Compounds > deguelin
Page last updated: 2024-09-02

deguelin and 2-(3,4-dimethoxyphenyl)-1-(5-methoxy-2,2-dimethyl-2h-chromen-6-yl)ethanone

deguelin has been researched along with 2-(3,4-dimethoxyphenyl)-1-(5-methoxy-2,2-dimethyl-2h-chromen-6-yl)ethanone in 4 studies

Compound Research Comparison

Studies
(deguelin)		Trials
(deguelin)		Recent Studies (post-2010)
(deguelin)		Studies
(2-(3,4-dimethoxyphenyl)-1-(5-methoxy-2,2-dimethyl-2h-chromen-6-yl)ethanone)		Trials
(2-(3,4-dimethoxyphenyl)-1-(5-methoxy-2,2-dimethyl-2h-chromen-6-yl)ethanone)		Recent Studies (post-2010) (2-(3,4-dimethoxyphenyl)-1-(5-methoxy-2,2-dimethyl-2h-chromen-6-yl)ethanone)
1820115909

Protein Interaction Comparison

ProteinTaxonomydeguelin (IC50)2-(3,4-dimethoxyphenyl)-1-(5-methoxy-2,2-dimethyl-2h-chromen-6-yl)ethanone (IC50)
Heat shock protein HSP 90-alphaHomo sapiens (human)0.09
Hypoxia-inducible factor 1-alphaHomo sapiens (human)2.15

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's4 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
An, H; Cha, JH; Chang, DJ; Han, YT; Jung, J; Kim, HH; Kim, JH; Kim, KS; Kim, KW; Kim, NJ; Kim, SG; Lee, G; Lee, HY; Lee, JM; Lee, JS; Lee, S; Lee, SC; Park, JH; Park, JW; Suh, YG; Yun, H1
Choi, H; Hong, M; Kim, HS; Kim, J; Kim, JH; Kim, JY; Kim, KW; Kim, YM; Lee, HY; Lee, J; Lee, SC; Oh, DC; Park, HJ; Park, SJ; Seo, JH; Suh, YG1
Ann, J; Choi, H; Hong, M; Kim, HS; Kim, J; Kim, JY; Kim, KW; Kim, YM; Lee, HY; Lee, J; Lee, SC; Nguyen, CT; Park, HJ; Park, SJ; Seo, JH; Suh, YG; Yoon, S1
Li, W; Ma, C; Wang, G; Xie, S; Xu, F; Xu, J; Xu, S; Yao, H; Zhu, Z1

Other Studies

4 other study(ies) available for deguelin and 2-(3,4-dimethoxyphenyl)-1-(5-methoxy-2,2-dimethyl-2h-chromen-6-yl)ethanone

ArticleYear
Design, synthesis, and biological evaluation of novel deguelin-based heat shock protein 90 (HSP90) inhibitors targeting proliferation and angiogenesis.
    Journal of medicinal chemistry, 2012, Dec-27, Volume: 55, Issue:24

    Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Benzopyrans; Cell Line, Tumor; Cell Proliferation; Drug Design; Drug Screening Assays, Antitumor; Embryo, Nonmammalian; HSP90 Heat-Shock Proteins; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Neovascularization, Physiologic; Protein Binding; Rotenone; Stereoisomerism; Structure-Activity Relationship; Zebrafish

2012
Ring-truncated deguelin derivatives as potent Hypoxia Inducible Factor-1α (HIF-1α) inhibitors.
    European journal of medicinal chemistry, 2015, Nov-02, Volume: 104

    Topics: Angiogenesis Inhibitors; Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Endothelial Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Molecular Structure; Retinal Vessels; Rotenone; Structure-Activity Relationship

2015
Synthesis and biological evaluation of C-ring truncated deguelin derivatives as heat shock protein 90 (HSP90) inhibitors.
    Bioorganic & medicinal chemistry, 2016, 11-15, Volume: 24, Issue:22

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; HSP90 Heat-Shock Proteins; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Models, Molecular; Molecular Structure; Neovascularization, Pathologic; Rotenone; Structure-Activity Relationship

2016
Design, synthesis, and biological evaluation of truncated deguelin derivatives as Hsp90 inhibitors.
    European journal of medicinal chemistry, 2019, Apr-01, Volume: 167

    Topics: Antineoplastic Agents; Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumor; Drug Design; Drug Screening Assays, Antitumor; HSP90 Heat-Shock Proteins; Humans; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasms; Proteasome Endopeptidase Complex; Rotenone; Structure-Activity Relationship

2019