Compounds > deltorphin i, ala(2)-

Page last updated: 2024-09-03

deltorphin i, ala(2)- and enkephalin, ala(2)-mephe(4)-gly(5)-

deltorphin i, ala(2)- has been researched along with enkephalin, ala(2)-mephe(4)-gly(5)- in 14 studies

Compound Research Comparison

Studies (deltorphin i, ala(2)-)	Trials (deltorphin i, ala(2)-)	Recent Studies (post-2010) (deltorphin i, ala(2)-)	Studies (enkephalin, ala(2)-mephe(4)-gly(5)-)	Trials (enkephalin, ala(2)-mephe(4)-gly(5)-)	Recent Studies (post-2010) (enkephalin, ala(2)-mephe(4)-gly(5)-)
122	0	4	151	0	71
122	0	4	2,727	1	374

Protein Interaction Comparison

Protein	Taxonomy	deltorphin i, ala(2)- (IC50)	enkephalin, ala(2)-mephe(4)-gly(5)- (IC50)
Muscarinic acetylcholine receptor M1	Rattus norvegicus (Norway rat)		0.003
Muscarinic acetylcholine receptor M3	Rattus norvegicus (Norway rat)		0.003
Muscarinic acetylcholine receptor M4	Rattus norvegicus (Norway rat)		0.003
Muscarinic acetylcholine receptor M5	Rattus norvegicus (Norway rat)		0.003
Muscarinic acetylcholine receptor M2	Rattus norvegicus (Norway rat)		0.003
Delta-type opioid receptor	Mus musculus (house mouse)		1.2415
Mu-type opioid receptor	Rattus norvegicus (Norway rat)		0.0132
Mu-type opioid receptor	Homo sapiens (human)		0.004
Delta-type opioid receptor	Homo sapiens (human)		0.0014
Mu-type opioid receptor	Mus musculus (house mouse)		0.0048
Mu-type opioid receptor	Cavia porcellus (domestic guinea pig)		0.0283

Research

Studies (14)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	7 (50.00)	18.2507
2000's	7 (50.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Lazarus, LH; Salvadori, S; Santagada, V; Tomatis, R; Wilson, WE	1
Jacobson, AE; Ni, Q; Rice, KC; Rothman, RB; Xu, H	1
Amodeo, P; Bianchi, C; Guerrini, R; Lazarus, LH; Picone, D; Salvadori, S; Tancredi, T; Temussi, PA; Tomatis, R	1
Mokhtari, M; Tafani, JA; Zajac, JM	1
Allard, M; Jordan, D; Kopp, N; Martin, D; Ries, C; Simonnet, G; Tafani, JA; Zajac, JM	1
Basbaum, AI; Hammond, DL; Nakashima, N; Wang, H	1
Desprat, C; Zajac, JM	1
Kieffer, BL; Maldonado, R; Matthes, HW; Melchiorri, P; Negri, L; Severini, C	1
Chen, Z; Clarke, S; Hill, R; Hsu, MS; Kitchen, I; Pintar, J	1
Filliol, D; Goody, RJ; Kieffer, BL; Kitchen, I; Oakley, SM	1
Georgieva, J; Kitchen, I; Rosin, A	1
Bagley, EE; Chieng, BC; Christie, MJ; Hack, SP	1
Kersanté, F; Mollereau, C; Roumy, M; Zajac, JM	1
Benaderet, TS; Bishop-Mathis, K; Dersch, CM; Partilla, JS; Prisinzano, TE; Rothman, RB; Simpson, DS; Wang, X; Xu, H	1

Other Studies

14 other study(ies) available for deltorphin i, ala(2)- and enkephalin, ala(2)-mephe(4)-gly(5)-

Article	Year
Function of negative charge in the "address domain" of deltorphins. Journal of medicinal chemistry, 1991, Volume: 34, Issue:4 Topics: Animals; Binding, Competitive; Brain; Cell Membrane; Enkephalin, Leucine-2-Alanine; Oligopeptides; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Structure-Activity Relationship	1991
Preliminary ligand binding data for subtypes of the delta opioid receptor in rat brain membranes. Life sciences, 1991, Volume: 49, Issue:18 Topics: Amino Acid Sequence; Animals; Binding Sites; Brain; Cell Membrane; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Kinetics; Molecular Sequence Data; Oligopeptides; Radioligand Assay; Rats; Receptors, Opioid; Receptors, Opioid, delta; Somatostatin	1991
Selective opioid dipeptides. Biochemical and biophysical research communications, 1994, Feb-15, Volume: 198, Issue:3 Topics: Amino Acid Sequence; Animals; Binding, Competitive; Brain; Cell Membrane; Dipeptides; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Isoquinolines; Kinetics; Models, Molecular; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Narcotics; Oligopeptides; Protein Conformation; Radioligand Assay; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Stereoisomerism; Structure-Activity Relationship; Synaptosomes; Tetrahydroisoquinolines	1994
Binding in vivo of selective mu and delta opioid agonists: localization by autoradiography. Neuropeptides, 1993, Volume: 25, Issue:3 Topics: Amino Acid Sequence; Analgesics; Animals; Autoradiography; Binding, Competitive; Brain; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Diffusion; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Intraventricular; Male; Mice; Molecular Sequence Data; Naltrexone; Oligopeptides; Pain Measurement; Protein Binding; Receptors, Opioid, delta; Receptors, Opioid, mu	1993
Evidence for multiple opioid receptors in the human posterior pituitary. Journal of neuroendocrinology, 1996, Volume: 8, Issue:11 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adult; Benzeneacetamides; Binding Sites; Binding, Competitive; Cadaver; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Humans; Male; Middle Aged; Narcotics; Oligopeptides; Pituitary Gland, Posterior; Pyrrolidines; Receptors, Opioid; Tissue Distribution	1996
Differential effects of intrathecally administered delta and mu opioid receptor agonists on formalin-evoked nociception and on the expression of Fos-like immunoreactivity in the spinal cord of the rat. The Journal of pharmacology and experimental therapeutics, 1998, Volume: 284, Issue:1 Topics: Analgesics, Opioid; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Formaldehyde; Male; Oligopeptides; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord	1998
Differential modulation of mu- and delta-opioid antinociception by neuropeptide FF receptors in young mice. Neuropeptides, 1997, Volume: 31, Issue:1 Topics: Age Factors; Analgesics, Opioid; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Mice; Mice, Inbred Strains; Morphine; Naltrexone; Narcotic Antagonists; Neuropeptides; Nociceptors; Oligopeptides; Receptors, Neuropeptide; Receptors, Opioid, delta; Receptors, Opioid, mu	1997
Activity of mu- and delta-opioid agonists in vas deferens from mice deficient in MOR gene. British journal of pharmacology, 2001, Volume: 132, Issue:7 Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Female; Genotype; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mice, Mutant Strains; Morphine; Muscle Contraction; Naltrexone; Narcotic Antagonists; Oligopeptides; Receptors, Opioid, delta; Receptors, Opioid, mu; Vas Deferens	2001
Quantitative autoradiographic mapping of the ORL1, mu-, delta- and kappa-receptors in the brains of knockout mice lacking the ORL1 receptor gene. Brain research, 2001, Jul-06, Volume: 906, Issue:1-2 Topics: Analgesics, Opioid; Animals; Autoradiography; Benzofurans; Binding Sites; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Gene Deletion; Mice; Mice, Knockout; Neurons; Neuroprotective Agents; Nociceptin; Nociceptin Receptor; Oligopeptides; Opioid Peptides; Pyrrolidines; Radioligand Assay; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tritium	2001
Quantitative autoradiographic mapping of opioid receptors in the brain of delta-opioid receptor gene knockout mice. Brain research, 2002, Jul-26, Volume: 945, Issue:1 Topics: Animals; Autoradiography; Benzofurans; Benzomorphans; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Female; Heterozygote; Homozygote; Male; Mice; Mice, Knockout; Oligopeptides; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu	2002
Effects of single and dual administration of cocaine and ethanol on opioid and ORL1 receptor expression in rat CNS: an autoradiographic study. Brain research, 2003, Jul-18, Volume: 978, Issue:1-2 Topics: Anesthetics, Local; Animals; Autoradiography; Binding Sites; Brain Mapping; Central Nervous System; Central Nervous System Depressants; Cocaine; Dihydropyridines; Drug Combinations; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Ethanol; Male; Nociceptin Receptor; Oligopeptides; Opioid Peptides; Oximes; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Tritium	2003
Induction of delta-opioid receptor function in the midbrain after chronic morphine treatment. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005, Mar-23, Volume: 25, Issue:12 Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Arrestins; beta-Arrestin 2; beta-Arrestins; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Excitatory Amino Acid Antagonists; G Protein-Coupled Inwardly-Rectifying Potassium Channels; gamma-Aminobutyric Acid; Glycine Agents; In Vitro Techniques; Isoquinolines; Male; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Knockout; Morphine; Narcotic Antagonists; Narcotics; Neurons; Oligopeptides; Patch-Clamp Techniques; Periaqueductal Gray; Protein Kinase Inhibitors; Receptors, Opioid, delta; Receptors, Opioid, mu; Strychnine; Sulfonamides; Synaptic Transmission; Time Factors; Xanthines	2005
Anti-opioid activities of NPFF1 receptors in a SH-SY5Y model. Peptides, 2006, Volume: 27, Issue:5 Topics: Calcium Channels, N-Type; Carbachol; Cell Line, Tumor; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Humans; Narcotic Antagonists; Neuroblastoma; Neuropeptides; Oligopeptides; Pertussis Toxin; Receptors, Muscarinic; Receptors, Neuropeptide; Receptors, Opioid, mu; Signal Transduction; Transfection	2006
Differential effects of opioid agonists on G protein expression in CHO cells expressing cloned human opioid receptors. Brain research bulletin, 2008, Sep-05, Volume: 77, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Benzamides; Blotting, Western; CHO Cells; Cricetinae; Cricetulus; Diterpenes, Clerodane; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Etorphine; Female; Furans; Gene Expression; GTP-Binding Protein alpha Subunits, G12-G13; GTP-Binding Protein alpha Subunits, Gi-Go; Humans; Morphine; Oligopeptides; Piperazines; Pyrones; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu	2008