deltorphin and ubenimex

deltorphin has been researched along with ubenimex* in 1 studies

Other Studies

1 other study(ies) available for deltorphin and ubenimex

Article	Year
The neuropeptide FF analogue, 1DMe, acts as a functional opioid autoreceptor antagonist in the rat spinal cord. European journal of pharmacology, 2001, Nov-02, Volume: 430, Issue:2-3 We assessed the possible influence of a neuropeptide FF analogue, 1DMe ([D-Tyr(1),(NMe)Phe(3)]neuropeptide FF), on the inhibitory action of endogenous and exogenous partial differential-opioid receptor agonists on K(+)-evoked [Met(5)]-enkephalin release from superfused rat spinal cord slices. 1DMe (0.1-10 microM) dose-dependently enhanced the increase in superfusate [Met(5)]-enkephalin content due to the peptidase inhibitors thiorphan (1 microM) and bestatin (20 microM), and prevented the reduction in [Met(5)]-enkephalin release due to stimulation of partial differential receptors by 1 microM deltorphin I. Because it had the same effects as partial differential-opioid receptor antagonists, 1DMe might act through the functional blockade of presynaptically located partial differential-opioid autoreceptors. Topics: Animals; Autoreceptors; Dose-Response Relationship, Drug; Enkephalin, Methionine; In Vitro Techniques; Leucine; Male; Naltrexone; Narcotic Antagonists; Oligopeptides; Potassium; Rats; Rats, Sprague-Dawley; Spinal Cord; Thiorphan	2001

Article

Year

The neuropeptide FF analogue, 1DMe, acts as a functional opioid autoreceptor antagonist in the rat spinal cord.

European journal of pharmacology, 2001, Nov-02, Volume: 430, Issue:2-3

We assessed the possible influence of a neuropeptide FF analogue, 1DMe ([D-Tyr(1),(NMe)Phe(3)]neuropeptide FF), on the inhibitory action of endogenous and exogenous partial differential-opioid receptor agonists on K(+)-evoked [Met(5)]-enkephalin release from superfused rat spinal cord slices. 1DMe (0.1-10 microM) dose-dependently enhanced the increase in superfusate [Met(5)]-enkephalin content due to the peptidase inhibitors thiorphan (1 microM) and bestatin (20 microM), and prevented the reduction in [Met(5)]-enkephalin release due to stimulation of partial differential receptors by 1 microM deltorphin I. Because it had the same effects as partial differential-opioid receptor antagonists, 1DMe might act through the functional blockade of presynaptically located partial differential-opioid autoreceptors.

Topics: Animals; Autoreceptors; Dose-Response Relationship, Drug; Enkephalin, Methionine; In Vitro Techniques; Leucine; Male; Naltrexone; Narcotic Antagonists; Oligopeptides; Potassium; Rats; Rats, Sprague-Dawley; Spinal Cord; Thiorphan

2001