deguelin has been researched along with sirolimus in 6 studies
| Studies (deguelin) | Trials (deguelin) | Recent Studies (post-2010) (deguelin) | Studies (sirolimus) | Trials (sirolimus) | Recent Studies (post-2010) (sirolimus) |
|---|---|---|---|---|---|
| 182 | 0 | 115 | 20,711 | 2,368 | 11,516 |
| Protein | Taxonomy | deguelin (IC50) | sirolimus (IC50) |
|---|---|---|---|
| Bile salt export pump | Homo sapiens (human) | 10 | |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | 1.25 | |
| Cytochrome P450 3A4 | Homo sapiens (human) | 2 | |
| Cytochrome P450 2C9 | Homo sapiens (human) | 2 | |
| Peptidyl-prolyl cis-trans isomerase FKBP1A | Mus musculus (house mouse) | 0.001 | |
| Cytochrome P450 2C19 | Homo sapiens (human) | 4 | |
| Serine/threonine-protein kinase mTOR | Homo sapiens (human) | 0.0897 | |
| Peptidyl-prolyl cis-trans isomerase FKBP1A | Homo sapiens (human) | 0.0042 | |
| Regulatory-associated protein of mTOR | Homo sapiens (human) | 0.225 | |
| Target of rapamycin complex subunit LST8 | Homo sapiens (human) | 0.225 | |
| Broad substrate specificity ATP-binding cassette transporter ABCG2 | Homo sapiens (human) | 1.9 | |
| Solute carrier organic anion transporter family member 1B1 | Homo sapiens (human) | 1.1 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 5 (83.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Batista-Gonzalez, A; Brunhofer, G; Fallarero, A; Gopi Mohan, C; Karlsson, D; Shinde, P; Vuorela, P | 1 |
| Bogush, A; Chan, T; Ehrlich, ME; Gieringer, T; Mao, Z; Pedrini, S; Pelta-Heller, J; Sluzas, E; Yang, Q | 1 |
| Dennis, PA; Memmott, RM | 1 |
| Arulampalam, V; Björklund, AC; Grandér, D; Hjortsberg, L; Kolosenko, I; Tamm, KP | 1 |
| Cai, S; Cichewicz, RH; Mooberry, SL; Robles, AJ | 1 |
| Chang, NC; Lee, TM; Lin, SZ | 1 |
6 other study(ies) available for deguelin and sirolimus
| Article | Year |
|---|---|
Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.
Topics: Acetylcholinesterase; Amyloid beta-Peptides; Benzophenanthridines; Binding Sites; Butyrylcholinesterase; Catalytic Domain; Cholinesterase Inhibitors; Humans; Isoquinolines; Kinetics; Molecular Docking Simulation; Structure-Activity Relationship | 2012 |
AKT and CDK5/p35 mediate brain-derived neurotrophic factor induction of DARPP-32 in medium size spiny neurons in vitro.
Topics: Androstadienes; Animals; Brain-Derived Neurotrophic Factor; Cells, Cultured; Cyclin-Dependent Kinase 5; Dopamine and cAMP-Regulated Phosphoprotein 32; Huntington Disease; Mice; Nerve Tissue Proteins; Neurons; Phosphatidylinositol 3-Kinases; Protein Kinases; Proto-Oncogene Proteins c-akt; Rotenone; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Wortmannin | 2007 |
The role of the Akt/mTOR pathway in tobacco carcinogen-induced lung tumorigenesis.
Topics: Animals; Carcinogens; Humans; Indoles; Inositol; Intracellular Signaling Peptides and Proteins; Lung Neoplasms; Mice; Nicotiana; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Rotenone; Signal Transduction; Sirolimus; Smoking; TOR Serine-Threonine Kinases | 2010 |
Activation of STAT1 is required for interferon-alpha-mediated cell death.
Topics: Apoptosis; Cell Death; Cell Line, Tumor; HSP90 Heat-Shock Proteins; Humans; Interferon-alpha; Mutant Proteins; Oncogene Protein v-akt; Phosphorylation; Protein Kinase Inhibitors; Rotenone; Signal Transduction; Sirolimus; STAT1 Transcription Factor; Transfection | 2011 |
Selective activity of deguelin identifies therapeutic targets for androgen receptor-positive breast cancer.
Topics: Animals; Antineoplastic Agents; Benzamides; Cell Line, Tumor; Cell Nucleus; Cell Proliferation; Cell Survival; Drug Synergism; Female; Gene Expression Regulation, Neoplastic; Humans; Mice; Nitriles; Phenylthiohydantoin; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Receptors, Androgen; Rotenone; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Triple Negative Breast Neoplasms; Xenograft Model Antitumor Assays | 2016 |
Effect of lithium on ventricular remodelling in infarcted rats via the Akt/mTOR signalling pathways.
Topics: Animals; Carrier Proteins; Dilatation; Fibrosis; GATA4 Transcription Factor; Heart Ventricles; Intracellular Signaling Peptides and Proteins; Lithium Compounds; Male; MAP Kinase Signaling System; Myocardial Contraction; Myocardial Infarction; NFATC Transcription Factors; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Rotenone; Sirolimus; Stimulation, Chemical; Time Factors; TOR Serine-Threonine Kinases; Ventricular Remodeling | 2017 |