dehydrovomifoliol has been researched along with loliolide* in 1 studies
1 other study(ies) available for dehydrovomifoliol and loliolide
Article | Year |
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Tigliane diterpenes from Croton mauritianus as inhibitors of chikungunya virus replication.
A bioassay-guided purification of an EtOAc extract of the leaves of Croton mauritianus using a chikungunya virus-cell-based assay led to the isolation of 12-O-decanoylphorbol-13-acetate (1) and the new 12-O-decanoyl-7-hydroperoxy-phorbol-5-ene-13-acetate (2), along with loliolide, vomifoliol, dehydrovomifoliol, annuionone D and bluemol C. The planar structure and the relative configuration of compound 2 were elucidated based on spectroscopic analysis, including 1D- and 2D-NMR experiments, mass spectrometry, and comparison with literature data. Compounds 1 and 2 inhibited chikungunya virus-induced cell death in cell culture with EC50s of 2.4±0.3 and 4.0±0.8 μM, respectively. Topics: Antiviral Agents; Benzofurans; Butanols; Chikungunya virus; Croton; Cyclohexanones; Diterpenes; Microbial Sensitivity Tests; Norisoprenoids; Phorbol Esters; Plant Leaves; Virus Replication | 2014 |