Compounds > deguelin
Page last updated: 2024-09-02

deguelin and wortmannin

deguelin has been researched along with wortmannin in 3 studies

Compound Research Comparison

Studies
(deguelin)		Trials
(deguelin)		Recent Studies (post-2010)
(deguelin)		Studies
(wortmannin)		Trials
(wortmannin)		Recent Studies (post-2010) (wortmannin)
18201154,0662726

Protein Interaction Comparison

ProteinTaxonomydeguelin (IC50)wortmannin (IC50)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoformHomo sapiens (human)0.0465
Myosin light chain kinase, smooth muscleGallus gallus (chicken)0.26
Metabotropic glutamate receptor 1Rattus norvegicus (Norway rat)0.0085
Phosphatidylinositol 3-kinase regulatory subunit alphaHomo sapiens (human)0.2368
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoformHomo sapiens (human)0.1309
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoformHomo sapiens (human)0.0493
Serine/threonine-protein kinase mTORHomo sapiens (human)0.04
Phosphatidylinositol 4-kinase alphaHomo sapiens (human)0.28
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Homo sapiens (human)0.0492
Serine/threonine-protein kinase PLK1Homo sapiens (human)0.4433
Myosin light chain kinase, smooth muscleHomo sapiens (human)2.3567
Phosphoinositide 3-kinase regulatory subunit 5Homo sapiens (human)0.019
Serine/threonine-protein kinase PLK3Homo sapiens (human)0.1057
Phosphatidylinositol 4-kinase betaHomo sapiens (human)0.44

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (33.33)29.6817
2010's2 (66.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Batista-Gonzalez, A; Brunhofer, G; Fallarero, A; Gopi Mohan, C; Karlsson, D; Shinde, P; Vuorela, P1
Bogush, A; Chan, T; Ehrlich, ME; Gieringer, T; Mao, Z; Pedrini, S; Pelta-Heller, J; Sluzas, E; Yang, Q1
Fujita, S; Inui, T; Kobayashi, M; Murayama, S; Ogiso, B; Takei, H; Yamamoto, K1

Other Studies

3 other study(ies) available for deguelin and wortmannin

ArticleYear
Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.
    Bioorganic & medicinal chemistry, 2012, Nov-15, Volume: 20, Issue:22

    Topics: Acetylcholinesterase; Amyloid beta-Peptides; Benzophenanthridines; Binding Sites; Butyrylcholinesterase; Catalytic Domain; Cholinesterase Inhibitors; Humans; Isoquinolines; Kinetics; Molecular Docking Simulation; Structure-Activity Relationship

2012
AKT and CDK5/p35 mediate brain-derived neurotrophic factor induction of DARPP-32 in medium size spiny neurons in vitro.
    The Journal of biological chemistry, 2007, Mar-09, Volume: 282, Issue:10

    Topics: Androstadienes; Animals; Brain-Derived Neurotrophic Factor; Cells, Cultured; Cyclin-Dependent Kinase 5; Dopamine and cAMP-Regulated Phosphoprotein 32; Huntington Disease; Mice; Nerve Tissue Proteins; Neurons; Phosphatidylinositol 3-Kinases; Protein Kinases; Proto-Oncogene Proteins c-akt; Rotenone; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Wortmannin

2007
Extracellular glucose-dependent IPSC enhancement by leptin in fast-spiking to pyramidal neuron connections via JAK2-PI3K pathway in the rat insular cortex.
    Neuropharmacology, 2019, 05-01, Volume: 149

    Topics: AMP-Activated Protein Kinase Kinases; Animals; Cerebral Cortex; Chromones; Cortical Excitability; Electric Stimulation; Flavonoids; GABAergic Neurons; Glucose; Inhibitory Postsynaptic Potentials; Janus Kinase 2; Leptin; Mitogen-Activated Protein Kinase Kinases; Morpholines; Patch-Clamp Techniques; Phosphoinositide-3 Kinase Inhibitors; Primary Cell Culture; Protein Kinases; Proto-Oncogene Proteins c-akt; Pyramidal Cells; Pyrazoles; Pyrimidines; Rats; Rats, Transgenic; Rotenone; Signal Transduction; Synaptic Transmission; Wortmannin

2019