dehydrocostus lactone has been researched along with sesquiterpenes in 91 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (1.10) | 18.7374 |
| 1990's | 6 (6.59) | 18.2507 |
| 2000's | 19 (20.88) | 29.6817 |
| 2010's | 53 (58.24) | 24.3611 |
| 2020's | 12 (13.19) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, HC; Chou, CK; Lee, SD; Wang, JC; Yeh, SF | 1 |
| Muro, MD; Olaguibel, JM; Quirce, S; Tabar, AI | 1 |
| du Peloux Menagé, H; Hawk, JL; Ross, JS; White, IR | 1 |
| Ando, M; Arao, K; Kataoka, T; Magae, J; Nagai, K; Nishimura, T; Otake, N; Suzuki, H; Taniguchi, M; Uramoto, M | 1 |
| Cantrell, CL; Castañeda-Acosta, J; Fischer, NH; Foroozesh, M; Franzblau, SG; Fronczek, FR; Nuñez, IS | 1 |
| Jang, MK; Kim, KM; Kim, NY; Lee, HJ; Lee, SH; Ryu, JH; Sohn, DH; Son, HJ | 1 |
| Kagerura, T; Matsuda, H; Morikawa, T; Toguchida, I; Ueda, H; Yoshikawa, M | 1 |
| Kawahara, Y; Matsuda, H; Morikawa, T; Shimoda, H; Uemura, T; Yoshikawa, M | 1 |
| Kato, K; Kawanishi, K; Matsumoto, K; Okugawa, H; Ueda, R | 1 |
| Alanko, K; Estlander, T; Jolanki, R; Kanerva, L | 1 |
| HIKINO, H; KUSANO, G; MEGURO, K; TAKEMOTO, T | 1 |
| Chon, BH; Chung, HT; Kwon, JW; Kwon, SY; Kwon, TO; Lee, JH; Oh, GS; Pae, HO; Yun, YG | 1 |
| Choi, BM; Chung, HT; Jang, SI; Kwon, JW; Kwon, TO; Oh, GS; Oh, H; Pae, HO; Yun, YG | 1 |
| Li, A; Liu, R; Sun, A | 1 |
| Guo, DA; Ma, XC; Wu, LJ | 1 |
| Castilho, PC; Costa, MC; González, HG; Luna-Herrera, J; Rodrigues, AI | 1 |
| Chung, HT; Jeong, GS; Jeong, SO; Kim, NS; Kim, YC; Kwon, TO; Lee, HS; Pae, HO; Park, SD | 1 |
| Kim, EJ; Kim, JS; Lim, SS; Park, JH; Park, SY; Shin, HK | 1 |
| Choi, JY; Ho Lee, S; Hyun Hwang, I; Na, M; Seog Ahn, J; Yeon Kim, B; Young Bae, E | 1 |
| Ahn, WS; Choi, EJ | 1 |
| Candeias, MF; Ramos, P; Tinoco, MT | 1 |
| Hsu, YL; Kuo, PL; Wu, LY | 1 |
| Hsu, YL; Kuo, PL; Ni, WC; Tsai, EM | 1 |
| Choi, EM; Kim, GH; Lee, YS | 1 |
| Peng, C; Yang, Z | 1 |
| Hsu, YL; Huang, MS; Hung, JY; Kuo, PL; Ni, WC; Tsai, YM; Yang, CJ | 1 |
| Chen, YN; Guan, H; Wang, D; Xu, WZ; Yang, L; You, S | 1 |
| Bi, Y; Feng, S; Hu, F; Li, W; Wang, C; Wu, Y | 1 |
| Chaudhuri, SK; Joel, DM; Plakhine, D; Steffens, JC; Ziadna, H | 1 |
| Choi, EM | 1 |
| Butturini, E; Cavalieri, E; Darra, E; de Prati, AC; Mariotto, S; Murayama, N; Rigo, A; Shoji, K; Suzuki, H; Watanabe, Y; Yamazaki, H | 1 |
| Cai, D; Liu, J; Zhang, Q | 1 |
| Hong, JE; Kim, EJ; Kim, J; Kim, JS; Kwon, GT; Lee, KW; Lim, SS; Park, JH | 1 |
| Choi, EM; Seo, MS | 1 |
| Chang, YL; Lee, KH; Pan, SL; Peng, CY; Teng, CM; Tsai, AC; Wang, CY | 1 |
| Hu, B; Lu, L; Wang, SF; Zhao, XP | 1 |
| Bao, X; Fu, C; He, Y; Hu, H; Mao, Q; Wang, Z | 1 |
| Chen, R; Ma, L; Wu, F; Zhang, T | 1 |
| He, C; Ma, G; Peng, Y; Wei, H; Xiao, P | 1 |
| Bauer, R; Boechzelt, H; Kaltenegger, H; Kretschmer, N; Kunert, O; Leithner, A; Lohberger, B; Rinner, B; Stuendl, N; Wolf, E | 1 |
| Duan, JA; Li, W; Li, Z; Liu, P; Qian, D; Shang, EX | 1 |
| Bauer, R; Bernhart, E; Bonyadi Rad, E; Kaltenegger, H; Kretschmer, N; Leithner, A; Lohberger, B; Rinner, B; Steinecker-Frohnwieser, B; Stuendl, N; Weinberg, AM | 1 |
| Liu, X; Luan, J; Wang, X; Yang, H; Yang, S; Yu, B; Zhang, YF | 1 |
| Fiorentino, A; Galasso, S; Gallicchio, M; Lorenz, P; Marciano, S; Monaco, P; Pacifico, S; Potenza, N; Stintzing, FC | 1 |
| Gao, W; Guo, H; Hu, X; Liu, C; Liu, Z; Qu, Z; Zhang, J | 1 |
| Ahmad, A; Butturini, E; Cuzzocrea, S; Di Paola, R; Mariotto, S; Paterniti, I; Suzuki, H | 1 |
| Gao, W; Guo, H; Liu, C; Qu, Z; Zhang, J | 1 |
| Ahn, YJ; Kim, CS; Koketsu, M; Lee, HB; Lee, HK; Ngan, LT; Song, HE | 1 |
| Gu, X; Guo, X; Peng, Z; Wang, Y; Yan, C | 1 |
| Chang, KC; Kim, HJ; Kwak, JH; Lee, DU; Park, EJ; Park, SW | 1 |
| Albanesi, C; Butturini, E; Cavani, A; Madonna, S; Mariotto, S; Scarponi, C; Sestito, R | 1 |
| Dong, GZ; Hyeon, JS; Lee, HJ; Ryu, JH; Shim, AR | 1 |
| An, W; Chen, H; Hu, X; Jiang, E; Kang, H; Sun, L; Sun, X; Wang, S; Yao, Y | 1 |
| Jeong, SJ; Jin, SE; Kim, OS; Lim, HS; Shin, HK | 1 |
| Kurita, M; Nishimura, Y; Suzuki, T; Tabata, K; Takeda, T; Uchiyama, T | 1 |
| Lin, X; Peng, Z; Su, C | 1 |
| An, W; Hu, X; Jiang, E; Kang, H; Sun, L; Sun, X; Yao, Y | 1 |
| Chen, YL; Gao, WY; Jin, ZX; Qu, Z; Wang, L; Zhang, JZ | 1 |
| Chen, Y; Ding, YH; Gao, X; Kuang, BJ; Long, J; Zhang, Q | 1 |
| Cao, K; Qian, W; Xu, Y; Zhang, Q; Zhang, X; Zhou, Z | 1 |
| Chen, Y; Gao, W; Huang, H; Jin, Z; Man, S; Wang, L; Zhang, J; Zheng, H | 1 |
| Ashok Yadav, P; Devi, A; Jain, N; Pavan Kumar, Ch; Rao Vadaparthi, R; Shankaraiah, G; Sowjanya, P; Suresh Babu, K | 1 |
| Fang, J; Gao, K; Han, X; Li, Y; Yang, M; Zhang, J | 1 |
| Fan, J; Ji, W; Lin, X; Liu, C; Peng, Z; Su, C; Wang, Y; Xu, Y; Yan, C | 1 |
| Cai, H; Qin, X; Yang, C | 1 |
| Álvarez, JA; Ayuso, J; Cala, A; Fernández-Aparicio, M; Macías, FA; Molinillo, JMG; Rubiales, D | 1 |
| Hwang, J; Im, DS; Kang, S; Lee, BK; Lee, SJ; Nam, SY; Park, SJ | 1 |
| Li, W; Lin, T; Ma, YB; Mao, YQ | 1 |
| Kang, U; Lee, K; Pyun, H; Seo, EK | 1 |
| Chen, A; Huang, Y; Ren, S; Wang, X; Zhang, Z; Zhao, Q; Zhao, Y; Zhu, Y | 1 |
| Chen, Y; Li, W; Tang, Y; Zeng, Z | 1 |
| Dong, S; Jia, HM; Liu, YT; Ma, LY; Yu, CY; Yu, M; Zhang, HW; Zou, ZM | 1 |
| Jin, H; Li, X; Liu, J; Qin, B; Su, A; Xie, M; Yan, Z; Yang, X | 1 |
| Han, J; Mao, H; Sheng, W; Wang, C; Yang, N; Zhang, Z | 1 |
| Chen, L; Feng, H; Li, Z; Lian, Z; Lin, X; Liu, Q; Song, F; Wang, X; Xie, D; Xu, J; Yao, G; Yuan, G; Zheng, J; Zhou, M | 1 |
| Chai, G; Li, B; Nie, Y; Qian, X; Tang, Z; Wang, Z; Wu, J; Xin, R; Xiong, Y; Zhang, H; Zhao, P | 1 |
| Hwang, D; Jeong, W; Kang, D; Kim, HJ; Kim, HS; Kim, N; Kim, NY; Kwon, M; Lee, GR; Lee, H; Lee, HI; Lee, J; Piao, D; Seo, EK | 1 |
| He, B; Hu, B; Shi, Z; Wu, F; Wu, H; Yan, S; Zhao, X | 1 |
| Cai, H; He, XL; Yang, CH | 1 |
| Heo, S; Kim, SH; Kim, SY; Kwon, M; Lee, MY; Park, SA; Ryu, AR; Sung, NJ; Youn, HS | 1 |
| Jeong, W; Kim, HJ; Kim, N; Kim, NY; Kwon, M; Lee, GR; Lee, HI; Lee, J; Park, JH | 1 |
| Hu, H; Li, Q; Wang, Z; Xie, Y | 1 |
| Ai, Y; Bai, Z; Chen, Y; Hou, X; Li, R; Shi, W; Sun, H; Wang, C; Wang, JB; Wang, Z; Xiao, X; Xu, G; Zhan, X | 1 |
| Chen, H; Chen, ZL; He, CM; Lian, CF; Liu, SY; Shao, TH; Sun, JL; Wang, M; Zhang, FC; Zhang, HZ; Zhang, S; Zhang, W; Zhao, LL | 1 |
| Guo, K; Hao, J; Liu, W; Wang, C; Wang, Q; Wu, Q; Yang, X; Zhang, R; Zhang, WK | 1 |
| Macías, FA; Molinillo, JMG; Rial, C; Tomé, S; Varela, RM | 1 |
| Fujita, H; Ohta, T; Okubo, S; Shoyama, Y; Uto, T | 1 |
| Chen, M; Liao, Z; Meng, F; Tao, Y; Wang, G; Wei, X; Zong, W | 1 |
| Chai, G; Che, H; Cui, X; Ge, G; Jiang, X; Nie, Y; Sun, H; Wang, Y; Xiong, Y; Zhao, P; Zhou, Y | 1 |
| Li, R; Lu, Z; Sheng, B; Xu, Q; Yang, G; Zhang, L | 1 |
| Bai, Q; Huang, H; Huang, Z; Su, J; Wei, S; Wu, W; Yun, X; Zhang, C; Zhang, Y | 1 |
2 review(s) available for dehydrocostus lactone and sesquiterpenes
| Article | Year |
|---|---|
Potential anti-cancer activities and mechanisms of costunolide and dehydrocostuslactone.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Cell Proliferation; Drug Resistance, Multiple; Humans; Lactones; Sesquiterpenes | 2015 |
Antitumor activity and mechanism of costunolide and dehydrocostus lactone: Two natural sesquiterpene lactones from the Asteraceae family.
Topics: Antineoplastic Agents, Phytogenic; Asteraceae; Cell Line, Tumor; Humans; Lactones; Sesquiterpenes | 2020 |
89 other study(ies) available for dehydrocostus lactone and sesquiterpenes
| Article | Year |
|---|---|
Active compounds from Saussurea lappa Clarks that suppress hepatitis B virus surface antigen gene expression in human hepatoma cells.
Topics: Antiviral Agents; Carcinoma, Hepatocellular; Drugs, Chinese Herbal; Gene Expression Regulation, Viral; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Humans; Lactones; Molecular Structure; Plant Roots; RNA, Messenger; RNA, Viral; Sesquiterpenes; Tumor Cells, Cultured | 1995 |
Airborne contact dermatitis from Frullania.
Topics: Adult; Aged; Aged, 80 and over; Benzoquinones; Dermatitis, Allergic Contact; Diagnosis, Differential; Female; Humans; Lactones; Male; Middle Aged; Patch Tests; Photosensitivity Disorders; Plants; Sesquiterpenes; Sesquiterpenes, Eudesmane | 1994 |
Sesquiterpene lactone contact sensitivity: clinical patterns of Compositae dermatitis and relationship to chronic actinic dermatitis.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Chronic Disease; Dermatitis, Allergic Contact; Female; Humans; Lactones; Male; Middle Aged; Photosensitivity Disorders; Plants; Sesquiterpenes; Sesquiterpenes, Eudesmane | 1993 |
Costunolide and dehydrocostus lactone as inhibitors of killing function of cytotoxic T lymphocytes.
Topics: 4-Butyrolactone; Cytotoxicity, Immunologic; Lactones; Phosphorylation; Sesquiterpenes; T-Lymphocytes, Cytotoxic; Tyrosine | 1995 |
Antimycobacterial activities of dehydrocostus lactone and its oxidation products.
Topics: Antitubercular Agents; Asteraceae; Lactones; Microbial Sensitivity Tests; Mycobacterium; Mycobacterium avium; Mycobacterium tuberculosis; Oxidation-Reduction; Sesquiterpenes; Structure-Activity Relationship | 1998 |
A sesquiterpene, dehydrocostus lactone, inhibits the expression of inducible nitric oxide synthase and TNF-alpha in LPS-activated macrophages.
Topics: Animals; Cell Line; Enzyme Inhibitors; Lactones; Lipopolysaccharides; Macrophage Activation; Macrophages; Male; Mice; Mice, Inbred ICR; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Sesquiterpenes; Tumor Necrosis Factor-alpha | 1999 |
Inhibitory effects of sesquiterpenes from bay leaf on nitric oxide production in lipopolysaccharide-activated macrophages: structure requirement and role of heat shock protein induction.
Topics: Animals; Enzyme Inhibitors; Heat-Shock Proteins; In Vitro Techniques; Lactones; Lauraceae; Lipopolysaccharides; Macrophage Activation; Macrophages; Male; Mice; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Plant Leaves; Protein Conformation; Sesquiterpenes | 2000 |
Alcohol absorption inhibitors from bay leaf (Laurus nobilis): structure-requirements of sesquiterpenes for the activity.
Topics: 4-Butyrolactone; Absorption; Animals; Blood Glucose; Drugs, Chinese Herbal; Ethanol; Furans; Humans; Lactones; Lauraceae; Magnetic Resonance Spectroscopy; Male; Mice; Molecular Structure; Plant Leaves; Rats; Rats, Wistar; Sesquiterpenes; Structure-Activity Relationship | 2000 |
Effects of sesquiterpenoids from "Oriental incenses" on acetic acid-induced writhing and D2 and 5-HT2A receptors in rat brain.
Topics: Acetic Acid; Analgesics; Animals; Lactones; Male; Mice; Mice, Inbred Strains; Pain; Plant Extracts; Polycyclic Sesquiterpenes; Radioligand Assay; Receptors, Opioid; Sesquiterpenes; Spiro Compounds; Tetrahydronaphthalenes | 2000 |
Patch test sensitization to Compositae mix, sesquiterpene-lactone mix, Compositae extracts, laurel leaf, Chlorophorin, Mansonone A, and dimethoxydalbergione.
Topics: Adult; Allergens; Asteraceae; Benzoquinones; Dermatitis, Allergic Contact; Female; Humans; Lactones; Male; Naphthoquinones; Patch Tests; Plant Extracts; Predictive Value of Tests; Resorcinols; Sesquiterpenes; Sesquiterpenes, Eudesmane; Stilbenes | 2001 |
STRUCTURE OF MOKKO LACTONE AND DEHYDROCOSTUS LACTONE.
Topics: 4-Butyrolactone; Chemistry, Pharmaceutical; Lactones; Research; Sesquiterpenes | 1964 |
Dehydrocostus lactone enhances tumor necrosis factor-alpha-induced apoptosis of human leukemia HL-60 cells.
Topics: Antineoplastic Agents; Apoptosis; Caspase 3; Caspase 8; Caspases; Drug Synergism; HL-60 Cells; Humans; Lactones; Neoplasm Proteins; NF-kappa B; Phytotherapy; Saussurea; Sesquiterpenes; Tumor Necrosis Factor-alpha | 2004 |
In vitro cytotoxicity of Mokko lactone in human leukemia HL-60 cells: induction of apoptotic cell death by mitochondrial membrane potential collapse.
Topics: 4-Butyrolactone; Antineoplastic Agents; Apoptosis; Caspase 3; Caspases; DNA Fragmentation; HL-60 Cells; Humans; Intracellular Membranes; Korea; Lactones; Membrane Potentials; Mitochondria; Plant Roots; Saussurea; Sesquiterpenes | 2004 |
Preparative isolation and purification of costunolide and dehydrocostuslactone from Aucklandia lappa Decne by high-speed counter-current chromatography.
Topics: Chromatography, High Pressure Liquid; Countercurrent Distribution; Drugs, Chinese Herbal; Lactones; Magnetic Resonance Spectroscopy; Sesquiterpenes; Spectrophotometry, Ultraviolet | 2005 |
Microbial transformation of dehydrocostuslactone by Mucor polymorphosporus.
Topics: Asteraceae; Biotransformation; Lactones; Magnetic Resonance Spectroscopy; Molecular Structure; Mucor; Plants, Medicinal; Sesquiterpenes; Species Specificity; Spectrophotometry | 2006 |
Synergistic antimycobacterial activities of sesquiterpene lactones from Laurus spp.
Topics: Drug Synergism; Fluorometry; Lactones; Laurus; Microbial Sensitivity Tests; Mycobacterium; Plant Extracts; Sesquiterpenes | 2007 |
The alpha-methylene-gamma-butyrolactone moiety in dehydrocostus lactone is responsible for cytoprotective heme oxygenase-1 expression through activation of the nuclear factor E2-related factor 2 in HepG2 cells.
Topics: 4-Butyrolactone; Active Transport, Cell Nucleus; Antioxidants; Cell Line; Cytoprotection; Heme Oxygenase-1; Humans; Lactones; NF-E2-Related Factor 2; Response Elements; Sesquiterpenes | 2007 |
Apoptosis of DU145 human prostate cancer cells induced by dehydrocostus lactone isolated from the root of Saussurea lappa.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Blotting, Western; Caspases; Cell Cycle; Cell Line, Tumor; Cytochromes c; Enzyme Activation; Hexanes; Humans; Indicators and Reagents; Lactones; Male; Membrane Potentials; Mitochondrial Membranes; Plant Extracts; Plant Roots; Poly(ADP-ribose) Polymerases; Prostatic Neoplasms; Proto-Oncogene Proteins c-bcl-2; Saussurea; Sesquiterpenes; Solvents | 2008 |
Isolation of betulinic acid, its methyl ester and guaiane sesquiterpenoids with protein tyrosine phosphatase 1B inhibitory activity from the roots of Saussurea lappa C.B.Clarke.
Topics: 4-Butyrolactone; Betulinic Acid; Enzyme Inhibitors; Humans; Lactones; Pentacyclic Triterpenes; Plant Roots; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Saussurea; Sesquiterpenes; Sesquiterpenes, Guaiane; Triterpenes | 2009 |
Antiproliferative effects of dehydrocostuslactone through cell cycle arrest and apoptosis in human ovarian cancer SK-OV-3 cells.
Topics: Apoptosis; Cell Cycle; Cell Cycle Proteins; Cell Division; Cell Line, Tumor; Cell Proliferation; Female; G2 Phase; Humans; Lactones; Ovarian Neoplasms; Sesquiterpenes | 2009 |
Effects of a hexane extract from Laurus novocanariensis leaves on the ethanol metabolism of Wistar rats.
Topics: Alcohol Dehydrogenase; Animals; Catalase; Ethanol; Gastric Emptying; Hemoglobins; Lactones; Laurus; Male; Plant Extracts; Plant Leaves; Protective Agents; Rats; Rats, Wistar; Sesquiterpenes | 2009 |
Dehydrocostuslactone, a medicinal plant-derived sesquiterpene lactone, induces apoptosis coupled to endoplasmic reticulum stress in liver cancer cells.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Calcium; Caspases; Cell Line, Tumor; Cell Proliferation; Endoplasmic Reticulum; Humans; Immunoblotting; Lactones; Liver Neoplasms; Mice; Mice, Nude; Oxidative Stress; Reverse Transcriptase Polymerase Chain Reaction; Saussurea; Sesquiterpenes; Xenograft Model Antitumor Assays | 2009 |
Dehydrocostuslactone disrupts signal transducers and activators of transcription 3 through up-regulation of suppressor of cytokine signaling in breast cancer cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Caspases; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Female; Humans; Janus Kinases; Lactones; Mice; Mice, Inbred BALB C; Mice, Nude; Sesquiterpenes; Signal Transduction; STAT3 Transcription Factor; Suppressor of Cytokine Signaling Proteins; Up-Regulation; Xenograft Model Antitumor Assays | 2009 |
Protective effects of dehydrocostus lactone against hydrogen peroxide-induced dysfunction and oxidative stress in osteoblastic MC3T3-E1 cells.
Topics: 3T3 Cells; Alkaline Phosphatase; Animals; Calcium; Collagen; Dose-Response Relationship, Drug; Hydrogen Peroxide; Interleukin-6; Lactones; Mice; Osteoblasts; Oxidative Stress; RANK Ligand; Sesquiterpenes | 2009 |
[Studies on chemical constituents of herbs of Oxytropis microphylla].
Topics: Chromatography, High Pressure Liquid; Flavanones; Flavonoids; Kaempferols; Lactones; Oxytropis; Sesquiterpenes; Sitosterols; Spectrometry, Mass, Electrospray Ionization; Stigmasterol; Triterpenes | 2009 |
Oxidative and endoplasmic reticulum stress signaling are involved in dehydrocostuslactone-mediated apoptosis in human non-small cell lung cancer cells.
Topics: Animals; Apoptosis; Calcium; Carcinoma, Non-Small-Cell Lung; Caspases, Initiator; Cell Line, Tumor; DNA-Binding Proteins; eIF-2 Kinase; Endoplasmic Reticulum; Endoribonucleases; Humans; Lactones; Lung Neoplasms; Membrane Proteins; Mice; Mice, Nude; Mitogen-Activated Protein Kinase Kinases; Neoplasm Transplantation; Oxidative Stress; Protein Serine-Threonine Kinases; Reactive Oxygen Species; Regulatory Factor X Transcription Factors; Sesquiterpenes; Signal Transduction; Transcription Factor CHOP; Transcription Factors; Tumor Burden; X-Box Binding Protein 1 | 2010 |
Stereoselective hydrogenation on the exocyclic and conjugated double bond of sesquiterpene lactones by Aspergillus versicolor D-1.
Topics: Aspergillus; Hydrogenation; Lactones; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Sesquiterpenes; Stereoisomerism | 2009 |
Quantitative analysis of costunolide and dehydrocostuslactone in rat plasma by ultraperformance liquid chromatography-electrospray ionization-mass spectrometry.
Topics: Animals; Chromatography, High Pressure Liquid; Drug Stability; Lactones; Linear Models; Rats; Rats, Wistar; Reproducibility of Results; Sensitivity and Specificity; Sesquiterpenes; Spectrometry, Mass, Electrospray Ionization | 2011 |
Dehydrocostus lactone is exuded from sunflower roots and stimulates germination of the root parasite Orobanche cumana.
Topics: Biological Assay; Germination; Helianthus; Lactones; Orobanche; Plant Roots; Rhizosphere; Sesquiterpenes; Species Specificity; Structure-Activity Relationship | 2011 |
Dehydrocostus lactone prevents mitochondrial dysfunction in osteoblastic MC3T3-E1 cells.
Topics: 3T3 Cells; Animals; Antimycin A; Calcium; Cytoprotection; Intracellular Space; Lactones; Mice; Mitochondria; Osteoblasts; Potassium; Sesquiterpenes; Superoxides | 2011 |
Two naturally occurring terpenes, dehydrocostuslactone and costunolide, decrease intracellular GSH content and inhibit STAT3 activation.
Topics: Base Sequence; Blotting, Western; Cell Line, Tumor; Chromatography, High Pressure Liquid; DNA Primers; Electrophoretic Mobility Shift Assay; Glutathione; Humans; Lactones; Phosphorylation; Polymerase Chain Reaction; Reactive Oxygen Species; Sesquiterpenes; STAT3 Transcription Factor | 2011 |
Matrix solid-phase dispersion extraction coupled with HPLC-diode array detection method for the analysis of sesquiterpene lactones in root of Saussurea lappa C.B.Clarke.
Topics: Chromatography, High Pressure Liquid; Drug Stability; Drugs, Chinese Herbal; Lactones; Linear Models; Plant Roots; Reproducibility of Results; Saussurea; Sensitivity and Specificity; Sesquiterpenes; Solid Phase Extraction | 2011 |
The hexane extract of Saussurea lappa and its active principle, dehydrocostus lactone, inhibit prostate cancer cell migration.
Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cell Movement; Cell Survival; Chromatography; Dose-Response Relationship, Drug; Epidermal Growth Factor; Humans; Lactones; Magnetic Resonance Spectroscopy; Male; Matrix Metalloproteinase 9; Mice; Phytotherapy; Plant Extracts; Prostatic Neoplasms; Saussurea; Sesquiterpenes; Tissue Inhibitor of Metalloproteinase-1; Tissue Inhibitor of Metalloproteinase-2 | 2012 |
The effects of dehydrocostus lactone on osteoblastic MC3T3-E1 cells in redox changes and PI3K/Akt/CREB.
Topics: Animals; Anti-Bacterial Agents; Antimycin A; Cell Line; Cyclic AMP Response Element-Binding Protein; Lactones; Mice; Osteoblasts; Oxidation-Reduction; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Sesquiterpenes; Signal Transduction | 2012 |
Dehydrocostuslactone suppresses angiogenesis in vitro and in vivo through inhibition of Akt/GSK-3β and mTOR signaling pathways.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Cells, Cultured; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Lactones; Mice; Neovascularization, Pathologic; Proto-Oncogene Proteins c-akt; Sesquiterpenes; Signal Transduction; TOR Serine-Threonine Kinases | 2012 |
[Screening and identifying hepatotoxic components in Aucklandiae Radix with GC-MS].
Topics: Drugs, Chinese Herbal; Gas Chromatography-Mass Spectrometry; Lactones; Sesquiterpenes | 2012 |
[Study on stability of major pharmaceutical ingredients of vladimiriae radix before and after being roasted in artificial gastric juice, artificial intestinal juice and isolated rat gastric, intestinal or colonic incubation juice].
Topics: Animals; Asteraceae; Chromatography, High Pressure Liquid; Colon; Drug Stability; Drugs, Chinese Herbal; Gastric Juice; Gastric Mucosa; Intestinal Mucosa; Intestinal Secretions; Lactones; Male; Plants, Medicinal; Rats; Rats, Wistar; Sesquiterpenes | 2012 |
[Chemical constituents from a portion of ethanolicextract of Saussurea lappa roots].
Topics: Ethanol; Glucosides; Lactones; Plant Roots; Saussurea; Sesquiterpenes; Sesquiterpenes, Eudesmane | 2012 |
[Chemical constituents of Dolomiaea souliei].
Topics: 4-Butyrolactone; Asteraceae; Betulinic Acid; Emodin; Lactones; Pentacyclic Triterpenes; Sesquiterpenes; Triterpenes; Ursolic Acid | 2012 |
Effect of costunolide and dehydrocostus lactone on cell cycle, apoptosis, and ABC transporter expression in human soft tissue sarcoma cells.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Blotting, Western; Caspase 3; Caspase 7; Cell Cycle; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Enzyme Activation; Gene Expression Regulation, Neoplastic; Humans; Inhibitory Concentration 50; Lactones; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Proteolysis; Real-Time Polymerase Chain Reaction; Sarcoma; Saussurea; Sesquiterpenes; Time Factors | 2012 |
Simultaneous determination of bioactive components in essential oil of Xiang-Fu-Si-Wu Formula in Beagle dog plasma by UPLC-MS/MS and its application to pharmacokinetics.
Topics: 4-Butyrolactone; Animals; Chromatography, High Pressure Liquid; Dogs; Female; Lactones; Reproducibility of Results; Sesquiterpenes; Tandem Mass Spectrometry | 2013 |
Sesquiterpene lactones downregulate G2/M cell cycle regulator proteins and affect the invasive potential of human soft tissue sarcoma cells.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Collagenases; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p27; Down-Regulation; Drug Screening Assays, Antitumor; G2 Phase Cell Cycle Checkpoints; Gene Expression; High-Throughput Screening Assays; Humans; Lactones; Neoplasm Invasiveness; Sarcoma; Sesquiterpenes; Tumor Suppressor Protein p53 | 2013 |
Dehydrocostuslactone, a sesquiterpene lactone activates wild-type and ΔF508 mutant CFTR chloride channel.
Topics: Animals; Colforsin; Cystic Fibrosis Transmembrane Conductance Regulator; Lactones; Mice; Mutation; Rats; Sesquiterpenes | 2013 |
Apolar Laurus nobilis leaf extracts induce cytotoxicity and apoptosis towards three nervous system cell lines.
Topics: Animals; Antioxidants; Apoptosis; Cell Line; Cell Line, Tumor; Gas Chromatography-Mass Spectrometry; Glioma; Humans; Lactones; Laurus; Neuroblastoma; Neuroprotective Agents; Plant Extracts; Plant Leaves; Rats; Sesquiterpenes; Sesquiterpenes, Eudesmane; Terpenes | 2013 |
Pharmacokinetic study on costunolide and dehydrocostuslactone after oral administration of traditional medicine Aucklandia lappa Decne. by LC/MS/MS.
Topics: Animals; Asteraceae; Drug Interactions; Lactones; Male; Medicine, Chinese Traditional; Molecular Structure; Rats; Rats, Wistar; Sesquiterpenes | 2014 |
Costunolide and Dehydrocostuslactone, two natural sesquiterpene lactones, ameliorate the inflammatory process associated to experimental pleurisy in mice.
Topics: Acute Lung Injury; Animals; Anti-Inflammatory Agents; Carrageenan; Disease Models, Animal; Lactones; Male; Mice; NF-kappa B; Pleurisy; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Sesquiterpenes; STAT3 Transcription Factor; Tyrosine | 2014 |
Gastrointestinal effect of methanol extract of Radix Aucklandiae and selected active substances on the transit activity of rat isolated intestinal strips.
Topics: Animals; Asteraceae; Dose-Response Relationship, Drug; Female; Gastric Emptying; Gastrointestinal Motility; Gastrointestinal Transit; Jejunum; Lactones; Male; Methanol; Mice; Muscle Contraction; Parasympatholytics; Plant Extracts; Rats; Rats, Wistar; Rhizome; Sesquiterpenes | 2014 |
Growth inhibitory, bactericidal, and morphostructural effects of dehydrocostus lactone from Magnolia sieboldii Leaves on antibiotic-susceptible and -resistant strains of Helicobacter pylori.
Topics: Anti-Bacterial Agents; Dose-Response Relationship, Drug; Drug Resistance, Bacterial; Helicobacter pylori; Hydrogen-Ion Concentration; Lactones; Magnolia; Microbial Sensitivity Tests; Microbial Viability; Molecular Structure; Plant Leaves; Sesquiterpenes; Urease | 2014 |
Study on the pharmacokinetics and metabolism of costunolide and dehydrocostus lactone in rats by HPLC-UV and UPLC-Q-TOF/MS.
Topics: Animals; Chromatography, High Pressure Liquid; Feces; Lactones; Mass Spectrometry; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sesquiterpenes | 2014 |
Dehydrocostuslactone inhibits LPS-induced inflammation by p38MAPK-dependent induction of hemeoxygenase-1 in vitro and improves survival of mice in CLP-induced sepsis in vivo.
Topics: Animals; Anti-Inflammatory Agents; Cecum; Cell Line; Cell Survival; Dinoprostone; Gene Silencing; Heme Oxygenase-1; Lactones; Ligation; Lipopolysaccharides; Liver; Lung; Macrophages; Membrane Proteins; Mice; NF-E2-Related Factor 2; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Sepsis; Sesquiterpenes | 2014 |
Inhibition of inflammatory and proliferative responses of human keratinocytes exposed to the sesquiterpene lactones dehydrocostuslactone and costunolide.
Topics: Anti-Inflammatory Agents; Apoptosis; Cell Cycle Checkpoints; Cell Movement; Cell Proliferation; Cells, Cultured; ErbB Receptors; Gene Expression Regulation; Glutathione; Humans; Interferon-gamma; Interleukin-22; Interleukins; Intracellular Space; Keratinocytes; Lactones; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; Sesquiterpenes; STAT1 Transcription Factor; STAT3 Transcription Factor | 2014 |
Inhibition of Wnt/β-Catenin Pathway by Dehydrocostus Lactone and Costunolide in Colon Cancer Cells.
Topics: beta Catenin; Blood Proteins; Cell Cycle Checkpoints; Cell Line, Tumor; Colorectal Neoplasms; Cyclin D1; Galectin 3; Galectins; Humans; Inhibitor of Apoptosis Proteins; Lactones; Plant Roots; Saussurea; Sesquiterpenes; Survivin; Wnt Signaling Pathway | 2015 |
Dehydrocostus lactone suppressed the proliferation, migration, and invasion of colorectal carcinoma through the downregulation of eIF4E expression.
Topics: Cell Cycle; Cell Line, Tumor; Cell Movement; Cell Proliferation; Colorectal Neoplasms; Down-Regulation; Eukaryotic Initiation Factor-4E; Humans; Lactones; Neoplasm Invasiveness; Sesquiterpenes | 2015 |
Alantolactone from Saussurea lappa Exerts Antiinflammatory Effects by Inhibiting Chemokine Production and STAT1 Phosphorylation in TNF-α and IFN-γ-induced in HaCaT cells.
Topics: Anti-Inflammatory Agents; Cell Line; Chemokine CCL17; Chemokine CCL22; Chemokine CCL5; Chemokines; Enzyme-Linked Immunosorbent Assay; Humans; Interferon-gamma; Interleukin-8; Keratinocytes; Lactones; Phosphorylation; Plant Extracts; Polycyclic Sesquiterpenes; Saussurea; Sesquiterpenes; Sesquiterpenes, Eudesmane; STAT1 Transcription Factor; STAT5 Transcription Factor; Tumor Necrosis Factor-alpha; Tumor Suppressor Proteins | 2015 |
Sesquiterpene lactones derived from Saussurea lappa induce apoptosis and inhibit invasion and migration in neuroblastoma cells.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Benzazepines; Caspase 7; Cell Line, Tumor; Cell Movement; Drug Design; Humans; Lactones; Neoplasm Invasiveness; Neuroblastoma; Saussurea; Sesquiterpenes | 2015 |
Dehydrocostus Lactone Inhibits Proliferation, Antiapoptosis, and Invasion of Cervical Cancer Cells Through PI3K/Akt Signaling Pathway.
Topics: Apoptosis; Blotting, Western; Cell Proliferation; Female; Humans; Lactones; Neoplasm Invasiveness; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Sesquiterpenes; Signal Transduction; Tumor Cells, Cultured; Uterine Cervical Neoplasms | 2015 |
[Pharmacokinetics study on costunolide and dehydrocostuslactone after administration of traditional Chinese medicine Weichang'an pills].
Topics: Administration, Oral; Animals; Drugs, Chinese Herbal; Lactones; Male; Rats; Rats, Wistar; Sesquiterpenes; Tablets | 2015 |
Dispirocyclopropyldehydrocostus lactone selectively inhibits acute myelogenous leukemia cells.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Caspase 9; Cell Line, Tumor; Cell Survival; Drug Screening Assays, Antitumor; Humans; Lactones; Leukemia, Myeloid, Acute; Mice; Mice, SCID; Neoplasms; Poly(ADP-ribose) Polymerases; Prodrugs; Sesquiterpenes; Transplantation, Heterologous; Up-Regulation | 2016 |
A new sesquiterpenoid from Saussurea lappa roots.
Topics: Countercurrent Distribution; Lactones; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Structure; Plant Roots; Saussurea; Sesquiterpenes | 2016 |
Evaluation of protective effects of costunolide and dehydrocostuslactone on ethanol-induced gastric ulcer in mice based on multi-pathway regulation.
Topics: Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Antioxidants; Ethanol; Lactones; Mice; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Oxidative Stress; Sesquiterpenes; Stomach; Stomach Ulcer; Tumor Necrosis Factor-alpha | 2016 |
"Click" reaction mediated synthesis of costunolide and dehydrocostuslactone derivatives and evaluation of their cytotoxic activity.
Topics: Antineoplastic Agents; Drug Screening Assays, Antitumor; Humans; Lactones; Molecular Structure; Plant Roots; Plants, Medicinal; Saussurea; Sesquiterpenes | 2016 |
Bioassay-guided isolation of dehydrocostus lactone from Saussurea lappa: A new targeted cytosolic thioredoxin reductase anticancer agent.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Cytosol; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; HeLa Cells; Hep G2 Cells; Humans; Inhibitory Concentration 50; Lactones; Oxidation-Reduction; Plant Extracts; Rats; Reactive Oxygen Species; Recombinant Proteins; Saussurea; Sesquiterpenes; Sulfhydryl Compounds; Thioredoxin-Disulfide Reductase | 2016 |
Costunolide and dehydrocostuslactone combination treatment inhibit breast cancer by inducing cell cycle arrest and apoptosis through c-Myc/p53 and AKT/14-3-3 pathway.
Topics: 14-3-3 Proteins; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Breast Neoplasms; Cell Cycle Checkpoints; Cell Line, Tumor; Cyclic AMP; Female; Humans; Lactones; Mice, Inbred BALB C; Mice, Nude; Oils, Volatile; Protein Interaction Maps; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-myc; Sesquiterpenes; Signal Transduction; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays | 2017 |
Dehydrocostus Lactone Suppresses Proliferation of Human Chronic Myeloid Leukemia Cells Through Bcr/Abl-JAK/STAT Signaling Pathways.
Topics: Cell Proliferation; Humans; Janus Kinase 2; K562 Cells; Lactones; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Proto-Oncogene Proteins c-abl; Proto-Oncogene Proteins c-bcr; Sesquiterpenes; STAT3 Transcription Factor; STAT5 Transcription Factor | 2017 |
Complexation of sesquiterpene lactones with cyclodextrins: synthesis and effects on their activities on parasitic weeds.
Topics: Cyclodextrins; Lactones; Models, Molecular; Plant Weeds; Santonin; Sesquiterpenes; Solubility | 2017 |
Anti-allergic effects of sesquiterpene lactones from Saussurea costus (Falc.) Lipsch. determined using in vivo and in vitro experiments.
Topics: Animals; Anti-Allergic Agents; Bronchoalveolar Lavage Fluid; Cell Degranulation; Cells, Cultured; Dose-Response Relationship, Drug; Female; Interleukin-13; Interleukin-4; Lactones; Lung; Mast Cells; Mice; Mucins; Plant Roots; Rats; Saussurea; Sesquiterpenes; Sesquiterpenes, Eudesmane | 2018 |
Dehydrocostus lactone suppresses cell growth and induces apoptosis in recombinant human papilloma virus‑18 HaCaT cells via the PI3K/Akt signaling pathway.
Topics: Apoptosis; Caspase 3; Caspase 9; Cell Cycle; Cell Proliferation; Cell Survival; Female; Human papillomavirus 18; Humans; Lactones; Papillomavirus Infections; Phosphatidylinositol 3-Kinase; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Sesquiterpenes; Signal Transduction; Uterine Cervical Neoplasms | 2018 |
Dehydrocostus lactone, a sesquiterpene from Saussurea lappa Clarke, suppresses allergic airway inflammation by binding to dimerized translationally controlled tumor protein.
Topics: Animals; Asthma; Biomarkers, Tumor; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Female; Hypersensitivity; Immunoglobulin E; Inflammation; Kinetics; Lactones; Mice, Inbred BALB C; Ovalbumin; Protein Multimerization; Saussurea; Sesquiterpenes; Surface Plasmon Resonance; Tumor Protein, Translationally-Controlled 1 | 2018 |
Protective effects of dehydrocostuslactone on rat hippocampal slice injury induced by oxygen‑glucose deprivation/reoxygenation.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Brain Ischemia; Glucose; Hippocampus; Lactones; Male; Neuroprotective Agents; Oxidative Stress; Oxygen; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Sesquiterpenes | 2018 |
(-)-Gochnatiolide B, synthesized from dehydrocostuslactone, exhibits potent anti-bladder cancer activity in vitro and in vivo.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Humans; Lactones; Mice; Models, Biological; Neoplasms, Experimental; Sesquiterpenes; Treatment Outcome; Urinary Bladder Neoplasms | 2018 |
Pharmacokinetics of costunolide and dehydrocostuslactone after oral administration of Radix aucklandiae extract in normal and gastric ulcer rats.
Topics: Administration, Oral; Animals; Asteraceae; Lactones; Male; Plant Extracts; Plant Roots; Random Allocation; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Stomach Ulcer | 2018 |
Main Allelochemicals from the Rhizosphere Soil of
Topics: Antioxidants; Lactones; Rhizosphere; Saussurea; Scopoletin; Sesquiterpenes | 2018 |
Dehydrocostus Lactone Enhances Chemotherapeutic Potential of Doxorubicin in Lung Cancer by Inducing Cell Death and Limiting Metastasis.
Topics: A549 Cells; Angiogenesis Inhibitors; Animals; Apoptosis; Cell Death; Cell Movement; Cell Proliferation; Doxorubicin; Female; Humans; Lactones; Lung Neoplasms; Mice; Mice, Inbred C57BL; Neoplasm Metastasis; Neovascularization, Pathologic; Sesquiterpenes | 2018 |
Dehydrocostus lactone (DHC) suppresses estrogen deficiency-induced osteoporosis.
Topics: Animals; Bone Resorption; Cell Survival; Female; Lactones; Macrophages; Mice; Mice, Inbred C57BL; Osteoporosis; Ovariectomy; RANK Ligand; Sesquiterpenes | 2019 |
Dehydrocostus Lactone Suppresses LPS-induced Acute Lung Injury and Macrophage Activation through NF-κB Signaling Pathway Mediated by p38 MAPK and Akt.
Topics: Acute Lung Injury; Animals; Anti-Inflammatory Agents; Cells, Cultured; Dose-Response Relationship, Drug; Lactones; Lipopolysaccharides; Macrophage Activation; Macrophages; Male; MAP Kinase Signaling System; Mice; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins c-akt; Sesquiterpenes | 2019 |
Dehydrocostus lactone suppresses osteoclast differentiation by regulating NFATc1 and inhibits osteoclast activation through modulating migration and lysosome function.
Topics: Animals; Bone Resorption; Cell Differentiation; Cell Movement; Cells, Cultured; Female; Lactones; Lysosomes; Macrophages; Mice; NFATC Transcription Factors; Osteoclasts; Sesquiterpenes; Signal Transduction | 2019 |
Dehydrocostus lactone attenuates osteoclastogenesis and osteoclast-induced bone loss by modulating NF-κB signalling pathway.
Topics: Actins; Animals; Biomarkers; Bone Resorption; Cell Differentiation; Gene Expression Regulation; Lactones; Lipopolysaccharides; Macrophages; Male; Mice, Inbred C57BL; NF-kappa B; NFATC Transcription Factors; Osteoclasts; Osteogenesis; Osteolysis; RANK Ligand; Sesquiterpenes; Signal Transduction; Skull | 2019 |
[Effect of Dehydrocostus Lactone on Proliferation of K562 Cells and Its Mechanism].
Topics: Apoptosis; Cell Proliferation; Fusion Proteins, bcr-abl; Humans; K562 Cells; Lactones; Sesquiterpenes | 2019 |
Suppressive effects of dehydrocostus lactone on the toll-like receptor signaling pathways.
Topics: Adaptor Proteins, Vesicular Transport; Animals; Anti-Inflammatory Agents; HEK293 Cells; Humans; Inflammation; Interferon Regulatory Factor-3; Inula; Lactones; Mice; Myeloid Differentiation Factor 88; NF-kappa B; RAW 264.7 Cells; Saussurea; Sesquiterpenes; Signal Transduction; Toll-Like Receptors | 2020 |
Dehydrocostus lactone inhibits NFATc1 via regulation of IKK, JNK, and Nrf2, thereby attenuating osteoclastogenesis.
Topics: Animals; Bone Resorption; Cell Differentiation; Female; I-kappa B Kinase; Lactones; Male; MAP Kinase Signaling System; Mice; Mice, Knockout; NF-E2-Related Factor 2; NF-kappa B; NFATC Transcription Factors; Osteoclasts; Osteogenesis; Proto-Oncogene Proteins c-fos; RANK Ligand; RAW 264.7 Cells; Sesquiterpenes; Signal Transduction; Transcription Factor AP-1 | 2020 |
Dehydrocostus lactone inhibits NLRP3 inflammasome activation by blocking ASC oligomerization and prevents LPS-mediated inflammation in vivo.
Topics: Adult; Animals; Apoptosis Regulatory Proteins; Calcium-Binding Proteins; CARD Signaling Adaptor Proteins; Caspase 1; Chemotaxis, Leukocyte; DNA-Binding Proteins; Drug Evaluation, Preclinical; Drugs, Chinese Herbal; Female; Humans; Inflammasomes; Inflammation; Interleukin-1beta; Lactones; Leukocytes, Mononuclear; Lipopolysaccharides; Macrophages; Mice; Mice, Inbred C57BL; Neutrophils; Nigericin; NLR Family, Pyrin Domain-Containing 3 Protein; Poly I-C; Polymerization; Sesquiterpenes; Specific Pathogen-Free Organisms; Uric Acid | 2020 |
Elevated EPSTI1 promote B cell hyperactivation through NF-κB signalling in patients with primary Sjögren's syndrome.
Topics: Adolescent; Adult; Aged; B-Lymphocytes; Case-Control Studies; Female; Humans; Lactones; Lymphocyte Activation; Male; Middle Aged; Neoplasm Proteins; NF-kappa B; NF-KappaB Inhibitor alpha; Phosphorylation; RNA, Small Interfering; Sesquiterpenes; Sjogren's Syndrome; Toll-Like Receptor 9; Transcription Factor RelA; Young Adult | 2020 |
Dehydrocostus lactone inhibits cell proliferation and induces apoptosis by PI3K/Akt/Bad and ERS signalling pathway in human laryngeal carcinoma.
Topics: Animals; Apoptosis; bcl-Associated Death Protein; Cell Line, Tumor; Cell Movement; Cell Proliferation; Endoplasmic Reticulum Stress; Female; Humans; Lactones; Laryngeal Neoplasms; Mice, Inbred BALB C; Mice, Nude; Models, Biological; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Sesquiterpenes; Signal Transduction | 2020 |
Phytochemical Study of Safflower Roots (Carthamus tinctorius) on the Induction of Parasitic Plant Germination and Weed Control.
Topics: Allelopathy; Carthamus tinctorius; Chromatography, Liquid; Germination; Lactones; Lolium; Orobanche; Plant Extracts; Plant Exudates; Plant Roots; Plant Weeds; Seeds; Sesquiterpenes; Tandem Mass Spectrometry; Weed Control | 2020 |
Costunolide and dehydrocostuslactone from Saussurea lappa root inhibit autophagy in hepatocellular carcinoma cells.
Topics: Autophagy; Carcinoma, Hepatocellular; Humans; Lactones; Liver Neoplasms; Medicine, Kampo; Plant Roots; Saussurea; Sesquiterpenes | 2021 |
Dolomiaea souliei ethyl acetate extract protected against α-naphthylisothiocyanate-induced acute intrahepatic cholestasis through regulation of farnesoid x receptor-mediated bile acid metabolism.
Topics: 1-Naphthylisothiocyanate; Acetates; Alanine Transaminase; Animals; Asteraceae; ATP Binding Cassette Transporter, Subfamily B, Member 11; Bile Acids and Salts; Cholestasis, Intrahepatic; Lactones; Male; Molecular Docking Simulation; Plant Extracts; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Sesquiterpenes | 2021 |
Dehydrocostus lactone inhibits BLM-induced pulmonary fibrosis and inflammation in mice via the JNK and p38 MAPK-mediated NF-κB signaling pathways.
Topics: Animals; Bleomycin; Cells, Cultured; Disease Models, Animal; Humans; Lactones; Lung; Macrophage Activation; Male; MAP Kinase Signaling System; Mice; NF-kappa B; Primary Cell Culture; Pulmonary Fibrosis; Sesquiterpenes | 2021 |
Dehydrocostus Lactone Induces Apoptosis and Cell Cycle Arrest through Regulation of JAK2/STAT3/PLK1 Signaling Pathway in Human Esophageal Squamous Cell Carcinoma Cells.
Topics: Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Humans; Interleukin-6; Janus Kinase 2; Lactones; RNA, Small Interfering; Sesquiterpenes; Signal Transduction; STAT3 Transcription Factor | 2022 |
Dynamics of germination stimulants dehydrocostus lactone and costunolide in the root exudates and extracts of sunflower.
Topics: Chromatography, Liquid; Exudates and Transudates; Germination; Helianthus; Lactones; Orobanche; Plant Extracts; Plant Roots; Sesquiterpenes; Tandem Mass Spectrometry | 2022 |