dehydrovomifoliol and boldine

dehydrovomifoliol has been researched along with boldine* in 1 studies

Other Studies

1 other study(ies) available for dehydrovomifoliol and boldine

Article	Year
5-Hydroxytryptamine2A receptor binding activity of compounds from Litsea sessilis. Phytotherapy research : PTR, 2009, Volume: 23, Issue:3 A 96-well microplate filtration based 5-HT(2A) receptor-radioligand binding assay was optimized and adopted to carry out a bioassay-guided fractionation of the methanol extract of the leaves of Litsea sessilis. This purification led to the isolation of two compounds identified as (+)-boldine (1) and (+)-dehydrovomifoliol (2). (+)-Boldine binds to 5-HT(2A) receptors at high concentrations with a K(i) value of 2.16 microm. However, (+)-dehydrovomifoliol showed minimal competitive inhibition on the binding of [(3)H]ketanserin to the same receptor with a K(i) value of 2.06 mm. These results suggest that (+)-boldine influences the activity of 5-HT(2A) receptors through competitive binding as an agonist or antagonist. Topics: Aporphines; Binding, Competitive; Cyclohexanones; Ketanserin; Litsea; Plant Extracts; Plant Leaves; Radioligand Assay; Receptor, Serotonin, 5-HT2A	2009

Article

Year

5-Hydroxytryptamine2A receptor binding activity of compounds from Litsea sessilis.

Phytotherapy research : PTR, 2009, Volume: 23, Issue:3

A 96-well microplate filtration based 5-HT(2A) receptor-radioligand binding assay was optimized and adopted to carry out a bioassay-guided fractionation of the methanol extract of the leaves of Litsea sessilis. This purification led to the isolation of two compounds identified as (+)-boldine (1) and (+)-dehydrovomifoliol (2). (+)-Boldine binds to 5-HT(2A) receptors at high concentrations with a K(i) value of 2.16 microm. However, (+)-dehydrovomifoliol showed minimal competitive inhibition on the binding of [(3)H]ketanserin to the same receptor with a K(i) value of 2.06 mm. These results suggest that (+)-boldine influences the activity of 5-HT(2A) receptors through competitive binding as an agonist or antagonist.

Topics: Aporphines; Binding, Competitive; Cyclohexanones; Ketanserin; Litsea; Plant Extracts; Plant Leaves; Radioligand Assay; Receptor, Serotonin, 5-HT2A

2009