Gene Expression; GTP-Binding Protein alpha Subunits, G12-G13; GTP-Binding Protein alpha Subunits, Gi-Go; Humans; Morphine; Oligopeptides; Piperazines; Pyrones; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu

2008
Ligand requirements for involvement of PKCε in synergistic analgesic interactions between spinal μ and δ opioid receptors.
    British journal of pharmacology, 2015, Volume: 172, Issue:2

    Topics: Analgesics, Opioid; Animals; Behavior, Animal; Drug Therapy, Combination; Female; Hot Temperature; Ligands; Male; Mice, Knockout; Morphine; Morpholines; Oligopeptides; Pain; Protein Kinase C-epsilon; Protein Multimerization; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord

2015