Page last updated: 2024-09-03

deltorphin i, ala(2)- and enkephalin, leucine

deltorphin i, ala(2)- has been researched along with enkephalin, leucine in 22 studies

Compound Research Comparison

Studies (deltorphin i, ala(2)-)	Trials (deltorphin i, ala(2)-)	Recent Studies (post-2010) (deltorphin i, ala(2)-)	Studies (enkephalin, leucine)	Trials (enkephalin, leucine)	Recent Studies (post-2010) (enkephalin, leucine)
122	0	4	11,524	80	754

Protein Interaction Comparison

Protein	Taxonomy	enkephalin, leucine (IC50)
Delta-type opioid receptor	Mus musculus (house mouse)	0.0142
Kappa-type opioid receptor	Mus musculus (house mouse)	0.0417
Mu-type opioid receptor	Homo sapiens (human)	9.5
Mu-type opioid receptor	Mus musculus (house mouse)	0.0308
Mu-type opioid receptor	Cavia porcellus (domestic guinea pig)	0.246

Research

Studies (22)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (4.55)	18.7374
1990's	19 (86.36)	18.2507
2000's	2 (9.09)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Chung, NN; Lemieux, C; Nguyen, TM; Schiller, PW; Weltrowska, G; Wilkes, BC	2
Crook, TJ; Hill, RG; Kitchen, I	1
Corsi, R; Melchiorri, P; Negri, L; Potenza, RL	1
Jacobson, AE; Ni, Q; Rice, KC; Rothman, RB; Xu, H	1
Burks, TF; Davis, P; Haaseth, RC; Hruby, VJ; Kramer, TH; Matsunaga, TO; Toth, G	1
Barra, D; Corsi, R; Erspamer, V; Falconieri-Erspamer, G; Kreil, G; Melchiorri, P; Negri, L; Severini, C; Simmaco, M	1
Bouzit, H; Hepp, AM; Heyl, DL; Johnson, TW; Kurtz, KR; Mousigian, C; Schmitter, SJ	1
Crook, TJ; Hill, RG; Kitchen, I; Muhammad, BY	1
Bilsky, EJ; Davis, P; Horváth, R; Kövér, KE; Lou, BS; Misicka, A; Porreca, F; Qian, X; Shenderovich, MD; Zalewska, T	1
Iwamoto, Y; Kamei, J; Kasuya, Y; Misawa, M; Nagase, H	1
Amodeo, P; Bianchi, C; Guerrini, R; Lazarus, LH; Picone, D; Salvadori, S; Tancredi, T; Temussi, PA; Tomatis, R	1
Mokhtari, M; Tafani, JA; Zajac, JM	1
Allard, M; Jordan, D; Kopp, N; Martin, D; Ries, C; Simonnet, G; Tafani, JA; Zajac, JM	1
Lattanzi, R; Melchiorri, P; Negri, L; Potenza, RL; Severini, C	1
Cavagnero, S; Davis, P; Horvath, R; Hruby, VJ; Misicka, A; Porreca, F; Yamamura, HI	1
Basbaum, AI; Hammond, DL; Nakashima, N; Wang, H	1
Desprat, C; Zajac, JM	1
Allouche, S; Jauzac, P; Marie, N; Roussel, M	1
Allouche, S; Hasbi, A; Homburger, V; Jauzac, P; Polastron, J	1
Bagley, EE; Chieng, BC; Christie, MJ; Hack, SP	1
Ejchart, A; Kosson, P; Kwasiborska, M; Olma, A; Wilczyńska, D	1

Other Studies

22 other study(ies) available for deltorphin i, ala(2)- and enkephalin, leucine

Article	Year
Conformationally restricted deltorphin analogues. Journal of medicinal chemistry, 1992, Oct-16, Volume: 35, Issue:21 Topics: Amino Acid Sequence; Animals; Binding Sites; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mice; Molecular Sequence Data; Oligopeptides; Protein Conformation; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vas Deferens	1992
TIPP[psi]: a highly potent and stable pseudopeptide delta opioid receptor antagonist with extraordinary delta selectivity. Journal of medicinal chemistry, 1993, Oct-15, Volume: 36, Issue:21 Topics: Animals; Binding Sites; Guinea Pigs; Male; Mice; Molecular Conformation; Oligopeptides; Receptors, Opioid, delta; Tetrahydroisoquinolines	1993
Effects of the delta-opioid receptor antagonist naltrindole on antinociceptive responses to selective delta-agonists in post-weanling rats. British journal of pharmacology, 1992, Volume: 107, Issue:2 Topics: Analgesics; Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Indoles; Male; Morphinans; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain Measurement; Rats; Rats, Wistar; Receptors, Opioid, delta	1992
Evidence for two subtypes of delta opioid receptors in rat brain. European journal of pharmacology, 1991, Apr-24, Volume: 196, Issue:3 Topics: Animals; Binding, Competitive; Brain; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Kinetics; Male; Membranes; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta	1991
Preliminary ligand binding data for subtypes of the delta opioid receptor in rat brain membranes. Life sciences, 1991, Volume: 49, Issue:18 Topics: Amino Acid Sequence; Animals; Binding Sites; Brain; Cell Membrane; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Kinetics; Molecular Sequence Data; Oligopeptides; Radioligand Assay; Rats; Receptors, Opioid; Receptors, Opioid, delta; Somatostatin	1991
Influence of peptidase inhibitors on the apparent agonist potency of delta selective opioid peptides in vitro. Life sciences, 1991, Volume: 48, Issue:9 Topics: Amino Acid Sequence; Analgesics; Animals; Dose-Response Relationship, Drug; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Mice; Mice, Inbred Strains; Molecular Sequence Data; Oligopeptides; Protease Inhibitors; Receptors, Opioid; Receptors, Opioid, delta; Vas Deferens	1991
Deltorphins: a family of naturally occurring peptides with high affinity and selectivity for delta opioid binding sites. Proceedings of the National Academy of Sciences of the United States of America, 1989, Volume: 86, Issue:13 Topics: Amino Acid Sequence; Animals; Anura; Brain; Enkephalins; Guinea Pigs; In Vitro Techniques; Kinetics; Male; Membranes; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Oligopeptides; Rats; Receptors, Opioid; Receptors, Opioid, delta; Skin; Vas Deferens	1989
Substitution of aromatic and nonaromatic amino acids for the Phe3 residue in the delta-selective opioid peptide deltorphin I: effects on binding affinity and selectivity. International journal of peptide and protein research, 1994, Volume: 44, Issue:5 Topics: Amino Acid Sequence; Analgesics; Enkephalins; Kinetics; Molecular Sequence Data; Oligopeptides; Phenylalanine; Protein Conformation; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Structure-Activity Relationship; Tritium	1994
Evidence that weaning stimulates the developmental expression of a delta-opioid receptor subtype in the rat. Brain research. Developmental brain research, 1994, Mar-18, Volume: 78, Issue:1 Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Enkephalin, Leucine; Female; Male; Naltrexone; Narcotic Antagonists; Oligopeptides; Rats; Rats, Wistar; Receptors, Opioid, delta; Weaning	1994
Newly discovered stereochemical requirements in the side-chain conformation of delta opioid agonists for recognizing opioid delta receptors. Journal of medicinal chemistry, 1994, Jun-10, Volume: 37, Issue:12 Topics: Amino Acid Sequence; Analgesics; Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; In Vitro Techniques; Magnetic Resonance Spectroscopy; Male; Methyltyrosines; Mice; Mice, Inbred ICR; Molecular Sequence Data; Oligopeptides; Peptides; Protein Conformation; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Stereoisomerism; Structure-Activity Relationship	1994
Streptozotocin-induced diabetes selectively enhances antinociception mediated by delta 1- but not delta 2-opioid receptors. Life sciences, 1994, Volume: 55, Issue:6 Topics: Analgesia; Animals; Benzylidene Compounds; Diabetes Mellitus, Experimental; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Mice, Inbred ICR; Naltrexone; Oligopeptides; Receptors, Opioid, delta; Receptors, Opioid, mu; Streptozocin	1994
Selective opioid dipeptides. Biochemical and biophysical research communications, 1994, Feb-15, Volume: 198, Issue:3 Topics: Amino Acid Sequence; Animals; Binding, Competitive; Brain; Cell Membrane; Dipeptides; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Isoquinolines; Kinetics; Models, Molecular; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Narcotics; Oligopeptides; Protein Conformation; Radioligand Assay; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Stereoisomerism; Structure-Activity Relationship; Synaptosomes; Tetrahydroisoquinolines	1994
Binding in vivo of selective mu and delta opioid agonists: localization by autoradiography. Neuropeptides, 1993, Volume: 25, Issue:3 Topics: Amino Acid Sequence; Analgesics; Animals; Autoradiography; Binding, Competitive; Brain; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Diffusion; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Intraventricular; Male; Mice; Molecular Sequence Data; Naltrexone; Oligopeptides; Pain Measurement; Protein Binding; Receptors, Opioid, delta; Receptors, Opioid, mu	1993
Evidence for multiple opioid receptors in the human posterior pituitary. Journal of neuroendocrinology, 1996, Volume: 8, Issue:11 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adult; Benzeneacetamides; Binding Sites; Binding, Competitive; Cadaver; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Humans; Male; Middle Aged; Narcotics; Oligopeptides; Pituitary Gland, Posterior; Pyrrolidines; Receptors, Opioid; Tissue Distribution	1996
Postnatal development of delta-opioid receptor subtypes in mice. British journal of pharmacology, 1997, Volume: 120, Issue:6 Topics: Animals; Animals, Suckling; Brain; Electric Stimulation; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Oligopeptides; Receptors, Opioid, delta; Vas Deferens	1997
Synthesis and biological properties of beta-MePhe3 analogues of deltorphin I and dermenkephalin: influence of biased chi 1 Phe3 residues on peptide recognition for delta-opioid receptors. The journal of peptide research : official journal of the American Peptide Society, 1997, Volume: 50, Issue:1 Topics: Aminobutyrates; Analgesics, Opioid; Animals; Binding, Competitive; Brain; Electric Stimulation; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Mice, Inbred ICR; Muscle Contraction; Oligopeptides; Protein Binding; Protein Conformation; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Stereoisomerism	1997
Differential effects of intrathecally administered delta and mu opioid receptor agonists on formalin-evoked nociception and on the expression of Fos-like immunoreactivity in the spinal cord of the rat. The Journal of pharmacology and experimental therapeutics, 1998, Volume: 284, Issue:1 Topics: Analgesics, Opioid; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Formaldehyde; Male; Oligopeptides; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord	1998
Differential modulation of mu- and delta-opioid antinociception by neuropeptide FF receptors in young mice. Neuropeptides, 1997, Volume: 31, Issue:1 Topics: Age Factors; Analgesics, Opioid; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Mice; Mice, Inbred Strains; Morphine; Naltrexone; Narcotic Antagonists; Neuropeptides; Nociceptors; Oligopeptides; Receptors, Neuropeptide; Receptors, Opioid, delta; Receptors, Opioid, mu	1997
Differential desensitization of human delta-opioid receptors by peptide and alkaloid agonists. European journal of pharmacology, 1999, Apr-29, Volume: 371, Issue:2-3 Topics: Adenylyl Cyclase Inhibitors; Alkaloids; Analgesics; Analgesics, Opioid; Cyclic AMP; Drug Interactions; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Etorphine; Humans; Naloxone; Neuroblastoma; Oligopeptides; Peptides; Receptors, Opioid, delta; Tumor Cells, Cultured	1999
Differential G-protein activation by alkaloid and peptide opioid agonists in the human neuroblastoma cell line SK-N-BE. The Biochemical journal, 1999, Aug-15, Volume: 342 ( Pt 1) Topics: Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Alkaloids; Animals; Azides; Cell Membrane; Colforsin; Cyclic AMP; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Etorphine; GTP-Binding Proteins; Guanosine Triphosphate; Humans; Isoelectric Point; Neuroblastoma; Neurons; Oligodeoxyribonucleotides, Antisense; Oligopeptides; Peptides; Pertussis Toxin; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Tumor Cells, Cultured; Virulence Factors, Bordetella	1999
Induction of delta-opioid receptor function in the midbrain after chronic morphine treatment. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005, Mar-23, Volume: 25, Issue:12 Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Arrestins; beta-Arrestin 2; beta-Arrestins; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Excitatory Amino Acid Antagonists; G Protein-Coupled Inwardly-Rectifying Potassium Channels; gamma-Aminobutyric Acid; Glycine Agents; In Vitro Techniques; Isoquinolines; Male; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Knockout; Morphine; Narcotic Antagonists; Narcotics; Neurons; Oligopeptides; Patch-Clamp Techniques; Periaqueductal Gray; Protein Kinase Inhibitors; Receptors, Opioid, delta; Receptors, Opioid, mu; Strychnine; Sulfonamides; Synaptic Transmission; Time Factors; Xanthines	2005
Synthesis and receptor binding of opioid peptide analogues containing beta3-homo-amino acids. Journal of peptide science : an official publication of the European Peptide Society, 2009, Volume: 15, Issue:11 Topics: Enkephalin, Leucine; Magnetic Resonance Spectroscopy; Molecular Structure; Oligopeptides; Opioid Peptides; Protein Binding; Receptors, Opioid; Receptors, Opioid, mu; Receptors, sigma; Structure-Activity Relationship	2009