Compounds > delta9-tetrahydrocannabinol hemisuccinate
Page last updated: 2024-09-04

delta9-tetrahydrocannabinol hemisuccinate and dronabinol

delta9-tetrahydrocannabinol hemisuccinate has been researched along with dronabinol in 14 studies

Compound Research Comparison

Studies
(delta9-tetrahydrocannabinol hemisuccinate)		Trials
(delta9-tetrahydrocannabinol hemisuccinate)		Recent Studies (post-2010)
(delta9-tetrahydrocannabinol hemisuccinate)		Studies
(dronabinol)		Trials
(dronabinol)		Recent Studies (post-2010) (dronabinol)
14148,3077853,094

Protein Interaction Comparison

ProteinTaxonomydelta9-tetrahydrocannabinol hemisuccinate (IC50)dronabinol (IC50)
Cannabinoid receptor 1Rattus norvegicus (Norway rat)0.218
Cannabinoid receptor 1Homo sapiens (human)0.0028
Cannabinoid receptor 2 Homo sapiens (human)0.0095
Cannabinoid receptor 2Rattus norvegicus (Norway rat)0.218

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (7.14)18.2507
2000's8 (57.14)29.6817
2010's3 (21.43)24.3611
2020's2 (14.29)2.80

Authors

AuthorsStudies
ElSohly, MA; Harland, EC; Hikal, AH; Jones, AB; Little, TL; Rider, JN; Stanford, DF; Walker, LA1
Berrendero, F; Bisogno, T; Cavaliere, P; Cebeira, M; Di Marzo, V; Fernández-Ruiz, JJ; González, S; Ramos, JA; Romero, J1
Dar, MS1
Azad, SC; Eberlein, I; Lutz, B; Marsicano, G; Putzke, J; Spanagel, R; Zieglgänsberger, W1
Ambrosio, E; Arévalo, C; Cascio, MG; Di Marzo, V; Fernández-Ruiz, J; González, S; Hernández, M; Nicanor, C; Ramos, JA1
Berding, G; Brooks, DJ; Buchert, R; Donnerstag, F; Emrich, HM; Fitschen, J; Gielow, P; Harke, H; Hofmann, M; Knapp, WH; Knoop, BO; Müller-Vahl, K; Schneider, U; Stuhrmann, M1
Curran, HV; Morgan, CJ1
Díaz, A; Pazos, A; Rodríguez-Gaztelumendi, A; Rojo, ML1
Gallinat, J; Gorynia, I; Juckel, G; Roser, P; Stadelmann, AM; Weinberg, G1
Avery, MA; ElSohly, MA; Gul, W; Kulkarni, SJ; Majumdar, S; Repka, MA; Upadhye, SB1
Abdelwahab, SH; Acheson, SK; D'Abo, A; Levin, ED; Rezvani, AH; Risher, ML; Swartzwelder, HS; Swartzwelder, NA; Wilson, WA1
Ho, RY; Horng, H; Li, K; Lynch, KL; Smollin, CG; Vo, KT; Wu, AHB1
Aouizerat, BE; D'Souza, DC; Ganesh, S; Hu, Y; Krystal, JH; Liang, X; Osafo-Addo, A; Ranganathan, M; Shu, C; Xu, K; Yan, C; Zhang, X1
Hoffman, AF; Hwang, EK; Lupica, CR1

Reviews

1 review(s) available for delta9-tetrahydrocannabinol hemisuccinate and dronabinol

ArticleYear
Impairment of Synaptic Plasticity by Cannabis, Δ
    Cold Spring Harbor perspectives in medicine, 2021, 05-03, Volume: 11, Issue:5

    Topics: Basolateral Nuclear Complex; Cannabinoids; Cannabis; Central Nervous System; Dronabinol; Hippocampus; Humans; Neuronal Plasticity; Synaptic Transmission; Ventral Striatum; Ventral Tegmental Area

2021

Trials

1 trial(s) available for delta9-tetrahydrocannabinol hemisuccinate and dronabinol

ArticleYear
Psychomotor performance in relation to acute oral administration of Delta9-tetrahydrocannabinol and standardized cannabis extract in healthy human subjects.
    European archives of psychiatry and clinical neuroscience, 2009, Volume: 259, Issue:5

    Topics: Administration, Oral; Adult; Analysis of Variance; Cannabidiol; Cannabinoids; Cannabis; Cross-Over Studies; Double-Blind Method; Dronabinol; Female; Fingers; Functional Laterality; Humans; Male; Neuropsychological Tests; Plant Preparations; Plant Structures; Psychomotor Performance; Reference Values

2009

Other Studies

12 other study(ies) available for delta9-tetrahydrocannabinol hemisuccinate and dronabinol

ArticleYear
Rectal bioavailability of delta-9-tetrahydrocannabinol from the hemisuccinate ester in monkeys.
    Journal of pharmaceutical sciences, 1991, Volume: 80, Issue:10

    Topics: Administration, Rectal; Animals; Biological Availability; Dronabinol; Gas Chromatography-Mass Spectrometry; Macaca fascicularis; Male; Prodrugs; Radioimmunoassay; Suppositories

1991
Enhancement of anandamide formation in the limbic forebrain and reduction of endocannabinoid contents in the striatum of delta9-tetrahydrocannabinol-tolerant rats.
    Journal of neurochemistry, 2000, Volume: 74, Issue:4

    Topics: Animals; Arachidonic Acids; Benzoxazines; Calcium Channel Blockers; Cannabinoid Receptor Modulators; Cannabinoids; Down-Regulation; Dronabinol; Endocannabinoids; Guanosine 5'-O-(3-Thiotriphosphate); Limbic System; Male; Marijuana Abuse; Morpholines; Naphthalenes; Phosphatidylethanolamines; Polyunsaturated Alkamides; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Sulfur Radioisotopes; Tritium

2000
Cerebellar CB(1) receptor mediation of Delta(9)-THC-induced motor incoordination and its potentiation by ethanol and modulation by the cerebellar adenosinergic A(1) receptor in the mouse.
    Brain research, 2000, May-12, Volume: 864, Issue:2

    Topics: Animals; Behavior, Animal; Central Nervous System Depressants; Cerebellar Ataxia; Cerebellum; Dose-Response Relationship, Drug; Dronabinol; Drug Synergism; Ethanol; Male; Mice; Mice, Inbred Strains; Movement; Oligonucleotides, Antisense; Pertussis Toxin; Receptors, Adrenergic, alpha-1; Receptors, Cannabinoid; Receptors, Drug; Virulence Factors, Bordetella; Xanthines

2000
Differential role of the nitric oxide pathway on delta(9)-THC-induced central nervous system effects in the mouse.
    The European journal of neuroscience, 2001, Volume: 13, Issue:3

    Topics: Animals; Brain; Dronabinol; Gene Expression; In Situ Hybridization; Injections, Intraperitoneal; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons, Afferent; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nociceptors; Pain Threshold; Receptors, Cannabinoid; Receptors, Drug; RNA, Messenger

2001
Behavioral and molecular changes elicited by acute administration of SR141716 to Delta9-tetrahydrocannabinol-tolerant rats: an experimental model of cannabinoid abstinence.
    Drug and alcohol dependence, 2004, May-10, Volume: 74, Issue:2

    Topics: Animals; Arachidonic Acids; Behavior, Animal; Brain; Cannabinoid Receptor Antagonists; Cannabinoid Receptor Modulators; Corticosterone; Dronabinol; Drug Administration Schedule; Drug Tolerance; Endocannabinoids; Glycerides; Male; Paraventricular Hypothalamic Nucleus; Piperidines; Polyunsaturated Alkamides; Prolactin; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Corticotropin-Releasing Hormone; Rimonabant; RNA, Messenger; Substance Withdrawal Syndrome

2004
[123I]AM281 single-photon emission computed tomography imaging of central cannabinoid CB1 receptors before and after Delta9-tetrahydrocannabinol therapy and whole-body scanning for assessment of radiation dose in tourette patients.
    Biological psychiatry, 2004, May-01, Volume: 55, Issue:9

    Topics: Adult; Brain; Chromatography, Thin Layer; Dronabinol; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Psychotropic Drugs; Radiation Dosage; Radiopharmaceuticals; Receptor, Cannabinoid, CB1; Time Factors; Tomography, Emission-Computed, Single-Photon; Tourette Syndrome; Whole Body Imaging

2004
Effects of cannabidiol on schizophrenia-like symptoms in people who use cannabis.
    The British journal of psychiatry : the journal of mental science, 2008, Volume: 192, Issue:4

    Topics: Adult; Analysis of Variance; Cannabidiol; Delusions; Dronabinol; Female; Hair; Humans; Male; Marijuana Abuse; Predictive Value of Tests; Psychoses, Substance-Induced

2008
Altered CB receptor-signaling in prefrontal cortex from an animal model of depression is reversed by chronic fluoxetine.
    Journal of neurochemistry, 2009, Volume: 108, Issue:6

    Topics: Animals; Antidepressive Agents, Second-Generation; Autoradiography; Cyclohexanols; Depression; Disease Models, Animal; Dose-Response Relationship, Drug; Dronabinol; Drug Administration Schedule; Exploratory Behavior; Fluoxetine; Guanosine 5'-O-(3-Thiotriphosphate); Immunosuppressive Agents; Isotopes; Male; Olfactory Bulb; Prefrontal Cortex; Protein Binding; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Signal Transduction; Time Factors

2009
Preparation and characterization of inclusion complexes of a hemisuccinate ester prodrug of delta9-tetrahydrocannabinol with modified beta-cyclodextrins.
    AAPS PharmSciTech, 2010, Volume: 11, Issue:2

    Topics: beta-Cyclodextrins; Computer Simulation; Dronabinol; Drug Compounding; Drug Design; Feasibility Studies; Models, Chemical; Prodrugs

2010
Effects of ethanol, Δ(9)-tetrahydrocannabinol, or their combination on object recognition memory and object preference in adolescent and adult male rats.
    Neuroscience letters, 2012, Oct-03, Volume: 527, Issue:1

    Topics: Aging; Animals; Decision Making; Dronabinol; Drug Combinations; Ethanol; Form Perception; Male; Mental Recall; Rats; Rats, Sprague-Dawley; Recognition, Psychology

2012
Cannabis Intoxication Case Series: The Dangers of Edibles Containing Tetrahydrocannabinol.
    Annals of emergency medicine, 2018, Volume: 71, Issue:3

    Topics: Adolescent; Adult; Candy; Cannabis; Child; Dronabinol; Female; Gas Chromatography-Mass Spectrometry; Humans; Hypnotics and Sedatives; Incidence; Male; Marijuana Abuse; Middle Aged; San Francisco; Substance Abuse Detection; Young Adult

2018
Single-cell Transcriptome Mapping Identifies Common and Cell-type Specific Genes Affected by Acute Delta9-tetrahydrocannabinol in Humans.
    Scientific reports, 2020, 02-26, Volume: 10, Issue:1

    Topics: Apoptosis; B-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Proliferation; Cluster Analysis; Cytokines; Dronabinol; Gene Expression Profiling; Gene Expression Regulation; Gene Regulatory Networks; Humans; Immunity, Active; Leukocytes, Mononuclear; Male; Receptor, Cannabinoid, CB2; Single-Cell Analysis; Young Adult

2020