dehydroretronecine has been researched along with monocrotaline in 39 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (41.03) | 18.7374 |
| 1990's | 9 (23.08) | 18.2507 |
| 2000's | 10 (25.64) | 29.6817 |
| 2010's | 4 (10.26) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Allen, JR; Hsu, IC; Robertson, KA; Shumaker, RC | 1 |
| Allen, JR; Johnson, WD; Pounds, JG; Robertson, KA | 1 |
| Ciaramitaro, D; Eisenstein, D; Huxtable, R | 1 |
| Allen, JR; Hsia, MT; Robertson, KA; Seymour, JL | 1 |
| Allen, JR; Carstens, LA; Hsu, IC | 1 |
| Curtain, CC; Edgar, JA | 1 |
| Buhler, DR; Guengerich, FP; Miranda, CL; Reed, RL | 1 |
| Buhler, DR; Kedzierski, B; Miranda, CL; Reed, RL | 1 |
| Hopkins, PB; Sigurdsson, ST; Weidner, MF | 1 |
| Mattocks, AR; Neal, GE; Skilleter, DN | 1 |
| Ahern, KG; Buhler, DR; Pearson, GD; Reed, RL | 1 |
| Buhler, DR; Kedzierski, B | 1 |
| Allen, JR; Chesney, CF; Hsu, IC | 1 |
| Jago, MV; Jarrett, RG; Peterson, JE; Reddy, JK | 1 |
| Driver, HE; Mattocks, AR | 1 |
| Robertson, KA | 1 |
| Bird, I; Mattocks, AR | 1 |
| Legg, RF; Mattocks, AR | 1 |
| Jago, MV; Peterson, JE | 1 |
| Huxtable, RJ; Yan, CC | 1 |
| Buhler, DR; Chung, WG | 1 |
| Jones, AD; Lamé, MW; Pan, LC; Segall, HJ; Wilson, DW | 1 |
| Couet, CE; Hanley, AB; Hopley, J | 1 |
| Dunston, SK; Lamé, MW; Morin, D; Reid, MJ; Segall, HJ; Wilson, DW | 1 |
| Buhler, DR; Cheeke, PR; Huan, JY; Miranda, CL | 1 |
| Beger, R; Chan, P; Chou, MW; Churchwell, M; Doerge, DR; Fu, PP; Yan, J; Yang, Y | 1 |
| Chan, PC; Chou, MW; Doerge, DR; Fu, PP; Yan, J; Yang, YC | 1 |
| Chou, MW; Churchwell, M; Doerge, DR; Fu, PP; Jian, Y; Williams, LD; Xia, Q | 1 |
| Beger, RD; Chou, MW; Doerge, DR; Fu, PP; Wang, YP; Williams, LD; Yan, J; Yang, YC | 1 |
| Buhler, DR; Craig, AM; Duringer, JM | 1 |
| Chou, MW; Fu, PP; Wang, YP; Yan, J | 1 |
| Chou, MW; Doerge, DR; Edgar, JA; Fu, PP; Xia, Q | 1 |
| Chou, MW; Fu, PP; Wang, YP | 1 |
| Chou, MW; Fu, PP; Xia, Q; Yan, J | 2 |
| Annie Bligh, SW; Crowder, J; Wang, ZT; Wardle, NJ; White, KN; Yang, L; Yang, YC | 1 |
| Cai, L; Doerge, DR; Fu, PP; Gamboa da Costa, G; Wang, S; Xia, Q; Zhao, Y | 1 |
| Fu, PP; He, X; Ma, L; Xia, Q | 1 |
| Chen, S; Fu, PP; He, X; Ma, L; Xia, Q | 1 |
39 other study(ies) available for dehydroretronecine and monocrotaline
| Article | Year |
|---|---|
Neoplastic transformation in tissues of rats exposed to monocrotaline or dehydroretronecine.
Topics: Animals; Carcinogens; Carcinoma, Hepatocellular; Injections, Subcutaneous; Liver Neoplasms; Male; Monocrotaline; Neoplasm Metastasis; Neoplasms, Experimental; Pyrrolidines; Pyrrolizidine Alkaloids; Rats; Rhabdomyosarcoma | 1976 |
Dehydroretronecine-induced skin tumors in mice.
Topics: Administration, Topical; Animals; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Female; Injections, Subcutaneous; Mice; Monocrotaline; Neoplasms, Experimental; Pyrrolizidine Alkaloids; Skin Neoplasms | 1978 |
The effect of a pyrrolizidine alkaloid, monocrotaline, and a pyrrole, dehydroretronecine, on the biochemical functions of the pulmonary endothelium.
Topics: Adenosine Monophosphate; Animals; Blood Pressure; Endothelium; Heart; In Vitro Techniques; Leucine; Lung; Male; Monocrotaline; Norepinephrine; Organ Size; Plants, Toxic; Pyrroles; Pyrrolizidine Alkaloids; Rats; Senecio; Serotonin; Time Factors; Tissue Distribution | 1978 |
Covalent interaction of dehydroretronecine, a carcinogenic metabolite of the pyrrolizidine alkaloid monocrotaline, with cysteine and glutathione.
Topics: Alkylation; Binding Sites; Carcinogens; Chemical Phenomena; Chemistry; Chromatography; Cysteine; Glutathione; In Vitro Techniques; Magnetic Resonance Spectroscopy; Monocrotaline; Pyrrolizidine Alkaloids; Spectrum Analysis; Sulfhydryl Compounds | 1977 |
Dehydroretronecine-induced rhabdomyosarcomas in rats.
Topics: Animals; Carcinogens; Depression, Chemical; Injections, Subcutaneous; Liver; Liver Regeneration; Male; Methanol; Mitosis; Monocrotaline; Neoplasm Metastasis; Pyrrolizidine Alkaloids; Rats; Rhabdomyosarcoma; Sarcoma, Experimental; Skin Neoplasms | 1975 |
The binding of dehydroheliotridine to DNA and the effect of it and other compounds on repair synthesis in main and satellite band DNA.
Topics: Animals; Cells, Cultured; DNA; DNA Repair; DNA Replication; DNA, Satellite; Kidney; Kinetics; Lymphocytes; Male; Mathematics; Monocrotaline; Pyrrolizidine Alkaloids; Spectrophotometry, Ultraviolet; Ultracentrifugation | 1976 |
Role of cytochrome P450IIIA4 in the metabolism of the pyrrolizidine alkaloid senecionine in human liver.
Topics: Antineoplastic Agents, Phytogenic; Carcinogens; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Humans; Immunoglobulin G; Kinetics; Liver; Microsomes, Liver; Mixed Function Oxygenases; Monocrotaline; Norpregnenes; Oxidation-Reduction; Pyrrolizidine Alkaloids; Troleandomycin | 1991 |
Mechanisms for pyrrolizidine alkaloid activation and detoxification.
Topics: Animals; Biotransformation; Glutathione; In Vitro Techniques; Inactivation, Metabolic; Male; Microsomes, Liver; Monocrotaline; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains | 1991 |
Sequence preferences of DNA interstrand cross-linking agents: dG-to-dG cross-linking at 5'-CG by structurally simplified analogues of mitomycin C.
Topics: Base Sequence; Cross-Linking Reagents; DNA; Mitomycin; Mitomycins; Molecular Sequence Data; Monocrotaline; Nucleic Acid Conformation; Pyrroles; Pyrrolizidine Alkaloids | 1990 |
Sensitivity of different phases of the cell cycle to selected hepatotoxins in cultured liver-derived (BL9L) cells.
Topics: Aflatoxin B1; Aflatoxins; Animals; Carcinogens; Cell Cycle; Cell Line; Drug Evaluation, Preclinical; Epithelial Cells; Epithelium; Flow Cytometry; Liver; Monocrotaline; Pyrrolizidine Alkaloids; Toxins, Biological | 1988 |
Crosslinking of DNA by dehydroretronecine, a metabolite of pyrrolizidine alkaloids.
Topics: Alkylation; Cross-Linking Reagents; DNA; DNA, Single-Stranded; Microscopy, Electron; Monocrotaline; Pyrrolizidine Alkaloids | 1988 |
The formation of 6,7-dihydro-7-hydroxy-1-hydroxy-methyl-5H-pyrrolizine, a metabolite of pyrrolizidine alkaloids.
Topics: Animals; Chromatography, High Pressure Liquid; Circular Dichroism; In Vitro Techniques; Male; Mass Spectrometry; Microsomes, Liver; Monocrotaline; Pyrrolizidine Alkaloids; Rats | 1986 |
Identification and toxicological effects of dehydroretronecine, a metabolite of monocrotaline.
Topics: Animals; Cell Division; Chromatography, Thin Layer; Gastrointestinal Hemorrhage; Injections, Subcutaneous; Liver; Liver Regeneration; Monocrotaline; Pyrrolizidine Alkaloids; Rats; Stomach Ulcer | 1973 |
Neoplasia and chronic disease associated with the prolonged administration of dehydroheliotridine to rats.
Topics: Age Factors; Animals; Body Weight; Injections, Intraperitoneal; Liver; Lung; Monocrotaline; Neoplasms, Experimental; Pyrrolizidine Alkaloids; Rats; Thioacetamide | 1983 |
A comparison of the pneumotoxicity of some pyrrolic esters and similar compounds analogous to pyrrolizidine alkaloid metabolites, given intravenously to rats.
Topics: Animals; Female; Injections, Intravenous; Liver; Lung; Male; Monocrotaline; Pyrroles; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 1983 |
Alkylation of N2 in deoxyguanosine by dehydroretronecine, a carcinogenic metabolite of the pyrrolizidine alkaloid monocrotaline.
Topics: Alkylation; Carcinogens; Chromatography; Circular Dichroism; Deoxyguanosine; Magnetic Resonance Spectroscopy; Mass Spectrometry; Monocrotaline; Plants, Toxic; Pyrrolizidine Alkaloids; Senecio; Spectrophotometry, Ultraviolet | 1982 |
Alkylation by dehydroretronecine, a cytotoxic metabolite of some pyrrolizidine alkaloids: an in vitro test.
Topics: Alkylating Agents; Benzaldehydes; Chemical Phenomena; Chemistry; Monocrotaline; Pyrrolizidine Alkaloids | 1983 |
Antimitotic activity of dehydroretronecine, a pyrrolizidine alkaloid metabolite, and some analogous compounds, in a rat liver parenchymal cell line.
Topics: Animals; Cell Line; Cell Survival; Liver; Mitosis; Monocrotaline; Pyrroles; Pyrrolizidine Alkaloids; Rats; Structure-Activity Relationship | 1980 |
Comparison of the toxic effects of dehydroheliotridine and heliotrine in pregnant rats and their embryos.
Topics: Abnormalities, Drug-Induced; Animals; Female; Fetal Death; Fetal Growth Retardation; Gestational Age; Monocrotaline; Pregnancy; Pregnancy, Animal; Pyrrolizidine Alkaloids; Rats | 1980 |
The relationship between the concentration of the pyrrolizidine alkaloid monocrotaline and the pattern of metabolites released from the isolated liver.
Topics: Analysis of Variance; Animals; Bile; Carcinogens; Dose-Response Relationship, Drug; Glutathione; In Vitro Techniques; Liver; Mass Spectrometry; Monocrotaline; Perfusion; Pyrroles; Rats | 1995 |
The effect of spironolactone treatment on the cytochrome P450-mediated metabolism of the pyrrolizidine alkaloid senecionine by hepatic microsomes from rats and guinea pigs.
Topics: Animals; Antineoplastic Agents, Phytogenic; Aryl Hydrocarbon Hydroxylases; Biotransformation; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Female; Guinea Pigs; Isoenzymes; Male; Microsomes, Liver; Monocrotaline; Oxidation-Reduction; Oxidoreductases, N-Demethylating; Pyrrolizidine Alkaloids; Rats; Rats, Sprague-Dawley; Species Specificity; Spironolactone | 1994 |
COR pulmonale is caused by monocrotaline and dehydromonocrotaline, but not by glutathione or cysteine conjugates of dihydropyrrolizine.
Topics: Animals; Body Weight; Cysteine; Glutathione; Lung; Male; Monocrotaline; Pulmonary Heart Disease; Rats; Rats, Sprague-Dawley | 1993 |
Metabolic activation of pyrrolizidine alkaloids by human, rat and avocado microsomes.
Topics: Animals; Antineoplastic Agents, Phytogenic; Biotransformation; Carcinogens; Chromatography, High Pressure Liquid; Fruit; Humans; Microsomes, Liver; Monocrotaline; Oxidation-Reduction; Pyrrolizidine Alkaloids; Rats | 1996 |
Effect of monocrotaline metabolites on glutathione levels in human and bovine pulmonary artery endothelial cells.
Topics: Analysis of Variance; Animals; Cattle; Cells, Cultured; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Endothelium, Vascular; Ethylmaleimide; Glutathione; Humans; Monocrotaline; Pulmonary Artery; Time Factors | 1998 |
Species differences in the hepatic microsomal enzyme metabolism of the pyrrolizidine alkaloids.
Topics: Animals; Animals, Domestic; Cattle; Chickens; Coturnix; Cricetinae; Cytochrome P-450 Enzyme System; Gerbillinae; Glutathione; Inactivation, Metabolic; Mesocricetus; Microsomes, Liver; Monocrotaline; Oxygenases; Pyrrolizidine Alkaloids; Rabbits; Rats; Rats, Sprague-Dawley; Species Specificity | 1998 |
Development of a (32)P-postlabeling/HPLC method for detection of dehydroretronecine-derived DNA adducts in vivo and in vitro.
Topics: Animals; Carcinogens; Cattle; Chromatography, High Pressure Liquid; Deoxyadenine Nucleotides; Deoxyguanine Nucleotides; DNA; DNA Adducts; Exonucleases; Female; Isotope Labeling; Micrococcal Nuclease; Monocrotaline; Phosphorus Radioisotopes; Pyrrolizidine Alkaloids; Rats; Rats, Inbred F344; Reproducibility of Results; Single-Strand Specific DNA and RNA Endonucleases; Spectrometry, Mass, Electrospray Ionization | 2001 |
Metabolic activation of the tumorigenic pyrrolizidine alkaloid, riddelliine, leading to DNA adduct formation in vivo.
Topics: Animals; Biotransformation; Carcinogens; Cattle; Chromatography, High Pressure Liquid; DNA; DNA Adducts; Female; Isotope Labeling; Liver; Liver Neoplasms, Experimental; Microsomes, Liver; Monocrotaline; Phosphorus Radioisotopes; Pyrrolizidine Alkaloids; Rats; Rats, Inbred F344 | 2001 |
Identification of DNA adducts derived from riddelliine, a carcinogenic pyrrolizidine alkaloid.
Topics: Adenine Nucleotides; Administration, Oral; Animals; Carcinogens; Cattle; DNA; DNA Adducts; Guanine Nucleotides; Isomerism; Liver; Micrococcal Nuclease; Monocrotaline; Phosphorus Radioisotopes; Pyrrolizidine Alkaloids; Rats; Spectrometry, Mass, Electrospray Ionization; Spleen; Thymine Nucleotides; Thymus Gland | 2003 |
Riddelliine N-oxide is a phytochemical and mammalian metabolite with genotoxic activity that is comparable to the parent pyrrolizidine alkaloid riddelliine.
Topics: Animals; Cattle; DNA; DNA Adducts; Female; Microsomes, Liver; Monocrotaline; Mutagens; Pyrrolizidine Alkaloids; Rats; Rats, Inbred F344; Thymus Gland | 2003 |
Comparison of hepatic in vitro metabolism of the pyrrolizidine alkaloid senecionine in sheep and cattle.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Blotting, Western; Cattle; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2B1; Cytochrome P-450 CYP3A; Glutathione; Microsomes, Liver; Monocrotaline; Oxidoreductases, N-Demethylating; Oxygenases; Pyrrolizidine Alkaloids; Sheep; Species Specificity | 2004 |
Human liver microsomal reduction of pyrrolizidine alkaloid N-oxides to form the corresponding carcinogenic parent alkaloid.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Biotransformation; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP3A; DNA Adducts; Female; Humans; Microsomes, Liver; Monocrotaline; Oxidation-Reduction; Oxidoreductases, N-Demethylating; Pyrrolizidine Alkaloids; Rats; Rats, Inbred F344 | 2005 |
Formation of DHP-derived DNA adducts from metabolic activation of the prototype heliotridine-type pyrrolizidine alkaloid, lasiocarpine.
Topics: Animals; Biomarkers; Carcinogens; DNA Adducts; Male; Microsomes, Liver; Monocrotaline; Pyrrolizidine Alkaloids; Rats; Rats, Inbred F344 | 2006 |
Metabolic activation of the tumorigenic pyrrolizidine alkaloid, retrorsine, leading to DNA adduct formation in vivo.
Topics: Animals; Biotransformation; Cells, Cultured; DNA; DNA Adducts; Female; Liver; Microsomes; Monocrotaline; Pyrrolizidine Alkaloids; Rats; Rats, Inbred F344 | 2005 |
Formation of DHP-derived DNA adducts from metabolic activation of the prototype heliotridine-type pyrrolizidine alkaloid, heliotrine.
Topics: Animals; Biomarkers; Biotransformation; Cattle; Chromatography, High Pressure Liquid; Circular Dichroism; DNA; DNA Adducts; In Vitro Techniques; Isotope Labeling; Male; Microsomes, Liver; Monocrotaline; Pyrrolizidine Alkaloids; Rats; Rats, Inbred F344; Stereoisomerism; Thymus Gland | 2008 |
Metabolic activation of retronecine and retronecine N-oxide - formation of DHP-derived DNA adducts.
Topics: Animals; Biotransformation; Cyclic N-Oxides; DNA; DNA Adducts; Female; Liver; Microsomes, Liver; Monocrotaline; Pyrrolizidine Alkaloids; Rats; Rats, Inbred F344 | 2008 |
¹H NMR study of monocrotaline and its metabolites in human blood.
Topics: Erythrocytes; Humans; Magnetic Resonance Spectroscopy; Molecular Structure; Monocrotaline; Pyrrolizidine Alkaloids | 2011 |
Reaction of dehydropyrrolizidine alkaloids with valine and hemoglobin.
Topics: Alkaloids; Animals; Chromatography, High Pressure Liquid; Female; Hemoglobins; Isothiocyanates; Magnetic Resonance Spectroscopy; Monocrotaline; Pyrrolizidine Alkaloids; Rats; Rats, Inbred F344; Tandem Mass Spectrometry; Valine | 2014 |
7-cysteine-pyrrole conjugate: A new potential DNA reactive metabolite of pyrrolizidine alkaloids.
Topics: Animals; Cysteine; DNA; DNA Adducts; Glutathione; Humans; Male; Microsomes, Liver; Monocrotaline; Pyrrolizidine Alkaloids; Rats, Inbred F344; Tandem Mass Spectrometry | 2016 |
Pyrrolizidine Alkaloid Secondary Pyrrolic Metabolites Construct Multiple Activation Pathways Leading to DNA Adduct Formation and Potential Liver Tumor Initiation.
Topics: Animals; Carcinogens; Cattle; Chromatography, High Pressure Liquid; DNA; DNA Adducts; Glutathione; Hep G2 Cells; Humans; Liver Neoplasms; Microsomes, Liver; Monocrotaline; Pyrrolizidine Alkaloids; Tandem Mass Spectrometry; Valine | 2018 |