Page last updated: 2024-09-03

deltakephalin and naloxone

deltakephalin has been researched along with naloxone in 20 studies

Compound Research Comparison

Studies
(deltakephalin)
Trials
(deltakephalin)
Recent Studies (post-2010)
(deltakephalin)
Studies
(naloxone)
Trials
(naloxone)
Recent Studies (post-2010) (naloxone)
790020,1341,2573,321

Protein Interaction Comparison

ProteinTaxonomydeltakephalin (IC50)naloxone (IC50)
Cytochrome P450 2D6Homo sapiens (human)2
Delta-type opioid receptorMus musculus (house mouse)0.043
Delta-type opioid receptorRattus norvegicus (Norway rat)0.0219
Mu-type opioid receptorRattus norvegicus (Norway rat)0.0019
Kappa-type opioid receptorRattus norvegicus (Norway rat)0.0019
Mu-type opioid receptorHomo sapiens (human)0.0397
Delta-type opioid receptorHomo sapiens (human)0.1896
Kappa-type opioid receptorCavia porcellus (domestic guinea pig)0.05
Kappa-type opioid receptorHomo sapiens (human)0.0795
Mu-type opioid receptorMus musculus (house mouse)0.0154
Mu-type opioid receptorCavia porcellus (domestic guinea pig)0.0089
Beta-2 adrenergic receptorCavia porcellus (domestic guinea pig)0.0055

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19909 (45.00)18.7374
1990's10 (50.00)18.2507
2000's1 (5.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bourgoin, S; Cesselin, F; Collin, E; Ferhat, L; Hamon, M1
Bourgoin, S; Cesselin, F; Collin, E; Hamon, M; Mantelet, S1
Calenco-Choukroun, G; Daugé, V; Féger, J; Gacel, G; Roques, BP1
Bourgoin, S; Cesselin, F; Chantrel, D; Collin, E; Hamon, M; Mauborgne, A1
Członkowski, A; Widy-Tyszkiewicz, E1
Kaneto, H; Shiigi, Y; Takahashi, M1
Cesselin, F; Hamon, M; Legrand, JC; Lutz, O; Mauborgne, A1
Benoliel, JJ; Berthier, JL; Bourgoin, S; Cesselin, F; Hamon, M; Hirsch, M; Mauborgne, A1
Gosnell, BA; Majchrzak, MJ1
Cunningham, FJ; Stansfield, SC2
Daugé, V; Roques, BP; Rossignol, P1
Itoh, Y; Nishibori, M; Oishi, R; Saeki, K1
Miller, L; Shaw, JS1
Benoist, JM; Gacel, G; Gautron, M; Guilbaud, G; Kayser, V; Roques, B; Zajac, JM1
Jauzac, P; Polastron, J1
Benoliel, JJ; Bourgoin, S; Cesselin, F; Collin, E; Hamon, M; Mauborgne, A1
Bourgoin, S; Cesselin, F; Collin, E; Frechilla, D; Hamon, M; Le Bars, D; Pohl, M1
Dragatsis, I; Gerozissis, K; Zioudrou, C1
Ballet, S; Cesselin, F; Collin, E; Hamon, M; Mauborgne, A1

Other Studies

20 other study(ies) available for deltakephalin and naloxone

ArticleYear
Kappa-opioid receptor stimulation abolishes mu- but not delta-mediated inhibitory control of spinal Met-enkephalin release.
    Neuroscience letters, 1992, Jan-06, Volume: 134, Issue:2

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Indoles; Injections, Spinal; Male; Morphinans; Naloxone; Naltrexone; Neurons; Oligopeptides; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord

1992
Feedback inhibition of met-enkephalin release from the rat spinal cord in vivo.
    Synapse (New York, N.Y.), 1992, Volume: 11, Issue:1

    Topics: Animals; Calcitonin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Feedback; Indoles; Injections, Spinal; Leucine; Male; Morphinans; Naloxone; Naltrexone; Oligopeptides; Radioimmunoassay; Rats; Rats, Inbred Strains; Spinal Cord; Thiorphan

1992
Opioid delta agonists and endogenous enkephalins induce different emotional reactivity than mu agonists after injection in the rat ventral tegmental area.
    Psychopharmacology, 1991, Volume: 103, Issue:4

    Topics: Animals; Anxiety; Emotions; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Exploratory Behavior; Indoles; Injections; Male; Morphinans; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Tegmentum Mesencephali

1991
In vivo tonic inhibition of spinal substance P (-like material) release by endogenous opioid(s) acting at delta receptors.
    Neuroscience, 1991, Volume: 44, Issue:3

    Topics: Amino Acid Sequence; Animals; Depression, Chemical; Indoles; Injections, Spinal; Male; Molecular Sequence Data; Morphinans; Naloxone; Naltrexone; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Secretory Rate; Spinal Cord; Substance P

1991
Normotensive Wistar rats differ from spontaneously hypertensive and renal hypertensive rats in their cardiovascular responses to opioid agonists.
    Clinical and experimental pharmacology & physiology, 1991, Volume: 18, Issue:12

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amino Acid Sequence; Analgesics; Animals; Blood Pressure; Endorphins; Heart Rate; Hemodynamics; Hypertension, Renal; Injections, Intraventricular; Male; Molecular Sequence Data; Naloxone; Oligopeptides; Pyrrolidines; Rats; Rats, Inbred SHR; Rats, Inbred Strains

1991
Facilitation of memory retrieval by pretest morphine mediated by mu but not delta and kappa opioid receptors.
    Psychopharmacology, 1990, Volume: 102, Issue:3

    Topics: Analgesics; Animals; Avoidance Learning; Benzeneacetamides; Electroshock; Male; Memory; Mice; Mice, Inbred Strains; Morphine; Naloxone; Oligopeptides; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu

1990
Opposite effects of delta and mu opioid receptor agonists on the in vitro release of substance P-like material from the rat spinal cord.
    Journal of neurochemistry, 1987, Volume: 48, Issue:2

    Topics: Animals; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; In Vitro Techniques; Male; Morphine; Naloxone; Oligopeptides; Potassium; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord; Substance P; Tetrodotoxin; Veratridine

1987
Enkephalinase is involved in the degradation of endogenous substance P released from slices of rat substantia nigra.
    The Journal of pharmacology and experimental therapeutics, 1987, Volume: 243, Issue:2

    Topics: Animals; Captopril; Dipeptides; In Vitro Techniques; Leucine; Male; Metalloendopeptidases; Naloxone; Neprilysin; Oligopeptides; Peptidyl-Dipeptidase A; Potassium; Protease Inhibitors; Rats; Rats, Inbred Strains; Substance P; Substantia Nigra; Thiorphan; Tiopronin

1987
Centrally administered opioid peptides stimulate saccharin intake in nondeprived rats.
    Pharmacology, biochemistry, and behavior, 1989, Volume: 33, Issue:4

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Dose-Response Relationship, Drug; Drinking Behavior; Eating; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Food Preferences; Male; Naloxone; Oligopeptides; Pyrrolidines; Rats; Rats, Inbred Strains; Saccharin; Time Factors

1989
Involvement of opiate receptor subtypes in the modulation of LHRH secretion by the cockerel (Gallus domesticus) mediobasal hypothalamus in vitro.
    The Journal of endocrinology, 1987, Volume: 114, Issue:1

    Topics: Animals; Benzodiazepines; Chickens; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Gonadotropin-Releasing Hormone; Hypothalamus; In Vitro Techniques; Male; Naloxone; Oligopeptides; Receptors, Opioid

1987
Comparison of the behavioural effects induced by administration in rat nucleus accumbens or nucleus caudatus of selective mu and delta opioid peptides or kelatorphan an inhibitor of enkephalin-degrading-enzymes.
    Psychopharmacology, 1988, Volume: 96, Issue:3

    Topics: Animals; Behavior, Animal; Caudate Nucleus; Dipeptides; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Motor Activity; Naloxone; Neprilysin; Norepinephrine; Nucleus Accumbens; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu

1988
Involvement of Mu receptors in the opioid-induced increase in the turnover of mouse brain histamine.
    The Journal of pharmacology and experimental therapeutics, 1988, Volume: 244, Issue:3

    Topics: Animals; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Histamine; Male; Methylhistamines; Methylhistidines; Mice; Naloxone; Oligopeptides; Receptors, Opioid; Receptors, Opioid, mu; Tetrodotoxin

1988
Characterisation of the delta-opioid receptor on the hamster vas deferens.
    Neuropeptides, 1985, Volume: 6, Issue:6

    Topics: Animals; Cricetinae; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; In Vitro Techniques; Male; Mesocricetus; Muscle, Smooth; Naloxone; Narcotic Antagonists; Narcotics; Oligopeptides; Receptors, Opioid; Receptors, Opioid, delta; Vas Deferens

1985
Differential depressive action of two mu and delta opioid ligands on neuronal responses to noxious stimuli in the thalamic ventrobasal complex of rat.
    Brain research, 1986, Nov-19, Volume: 398, Issue:1

    Topics: Action Potentials; Animals; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Hot Temperature; Male; Naloxone; Neurons; Oligopeptides; Pain; Physical Stimulation; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Thalamus

1986
Attenuation of endogenous opioid peptide inhibition of [Gln8]luteinizing hormone-releasing hormone secretion during sexual maturation in the cockerel.
    Endocrinology, 1988, Volume: 123, Issue:2

    Topics: Animals; Chickens; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Gonadotropin-Releasing Hormone; Hypothalamus, Middle; Male; Naloxone; Oligopeptides; Pyrrolidonecarboxylic Acid; Sexual Maturation; Testosterone

1988
Different subtypes of opioid receptors have different affinities for G-proteins.
    Cellular and molecular biology (Noisy-le-Grand, France), 1994, Volume: 40, Issue:3

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenylyl Cyclases; Amino Acid Sequence; Animals; Binding, Competitive; Cerebellum; Colforsin; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Etorphine; GTP-Binding Proteins; Guinea Pigs; Humans; Hybrid Cells; Molecular Sequence Data; Morphine; Naloxone; Neoplasm Proteins; Nerve Tissue Proteins; Neuroblastoma; Oligopeptides; Pyrrolidines; Rabbits; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Tumor Cells, Cultured

1994
Morphine reduces the release of met-enkephalin-like material from the rat spinal cord in vivo by acting at delta opioid receptors.
    Neuropeptides, 1994, Volume: 27, Issue:1

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Injections, Spinal; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Pyrrolidines; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Spinal Cord

1994
Opioid control of the release of calcitonin gene-related peptide-like material from the rat spinal cord in vivo.
    Brain research, 1993, Apr-23, Volume: 609, Issue:1-2

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Calcitonin Gene-Related Peptide; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Spinal; Iodine Radioisotopes; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Pyrrolidines; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord

1993
Specific delta-opioid antagonists exert an agonist-independent inhibitory effect, similar to the agonist, on the release of GnRH in vitro.
    Cellular and molecular neurobiology, 1995, Volume: 15, Issue:4

    Topics: Animals; Arachidonic Acid; Arcuate Nucleus of Hypothalamus; Dinoprostone; Eicosanoids; Gonadotropin-Releasing Hormone; Leukotrienes; Male; Median Eminence; Naloxone; Narcotic Antagonists; Oligopeptides; Rats; Rats, Wistar; Receptors, Opioid, delta

1995
Altered opioid-mediated control of the spinal release of dynorphin and met-enkephalin in polyarthritic rats.
    Synapse (New York, N.Y.), 2000, Sep-15, Volume: 37, Issue:4

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthesia; Animals; Arthritis; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Iodine Radioisotopes; Ligands; Male; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord

2000