Page last updated: 2024-08-17

dehydroepiandrosterone and metformin

dehydroepiandrosterone has been researched along with metformin in 41 studies

Research

Studies (41)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	3 (7.32)	18.2507
2000's	13 (31.71)	29.6817
2010's	18 (43.90)	24.3611
2020's	7 (17.07)	2.80

Authors

Authors	Studies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Crave, JC; Cugnardey, N; Déchaud, H; Fimbel, S; Lejeune, H; Pugeat, M	1
Beer, NA; Beer, RM; Jakubowicz, DJ; Nestler, JE	1
Koivunen, RM; Martikainen, HK; Morin-Papunen, LC; Ruokonen, A	1
Bicíková, M; Hill, M; Stárka, L; Tallová, J; Vrbíková, J	1
Connell, JM; Perry, CG	1
Lin, JJ; Lin, WQ; Yang, HY; Ye, BL; Zhao, JZ	1
El Beltagy, K; Honda, K; Ishiko, O; Misugi, T; Ozaki, K; Tokuyama, O	1
Di Girolamo, G; Elia, E; Gonzalez, C; Luchetti, CG; Motta, AB; Sander, V; Solano, ME	3
Bayat, R; Hamedi, M; Nazari, T	1
Bahtiyar, G; Sacerdote, AS; Weiss, K	1
Motta, AB; Sander, V; Solano, ME; Wald, MR	1
Luchetti, CG; Mikó, E; Motta, AB; Paz, DA; Szekeres-Bartho, J	1
Belgorosky, D; Elia, EM; Faut, M; Luigi, D; Motta, AB; Pustovrh, C; Vighi, S	1
Facorro, GB; Motta, AB; Piehl, L; Rubín de Celis, E; Sander, VA	1
Motta, AB	1
Amalfi, S; Devoto, L; Elia, EM; Motta, AB; Pustovrh, C	1
Atkin, SL; Coady, AM; Kilpatrick, ES; Sathyapalan, T; Smith, KA	1
Barrett-Connor, E; Golden, SH; Kim, C; Kong, S; Laughlin, GA; Mather, KJ; Nan, B; Randolph, JF	1
Belfiore, A; D'Orrico, B; Fava, A; Fruci, B; Guzzi, P; Malaguarnera, R; Mazza, A; Veltri, P	1
Gao, Q; Shen, S; Wang, Y; Xia, Yj; Yi, L; Zhang, C; Zhang, X	1
Krysiak, R; Okopien, B	1
Betea, D; Racaru-Honciuc, V; Scheen, AJ	1
Abramovich, D; Bas, D; Bianchi, MS; Di Pietro, M; Irusta, G; Parborell, F; Pascuali, N; Tesone, M	1
Abbas, HA; Awwad, J; Ghazeeri, G; Harajly, S; Skaff, B	1
Gao, J; Huang, Y; Li, R; Qiao, J; Yu, Y; Zhang, C; Zhao, H; Zhao, Y	1
Ge, SQ; Tao, X; Zhang, B; Zhang, EH; Zhang, X	1
Bi, Y; Feng, W; Ji, C; Jin, L; Li, P; Shen, S; Sun, L; Zhu, D	1
Chen, Y; Chu, S; Liu, D; Zhang, S; Zhao, H; Zhou, D	1
Ceylan, S; Eraldemır, C; Furat Rencber, S; Guzel, E; Kum, T; Kurnaz Ozbek, S; Sezer, Z	1
Gu, YY; Guan, QB; Jing, F; Yang, S; Yu, CX	1
Dong, X; Dong, Y; Lei, H; Li, K; Li, X; Liu, P; Sha, L; Wang, H; Wang, Z; Xue, J; Yang, X; Zhang, L; Zhang, X; Zhu, L	1
Chen, MH; Fu, BB; Fu, XP; He, SW; Hong, ZW; Huang, XH; Li, FP; Liao, BQ; Lin, YH; Liu, Y; Wang, HL; Wang, YL; Wei, KN; Xu, CL; Xu, L	1
Amidi, F; Ebrahimi, F; Nekoonam, S; Rashidi, Z; Rostami, S; Sobhani, A	1
Amani Abkenari, S; Amidi, F; Aryanpour, R; Hosseini, A; Safdarian, L; Salahi, E; Sobhani, A	1
Chen, P; Huang, J; Liang, Q; Liang, X; Liu, J; Wu, T; Xiang, Y; Zeng, H; Zeng, Y; Zhou, C	1
Abo-Zeid, FS; Al-Karmalawy, AA; Ebrahim, YA; El Leithy, AA; Elkaeed, EB; Khalifa, AS; Youssif, OM	1
Chen, YR; Feng, C; Huang, CC; Jin, M; Yin, WW; Yu, DQ	1
Cheng, L; Gong, F; Li, X; Lin, G; Lu, G; Peng, J; Su, X; Wang, J; Wang, T; Xiao, N; Xiong, X; Yang, C; Zhou, J	1

Reviews

4 review(s) available for dehydroepiandrosterone and metformin

Article	Year
Key developments in endocrinology. The Practitioner, 2003, Volume: 247, Issue:1648 Topics: Addison Disease; Adjuvants, Immunologic; Dehydroepiandrosterone; Endocrine System Diseases; Female; Humans; Hypoglycemic Agents; Metformin; Osteoporosis, Postmenopausal; Parathyroid Hormone; Polycystic Ovary Syndrome	2003
Dehydroepiandrosterone to induce murine models for the study of polycystic ovary syndrome. The Journal of steroid biochemistry and molecular biology, 2010, Volume: 119, Issue:3-5 Topics: Androgens; Animals; Dehydroepiandrosterone; Disease Models, Animal; Embryo Loss; Female; Humans; Hyperandrogenism; Hypoglycemic Agents; Metformin; Mice; Ovulation; Polycystic Ovary Syndrome; Pregnancy; Uterus	2010
The Effect of Statins on Levels of Dehydroepiandrosterone (DHEA) in Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis. Medical science monitor : international medical journal of experimental and clinical research, 2019, Jan-20, Volume: 25 Topics: Adult; Atorvastatin; China; Dehydroepiandrosterone; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemic Agents; Metformin; Middle Aged; Polycystic Ovary Syndrome; Simvastatin	2019
The effect of medication on serum anti-müllerian hormone (AMH) levels in women of reproductive age: a meta-analysis. BMC endocrine disorders, 2022, Jun-14, Volume: 22, Issue:1 Topics: Anti-Mullerian Hormone; Dehydroepiandrosterone; Female; Gonadotropin-Releasing Hormone; Humans; Metformin; Ovarian Reserve; Peptide Hormones; Polycystic Ovary Syndrome	2022

Trials

8 trial(s) available for dehydroepiandrosterone and metformin

Article	Year
Effects of diet and metformin administration on sex hormone-binding globulin, androgens, and insulin in hirsute and obese women. The Journal of clinical endocrinology and metabolism, 1995, Volume: 80, Issue:7 Topics: Androgens; Apolipoprotein A-I; Apolipoproteins B; Blood Glucose; Body Composition; Cholesterol; Cholesterol, HDL; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Diet, Fat-Restricted; Diet, Reducing; Female; Hirsutism; Humans; Insulin; Insulin Secretion; Metformin; Obesity; Placebos; Sex Hormone-Binding Globulin; Triglycerides	1995
Metformin therapy improves the menstrual pattern with minimal endocrine and metabolic effects in women with polycystic ovary syndrome. Fertility and sterility, 1998, Volume: 69, Issue:4 Topics: 17-alpha-Hydroxyprogesterone; Adult; Androstenedione; Blood Glucose; Cohort Studies; Dehydroepiandrosterone; Female; Follicle Stimulating Hormone; Humans; Hypoglycemic Agents; Insulin; Luteinizing Hormone; Menstruation; Metformin; Obesity; Polycystic Ovary Syndrome; Prospective Studies; Sex Hormone-Binding Globulin; Testosterone; Time Factors	1998
[Endocrine and metabolic effects of metformin in combination with compound cyproterone acetate in women with polycystic ovarian syndrome]. Zhonghua fu chan ke za zhi, 2003, Volume: 38, Issue:12 Topics: Adult; Antineoplastic Agents; Cholesterol, HDL; Cyproterone Acetate; Dehydroepiandrosterone; Drug Therapy, Combination; Female; Gonadotropins; Humans; Hypoglycemic Agents; Insulin; Luteinizing Hormone; Metformin; Polycystic Ovary Syndrome; Prospective Studies; Sex Hormone-Binding Globulin; Testosterone; Treatment Outcome	2003
Metformin therapy in girls with polycystic ovary syndrome: a self-controlled clinical trial. Archives of Iranian medicine, 2007, Volume: 10, Issue:2 Topics: Adolescent; Adult; Dehydroepiandrosterone; Female; Follicle Stimulating Hormone; Humans; Hypoglycemic Agents; Luteinizing Hormone; Metformin; Polycystic Ovary Syndrome; Testosterone; Treatment Outcome	2007
Atorvastatin therapy decreases androstenedione and dehydroepiandrosterone sulphate concentrations in patients with polycystic ovary syndrome: randomized controlled study. Annals of clinical biochemistry, 2012, Volume: 49, Issue:Pt 1 Topics: Adrenal Glands; Adult; Androstenedione; Atorvastatin; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Double-Blind Method; Female; Heptanoic Acids; Humans; Hyperandrogenism; Insulin; Metformin; Ovary; Placebos; Polycystic Ovary Syndrome; Pyrroles; Testosterone; Treatment Outcome; United Kingdom	2012
Racial/ethnic differences in sex hormone levels among postmenopausal women in the diabetes prevention program. The Journal of clinical endocrinology and metabolism, 2012, Volume: 97, Issue:11 Topics: Aged; Blood Glucose; Body Mass Index; Dehydroepiandrosterone; Estradiol; Ethnicity; Female; Glucose Intolerance; Humans; Hypoglycemic Agents; Life Style; Metformin; Middle Aged; Postmenopause; Sex Hormone-Binding Globulin; Testosterone	2012
In PCOS patients the addition of low-dose spironolactone induces a more marked reduction of clinical and biochemical hyperandrogenism than metformin alone. Nutrition, metabolism, and cardiovascular diseases : NMCD, 2014, Volume: 24, Issue:2 Topics: Adult; Androstenedione; Dehydroepiandrosterone; Dose-Response Relationship, Drug; Female; Hirsutism; Humans; Hyperandrogenism; Hypoglycemic Agents; Insulin Resistance; Metformin; Polycystic Ovary Syndrome; Spironolactone; Testosterone; Young Adult	2014
Inadequacy of initiating rosuvastatin then metformin on biochemical profile of polycystic ovarian syndrome patients. Journal of endocrinological investigation, 2015, Volume: 38, Issue:6 Topics: Adult; Blood Glucose; Dehydroepiandrosterone; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemic Agents; Insulin; Lipids; Metformin; Polycystic Ovary Syndrome; Prospective Studies; Rosuvastatin Calcium; Testosterone; Treatment Outcome	2015

Other Studies

29 other study(ies) available for dehydroepiandrosterone and metformin

Article	Year
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Effects of a reduction in circulating insulin by metformin on serum dehydroepiandrosterone sulfate in nondiabetic men. The Journal of clinical endocrinology and metabolism, 1994, Volume: 78, Issue:3 Topics: Adult; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Humans; Hypertension; Insulin; Lipids; Male; Metformin; Obesity; Reference Values	1994
Homocysteine and steroids levels in metformin treated women with polycystic ovary syndrome. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 2002, Volume: 110, Issue:2 Topics: 17-alpha-Hydroxypregnenolone; Adolescent; Adult; Blood Glucose; Body Constitution; Body Mass Index; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Female; Homocysteine; Humans; Hydrocortisone; Hypoglycemic Agents; Insulin; Metformin; Polycystic Ovary Syndrome; Pregnanolone; Steroids	2002
Insulin-lowering agents inhibit synthesis of testosterone in ovaries of DHEA-induced PCOS rats. Gynecologic and obstetric investigation, 2006, Volume: 61, Issue:4 Topics: 17-Hydroxysteroid Dehydrogenases; Adjuvants, Immunologic; Animals; Chromans; Dehydroepiandrosterone; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Female; Hypoglycemic Agents; Immunohistochemistry; Insulin; Metformin; Ovary; Pioglitazone; Polycystic Ovary Syndrome; Rats; Rats, Wistar; Testosterone; Thiazolidinediones; Troglitazone	2006
Role of the N, N'-dimethylbiguanide metformin in the treatment of female prepuberal BALB/c mice hyperandrogenized with dehydroepiandrosterone. Reproduction (Cambridge, England), 2006, Volume: 131, Issue:3 Topics: Androgens; Animals; Blood Glucose; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Dehydroepiandrosterone; Estradiol; Fasting; Female; Flow Cytometry; Hypoglycemic Agents; Insulin; Lymph Nodes; Metformin; Mice; Mice, Inbred BALB C; Models, Animal; Ovary; Polycystic Ovary Syndrome; Progesterone; Prostaglandins E; Retroperitoneal Space; Sexual Maturation; Tumor Necrosis Factor-alpha	2006
The mechanisms involved in the action of metformin in regulating ovarian function in hyperandrogenized mice. Molecular human reproduction, 2006, Volume: 12, Issue:8 Topics: Adjuvants, Immunologic; Administration, Oral; AMP-Activated Protein Kinases; Animals; Catalase; Cyclooxygenase 2; Dehydroepiandrosterone; Enzyme Activation; Female; Glutathione; Hyperandrogenism; Hypoglycemic Agents; Lipid Peroxidation; Metformin; Mice; Mice, Inbred C57BL; Multienzyme Complexes; Nitric Oxide Synthase; Ovary; Phosphorylation; Polycystic Ovary Syndrome; Prostaglandins E; Protein Serine-Threonine Kinases	2006
Metformin prevents embryonic resorption induced by hyperandrogenisation with dehydroepiandrosterone in mice. Reproduction, fertility, and development, 2006, Volume: 18, Issue:5 Topics: Animals; Blood Glucose; CD4-CD8 Ratio; Dehydroepiandrosterone; Estradiol; Female; Fetal Resorption; Hyperandrogenism; Insulin; Metformin; Mice; Mice, Inbred BALB C; Nitric Oxide; Nitric Oxide Synthase; Ovary; Oxidative Stress; Pregnancy; Progesterone; Tumor Necrosis Factor-alpha; Uterus	2006
Novel endocrine disrupter effects of classic and atypical antipsychotic agents and divalproex: induction of adrenal hyperandrogenism, reversible with metformin or rosiglitazone. Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists, 2007, Volume: 13, Issue:6 Topics: 17-alpha-Hydroxyprogesterone; Adolescent; Adrenal Glands; Adult; Aged; Antipsychotic Agents; Cortodoxone; Dehydroepiandrosterone; Endocrine Disruptors; Estradiol; Estrone; Female; Follicle Stimulating Hormone; Humans; Hyperandrogenism; Hypoglycemic Agents; Insulin Resistance; Luteinizing Hormone; Male; Metformin; Middle Aged; Radioimmunoassay; Rosiglitazone; Testosterone; Thiazolidinediones; Valproic Acid	2007
Dehydroepiandrosterone and metformin regulate proliferation of murine T lymphocytes. Clinical and experimental immunology, 2008, Volume: 153, Issue:2 Topics: Animals; Antioxidants; Apoptosis; Cell Proliferation; Cell Survival; Cells, Cultured; Dehydroepiandrosterone; Female; Glutathione; Lipid Peroxidation; Lymphocyte Activation; Metformin; Mice; Mice, Inbred BALB C; Necrosis; Nitric Oxide Synthase; Oxidative Stress; Polycystic Ovary Syndrome; T-Lymphocytes	2008
Dehydroepiandrosterone and metformin modulate progesterone-induced blocking factor (PIBF), cyclooxygenase 2 (COX2) and cytokines in early pregnant mice. The Journal of steroid biochemistry and molecular biology, 2008, Volume: 111, Issue:3-5 Topics: Animals; Cyclooxygenase 2; Cytokines; Dehydroepiandrosterone; Embryo Implantation; Embryo Loss; Embryo, Mammalian; Female; Hypoglycemic Agents; Male; Metformin; Mice; Mice, Inbred BALB C; Pregnancy; Pregnancy Proteins; Pregnancy, Animal; Suppressor Factors, Immunologic	2008
The effects of metformin on uterine tissue of hyperandrogenized BALB/c mice. Molecular human reproduction, 2009, Volume: 15, Issue:7 Topics: Animals; Blotting, Western; Catalase; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cyclooxygenase 2; Dehydroepiandrosterone; Dinoprost; Enzyme Activation; Female; Flow Cytometry; In Vitro Techniques; Metformin; Mice; Mice, Inbred BALB C; Nitric Oxide Synthase; Oxidative Stress; Polycystic Ovary Syndrome; Radioimmunoassay; Superoxide Dismutase; Uterus	2009
Effect of DHEA and metformin on corpus luteum in mice. Reproduction (Cambridge, England), 2009, Volume: 138, Issue:3 Topics: Animals; Corpus Luteum; Dehydroepiandrosterone; Dinoprost; Female; Hyperandrogenism; Hypoglycemic Agents; Lipid Peroxidation; Metformin; Mice; Mice, Inbred BALB C; Ovary; Oxidative Stress; Pregnancy; Prostaglandins E	2009
Link between metformin and the peroxisome proliferator-activated receptor γ pathway in the uterine tissue of hyperandrogenized prepubertal mice. Fertility and sterility, 2011, Jun-30, Volume: 95, Issue:8 Topics: Animals; Arachidonate 12-Lipoxygenase; Arachidonate 15-Lipoxygenase; Dehydroepiandrosterone; Disease Models, Animal; Down-Regulation; Female; Hyperandrogenism; Hypoglycemic Agents; Ligands; Metformin; Mice; Mice, Inbred BALB C; PPAR gamma; RNA, Messenger; Sexual Development; Uterus	2011
Dehydroepiandrosterone induces ovarian and uterine hyperfibrosis in female rats. Human reproduction (Oxford, England), 2013, Volume: 28, Issue:11 Topics: Animals; Dehydroepiandrosterone; Female; Fibrosis; Hypoglycemic Agents; Hypolipidemic Agents; Metformin; Ovarian Diseases; Polycystic Ovary Syndrome; Rats; Rats, Sprague-Dawley; Simvastatin; Transforming Growth Factor beta; Uterine Diseases	2013
The effect of metformin on androgen production in diabetic women with non-classic congenital adrenal hyperplasia. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 2014, Volume: 122, Issue:10 Topics: 17-alpha-Hydroxyprogesterone; Adrenal Hyperplasia, Congenital; Adult; Androgens; Blood Glucose; Dehydroepiandrosterone; Diabetes Mellitus, Type 2; Female; Humans; Hyperandrogenism; Hypoglycemic Agents; Metformin; Middle Aged; Testosterone; Treatment Outcome	2014
[Hormonal deficiencies in the elderly: is there a role for replacement therapy?]. Revue medicale suisse, 2014, Aug-27, Volume: 10, Issue:439 Topics: Adjuvants, Immunologic; Aged; Aging; Androgens; Dehydroepiandrosterone; Diabetes Mellitus, Type 2; Female; Glucagon-Like Peptide 1; Growth Hormone; Health Status; Hormone Replacement Therapy; Humans; Hypoglycemic Agents; Insulin; Male; Metformin; Testosterone; Thyroid Hormones	2014
Metformin regulates ovarian angiogenesis and follicular development in a female polycystic ovary syndrome rat model. Endocrinology, 2015, Volume: 156, Issue:4 Topics: Angiogenesis Modulating Agents; Angiopoietin-1; Angiopoietin-2; Animals; Dehydroepiandrosterone; Female; Insulin; Insulin Resistance; Metformin; Neovascularization, Pathologic; Ovarian Follicle; Platelet-Derived Growth Factor; Polycystic Ovary Syndrome; Rats; Rats, Sprague-Dawley; Vascular Endothelial Growth Factor A	2015
Impaired oocyte quality induced by dehydroepiandrosterone is partially rescued by metformin treatment. PloS one, 2015, Volume: 10, Issue:3 Topics: Animals; Cell Differentiation; Dehydroepiandrosterone; Embryonic Development; Estrous Cycle; Female; Glucose; Hormones; Lipid Metabolism; Membrane Potential, Mitochondrial; Metformin; Mice; Mitochondria; Oocytes; Ovary; Spindle Apparatus	2015
Expression of SIRT1 in the ovaries of rats with polycystic ovary syndrome before and after therapeutic intervention with exenatide. International journal of clinical and experimental pathology, 2015, Volume: 8, Issue:7 Topics: Animals; Dehydroepiandrosterone; Disease Models, Animal; Exenatide; Female; Gene Expression Regulation, Enzymologic; Immunohistochemistry; Metformin; Ovary; Peptides; Polycystic Ovary Syndrome; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; RNA, Messenger; Sirtuin 1; Up-Regulation; Venoms	2015
Effects of Exenatide on Metabolic Changes, Sexual Hormones, Inflammatory Cytokines, Adipokines, and Weight Change in a DHEA-Treated Rat Model. Reproductive sciences (Thousand Oaks, Calif.), 2016, Volume: 23, Issue:9 Topics: Adipokines; Animals; Body Weight; Cytokines; Dehydroepiandrosterone; Disease Models, Animal; Exenatide; Female; Gonadal Steroid Hormones; Inflammation Mediators; Metformin; Ovary; Peptides; Polycystic Ovary Syndrome; Rats; Rats, Sprague-Dawley; Venoms	2016
Beneficial effects of Heqi san on rat model of polycystic ovary syndrome through the PI3K/AKT pathway. Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences, 2017, Oct-11, Volume: 25, Issue:1 Topics: Animals; Dehydroepiandrosterone; Disease Models, Animal; DNA-Binding Proteins; Drugs, Chinese Herbal; Female; Gene Expression Regulation; Hormones; Insulin Resistance; Metformin; MicroRNAs; Phosphatidylinositol 3-Kinases; Plants, Medicinal; Polycystic Ovary Syndrome; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Random Allocation; Rats; Rats, Sprague-Dawley; Signal Transduction; Transcription Factors; Treatment Outcome	2017
Effect of resveratrol and metformin on ovarian reserve and ultrastructure in PCOS: an experimental study. Journal of ovarian research, 2018, Jun-29, Volume: 11, Issue:1 Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Cell Count; Dehydroepiandrosterone; Disease Models, Animal; Drug Therapy, Combination; Female; Hormones; Lipid Peroxidation; Metformin; Ovarian Follicle; Ovarian Reserve; Ovary; Polycystic Ovary Syndrome; Rats; Rats, Wistar; Resveratrol; Sirtuin 1; Stilbenes; Tumor Necrosis Factor-alpha; Vagina	2018
Inulin and metformin ameliorate polycystic ovary syndrome via anti-inflammation and modulating gut microbiota in mice. Endocrine journal, 2019, Oct-28, Volume: 66, Issue:10 Topics: Animals; Anti-Inflammatory Agents; Bacteria; Biomarkers; Cytokines; Dehydroepiandrosterone; Diet, High-Fat; Disease Models, Animal; Female; Gastrointestinal Microbiome; Inflammation; Inulin; Metformin; Mice; Ovary; Polycystic Ovary Syndrome	2019
Pachymic acid protects oocyte by improving the ovarian microenvironment in polycystic ovary syndrome mice†. Biology of reproduction, 2020, 10-29, Volume: 103, Issue:5 Topics: Animals; Dehydroepiandrosterone; Disease Models, Animal; Female; Metformin; Mice; Oocytes; Ovary; Polycystic Ovary Syndrome; Triterpenes	2020
The Effect of Astaxanthin and Metformin on Oxidative Stress in Granulosa Cells of BALB C Mouse Model of Polycystic Ovary Syndrome. Reproductive sciences (Thousand Oaks, Calif.), 2021, Volume: 28, Issue:10 Topics: Animals; Dehydroepiandrosterone; Female; Granulosa Cells; Metformin; Mice; Mice, Inbred BALB C; Oxidative Stress; Polycystic Ovary Syndrome; Xanthophylls	2021
Metformin improves epigenetic modification involved in oocyte growth and embryo development in polycystic ovary syndrome mice model. Molecular reproduction and development, 2021, Volume: 88, Issue:12 Topics: Animals; Dehydroepiandrosterone; Embryonic Development; Epigenesis, Genetic; Female; Metformin; Mice; Mice, Inbred BALB C; Oocytes; Polycystic Ovary Syndrome	2021
Gut microbiota dysbiosis-derived macrophage pyroptosis causes polycystic ovary syndrome via steroidogenesis disturbance and apoptosis of granulosa cells. International immunopharmacology, 2022, Volume: 107 Topics: Animals; Apoptosis; Dehydroepiandrosterone; Disulfiram; DNA, Ribosomal; Dysbiosis; Estrogens; Female; Gastrointestinal Microbiome; Granulosa Cells; Humans; Lipopolysaccharides; Macrophages; Metformin; Mice; Polycystic Ovary Syndrome; Pyroptosis	2022
Spirulina therapeutic potentiality in polycystic ovarian syndrome management using DHEA-induced rat model. European review for medical and pharmacological sciences, 2022, Volume: 26, Issue:8 Topics: Animals; bcl-2-Associated X Protein; Dehydroepiandrosterone; Disease Models, Animal; Female; Humans; Metformin; Multienzyme Complexes; Polycystic Ovary Syndrome; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Wistar; Spirulina	2022
Metformin abrogates pathological TNF-α-producing B cells through mTOR-dependent metabolic reprogramming in polycystic ovary syndrome. eLife, 2022, 06-24, Volume: 11 Topics: Animals; Dehydroepiandrosterone; Disease Models, Animal; Female; Humans; Metformin; Mice; Polycystic Ovary Syndrome; TOR Serine-Threonine Kinases; Tumor Necrosis Factor-alpha	2022